Who are u sir!where are u from!u helped me a lot like a angel❤my 20 years burden has gone just 30+ minutes.....love and thanks from india (state tamilnadu)🎉
Predictive model is the best! I'm dumbfounded why so many instructors and textbooks don't teach it and just dump a bunch of facts and trends onto students and not even attempt to systematize them.
You're very welcome. I actually have a couple more combined videos like this one on it on my channel with more practice questions, so if you're doing a review for the text, you might wanna check those out as well.
I have a question. According to the predictive model, if we have an N.B. reagent with a 2° or 3° carbon, the reaction is classified as E2. However, after researching this, I noticed that many sources emphasize the importance of the solvent and temperature. Specifically, it seems that the reaction only proceeds via the E2 mechanism at high temperatures. Can you clarify this?
While higher temperatures do generally favor elimination reactions, high T is hardly necessary for E2 reactions. As the matter of fact, reactions with strong bases like LDA or amides are typically done at -78°C! It’s the base that matters the most for E2. And for the solvent, remember-it’s the facilitator of the reaction. It’s not as important as people make it seem. There’s only a handful of examples where the solvent might be actually crucial for the mechanism determination. I have more tutorials on the substitution and elimination and the predictive model if you wanna go into more details. This video is only a brief review.
Who are u sir!where are u from!u helped me a lot like a angel❤my 20 years burden has gone just 30+ minutes.....love and thanks from india (state tamilnadu)🎉
Thank You! Love the predictive model!!!!
Predictive model is the best! I'm dumbfounded why so many instructors and textbooks don't teach it and just dump a bunch of facts and trends onto students and not even attempt to systematize them.
I pressed the like button and the predictive model worked!
ROFL
Yep, that's how it works! Told ya! 🤣
This is so helpful.. Thank you
You're very welcome. I actually have a couple more combined videos like this one on it on my channel with more practice questions, so if you're doing a review for the text, you might wanna check those out as well.
I have a question. According to the predictive model, if we have an N.B. reagent with a 2° or 3° carbon, the reaction is classified as E2. However, after researching this, I noticed that many sources emphasize the importance of the solvent and temperature. Specifically, it seems that the reaction only proceeds via the E2 mechanism at high temperatures. Can you clarify this?
While higher temperatures do generally favor elimination reactions, high T is hardly necessary for E2 reactions. As the matter of fact, reactions with strong bases like LDA or amides are typically done at -78°C! It’s the base that matters the most for E2.
And for the solvent, remember-it’s the facilitator of the reaction. It’s not as important as people make it seem. There’s only a handful of examples where the solvent might be actually crucial for the mechanism determination. I have more tutorials on the substitution and elimination and the predictive model if you wanna go into more details. This video is only a brief review.
Ammazing tutoriels ❤
If you help us with vedio tutoriel about regioselectivity and stereoselectivity of Sn1/2 and E1/2
I have dedicated tutorials on those as well. Check the video suggestions in the description or go to my website.
Thank you so much