Plasma Proteins Course (Transthyretin - Albumin)

الدرس الاول من الكورس المجاني بعنوان بروتينات البلازما
الترانسثيرتين - الالبيومين
Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T4) and retinol to the liver. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes TTR into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.
Albumin is synthesized in the liver from 585 amino acids
at the rate of 9 to 12 g/d with no reserve or storage. It
is the protein present in highest concentration in the
plasma. Albumin also exists in the extravascular (interstitial)
space. In fact, the total extravascular albumin
exceeds the total intravascular amount by 30%, but the
concentration of albumin (plasma albumin concentration
= intravascular albumin mass/plasma volume) in
the blood is much greater than its concentration in the
interstitial space. Albumin leaves the circulation at a rate
of 4% to 5% of total intravascular albumin per hour. This
rate of movement is known as the transcapillary escape
rate, which measures systemic capillary efflux of albumin.
Albumin is responsible for nearly 80% of the colloid
osmotic pressure (COP) of the intravascular fluid, which
maintains the appropriate fluid balance in the tissue.
Albumin also buffers pH and is a negative acute-phase
reactant protein.
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