Those last two minutes cleared up a huge misconception I had in my understanding of Immunology. It was a huge lightbulb moment. I'd been taught that the 1st signal induced the expression of co-stimulatory molecules on the APC. This makes so much sense. Thank you for the discovery!
It have been more than 20 years that Janeway and Medzhitov proposed it, and there is still biologist in universities explaining things that do not make sense... T cells would never go to anergy if the TCR + (MHC II + self-antigen) [signal 1] was the one to generate BH7 expression [signal 2]. Of course, T cells do not know if the antigen they are binding to is self or not without PRRs from APCs 🙂 Thanks Ruslan!
Is the leucine component of TLR not random? For some TLRs, asparganine is not random either. The textbook "Cellular and Molecular Immunology" gives the sequence LxxN, where L is Leucine and N is asparganine. Also, what secondary structures make up TLR? Alpha helices and beta-pleated sheets are not random. There are geometrical restrictions to which amino acids can form the main two secondary structures.
Can Dr. Ruslan elaborate in a new talk as to the origin of autoimmune response?...in terms of involvement of signal 1 or 2...and also toll like receptors...
A privilege to have access to this on you tube.
Those last two minutes cleared up a huge misconception I had in my understanding of Immunology. It was a huge lightbulb moment. I'd been taught that the 1st signal induced the expression of co-stimulatory molecules on the APC. This makes so much sense. Thank you for the discovery!
Same here!
Ruslan is a great storyteller! This was a really great lecture
Teaching at its best..!!
It have been more than 20 years that Janeway and Medzhitov proposed it, and there is still biologist in universities explaining things that do not make sense...
T cells would never go to anergy if the TCR + (MHC II + self-antigen) [signal 1] was the one to generate BH7 expression [signal 2].
Of course, T cells do not know if the antigen they are binding to is self or not without PRRs from APCs 🙂
Thanks Ruslan!
Great lecture..
Thank you Ruslan🤩🙌🏻
thanks a lot!
continue please
Is the leucine component of TLR not random? For some TLRs, asparganine is not random either. The textbook "Cellular and Molecular Immunology" gives the sequence LxxN, where L is Leucine and N is asparganine. Also, what secondary structures make up TLR? Alpha helices and beta-pleated sheets are not random. There are geometrical restrictions to which amino acids can form the main two secondary structures.
Can Dr. Ruslan elaborate in a new talk as to the origin of autoimmune response?...in terms of involvement of signal 1 or 2...and also toll like receptors...
Very interesting, thank you!
Bravo!
What program do these speakers use to teach?
They speak while explaining to pics
is it thrue the covid vaccine block these receptor ??
I've heard it binds TLR4
The spike protein can bind TLR4 they say
@@davidjuliesmiththomas7983 thank
What TLR is he talking about ? 4 for LPS
5 for flagella
And others for viral nucleotides
www.nature.com/articles/41131.
tlr4 (lps receptor) was the first one to be identified in human innate immunity..
Less uh, uh, uh and better articulation