Just found your lecture. My son had extra material on the distal arm of his 11th chromosome. They called it 11q+ syndrome, for lack of a better term. In the 23 years that he lived I was never given any explanation about what that meant or any positive prognosis on how he would develop. Tho I and my husband were not exposed to radiation in our environment, we were both exposed to high lead levels, and he in his work place, to trichlorethylene and other industrial solvents, which he brought home on his clothes. Your lecture has done more to explain the several possibly actions of chromosome's than all the doctors I had my son to in the 23 years of his life. I thank you, even tho he is now deceased, for clarifying in my mind his chromosomal anomaly and the mechanics of how he received it.
Hi Lesa, So sorry for your loss. I have a 5 year old son with a Micro-Duplication on his 5p13 and 8q11 chromosomes, and he presents with mild Autistic-like symptoms and Apraxia - he can’t talk yet, just babbles. Although, he seems happy and is affectionate. It’s so sad, and we don’t have any about his Prognosis because all the Doctors and Geneticists we’ve seen are near-useless! Every answer to any of our questions is: “Oh well, Yes & No”; or “Possibly”; or “We don’t really know...who can say?” I’m was concerned hearing about your Son who tragically passed at 23... my Wife & I have never been told of any shorter Life Expectancy for our Son...? He’s is perfect health. Do you mind if I ask you if his passing was attributed in any way to his Micro-Duplication? Thank You so much for your help 🙏
@@ITS_ALL_LlES Only in the sense that it left him very vulnerable to colds, flu's, and pneumonia. He died of H1N1-A in 2009. His heart and lungs simply could not handle the severe form of this flu.
You have helped me through undergrad, studying for the MCAT, and now medical school. Your videos and explanations are amazing. I just want to say thank you!
@@AK961.1 yeah we obviously learn this before med school but we forget it. This a review in med school. Just like the kreb cycle, some things you learn it 50x in school and still have to relearn it.
I cannot really express how thankful I am for this lecture of yours. I have a report regarding this tomorrow and I was really on the edge of breaking down when I saw this video of yours. Thank you very much.
I'm in awe 😳😳. Don't mean to bash my lecturer....but he confused me and did not explain this topic well... when I heard your explanation I was so grateful for the clear and concise explanation!!!! Thank you❤❤
fantastic content, and 100% applicable to the chapter I'm studying on "Large-scale chromosome changes." I give you credit for being a much more focused person than I am.
Shannon Mace Sorry about the volume Shannon, I did not realize the mic volume was not calibrated at the time of recording! Luckily I realized pretty quickly (only after several lectures) :)
My partner has pericentric inversion of chromosome 9, p11q13. What does that mean for having children in future? Are we at a higher risks for having children with health problems?!
Thanks for the video! I'm curious if there's a particular phase in the cell cycle where translation can occur or can it be during any phase of the cell cycle?
quick question, the chromosome breakage that is being caused by radiation, are the factors such as radiation or viral infection called clastogens? I read about this in my book, but I gotta make sure :)
How does the detached DNA sequence insert itself into another chromosome, whether or no homologous? Do the DNA strands of the DNA disjoin to let the detached sequence in?
It's basic but I feel like you can be more in depth. For example, there are 2 types of inversion mutations. ParAcentric (one arm of the chromosome) and PerIcentric (two arms of the chromosome).
That's why I came here for, honestly. I couldn't wrap my head around the two types of inversion. But your comment made it more clearer in a way so fuck yeah, I'll take that. Thanks .
Man! You are an amazing teacher! I have a question: does the duplication occur just in this way? Is it possible that a gene duplicates bc of an error of the DNApol? I mean, is it possibile that 2 homologous both have the gene and in one there is also an extra copy that doesnt derive from the homologous but from an error in duplication?
Regarding duplication, you stated that it was a GENE that would break off and reattach to the other chromosome. In the other 3 structural pathways then, are those segments of DNA genes too or can they be any random bits?
Just found your lecture. My son had extra material on the distal arm of his 11th chromosome. They called it 11q+ syndrome, for lack of a better term. In the 23 years that he lived I was never given any explanation about what that meant or any positive prognosis on how he would develop. Tho I and my husband were not exposed to radiation in our environment, we were both exposed to high lead levels, and he in his work place, to trichlorethylene and other industrial solvents, which he brought home on his clothes.
Your lecture has done more to explain the several possibly actions of chromosome's than all the doctors I had my son to in the 23 years of his life. I thank you, even tho he is now deceased, for clarifying in my mind his chromosomal anomaly and the mechanics of how he received it.
Lesa Hanners i'am very sorry for your loss😔😔
Surprise mechanics.
Hi Lesa,
So sorry for your loss.
I have a 5 year old son with a Micro-Duplication on his 5p13 and 8q11 chromosomes, and he presents with mild Autistic-like symptoms and Apraxia - he can’t talk yet, just babbles. Although, he seems happy and is affectionate.
It’s so sad, and we don’t have any about his Prognosis because all the Doctors and Geneticists we’ve seen are near-useless!
Every answer to any of our questions is:
“Oh well, Yes & No”; or “Possibly”; or “We don’t really know...who can say?”
I’m was concerned hearing about your Son who tragically passed at 23... my Wife & I have never been told of any shorter Life Expectancy for our Son...? He’s is perfect health.
Do you mind if I ask you if his passing was attributed in any way to his Micro-Duplication?
Thank You so much for your help 🙏
@@ITS_ALL_LlES Only in the sense that it left him very vulnerable to colds, flu's, and pneumonia. He died of H1N1-A in 2009. His heart and lungs simply could not handle the severe form of this flu.
@@ITS_ALL_LlES didn't u get in pregrancy??
Was ur baby iugr in third trimester??? Wat was birth weight
You have helped me through undergrad, studying for the MCAT, and now medical school. Your videos and explanations are amazing. I just want to say thank you!
You take this in medical school?
@@AK961.1 Unfortunately, yes.
@@angelikakreling im studying this and im 16 years old!
@@AK961.1 yeah we obviously learn this before med school but we forget it. This a review in med school. Just like the kreb cycle, some things you learn it 50x in school and still have to relearn it.
@Sejoon Jun ok "bro"
I cannot really express how thankful I am for this lecture of yours. I have a report regarding this tomorrow and I was really on the edge of breaking down when I saw this video of yours. Thank you very much.
I understand when I watch your lectures. They're empowering. Thank you.
You're a such a good teacher!! Keep up the good work, greetings from Brazil!
I'm from Bangladesh....this channel is really very helpful....
Me too I am from somalia this channel is very important
I'm in awe 😳😳. Don't mean to bash my lecturer....but he confused me and did not explain this topic well... when I heard your explanation I was so grateful for the clear and concise explanation!!!! Thank you❤❤
This is so incredibly helpful! Thank you
Best video...just watched 20 mins before my University exam
I had no idea this could be explained this easily! Thankyou so much!
Made things simple and Understandable with his lecture. Would recommend it to everyone.
fantastic content, and 100% applicable to the chapter I'm studying on "Large-scale chromosome changes."
I give you credit for being a much more focused person than I am.
Everything was clearly explained in the most detailed manner 👏
Clear and right to the point, really helped me a lot! Keep it going
oh wow , you such a good teacher considering that i am a visual student i will never forget this , thank you so much.
really no words can explain how amazing are your videos
you are the reason i understand biology. thank you sooooooo much
Hi sir I am from Pakistan your lecture is very helpful for us bundle of thanks sir
amazing teacher ❤️ following from Egypt
thank you so much...i would be lost without you !
You're amazing! love your channel, im learning from it to my genetics exam!
Greetings from Buenos Aires-Argentina
We have our courses in French but honestly this video helped a lot THANK U SOOO MUCH 🙏
Thank you for this very clear and understandable explanation!
Thanks a lot I really appreciate this lecture, I understood everything perfectly well.
short, easy, interesting video thank you so much
Nice lecture. I'd love to see one that delves more into FISH and Nomenclature.
no one can put it at point like you do sir
This video was really helpful! Your explanation was clear and very easy to follow. The only problem I had was with the volume. Thanks so much though!
Shannon Mace Sorry about the volume Shannon, I did not realize the mic volume was not calibrated at the time of recording! Luckily I realized pretty quickly (only after several lectures) :)
(i also feel that) the volume is too soft.
You have a genetics channel too?!! Why did I even bother enrolling in such courses.
+Cader Locke lol! the more, the merrier! check out my website for a complete list of subjects! :)
***** love it!
Raeda
Thankyou Sir
This video helped me a lot.
Your lectures are amazing! Thank you
A great explanation, it is vert helpful for us students.
thank you very much. this indeed will help me on my mrcpch exam
Thank you. It helped ease my doubts.
This video is truly helpful!
Thank you so much! This really helped me alot!!
Thanks for the video! Very helpful
My partner has pericentric inversion of chromosome 9, p11q13. What does that mean for having children in future? Are we at a higher risks for having children with health problems?!
Thank you, sir, for this lecture, it really helped me.🙌
👏Great explanation👏
Now I got it.. thanks teacher 🙏
It would be great if you will make more videos about human diseases and explain their mechanisms and effects on body from a biochemistry point of view
Thanks for the video! I'm curious if there's a particular phase in the cell cycle where translation can occur or can it be during any phase of the cell cycle?
My problem solved,,,excellent lecture
This really helped 😊❤️ thank you so much 💕
Best teacher!
Thank you, you explained this so well
Thanku sooo muchh good explanation.👌👌
Great ! Made it a lot easier. Thanks
Very helpfulll..a big thumbs up to this vid
Can the body fix a chromosome inversion on it's own?
A great explanation 👍🏼
Love from INDIA sir
Helped me a lot thank you
Thank you very much👍🏻👍🏻👍🏻
thanks so much, really helped!
Well explained
EXCELLENT EXPLANATION!!!!
another great video, thank you very much
good lecturer
Super explanation sir
Amazing! Thank you
quick question, the chromosome breakage that is being caused by radiation, are the factors such as radiation or viral infection called clastogens? I read about this in my book, but I gotta make sure :)
When inversion takes place do we have DNA loss? Is the gene "destroyed" afterwards because it's flipped?
That was so helpful. Thank You
Just WOW...Thank you so much!!!
Good job, thank you!
I would like to ask you, do you know how these mutations could be seen in the PCR technique?
What is homologous translocation
wow u simplified it thx!
What is the different between interchromosomal and intrachromosomal mutations ? Please, explain me it
i want to where (which plant or animals) these types of chromosomal abnormalities are found?
is it possible to have deletion and duplication in a paracentric inversion?
Thanks a lot for this amazing and clear explanation. My question is during exposure to radiation, are all cells affected or, single or group of cells?
How does the detached DNA sequence insert itself into another chromosome, whether or no homologous? Do the DNA strands of the DNA disjoin to let the detached sequence in?
thank you so much ! very useful
You are great!
Thank you 😭😭
Thank you soooo much 😢
Veryyyyyy GOOD explanation
Awesome job!
+Ashley Long Thanks Ashley!
Thank you so very much!!!
Do you have any videos about Paracentric inversions? Thank you.
whats the difference between a pericentric and paracentric inversion?
Thank u ...
If I have deletion I will have the chance for
1..translocation
2..duplication ???!
Thank you very much
but how does trisomy 21 actually cause developmental delay?
Nice now I can skip more classes in college
Thank you so much.
Thank you!!
It's basic but I feel like you can be more in depth. For example, there are 2 types of inversion mutations. ParAcentric (one arm of the chromosome) and PerIcentric (two arms of the chromosome).
That's why I came here for, honestly. I couldn't wrap my head around the two types of inversion. But your comment made it more clearer in a way so fuck yeah, I'll take that. Thanks .
thank u so much! its really helpful :)
شكراً لك :)
Man! You are an amazing teacher!
I have a question: does the duplication occur just in this way? Is it possible that a gene duplicates bc of an error of the DNApol? I mean, is it possibile that 2 homologous both have the gene and in one there is also an extra copy that doesnt derive from the homologous but from an error in duplication?
Can you please make videos on the genetic detection of this abberations in Drosophila melanogaster
Huh? Sorry thats definitely not my area of interest ;-)
bruh this is pretty good
Regarding duplication, you stated that it was a GENE that would break off and reattach to the other chromosome. In the other 3 structural pathways then, are those segments of DNA genes too or can they be any random bits?
Nicholas Zuraw On the board, I used genes. But there is no reason why they cannot be random bits of DNA.
Thank you but dont know if its my device but I cant hear you well :(
I guess.. The problem is with your device bc I could hear him properly.
Same the volume is very low
Sir please describe their types and effects on organism(significance)
God bless you
Andrey K respect