What is LP(a)? Does It Cause Heart Disease?
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- เผยแพร่เมื่อ 13 ก.ย. 2021
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Wow! This was the detoxing that I needed after watching Peter Attias LP a talk
These past two years of watching various online doctors presenting information has horrified me at how *evil* the pharma industry and the captured government agencies are.
I absolutely love this man - his teachings AND his humor! He’s definitely worth listening to…
1¹W¹
Good in depth analysis. I wish all doctors had research this to this level.
This is exactly what I needed at the exact right time. Excellent job Dr. Nadir!
My internist, PCP, thinks I'm killing myself on the carnivore diet because I'm not taking a statin and my LP(a) is 48. She has such a closed mind to anything other than what corporate medicine has to say. It is so sad that we have to get the truth from TH-cam. Thank you Dr. Ali.
After a lipid panel with low triglycerides, high HDL (1:1) and 'high' LDL in which my doctor immediately suggested statins, I have been on a three day deep-dive of lipids and heart disease including articles, youtube videos and Malcolm Kendrick's latest book (excellent), I had one last question that was proving difficult to find an answer for amidst the tangle of lipid discussions - 'could I have high LP(a) and do I care?' This excellent video has cleared this up thoroughly and efficiently and with zero impulses to choose a higher speed :-) Thanks!!!
I'm kind of in the same boat. I'm a 65-year-old male, BMI of 19 (135 lb / 61kg), total cholesterol 553, LDL 474 (large or Pattern A), HDL 86, trig 56, VLDL too low to be measured, Lp(a) 18, HS-CRP 0.95 and insulin of 6.7. The LabCorp test results said the ApoB (at 256) was high, and it took some research to learn that high TC also means a high ApoB.
@@ssa8479 you are going to have a HA - I would jump on a statin and get lp(a) checked abd calcium score - good luck you but those numbers are crazy dangerous
@@mrjeffvan I have a screen shot of an old Lipitor ad that says it hasn't been shown to prevent heart disease or heart attacks.
I consulted a cardiologist and looked up the Mayo, Framingham and Reynolds statin calculators online. I have a 9% risk of 'cardiac event' in the next 10 years WITHOUT a statin, 7% risk WITH a statin. I count that as a difference of 2%.
My Lp(a), at 18.2, is low/very good; it should be
@@mrjeffvan I posted a detailed reply, which seems to have been blocked. I don’t care enough to do it again. You could search in TH-cam for ‘Dr. Robert Lustig carbs statins’ for a short answer that offers insights.
You’re my absolute favorite low-carb centric influencer., and at the very top of my list. Your talks help us to deepen our understandings of our metabolism, and are at the same time very understandable. Keep it up!
Wonderful presentation by Dr Ali. Watched it for the third time. In fact I watch all his videos repeatedly and every time I get amazed at the foolishness of mainstream medicine. Dr Ali, pl keep educating the public, you are doing the job of God.
This is tremendously good analysis. Finally someone who is willing to see through the bullshit and form a hypothesis that actually fits the data. Kudos! Excellent information!
Since this video was 2 years ago, does this information still hold true? Now that I’ve been searching this topic, this damn Lp(a) is filling my feed with all kinds of videos and stressing me out. lol. Seems other doctors want to push lowering it using pcsk9s and yet sounds like Dr Ali would not necessarily treat someone with a high Lp(a). Do you have any current Dr Ali information on this topic?
@@garybritting1892I’ve been searching as well. Just got a score of 100mg little a. It sucks but I’m glad that at least I know I have it.
@@garybritting1892 From this information, I'm inclined to believe Lp (a) may have some evolutionary benefits that outweigh it's clotting capacity associated problems? I have off planet high Lp (a) and heal extremely rapidly from cuts/wounds.
@@wolfwalker5924 I appreciate the reply and optimism. I find it hard to believe, evolutionarily, that the human body would evolve to destroy itself with this unique blood lipid molecule. I can control outside factors like diet, stress, & exposure to toxic chemicals, etc, but to think this blood marker alone would be designed to kill off a human early seems unrealistic. I wonder if big pHARMA is looking for more ways to stir the fear pot since having high LDL isn’t doing it anymore. Definitely makes me wonder.🤔
@@garybritting1892 Very fair and astute conclusion. Watch this Your Tube video, especially the end, to confirm your suspicion. "Advances in Lipoprotein (a) | Cardiology Grand Rounds" I'd give the link but You Tube doesn't allow it and if I did so this reply would be deleted.
Doctor 🧑⚕️ i hope you reads this
The way you started from ground zero assuming we dont know much about LP (a) shows you are willing to explore the truth and start again. Thanks and continue the critical work
I was diagnosed through the Boston Heart program with high Lp(a), and put on a statin and a Vegan, no oil diet. I GAINED weight and my Lp(a) went up and my doctor was unable to explain it. Thank you for explaining it.
I think western doctors don't know crap about lp(a)
@ dawnmc3101 apo(a) goes up when on statin. The main goal is to lower ApoB and the inflammation with a statin. No treatment for lp(a) for the moment, only PSCK9 which lowers it by 20/30%.
Nerdiness is necessary for me. If I understand why, it makes sense and helps me remember the process. Also, I am a visual learner with a slow processor and the slides really help! I listened first, then watched, and took notes. A definite nerd!
Your presentation reminds me that Linus Pauling (Nobel prize winner in chemistry) and a Dr. Rath from Germany, received a US Patent 5,278,189 for treating blocked arteries in the 1990s which is apparently not well known today. Their theory was that arteries are subject to high pressure due to the force of the heart ejecting blood into the circulatory system, which could cause lesions/inflammation to the artery walls. To heal the lesions, the body must create collagen to patch up the "hole". Satisfactory levels of Vitamin C and certain amino acids such as l-Lycine and l-Proline were suggested as necessary to patch the lesions. As you point out in the video, the great apes are seemingly alone in creating lipoprotein (a). Interesting, we are also seeming alone (except for guinea pigs) in being unable to self-manufacture Vitamin C which is required for the manufacture of collagen. They postulated that lipoprotein (a) was a "work around" to compensate for low levels of vitamin C, especially in the 6 months of the year that vitamin C was low in the diet (outside of the equator), to ensure our survival as a species. (Think of the Ice Ages when the human race almost became extinct due to famine, malnutrition, exposure etc.) Lipoprotein (a) was postulated as a "band aid" to patch the lesion pending true healing with collagen mediated by Vitamin C, and to prevent death by way of subclinical(?) scurvy. Just a few years ago in 2018 Dr Rath, who is based in Germany, used genetically modified mice which produce lipoprotein (a), and which can not produce vitamin C (unlike normal mice) to successfully demonstrate the proposed mechanism in the lab. (See: www.drrathresearch.org/research/projects/heart-disease) Presentations were made in the Netherlands. I don't think this attracted much attention in the US, where we are apparently more preoccupied with reducing cholesterol levels rather than than solving the underlying problem of arterial injury and inflammation!? So yes, perhaps lipoprotein (a) may have ensured the survival of our species. Your thoughts as a true subject matter expert would be welcomed!!
Thanks for sharing the information. I keep my ears open to seek the truth of Lp(a)
Here, in the ancient Indian system of medicine, Ayurveda, the underlying issue of inflammation is targeted and the focus is always on lowering inflammation.
Amen brother! From all my research, I agree with your assessment that because we cannot produce our own vitamin C, we have to depend on LDL and LP(a) to patch a tear or deal with inflammation of our damaged arteries...If we keep enough vitamin C in our system, then this could provide the needed collagen to repair the damaged artery without LDL, LP(a) and all the immune cells getting involved and thus avoiding the typical plaque buildup...
(I have read that endothelium dysfunction is a type of minor scurvy that needs vitamin C to heal properly)
Hi Keith! I have been searching for more info about Dr. Rath and his findings about this particularly the protocol suggested to use vitamin c, proline and lysine in order to unblock already clogged arteries of the heart or wherever in patients who are already diagnosed with CAD. I find so much conflicting information on this, I don't know what to believe. Have you found the right dosages to not only prevent plaque from forming new but also optimally enough to repair old blockages? My doctors don't care about any of this and I want to do something that gives me the best chance at reversing my condition and not just stopping how i got here. Please Keith, whatever you can share would be seriously appreciated sir... I really need help and I believe in the findings of Pauling and Rath but that their findings are purposely being held back
Amen...agree 100%...but how many more years will it take main stream medical doctors to acknowledge this true science of how atherosclerosis is formed.
Thank you so very much for explaining Lp(a)! You may be nerdy but you did a completely understandable lecture.
Stay “Nerdy” doctor…we really need more critical thinking in the medical field, instead of all resources on new drug development (to get rich on!). Thank you for your good work and trying to spread knowledge to the masses!
Hope an independent researchers will be financed by the government
Money maker drugs “fix” a made up problem and causes 10 other problems that all need drugs that big pharma of course has a pill for.
This was so timely 🙏🏽 god bless you doc :)👍
love your nerdiness!! 10 min ago I thought I was doomed! After listening to you I am very encouraged!! Yes my high CRP and high lipoprotein A are probably correlated. thank you for this info!!!
I had a similar reaction
Ditto...
Dr. Ali i appreciate your out of the box thinking. Keep the lectures coming.
THAT WAS REALLY GREAT! Very thorough and enlightening :D Thank you!
What a great doctor and researcher you are, bravo
ThIs PRESENTATION was ABSOLUTELY INCREDIBLE!
Dr. Nadir it is a pleasure to listen you. You put into words what I have believed for long time. Critical thinking in medicine is dead. Everything is protocol. I can’t wait to purchase your book.
Ginge Brien, M.D.
Thank you for this video as it makes me more hopeful. Much appreciated.
Brilliant presentation, as usual!
Thank you so much for sharing this info. Very useful. I really liked how you presented it.
Excellent content! Very helpful thank you!!
Thank you, Dr. Ali. This presentation is marvelous. Your verbal skills are clear and precise, and I appreciate your speaking slowly and deliberately when discussing these complex topics.
By the way, you look very good and youthful. The diet and biking are serving you well. All the best.
We might have got away from using blood letting as a means of curing disease, but we certainly havent got away from the knee jerk reaction without understanding what we are doing. I have to admit I struggle to follow some of your videos, but its slowly sinking in, I'll get there eventually, please keep up the good work, its definitely appreciated ❤
Highly informative! Everything you said makes so much sense. Thank you, sir.
Hope there will be a debate for us to balance and know the truth. We want Dr. Ali for challenging the status quo.
Wow.. great presentation of all of the data on Lp(a) not just what big pharma wants us to see.
Thank you.. I find it interesting b/c I kept thinking of those points after I was told I have a high Lp (a)-why does the body make it? It’s gotta have a purpose..🤔
All my other markers are completely normal except for the amount of small particle sized cholesterol-hope you have another video on that.. I will look ..🤓
Wow! I always wondered why nature would make Lp(a) to cause harm and Dr. Nadir Ali's nerdy talk explained a new perspective wonderfully. Keep such educative talks coming Dr. Ali - there are enough nerds out there who love to learn from your talks!
Fantastic video. Thank you!
Thanks to your detailed view of LP(a), with mine elevated, you are helping me to believe that it is not necessarily my death sentence. A year ago, since diagnosed with ACVD, thanks to a requested CAC test, I have lost 85 lbs.(235 down to150), BP down below normal, and only eating clean foods, those from the ground-and animals that eat the food from the ground...basically clean as possible. CRP and every other bio marker (apart from LP(a)) are down to better than normal levels. But, until now, I believed my elevated LP(a) was a sure immediate death sentence. Your excellent presentation (firefighter vs arsonist), gave me encouragement to continue the new path I've chosen. That is, I now have a better chance to affect health span as well as Lifespan! Thank you!
your are right. the last couple of days since I found out my LPa level I almost started to wonder why I don't have a heart attack or stenosis by now at 66. Finally, Dr Ali presents the nuance that is missing in the Quest result.
If you look at comments from people here it will be difficult to not get some critical thinking about how bad LP (a) realy is(if bad at all) . The root problem can't be the colesterol, but what makes the colesterol bad,(inflamation) it's certanly not the colesterol itself. So Dr.Nasir it's great listening to you!
Yes. Inflammation is the part that makes cholesterol bad. Just stop the inflammation.
Lp-a is extremely sticky, it's used by the body as a substitute for vitamin C. It is responsible for starting the plaqueing process of the artery in the absence of vitamin C.
Just the arterie, not the vains? Why? I don't think it will do harm at all , until the damaging of blood wessels appear!
Another excellent presentation. Be it known that I have stolen your line . “Is cholesterol the arson or the fighter fighter. And I give you the credit! 😁
Excellent information. I am a 55 fit female who’s recent labwork shows elevated LPa at 74. Remaining lipid profile normal with cholesterol tipping toward higher end of normal. I was started on niacin to bring down LPa. The studies you share are mind blowing as to what mainstream Healthcare is sharing. Thanks so much.
How are you doing on the niacin?
@@dougcoleburn1579 I need to get follow up blood work done. My HDL is high too which is good but mine may be contributing to high LPa. That said I stopped taking omega 3’s and in a couple months I will re-evaluate with blood work.
Has Niacin helped? Any pointers helpful
My LPa has come down slightly with Niacin although I stopped taking as my liver enzymes shot up. My ALT and AST are slightly elevated. A liver scan shows no fibrosis. Sometimes I wonder if because we are all different, blood work is just relative to how our bodies work. I am not getting over anxious about the LPa anymore. I eat nutritious, avoid seed oils and processed foods and continue working out regularly both cardio and weights. I feel good, really good so am not going to stress to much.
@@vlholla -
-Niacin decreases Lp(a) levels by 23%; however, it is not recommended for use because it lacks mortality and morbidity benefit in patients at risk of cardiovascular disease (CVD). Additionally, its adverse effect profile limits use.
This is so good for me to hear as I have high levels of LPa
Thanks Dr Ali for wonderful explanation making me so happy because I had a history of constantly Lp(a) 150 and 3 MIs with Stent.
How was your lifestyle and diet? Smoker? Also measurement was in mg/dl or nmol/l?
Thank you for asking.
I was never smoker or drinker, hard working responsible person, living on poor carbohydrate food and cotton seeds Oil fried food. Sorry, many people lives were the same and noway complains.
We were young and live was beautiful 😊
@@davidcameron9151I was measured first in nmol in russia and second time in mgdl in india?in which should we measure
First encouraging message for people with high LpA. Thanks for the detailed analysis Doctor. I was never convinced how it is ok for statins to be considered ok for someone with LpA even as it raises it. Unrelated, I have seen it go down wity diet, so in my view more studies are needed before they conclude that it is invariant all life. Thanks again.
This was fascinating, thanks! My LP(a) was 121 at my last lab test, and really had me scared. Thanks for this information!
mine is 250!
Mine is 141
242 here. I am 60 and still alive with no heart events. They say this level is set from age 5. So me and my LP(a) have been together over 50 years now! I take it serious as a risk marker. And want to know more about it.
@@markhicks5569hello sir what diet you are eating and how lipoprotien a should check in mgdl or nmoll
@@RohitKumar-ei2dwhigh protein low carb. 150 grams proteins and less then 20 grams carbs. Fats around 50 grams as they come with the whole real foods I eat. Lost 75 lbs. vastly improved all markers and have fasting insulin of 4 and crp .4. Inflammation is critical to resolve if high lp(a).
Thank you for sharing your knowledge ; sharing is caring . Bless you Dr & I am grateful .
absolutely great, enjoyed it much :)
regarding L8a) in severe infections: I think it is actively downregulated, since everything the body is trying to improve flow = reducing viscosity at all costs.
But surely, there is regulation, up and down, across a wide range
Excellent! Thank you.
Great video I would like to see you as a patient. Own very busy anesthesia practice. Tell me Easiest way to go about this. Thank you Doc
Thank you for sharing this worthful information. It gives me hope for longevity with high Lp (a).
So the bottom line is to protect the vascular system. No injury to vessels, no thrombosis, regardless of LPa levels. However if there is a little vessel injury with high levels LPa then thrombi can propagate more intensely. Perhaps for these patients with high CAD risk they would benefit from anti platelets or prescribed anti coagulant. Or perhaps one in supplement form such as Omega 3 or Nattokinase. Who knows. Excellent presentation 🎉
I'm a little late finding this, but I just want to say that i think Dr. Ali is just the right amount of nerdy!
Your tolks are clear i helpfull. Thank you.
Very interesting. A reminder that we are in the early days of understanding Lp(a). The idea that it might be more friend than foe is worth examining.
Is this still applicable today? This presentation was 2 years ago. Recent Dr Tom Dayspring information says get on pcsk9 if you can until Lp(a) reducing drugs are available. I also have ApoB at 130 my/dL.
@@garybritting1892 Good question. I don't believe there's any consensus. I've yet to have my ApoB checked, it's next on my list, although I've had my Lp(a) checked in the last two weeks as it's been a family issue. Fortunately, it's a low number, but my LDL-C is too high. I'll be curious to see if ApoB tracks that and is also high.
You mentioned the Quest test which utilizes Immunoturbidimetric methodology, curious what you think of the ion mobilization methodology for arriving at the LP (a) particle count, which Quest uses in their 'Cardio IQ' advanced lipid panel, which includes the LP (a) number... And also the NMR Nuclear Magnetic Resonance methodology.
Thank you very much for extremely helpful lecture and insights!
Congratulations on your son's wedding!!
Thank you for this video.
Can you please add the links you mention at the end into the description of this video? They are very difficult to find.
Excellent talk like always. Is there any benefit of checking Lpa level then??
there will be a benefit to me as I had given up my statin 6 months before getting tested for LPa and now I can say to my dr why would I go back onto a statin if it raises this 'bad' LPa by 20%?
I am a big fan of Dr. Ali, but I have to criticize him for referring to hazard ratios as odds ratios. There are similarities in how they can be interpreted, but they are different. Odds ratios, relative risks, and hazard ratios come from different types of analyses and they are not interchangeable. Hazard ratios come from proportional hazards regression of time-to-event data. Odds ratios, generally derived from logistic regression, are appropriate for very different types of study design, such as case-control studies.
My lp iz 54.5 and my doctor really freaked me out. Like I would drop dead any time soon... this is really helpfull... thank you so much... you bring comfort with facts...
I am 23 years old having an Lp(a) of 50 mg/dl which should be below
Who said it should be
@Notme-tq4xs It is even better if it were zero!
I read of a medical professor getting his to zero by including Proline with his Lysine supplement, eventually getting it to zero.
Lp-a is the most dangerous subparticle of LDL. The first to the scene of a damaged artery because the artery is vitamin C deficient and Lp-a is the bodies substitute for vitamin C. The RDA for C is not enough.
My Lp-a is 20mg, reversing my CAC Score with the Linus Pauling Heart Protocol.
@mohammadanif8134 Specifically, how can I help you?
First and foremost, is to get on the Linus Pauling Heart Protocol.
The Protocol is all powders high dose vitamin C in divided doses 3-4 times per day. You need to do at least 10 grams per day more if you can early evening can be your biggest dose as it's well tolerated because of reduced physical activity.
Lysine and Proline 6 grams each per day.
I have been successfully reversing my coronary artery calcium.
The Lysine and Proline are used to neutralize Lp-a as they are binding inhibitors of Lp-a.
I've been on this 3 yrs and feel great!
@Notme-tq4xs Higher levels of Lp-a make your blood clot more, and higher levels make it harder for blood clots to break down. And inflammation from Lp-a makes it more likely those speed bumps of plaque will break open, attracting more blood clots.
But also know there are plenty of seniors with high Lp-a that have never had a cardiac event.
It's my thought that if these people are vitamin C sufficient that there wouldn't likely ever be an issue with Lp-a as you may know, Lp-a is the bodies substitute for vitamin C. I have read recently that some Lp-a is of benefit, so I'm happy to be at 20mg/dl myself.
The information above was from the Cleveland Clinic, well known in the US.
My LabCorp results said it should be
Thank you Doctor! LPa is so villianized, yet we know the human body always has reason for its design. Your critical thinking is so appreciated and needed with the current standard of care in medicine. I believe CRP as a measure of inflammation is the most telling marker of cardiac health even with high levels of “bad” cholesterol. Brilliant video.
@Bladerunner2049 yes. I do keto, no seed oils, time restricted 18/6 eating. My Crp was .17 which is nearly off the scale on the low side. They low end of the range starts at 1.00
Docs almost always assume we should fight our body’s processes as “unnatural.” Don’t eat what you want (fat). Don’t trust your liver production of cholesterol because baaaaad. I certainly trust my body more than science and doctors. I certainly trust my body more than big pharma. I certainly don’t trust being a human test subject (PCSK9 inhibitors have not been through trials - you are the trial - good luck - RIP).
Thank you Doc. I thank God for doctors like you who take time to research understand and explain in layman’s terms the biology and functioning of the human body. Truly appreciate the time and effort you have put in to put our fears to rest 🙏🏼. God bless
Thanks for the great video! I would like to see a study of people in cultures where coronary artery disease is nonexistent (rural China, Papua Highlands of New Guinea,etc) and look at their lp(a) levels.
In the French study at 22:39 into the video, Dr. Ali has it backwards. He states that the centarians are the hatched bars with the higher lp(a) levels. The label to the left says that the centarians are the dark bars -- which have the lower lp(a) levels as might be expected.
Yeah, u r ri8 centenarians hav low lp(a)
I think lp(a) serves good only during acute inflammation, it prevents breaking of clot & healing.
But when endothelium is injured, it prevents clot breaking eventually leading to complete block.
Similar to autoimmune disorders , where our immune system wanted to do good , but too of collateral damage.
I noticed that too and I just assumed he added the labels to the slide and just accidentally got them backwards?
"Nonetheless, the apo(a) size distribution in centenarians did not entirely explain the high Lp(a) levels observed in this population. Factors other than apo(a) size, and which may be either genetic or environmental in nature, appear to contribute to the elevated plasma Lp(a) levels of our centenarian population. We conclude therefore that high plasma Lp(a) levels are compatible with longevity." 1998 article by J Thillet
No. Please understand that LP(a) levels less than 0.3mg/ml are considered desirable. So what the chart basically conveys is that centenarians are impressively high even with lp(a) in a range of 0.8mg/ml or more.
If you notice, no. of centenarians take a dramatic drop with lp(a) levels falling below 0.6mg/ml (or 60mg/gl)
@pierpartnersgmail Yes, that is what it looks like. i.e., the added labels to the left are switched.
Excellent talk! Perhaps oversimplified but as I understand it.. LDL gets oxidized in the presence of cells that send out inflammatory signals. Those oxLDL then serves as a signaling of inflammation and bind with ApoA to form lp(a) so that it can assist in the healing process. People who have chronic high lp(a) may also simply have chronic elevated inflammation. As such it can be used as a proxy for CVD.
In a healthy system however, high levels of LDL may actually be beneficial in cases of acute inflammation as it is an important source for the formation of lp(a).
I heard something like this on a talk from Dr Paul Mason. So that means that LPa levels is something that can be changed.
Please have a video on the mechanism of action on how Vitamin K1 is converted to K2.
Please verify if fermented meat, fermented fish and Fermented shrimp have Vitamin K2?
Can you use a fibrinolytic enzyme while on Plavix? If not, how long after discontinuing Plavix could you start using Natokinase, Serrapeptase etc?
Also, can you use fibrinolytic enzymes while on Statins?
Thxs for this excellent presentation..my lp(a) is > 170 ...I ll try taking Vit C, Niacin and Cysteine
I have been on Linus Paulings Heart Protocol. High dose vitamin C 25 grams in divided doses per day with 6 grams of Lysine and 8 grams of Proline.
Lysine and Proline neutralize Lp-a.
I have been on this for 3 years.
I had a CAC calcium score of 660 when I started. After 20 months, it was 458.
Just had my first Lp-a test. It was 20mg/dl.
I have no idea what it might have been before I started Paulings Protocol, but I'm thankful it's 20mg. I would imagine it would be much higher!
Wonderful talk by Dr. Ali. My lp(a) was 52 mg/dl when i measured in the month of April 2021. After that i had recovered from Covid-19 with mild symptoms. And June 2021 the reading of lP(a) was 86mg/dl. A research on these lines is advised evaluating the effect of Covid infection on Lp(a) alone. I am 41 years old. I have two queries i) Will Lp(a) reading change or constant throughout the life time. ii) The rise in the level after infection is reversible or not?
I recall hearing lp(a) can behave like an acute phase reactant, so hopefully your level will return to previous measurement. Was it the same lab?
I to have heard that it can vary in times of I'll health going higher but returning to normal levels in good health....
Would it be possibly helpful to raise Lpa by using a statin since your data showed better results (small amounts) for some conditions? Recall a website that was started by people who had high Lpa and had heart attacks... but it said need to test right way (forget if by mass or weight). Also read article by a Dr with Lpa, that were trying some nutrients and also some diet changes did effect amount Lpa. read Dr Rath had article also and said vitamin C can be helpful (said Lpa was used by body when not enough vite C I think).
Dr. Ali; Please revisit the subject of Lipoprotein a. I'll be interested in hearing any new thoughts/developments now that more information and research is available. Please and thanks!
Great presentation on LP(a)!! At about min 36 you talk about "oxidized LP(a)" ... and i think you got something mixed up. What is shown on that chart on the right are "Oxidized phospholipids" which are actually carried by LP(a) and could be the main reason for the atherogenicity of LP(a)...
At time 22:29, it was said that the centenarians were represent by hatches, and the controls represented by dark bars. This description however does not align with the legend provided on the graph indicating the opposite.
What about the study "Effects of a Low Carbohydrate diet on insulin resistant dyslipoproteinemia, in the American Journal of Nutrition, Jan 2022? They claim lowering lp(a) with low carb diet with a sample size of 147. What are your thoughts on low-carb?
Good stuff..but sheesh. My first stent was 20 years ago and two since. As one who keeps up with this stuff it can be mind bending. Back in those days we were told to avoid fats..all of them. My first LPa test was probably 12 years ago and it was 220. My cardiolgist has always said he wasn't really sure if this was just a marker or causation so he was honest about it(he has high LPa) as well. I don't really blame big pharma (for this anyway). It takes so long to develop and test meds that they can't really wait until we are 100% certain of what we are dealing with. We in fact have meds that work well though we aren't always sure of the mechanism.
Thanks for this.. listening to too much Peter Attia, he is freaking me out... you make me feel better about my high LP a, etc..
Hi I'm 61 years old and have gene determined high Lp(a). It was 403mg/l in 2012 and 400mg/l this summer. Yesterday I had a scan and feared a dead sentence. However the outcome was quite positive. I have very litle to no plaque. Only 3% at my age have less plaque I was told. My cardio age was judged to 34-39 years! I'm quite healthy and my triglyceride have been low the few times measured, which should hint I'm metabolic healthy. Maybe that's what matters? Not the level of cholesterol or Lp(a) ?
What was your experience like getting a scan? I’m considering getting a CAC. I was surprised that the cardiologist discouraged me for doing so.
@@robbygirl2019 my Cardiologist is discouraging me from getting a repeat CIMT. Had a decent one 2019. Trig are good as are HDL and VLDL. ???
@Gunnar Hop ; let's talk
@Bladerunner2043 you mean to tell me he ain't real?
@Bladerunner2043 But what's the factual or medical connection to lpa being the culprit, how do we know? Did your whole family take a lpa test or just you? Did you take a calcium scan? What is your lipid numbers? Im trying to understand how are we connecting one little test to chd. Your reply would be great thanks
22:23 "centanarians represented in hatches" -but the graph labeling seems to indicate the controls are the hatches???
OMG! You are correct. Dr. Ali got confused with graph labelling - it is the controls that are being represented in hatches. That's very important!
Darn I was happy that I had low Lp(a),
How Much ?
@@omaditya5275 I'm told "normal" is 30, mine was 7. I don't remember the units. Maybe mg/dL?
@@justrusty you should be. He had the study backwards, it’s the ones with LOW LPa that live longer. Not the other way around.
22:40 I don’t think this is what you are saying. The controls have higher levels of lpa for a given genetic kringle size, than centenarians. So the centenarians have lower lpa levels than controls even for same genetics.
So far it seems all we know is that the lpa number needs to be standardized by your kringle factor to be meaningful. The previous slide also didn’t say longevity was linear in lpa, but that there was a sweet spot.
I would conclude from that that in very old people, having low lpa is beneficial because by that age they would have severe arteriosclerosis (not because of lpa, but because they are old), so wound repair is not as important as reduced chance of persistent clots, which outweighs the risk of hemmorrhagic stroke at that point.
32:40 lpa can’t be high in the higher CVD event patients to protect them from CVD, since it didn’t protect them. These values were measured before the cardio event, not during.
Looks like lpa has nothing to do with cvd progression, but might be helpful to lower levels to reduce blood clots and thereby reduce events in cvd. Just another blood thinner. And statins as usual do squat, in this case increase lpa.
As a research scientist, I'm afraid the figure for Lp(a) values in centenarians (minute 22 in the video), as presented, is meaningless. Each black bar is the mean (average) Lp(a) concentration, but the number of individuals in each black bar is not specified. To illustrate, suppose there were 200 centenarians in the study population. The five tall bars taken together, which seemingly represent individuals with high levels of Lp(a), might only account for, say, 30 of the 200 centenarians (15%), whereas the remaining (smaller) 14 bars would represent the much larger remainder (170) of the study subjects. In that scenario, the conclusion would be that 85% of the centenarians had low levels of Lp(a). In short, we need to know the relative proportion of centenarians with high Lp(a) levels in order to make a reasonable conclusion. Hopefully this is explained clearly in the original publication.
My lpa is very low less than 8.4nmol/L. I remember a deep cut on my index finger didn't clot well and healed slowly. This might explain why.
I have O-Negative blood myself. It has a 30% less of a clotting factor than most blood types.
I was told I have high LP(a) at 138 nmol/L in the UK - trying to compare with the units in studies here but computer says no! Can you shed light on this? Btw recently had a CT angio with calcium score 0 and clean arteries. Doc desperately wanted to give me statins for the lp(a) but refused
@@hikerJohn "computer says no" is a reference from comedy series called 'Little Britain'
You can't convert lpa units of measurement due to Kringle repeaters and the fact everyone's particle size is different, so two people with 50mg/dl ( molecular weight) can have very different levels in Nmol/l ( particle number)
I also have 120-166nmol/l and I am in the UK.
Also cac score of 0, also do a CIMT test too for soft plaque in the carotid artery.
Did you do an angiogram with the dye and tube into your heart to check for plaque build up?
Also what's your age?
@@davidcameron9151 Please where did you do these tests in the UK, would like to take the tests if private
@@davidcameron9151hi
How much cost
Stay nerdy my friend :)
I am a basic person with an environmental policy law degree. I have watched at least 50 of these videos and I'm finally understanding the language of cholesterol. My doctor says nothing and just prescribes medication without explanation. Another specialist in cholesterol insists that I take all kinds of meds and also get this new type of shot every two weeks that I give myself to get rid of my LDL-LP(a) cholesterol without explaining why I need to do that. I am 118 pounds, female, 61 years old, exercise seven days a week and I am 90% vegan for the last 25 years. Yet I have high cholesterol but I don't feel ill. When I take cholesterol medication, I feel bad. I have all kinds of issues. I want to change my lifestyle so I will take CO Q 10, K2 vitamin supplements, three different pure omega 3 supplements from garden of life like the rest of my vitamins,. I feel better already. And now that I am watching number 51 of my cholesterol videos, I also feel reassured if not vindicated. Can watching a cholesterol video be comforting?
Watch out for the Omega3 causing heart A-fib as European users of Omega3 supplements stated that when they got off of them, their A-fib stopped. Mine completely dissappeared. And I'm very happy about that!
I'm confused. At 22min the graph shows hatches for the control, and solid for the centenarians, but he described it in the opposite way? 22:29
Is the legend wrong or his description?
This is what happened to me....I had a CABGx4 a year ago and went plant based and was off all eds except B12 and low dose aspirin. Then my numbers crept up, so they said back to statins. They did a LPa and b. Well my numbers are very very high and was told I need statins and that no exercise or diet will help. So I have no clue what to do..
I just got my results back and my Lp(a) is 246, ApoB 93, and my Patrice count is high also. I just went 100% plant based also to try to reverse it or at least prevent something bad from happening. How are you doing now?
How are you doing? Hopefully well@@plants_and_wellness1574
My LP(a) result was 1371mg/l. The range says
Your level of Lp(a) is similar to mine. You should definately consult with a cardiologist who specializes in Lp(a). Many people at our level of Lp(a) have heart events in their 40s and 50s. At the same time, some seem to tolerate the high levels fine. You should probably talk to your cardiologist about getting a CAC= calcium scan, to see if you have significant plaque caused by your Lp(a). Until you have been property evaluated, do not let anyone tell you it is nothing to be concerned about. With our level of Lp(a) you should be evaluated and monitored.
@@mybjj9643 EXCELLENT advice. I was in the same boat and just found out I had a CAC score of 598.
@@tommccarty5 It is interesting because some with high Lp(a) seem to have a really high arterial plaque burden and some do not.
One thing that is super important to watch, especially if one has high Lp(a), is insulin resistance. If you have pre-diabetes you should make every lifestyle change possible to try to reverse it. Lp(a) and hyperglycemia are a very deadly combination.
@@mybjj9643 I did have IR after doing the OGTT and have started IF to
hopefully reverse it
@@tommccarty5 Good luck with the IF. I've had good success with IF in increasing my insulin sensitivity
What is considered “really high” Lp(a)? I just got my results back and my Lp(a) is 246 😳 ApoB 93, LDL particle count 1867. I ordered all my test online, I don’t have a doctor. I’ve googled everything and apparently this is really bad?
That is definitely a high LPA
My results also came and it says 217 mg/dl..Whole night was having panic attack since it was so shockingly high..was watching material where they say theres nothing u can do...Also have family risk factor and so.. Rly makes me feel miserable!
@@plants_and_wellness1574 Let us know your numbers after your next tests. Would you know what's the relationship between ApoB and Lp a? Is Lp a just "attached" to ApoB? There's this new metrics saying that high ApoB is bad and definitely get you a high chance of ASCVD, and then says that's genetic, eating saturated fat increases ApoB, drinking coffee > 2 cups increases ApoB. Is ApoB pretty much the same as Lp a then? Are your LDL P size mostly large? >20? Actually found my answer of ApoB and Lp(a) here: www.ncbi.nlm.nih.gov/pmc/articles/PMC4095745/
@@dknc7393 so, my numbers actually came back higher in September than they were in June, that’s after going strictly plant based 🙃. I had my mom take those test, ApoB and Lp(a), and her ApoB at the age of 69, and she’s been smoking for 40 years, but hers was 90, and her LP(a) was in the high hundreds. She has never taken a statin or had heart problems and she just turned 70. So, at this point in my life, I’m just not going to worry about it. I couldn’t eat cleaner but I also don’t deprive myself if I want pizza, but it’s usually the best quality ingredients when I do but I’m just going to live my life and not stress about any of it anymore. I eat healthy and I’m only here for a short while so I’m going to enjoy myself as much as I can. I really think living a long life has a lot to do with your outlook on life. My husbands grandma is almost 90, lives alone, drives, has more energy than I do, more of a social life than I do, etc, and she eats everything, like wonder bread and bologna. Everything processed and horrible, yet she’s in great health lol. I’m not going to eat that way but I’m just making a point. Don’t stress, eat healthy but live your life to the fullest while you can 🙏
@@eduardseizenbergs3055There is something you can do! I had a CAC Score of 660 and my last CAC was 458.
I'm using the Linus Pauling Heart Protocol which uses high dose vitamin C with Lysine and Proline that neutralize Lp-a. I have been on the protocol for 3 years. Just had my first Lp-a test 20mg. Now I'm afraid to ever stop Lysine and Proline. I can't imagine what my score was before!
I know one thing I'll never stop the protocol......CAC Score down from 660 to 458....
Interesting🤔 i had a heart attack with 2 stents a month ago. Took the blood test , it was confirmed the cause was elevated lpa. Im vegan, no oils no alcohol no smoking no dairy. Exercised daily and had a major heart attack 100% blockage . I was lifw flighted from one hospital to another. Im scared to death on what to believe
Jill, I don't blame you. When I was a vegetarian, I had a CAC score of 299, then 5 years later, 660.
That scared me, knowing that it could double again in 5 years . I dove into research, and I found a great humble man, a 2-time Nobel Prize winner who developed a heart protocol.
His name is Dr. Linus Pauling he was also awarded 48 PhD's over his lifetime.
He came up with high dose vitamin C with Lysine and Proline to repair your arteries.
The Lysine and Proline neutralize Lp-a so the vitamin C can do the repairs of the vitamin C deficient arteries.
I have reversed my CAC by 30% in 20 months.
I am no longer a vegetarian, but I am grain and sugar-free.
Unfortunately, your Lp(a) number is hereditary and there's not much you can do to change it if anything. My husband is in the same boat as you but fortunately has not had any sign of heart disease yet. From what I've learned is your best bet is to optimize all other factors that affect heart health: keep your weight down in healthy range, keep blood pressure as low as safely possible, lower LDL if it's too high , never smoke, exercise moderately, get good sleep, lower stress levels and keep following up with your cardiologist.
BEING Vegan is the problem here
@@mels.3750good advice
Thanks doc for giving us (with high LP(a)) hope! I’m 59, have extremely high LP(a) but my CAC score is zero.
Hey what is ur lp(a)
Doesn't mean that a CAC of zero you don't have a Plaque build-up! And with a high Lp-a you likely do and your chance of a cardic event is 3-4 times higher.
I have 97/% blockage in my R heart artery. I have been given 40mg rosuvastatin.
My concerns are I have a fatty liver, raynauds, osteo arthritis, am 65yrs old. Had gestational diabetes. Am now Insulin resistant.
Cholestrol level is 6.8 I have been diagnosed with lipo little A, my parents and brother have diabetes Brother had 3 heart attacks and triple bypass surgery when he was around my age.
I am worried about taking rosuvastatin 40mg, as I have fatty liver, and worry about damaging my kidneys on that dosage.
A warning on the pkge advises you don't use it if you have liver disease. The medication also raises inflammation in the body, which doesn't help.
What else is there that I can use to halt the progression of artheliosis , little lipid A build up? Thank you. My BP is between 117=130 over 76=84
Hi
Linus Pauling said that Lp(a) levels increase when a Vitamin C deficiency exists and that Lp(a) is an emergency repair molecule which stops bleeding in an arterial wall which is falling apart due to collagen breakdown. So, like Dr. Ali, he consideted it a beneficial molecule but only in an emergency setting;.if the Vitamin C deficiency is chronic then the repair mechanism of Lp(a) would ultimately result in atheroscletotic plaque buildup, he said. Dr. Pauling recommended supplemental Vitamin C, proline, and lysine to rebuild blood vessels.
The Linus Pauling institute published this vitamin C, Lp(a) hypothesis in 1990. To my knowledge there is no clinical data supporting this hypothesis. I have elevated Lp(a) and I do take a large dose daily of vitamin C, just in case in might do some good for my Lp(a) and in that it will not do me harm, but one should not rely on taking vitamin C and assume that they will be fine if they have elevated Lp(a). There just is not the evidence to support this at this time. Anyone with high Lp(a) should be evaluated by a cardiologist specializing in Lp(a).
@@mybjj9643 Pauling recommended that the C be delivered ideally intravenously. Most of the studies that were designed to “test” his theories were designed to fail trials (Mayo Clinic I’m looking at you). If a theory of his called for intravenous C, they would use oral. If it called for oral, they would use a lesser amount. Predetermined conclusions would then be laid out and his views declared as bunk.
There are a lot of vested interests in keeping people sick and in the dark about their health.
Fact: when doctors go on strike, life expectancy goes up.
In 2002 Dr. Peter Libby, the top cardiology researcher at Harvard, wrote an article titled "Vitamin C, Collagen, And Cracks In The Plaque" that appeared in the AHA Journal. His theory was that Vitamin C aids collagen synthesis in arteries and helps fight plaque rupture. His article seems very compatible with Linus Pauling's ideas.
Couldn't have said it better myself. Have been on the Linus Pauling Heart Protocol now for 3 years and my coronary artery calcium score is reversing. I just had my first Lp-a test at 20mg/dl. Can't imagine were my Lp-a level was before using Lysine and Proline to neutralize Lp-a so that vitamin C could go to work repairing the artery correctly rather than calcyfying it....
@@mybjj9643Wow just how much vitamin C were you taking? I take mine to bowel tolerance which is 25 grams per day in divided doses with 6 grams of Lysine and 8 grams of Proline. My CAC Score went from 660 to 458 in 20 months. I just got my first Lp-a test back at 20mg/dl as you must know Lysine and Proline neutralize Lp-a.
I follow Dr Thomas Levy Cardiologist author of "Stop America's #1 Killer " Proof that the Origin of All Coronary Heart Disease is Clearly Reversible Arterial Scurvy.
Clearly Paulings Heart Protocol is working for me....
I believe it stops injury to the vessel but also kills plenty of people. Mine is sky-high and I had a heart attack at 39 and about every 20 months I go back into the hospital for another stent. My last visit I got four stints. They wanted to do open heart surgery but I talked them out of it. I'm wondering what the role of sugar plays in all of this because sugar compete with vitamin C.
Low Vitamin C using means higher LPA.
A diet that cut out meat lower Dale PA in 4 weeks pretty substantially. But when I read the details I also saw that they cut out most of the grains and sugars and cooked vegetables
What was your Lp(a) when you had your heart attack?!! I just got my results back and my Lp(a) is 246, ApoB is 93, and I have a high LDL particle count. How about your ApoB? Did you have high LDL? My LDL is at 108 currently.
@@plants_and_wellness1574 not sure, I don't remember them saying. They may not have checked it
@@plants_and_wellness1574 I don't know if they checked back then. at some point about 4 years after that period it was being checked, but I don't remember anything before the heart attack. My ldl has always been high, hdl was about 45. I do remember that my triglycerides were like 500. They were horrible.
Now my LDL still sits around 125 but my triglycerides are like 79 my HDL is like 55 . But I can't really seem to get my LPA down I can fluctuate it from 317 to about 5:00 but I can't get under 317. And I'm not sure what causes that fluctuation I haven't been able to figure it out
@@edwardbanegas2153 I wonder if there’s a correlation between your high triglycerides and high LPa and those together caused your heart attack ? My HDL is 56, triglycerides are 66, LDL is 108 but probably lower now because I went 100% plant based. My homocysteine is slightly elevated at 11. Trying to do everything I can to prevent having a heart attack or stroke.
@@plants_and_wellness1574 I don't believe since my triglycerides are good now.
Plant based is good but didn't help my lpa levels.
I believe lower carb helps and cut out added sugar. No breads
D"r I have high Lp(a), and I did bypass surgery
has anybody seen dr. peter attia the drive podcast 210?
Good doctors seem to understand the body isn’t producing excess anything for no purpose. Every molecule produced has a purpose - the body does not waste resources…
Dr. Ali's bottom line research analysis: Statins elevate the risk of CVD, This is the smoking gun. Brilliant!
Is Lp(a) same as pattern A?
My Lipo(a) is 198 mg/dL, but my hs-CRP is low. If Lipo(a) is a fireman, what fire is it working on??