I've published a free concise report on quercetin after 6 months of research with 300+ studies, at: www.WellnessMessiah.com/Gift This is the follow-up video: th-cam.com/video/DfZc4zbrPds/w-d-xo.html
HMMMM, anyone else smelling raw fish: ITP's Dr. MILLER SOUNDING LIKE Fauci or one of his Orian minions has touched him. Forget their rapid about Face. Quercetin has saved countless lives and shied off C19 i'lls and wows now, all of a sudden it no l ok nger works . PLEASE !
I have a friend who is 92 years old. His leg was swollen and painful. He was using a cane. I bought him a bottle of Quercetin and told him to take one at night and one in the morning. I saw him 2 weeks later and he said, “I feel like I’m 35 again!” That is better than a study on mice!
If I was Brad Stanfield's age I wouldn't take fisetin either. But I am 71. I take 2,400 mg in 1 dose 3 days in a row monthly. I take it with fat, usually olive oil and piperine because it is hard to absorb. When I first started 2 years ago I felt distinctly different on the days that I took it. I believe I was killing a lot of senescent cells. I do not have as much of a reaction now as I believe the senescent cells are now under control. Ironically I use Brad's discount code when I buy it. Personally I don't have time to wait for a published study when I can see results myself.
Very interesting experience. It definitely sounds like something happening in your body. if only senescent cells would indicate their own demise, we should not have waited for other human studies to be sure what happens inside
May I ask, what differences have you seen since starting Fisetin? In particular changes to joint health, skin and hair, if any. Also where do you get your piperine. Thanks in advance.
Piperine is extracted from black pepper. You might/should be able to get all your peperine requirements from simply using ground black pepper! @@g.......g
I’ve said it before and I’ll say it again-YOU HAVE THE BEST BRAIN OUT THERE IN THE THE LONGEVITY FIELD ! Thank you so much for figuring this stuff out and sharing it with us. I love you.
Hi Joan you make me blush again. I'm just a cog in the system of information, trying to make sense of it all (of things that sometimes seemingly make no sense) :)
@@WellnessMessiah You are more than just a cog. I hope you don’t lose your humility and goodness as they are far important than intelligence. Every now and then I see this childlike funny little boy in you. I bet you were the most adorable little boy ! Im old enough to be your grandmother-if you ever need a grandmother-I’d like to adopt you 😊. I pray your wife is improving. Considering all you’ve been through and are still going through it’s amazing to me that you can still maintain your focus so well. God bless you 🙏🏻❤️
thing is you would have to have the best brain in the field to know he had the best brain in the field, lol, im wondering if he might actually be the worst brain in the field. GENERALLY ANYONE WHO USES CAPS TO MAKE A POINT IS REALLY A MORON
Impressed with your approach to addressing this topic logically without any individual disparagement. Appreciate you helping people find their way to the truth.
Hi Mike, sometimes humans, the more we are alike (e.g. me and Brad) the more we try to hurt one another. It's really stupid, I think anyone has their own values, contributes and we're all in this together. I age, you age, and Brad ages. Trying to cause pain to others because they are similar doesn't help much.
It's worth noting that Brad is pretty young. Him deciding to wait for further research is pretty reasonable. If he were 50, 60, I imagine his risk calculus would be different.
Make sense Coyork. I'm 36 and that's exactly what I do. So far this is the interpretation of the study this is what we know. th-cam.com/video/DfZc4zbrPds/w-d-xo.html
@@johna5484You obviously don't understand what's going on here. Bloviating BS seems to be what people like to do these days. The whole point is He's young and not old and old is when toxic buildups accumulate
I have approximately over 60 supplements and drugs including fisetin, quercetin, nmn, resveratrol and spermidine. What i found according to my experience is that nmn has strong results. Fisetin is also effective in increasing oxygen tolerance throughout the body. In fact all of the five longevity supplements do have a positive effects. Remember i m not referring to any lab results, i am all about what i felt or experienced on my own.
Its pretty well established that resveratrol doesn't promote longevity and nmn, although increases NAD in the bloodstream, does not increase NAD in tissues, thus severely limiting what positive benefits it could have. Once again, it doesn't do much for increasing longevity.
@@WellnessMessiah well, apparently they DID object to sharing proof of their claim about fisitin's ' increasing oxygen tolerance throughout the body' (someone explain to me please, what that statement even means)😅 And... TADA! No answer to your request. ... And therein lies your answer. 😊
That was a lot of work putting these interviews and studies together… thank you for shedding light on fisetin / quercetin … I’m going to keep taking it for now 🤷🏼♀️
I think Brad also states he’s around 30 or 35 so it doesn’t make sense for him to take them personally since senescent cells do not build up until older. Age matters.
Hi could be. In the videos I showed addressing specifically fisetin+quercetin, he didn't mention that at all. But he might have mentioned that in following videos that are not around fisetin-quercetin.
@@WellnessMessiah he does take decisions based on his age, I think I remember him saying, for example, that he will not take NAC until he's 45. Regarding Fisetin, I don't recall him talking about his age
@@TudorIrimescu I don’t remember… Anyway, it’s in the video about the five supplements that he recommends. It’s easy to find it if you search for it in TH-cam.
Thanks Rimon, I was very disappointed and confused over Brad Stansfield’s decission on Fisetin and Quercetin although on balance decided to continue my own regime. So hearing your take on it I agree strongly that accurate data interpretation is vital on which we can all base our personal approach to supplementation
You made a HUGE mistake in your illustration of Fisetin and Quercetin similarities and differences (18:46). There's a big red circle around the catechol adduct on quercetin, implying that it's an important difference vs. fisetin. It's not. The two hydroxyls are on the 3' and 4' carbons of the "B" ring of BOTH molecules. Simply put, the catechol moiety (B ring) is covalently bonded to the #2 carbon of the "C" ring on BOTH molecules by a sigma covalent bond which can freely rotate. The graphic you chose minus carbon numbering make them LOOK different on that B ring. They're not. Both graphics (minus carbon numbering) are correct. The only difference between fisetin and quercetin is a hydroxyl on the quercetin carbon 5 of the "A" ring. That renders it slightly more hydrophilic, but not much. The B-ring moiety on both molecules are identical.
No doubt that data interpretation is important along with scientific replicability. All data should be submitted to independent examination(there is far too little of this!). Apart from the effects of Fisetin & Quercetin, IMO the best way to get rid of senescent cells is to do 24 hr, fasts, which I do every weekend. This promotes effective autophagy & as a 79 year old, it is most likely I have a plethora of senescent cells. Maybe autophagy using the body's own processes is more effective than adding exogenous molecules through supplementation, I have lists of foods that supply Fisetin & Quercetin & I try to eat these as much as possible as well. Congrats on your thorough analysis of the science. As for Stanfield, I find him to be somewhat impulsive in drawing conclusions.
Dr. Stanfield is very cautious about spending for supplements that have doubtful effect. Quercetin and fisetin may require large doses that would be waste and reduce our budget for the more important ones.
@@PedroGonzalez-me1qb Lots of things, but melatonin is among them. Quercetin and fisetin are not expensive, especially when used episodically; cost is not an issue. And whether or not they eliminate senescent cells is not the only issue. They have many other benefits. Re fisetin, see: "Fisetin: A Dietary Antioxidant for Health Promotion" on pubmed. It is dumb to rule out fisetin just b/c it may have failed at ONE thing (expunging senescent cells) in ONE study. But then, Stanfield is none too bright.
Thanks for the video. As for Dr Stanfield, his channel was really helpful at first. Then all of a sudden he became pessimistic and negative about everything, to the point I didn't feel his channel was useful anymore. Glad I found yours!
Brad Stanfield has been caught out on the Vitamin E (tocopherols vs tocotrienol) debate using similar illogical arguments. It's starting to look like a pattern.
Hi. I am continually amazed by your insights into studies done by other researchers, and how you often find significant issues being overlooked. Well done!
Hi Rimon, you videos are great! With the Quercetin intermittent hit and run, alternate days for 3 days exposure, how frequently should we do this please? Weekly, monthly or what time intervals are best in your opinion please? Thank you
Quercetin has other benefits aside acting as senolytic. It tackles nad+ depletion from a different angle of that taken by NR or NMN by affecting cd38 levels and act as attenuator. So that alone is a good reason to take this supplement. The claim is that in high dosage it also could operate as a senolytic and was shown to act as sirt6 activator.
YES. Many other benefits. This thing of rejecting a substance because it failed in ONE study of ONE action is just ridiculous. But that's the kind of thing that I expect from Stanfield, sadly.
Dr. Kirkland's observations in the video regarding the lack of senescent cell markers leads me to wonder: 1.How are the senescent cells themselves detected...and characterized? Does one detection methodology fit all senescent cells? 2.Are there degrees of senescence? 3.Can senescent cells definitely NOT be resuscitated? If not, why not? 4.Can senescent cells be typed by origin, i.e., used as organ early warning indicators in their own right? 5. Are there common and predictable epigenetic markers for senescent cells, or are they all unhappy in their own way? Declaring senescent cells themselves the problem seems analogous to a mechanic discovering metal in an oil pan and installing a magnet in the oil filter as a "solution." Some bearing is in trouble.
Good questions. I can tell you that in longevity research senescent state is 100% recognized once you look at the cell. It's irreversible on principle (albeit they can become cancerous. Low chance of that happening.). But when we try to see the accumulation of MANY cells, we need markers cells that show different markers. This is where we're unsure. What Kirkland addressed.
Dr Stansfields stand on quercetin was probably based on that research (Kirkland, perhaps) showed that fisetin was more effective than quercetin. So, if fisetin doesn't work, the weaker quercetin wouldn't work either. This is just my guess. That quercetin works better together with that cancer pharmaceutical might indicate that senolytics work better in combinations. Such as quercetin and fisetin together, perhaps.
Since it is likely that senolytic cells start accumulating above the age of 50, it is not a big risk to younger people to delay the taking of anti-senolytics compounds until further evidence. Also, there are researchers that hypothesize a delicate balance between senolytic cells and cancer cells that is not yet understood.
Brad is too rigid and swayed by every latest study, no matter what it says. He will be changing his mind when the next study says the exact opposite. The fact is that fisetin is proven many times over to be effective.
Spot on. My son is autistic and I’ll go he if Stanfieid isn’t also autistic. He’s far to conservative for my liking and places waaaaay to much emphasis on studies, as if studies are 100%. Imo studies should be one of the more important factors in deciding which supplement to take and they shouldn’t always have the same emphasis in every situation, for every supplement. These kinds of attitudes are common for autistics, especially autistic drs, they’re extremely inflexible in their thinking and cling to rules and studies to calm their anxiety about uncertainty. Also stanfield is young and healthy, I’m not, I don’t have the luxury of being so cautious, I’ve been sick for 4 years and my autistic dr, whose alot like Stanfieid Has done very little to attenuate my condition- hence why I’m here. I like this guys insights, but the aesthetic on the channel is insufferable, like some unbearable PowerPoint conference at work.
That's what I would expect from people that follow the evidence, though. I'd be more worried if he didn't change his mind if more evidence comes to light.
@@ingramdw1 not when it’s back and forth, back and forth, though. He’s blown by every wind, it seems. Interpreting the studies properly is important, as we both know. I think the Fisetin video he just wrote off Fisetin when the study didn’t even say whether the Fisetin was taken with food or not. If it wasn’t taken with food, then it wouldn’t be absorbed well at all, and that changes the entire results. But Brad just made up his mind about it based on that.
Proven where? The more I look into studies the less I believe "longevity community" hypes. More often than not either studies are deeply flowed or interpretations are taken to absurd. Sometimes both. And let's not even go into ridiculousness of looking at some half-assed study done on worms and flies showing that something might work and extrapolating that into "I must stuff my mouth with a bunch of shady pills to live longer". The quackery masquerading as science is rampant in "longevity community".
@@alterego157 I agree with much of what you said. But it sounds like your taking it to the extreme and being cynical , there is a lot of exciting cutting edge science coming out of this space, if your saying there isn’t, then your definitely a cynic. I mean you can’t argue with some of the results from prominent longevity personalities, also there’s a tonne of formerly - very sick people who’ve been sick for a really long time and have exhausted all options through specialists and gps, once they discover sone supplements in the longevity community there lives turn around for the first time in years. I’m one of those people, I could barely get off the couch after work and was struggling to even get to work most days, I had dementia like symptoms and had one illness after the next, now after developing my own stack my life has completely turned around, I have enough energy to go to the gym 3 times a week and am now looking to increase that too. Not to mention all my blood work has improved and I no longer need blood pressure medications. So this is compelling evidence for me too. And yes I was already growing my own food and doing keto, I.f. Before I discovered the longevity community, I was doing everything the drs suggested and more and still wasn’t getting results.
I do apreciate your angle and interperetations very much so. it is of the essence to keep this community (and any other community for that matter ) properly and accuratly informed. i feel your coments and findings are genuine and sincere and that helps a lot. ive learned a lot from you. please go on.
I was ready to not like your video but your honest and open manner converted me into a subscriber. I do like Dr. Brad although I certainly do have differences of opinion from him in certain areas. I also credit Dr. Sinclair for getting me interested in longevity to begin with although I question his motives sometimes after the debacle with Resveratrol where his studies seem to have been found flawed while his company made over $700 million from selling it to GSK who then shut it down once it didn't look like they could profit from it.
Thank David, in my opinion, confusing contradicting information prevents us from sticking with habits. I view that as damaging if not based on solid science. Better to stick to what you're certain about and wait until the data is out. I have the privilege of seeing results with clients, to make me more certain that interpret data correctly.
I like clear logic, different molecules & unpublished, enough. I am on Quercetin started today (side effect it fixes exercise rhinitis and I exercise daily, no more runny itchy nose is awesome). Will play with dose/frequency. subbed.
There are a variety of positive reasons to take Quercetin and perhaps Fisetin aside from senescence - incidentally assisting longevity. Unless testing a specific pathogen, most test mice, worms, etc. are NOT exposed to various viral, bacterial or fungal infections. Zinc is VERY valuable to strengthen the immune system and resist viral infection, but unassisted zinc has trouble. Quercetin appears to be a zinc ionophore, assisting more zinc cations to cross the plasma membrane.
In a way, you have confirmed Dr. Brad's conclusion. If the information/data does not show efficacy of the compound the default should be to NOT take the supplements. Too many people in this community are too quick to get on the next supplement, the next drug, the next go to product. There are not enough studies or proof of the efficacy of these supplements, so every professional should be advising their community to be careful, and only take that which science and studies have proven with a statistical confidence. You should be an advocate for science and proven studies and the interpretation of those studies by the scientists who are associated with those studies.
I got a totally different understanding from the video. I understood that when taking fisetin supplements, the total amount amount taken per kg of body weight is very important. If enough is not taken, then one will not experience the longevity benefits of fisetin, it will only kill senescent cells at the correct dosage as related to body weight.
Stanfield just makes contrarian headlines to generate clicks. Then he cherry picks data/studies to support the video title. I've unsubscribed from him recently. Particularly when he singled out one of my comments in his IF video and then misrepresented the study i cited to him.
What’s the ideal frequency for taking these? I’ve seen some reports that taking these infrequently was a better approach. A couple times per week for Quercetin and as little as one or two per month for Fisetin. I can’t remember where I saw this but Rimon if not for you I’d be taking too much Resveratrol daily until I saw your video so I thought you might have insight into quercetin and fisetin frequency.
As I will show more research on these in the next episodes, possibly you can make up your own mind. Remember we don't have a ton of data on the perfect doses right now, but close.
@@WellnessMessiah Thanks Rimon. Understood, I are an engineer and appreciate the way you approach these from not just your scientific profession but also an engineering mindset. You also gave me some additional insight that being 43 and healthy/fit (and told I look a lot younger), maybe senolytics should be the least of my focus now but for a once a month dosage? Always interested in your feedback and your next video with more of this research.
Thank you! I have been a big fan of quercetin and have tried fisetin. I think the research is young and since these compounds are widely distributed in nature. They seem to be well tolerated. I don't think it hurts to err on the side of taking them.
I like Brad Stanfield and he does very good work analyzing the various studies out there - better than most by far. Lots of people jump on the longevity hypewagon and ride it as far as they can citing mice data and seriously flawed human studies. So, my question would be where is the long term, human studies (properly conducted) that show that either fisetin or quercetin provide senolytic benefits? I don't think there are any and that's what Brad says most often. If there isn't solid science around it he's not going to recommend it. He almost always says that it's your choice and if it works for you do it as long as there are no harmful or long term side effects. Mice data is only "interesting" at best. There are an almost uncountable number of tests on mice with various interventions that yielded no result in humans. There's still questions about the bioavailability of fisetin and quercetin in the first place when taken orally. So, let's not misquote Brad here. He says this is why HE stopped taking it. He didn't say you should stop taking it nor did he say it's ineffective. What he did say is that from what he sees of the science, there just isn't enough evidence yet to say it's truly effective. I tend to agree and want to limit my supplement stack to those things that we know are effective instead of making the pharma and supplement companies rich. Also, let's be honest and build in a little "bias interpretation" into our opinions. Brad has nothing to gain from recommending or discouraging the use of certain supplements and drugs. Sinclair and the rest of them often do since they have built a business around selling them. Show me some unequivocal proof and science that this stuff works and I'm all in. Until then, it remains "interesting" to me.
Hi, I didn't misquote him. I put the exact segments of him, speaking and said what is my understanding (which I said, could be wrong). I will add that I do like Brad channel, as I said. Sometimes humans, the more we are alike (e.g. me and Brad) the more we try to hurt one another. It's really stupid, I think anyone has their own values, contributes and we're all in this together. I age, you age, and Brad ages. Trying to cause pain to others because they are similar doesn't help much.
@@WellnessMessiah It's all good. I appreciate the efforts of everyone who's trying to earnestly and honestly help us all understand to extend lifespan and healthspan. The biggest problem I think we (people in general) face today is that there just haven't been enough good studies yet to tell us what supplements are ideal AND the mechanisms by which they work. Even with the enormous amount of research being done into lifespan and healthspan it's shocking how little we really know and how much is changing. Remember the resveratrol hype? Sinclair made a fortune on that molecule and now there are new studies showing that is doesn't do what he claimed it would - that it was a lab error related to the dye used. It might even have some detrimental effects. Someone here commented to the effect that Brad changes his mind on things a lot. GOOD! that's not him, that's a result of the test results being published that tell us new things. We should all be changing our minds regularly on this issue as new data becomes available.
Yes, indeed he just argued that this is why HE stopped taking it. He didn't say you should stop taking it nor did he say it's ineffective. However, it should be clear to you that your are following an idol. You model him as a saint, kind of. He is running a channel, meaning he is trying to build trust in what he is saying,, and with that and his title comes authority.. AND responsibility. In such a channel, there is no "neutral zone". He himself was removing that. Furthermore, he is not just telling it, he is preaching it. Trying to appear as important as it can get. Body language, intonation, just look at it. IT IS DISGUSTING. Boy, that's not serious, honest communication. I got his channel recommended by others ...and found a clown, who wants to be important, and has no clue about the things he is talking about.
I am happy for once somebody said the word that many peoples think, it’s very frustrating for the consumers to receive contredit confirmation on product he invest and use for a certain time and moneys, thank you.
Yes, listen I'm just like you. I'm too confused and then try to clarify by research and thinking. This is why I don't cooperate with supplement companies, because I think it will reduce the clarity of my videos, hurting the very purpose of trying to alleviate confusion instead of causing one.
Brad is driven by peer reviewed studies that are well designed. Sure he can change his mind, but that’s what you are supposed to do in light of new evidence.
I appreciate when we hold each other accountable for accurate scientific conclusions…especially in this rapidly developing field of longevity. Thank you for being additive to this process!
Great background information! As there are no risks found (yet?) taking Quercetin/ Fisitin other than spending money on a possibly useless drug, I will take it and wait for more data.
Yes, as you said, in situations where we have limited data, sometimes taking things that are unlikely to cause harm yet don't have absolutely 100% proven benefits, make sense nevertheless as aging is a much greater risk factor.And a certain one.
oooops. My jaws dropped... You are doing great work. Thank you!!! It is this kind of work that makes your channel so trustworthy. You are a genius :)) ...so they claim to made a study in 2018, Stanfield talks about it in 2021 \ 2022, and in 2023 it is still not published ??? Serious academic research works differently (I am trained as a natural scientist, in biology). In a world where publishing is everything, not to publish for 5y means that the persons doing the study long left the organization, and the studies were not at all clear. Also, they refer to a Fisetin hydrogen sulfide study... Interesting part, this hydrogen sulfide. Probably it was a study about provoked senescence. ....and Mr. Stanfield is just a clown. His way of thinking, as revealed in this affair regarding the relation of fisetin and quercetin, has structural deficits and he should not feel entitled to give any recommendation, not even express his opinion on YT. That was not just a small mis-take. He has absolutely no clue about biochemistry.
@@RandomGuy-qg9xf they started at age 20months (@15:40), and they live maybe 28..34 mo... so it is +8 to +14, roughly a year. I correct. study finished in 2019 etc etc
@@RandomGuy-qg9xf why not scientific? It is done in many studies. In some studies they start even later in their life. And no, it does NOT start a age 0. check out the few moments around 15:40. They start giving the substance at age 20 mo. (ps. the scientific principle is : ceteris paribus, as long as everything (!) is controlled, it is fine. Now, that institute makes a huge mistake regarding that, but i will not spoil Rimons next episode :)
My jaws dropped as well. When I said "am I turning blind or what" I indeed thought I was to blame for not finding the study :) Thanks for the compliments, you're very kind.
And I'm a physicist working with medical data and I'd say one can still publish an inconclusive study. Maybe not on Elsevier, but on your own website, but publish it somehow nonetheless. More than once my team published such studies, it's a way to say "don't try my target because you'll hit a dead end or, if you try, change the study design". I think the only reason a study cannot be published is if there is a design flaw that nobody caught until the study was finished. Now, there's the small matter of the money this study consumed, but that's another problem.
Great video Ramon. You are a brilliant guy. Thank you. Your channel should grow into one of the most followed on the internet in the field of longevity.
I'm 50 yrs old had covid twice thought I was gonna die. Started taking queceritin and been around several people really sick and I haven't been sick with anything g for at least a year I think it works at keeping me from getting sick
Hi Rimon, it’s important to note that no clinical guideline suggests using Quercetin or Fisetin. We don’t have any robust human data showing benefit for either molecules, plus the Interventions Testing Program found NO BENEFIT for mice who took Fisetin. I’d much prefer to focus on diet, exercise, sleep, and the occasional supplement that has proven benefits such as creatine. ✌️
Hi Brad thanks for the response! I invite you to make a response video, which could benefit your followers greatly. It's a very interesting discussion and it will get proper attention.
Rimon, thanks for your work. With regards to Dr. Stanfield, I stopped following him awhile ago as I believe he is more interested in click bait than actual analysis. I have confidence in your data interpretation so please continue the great work. Any update on your wife’s condition?
Hi, thank you for asking. Well, she's at home and it's not easy. We're doing oxygen chambers almost every day, I estimate at least 6 more months of intense recovery and then slow and gradual over a period of 1-2 years.
I generally trust Dr Stanfield. However, his fundraising to finance his own Rapamycin study gives me concern. Any such study is probably beyond his capability (no insult to him). Such a study is a huge undertaking requiring expertise in many advanced fields including statistics. Does he have that depth? So, is the fundraising on the up and up? I question it.
Whether on not Fisetin or Quercetin help clear senescent cells, each has other things that they may do that may beneficial, and neither has been shown to have any downside other than price. I personally take Quercetin for it's effect on mast cells and allergies. Here is another video related to Fisetin and effects that it may have against cancer: th-cam.com/video/7ppEtPi_ZHE/w-d-xo.html
Hi! Big fan here in Brazil. Regarding your couse, how the content is delivered? It is video lessons, pdf material, zoom meetings, telegram groups? I am willing to join but could not find this piece of information in the subscription page. Thank you!
HI I haven't researched it enough. I'm not sure it was extensively researched for senolytic activity as fisetin and quercetin, so it's difficult to make data interpretation.
Rimon: In your experience is it normal for a study (being run by ITP?) in 2018 still NOT being published in 2023? Is it due to the study only being started in 2018 and not being completed until recently? If so, how could the 'experts' on fisetin / quercetin risk their credibility by commenting on an incomplete study before it is published? If the target of fisetin / quercetin is removing/recycling senescent cells (in all their varieties), how effective are each of the various types of fasting (8/16, OMAD, 3 day water fast, 7 day water fast) when compared with the two supplements noted?
HI Ken, I think they only started the study in 2018. The issue is even if the ITP completes t the study - then they work on publishing previous studies, a waiting list kinda thing. They are slow, so it is normal. As to whether the researcher comes out with their findings 2 years prior to the data... that's up to you to decide.
Hi there, autophagy could only be measured locally, by tissue sampling. Senescent celll death, it depends on the study. So far this is the interpretation of the study this is what we know. So far this is the interpretation of the study this is what we know. th-cam.com/video/DfZc4zbrPds/w-d-xo.html
LE produces Senolytic Activator, I don't have it yet, but I want it, the fisetin and quercetin are in phytosomes, stabilized with galactomannan fiber gel etc. to get it past the stomach and the phytosomes get it into the bloodstream. 3/week is all they recommend.
For someone who attacks other doctors because there is no data to support taking nmn only to turn around to have an opinion based on no data is all I need to know about him.
Man, it takes one week or less to write and publish the study once you have all data! That's because you already have the framework for what you're going to do. You set a target, you design the study, you gather and adapt your tools, you start gathering data while making adjustments to your tools and, by the time you close the study, you already have 80% of the paper. Everything else after that is statistics and letter picking from the keyboard. And, one more point, you hurry up because you don't want other teams who are working on the same subject, to have their studies published before you. The only reason you don't publish your study is if your resident statistician was already dead at the start of the study and you can't guarantee that the sampling stage/process was correct.
Any chance you could get an interview with the head or a researcher at the ITP? Would be interesting if you’d ask all those questions directly to the people working on those studies.
I am confused about the comment about losing our only arsenal of defense against senescent cell buildup. Not only are there alternatives, there are free alternatives. Mankind has been fasting for thousands of years. Although not popular with the masses, we have know since the early part of the 20th century about clinical proof of caloric restriction with optimal nutrition. Among the many approaches to finding longevity, caloric restriction (CR) has received a lot of attention in the last few years. The first evidence indicating the benefits of CR date back to the 1930s in studies conducted by Clive McKay, an American biochemist and gerontologist. Most people myself included would love nothing more than to be able to pills as a first line defense against aging.
Hi Michael, I didn't refer to habits as much as external agents (supplements) and nothing innate. Apologize for the confusion. Obviously, a strong immune system will be able to clear them as well, depending on what you mean by "tools".
I'm going to start taking Fisetin a few days a month as I'm in my mid 40s now. There are brands formulated to be much more bioavailable and that seems the route to go. The same goes for Quercetin, which I've bought in bulk powder but haven't taken because it tastes awful. I'll get a more absorbable form in a pill instead.
From my experience you must beware of fisetin and dosage if you've any kind of degenerative condition. I've noticed when I take it in high doses the pain is greater where I have the condition and subsides when I stop taking it. Maybe it's doing what it does on the senescent cells or maybe its just me but I'm wary of fisetin.
Curcumin is ALSO a serious senolytic - why is everyone ignoring it? I know it's not easily bioavailable, but there are solutions for that, e.g., Longvida's preparation.
Careful about this, there are studies that show that supplementation of D3 in large doses can crete problems in the long term. What Brad is saying (I think) is that is better to eat more fat fish and reduce D3 supplementation, rather than taking only large doses of D3 through supplements
Giovanni Dominoni you are right about the nutrition but then you need to explain it every time ..D3 800iu is like Zero.. if you eat a Hering per day you got it all covered
I still take Fisetin and Quercetin and my wife also. We take a week break, and then continue with these supplements. We also take NMN, and NR plus AKG from ProHealth Longevity.❤
Nice to meet you here. I've published a free report on quercetin in a few days after 6 months of research with 300+ studies, into short at www.Wellnessmessiah.com/gift
Brad should look into the research from Life Extension who has introduced compounds that allows for body to actually absorb them. Most if not all of these compounds aren't absorbed as capsules. You would likely need to get expensive shots to make them work and even then, the absorption issues are still there.
We've always known from the advice of the elderly that there was an effect of eating an apple with(quercetin) or without the skin, so the bottom line in my opinion is don't listen to studies that try to distract you from reality ! It is healthier to eat a whole apple than to peel it. So that effect cannot be removed by a study that has not been published!
Knowledge is dimensional. Not linear. Finding your way requires intuition and listening to internal inspiration and external authority findings. We might ask; What was the mineral balance of the people/ beings studied? Who funded the study? How much should we question the orthodoxy ? In my estimation any study needs to be questioned, as we do not know the motivations of those doing the study. Science is about ready to change exponentially over the next five years, put on your seatbelt.
Let Brad stop taking all the supplements what he has consumed so far. He can then use the money for his rapamycin study. Unfortunately his fundraising efforts for this are not moving forward 🤷
Brad Stanfield has a lot more videos that have lot of almost believable misinformation and sensationalism and debate based on no data, bad data, or just professional jealousy against other researches. So refreshing to see you take him out on this piece of sensational misinformation on bad data politely.
Another great video, Rimon! I also like Brad Stanfield quite a bit, in fact I added creatine and collagen peptides to my supplement routine based on his videos. However, like anyone, he's not perfect and sometimes gets it wrong. I find his videos about why he stopped taking things less convincing than his other ones which are usually really good. Like his resveratrol video which you replied to earlier. Here with fisetin and quercetin is another example of how he incorrectly interprets data. And his reasoning for why he stopped taking quercetin is particularly bad - it's a different molecule than fisetin to begin with. But setting its senolytic properties aside, it is an iron chelater, which is critical because excess iron hurts your health and longevity, is a zinc transporter, which is important because zinc needs to cross into cells to help your immune system, and it is a sirt6 modulator, meaning it stimulates or represses sirt6 activity depending on the circumstances. So deciding whether to take quercetin based on how its senolytic properties compare to fisetin seems ill reasoned. And fisetin has good things going for it besides its ability to eradicate senescent cells. To do that you need to to the high dose pulse protocol that Dr. Kirkland is testing. But low dose may induce cells to clean themselves by eliminating old or damaged organelles or other proteins and reduce senescent cell toxins in the system. So you can't even judge fisetin on its ability to reduce senescent cells alone, you have to consider everything. Regardless of Stanfield's videos, I take both fisetin (liposomal form) and quercetin (phytosome). An unexpected result of the fisetin is my skin softening and becoming smoother. Anecdotal of course, but I was very surprised this happened after adding fisetin to my supplements. And when I looked into it out of curiosity it turns out there is some evidence for it improving skin health. Go figure! To sum up, I think Brad Stanfield is a big asset to the longevity community, especially given he's on the side of allowing NMN to be sold even though he doesn't use it, but like all of us, you can't just take his word on anything uncritically without validating his reasoning and conclusions.
Hi Jason I'm impressed with your knowledge about quercetin. indeed it seems like an iron chelator. And it's activity on SIRT-6 changes - just like you said. I myself haven't completely grasped how this powerful molecule works. I'm going again over some studies. How did you know it's fisetin and not quercetin lead to smoother skin if you take both?
@@WellnessMessiah I had been taking quercetin phytosome for a long time before beginning liposomal fisetin. The skin changes coincided with starting fisetin. I also noticed similar skin benefits when starting hyaluronic acid, by the way. Again, anecdotal and clearly not scientific, just reporting my personal experience. One other thing, since you recently made your video on synergy between foods and supplements, there is evidence that quercetin has synergy with curcumin.
@@jasonbromano Do you take the recommended dose (on bottle) everyday? Once a week... or some other frequency? Has there been any perceptible improvements in joint health for you (if you had an issue with the joints to begin with).
The study he based his decision on was one without a lipid but only water. If no oil is included the fisefin and quercetin may not have absorbed at all??
Sorry Brad, as a practicing physician, does what most busy clinical physicians do. Doesn’t read papers, at best they read the abstracts and perhaps the bottom line of the conclusion. These are the good Doctors! I had a local GP who confessed, he never read “articles” he was a qualified doctor! To my point Brad is a master at the shortcut conclusion, hence his frequent change of “personal” practice. He seems to have upped his game, reacting to a single statement on a paper yet to be written. My real point is that all study papers are written to be published, in doing so they need to satisfy the peer review, to do so they often need to “massage” the abstract and conclusions to pass peer review, sometimes to a point where they don’t match there own study data. Of course this assumes that a study like this wasn’t set up to fail by design. Usual tricks: inappropriate and low P study population, under dosing, short duration. Inappropriate markers and peculiar statistical categories. Perhaps the best is “adjusted for cofounders” without identifying what the cofounders were or how they were weighted. Final note Dr Kirkland is perhaps the most experienced researcher into senolytics we have, while that doesn’t make him correct, his informed understanding of senolytic research is discounted at your peril.
Doctors aren’t supposed to read individual papers - there are committees that read the latest evidence and summarise it into guidelines and that’s the safest and best practice - perhaps understand the mechanics of the profession before you judge
@@heyyou9839 Having spent decades in hospital medicine, I think I have some insight. If your point is that medical practitioners operate as a consensus, a collective and therefore should only conduct interventions from defensible positions, I can agree with you. However as medical journals are filled with individual peer reviewed papers and well as meta analysis and multiple paper review articles, your suggestion that doctors shouldn’t read individual papers is faintly ridiculous.
A lot of scientists build their whole careers and obtain millions in grant research dollars on flawed theories. When their research eventually produces data that disagrees with their theory they either never report it or throw it out.
I like your humorous use of music... i.e. "another one bites the dust"... I've always thought that it be apropos for your name to sung for the intros to your podcasts... ...in the style of "dream on"...
I wonder why Dr Stanfield would want to take such supplements now, when he is so young. Maybe better to take these things when he is older and the evidence for their effectiveness is more affirmitive. There are other compounds, such as NMN that Dr Stanfield doesn't personally take, but Dr Sinclair does. And I find Dr Stanfield's nay-saying around such compounds, the perfect antidote to the possibility of a blind obedience that could be displayed by some consumers, who could be influenced by Dr Sinclair's superstar status. As a potential consumer myself, monitoring the identity of the supplements that both of the Doctor's agree have undeniable, (evidence based), efficacy, will go some way for me making the right choices and not wasting so much money. Dr Stanfield is a General Practitioner in his country of New Zealand and presumably has to satisfy the governing body of his own profession there and presumably his own conscience, that he doesn't make poor recommendations to his own patients in particular and his You Tube audience in general. Dr Sinclair on the other hand is outside that sphere, in the world of academic research. Longevity researchers like himself, can turn around in the long-run and say, 'hey, evidence doesn't support our premises or early research after all', or vice versa, because this field of Longevity research is still so young. Personally, I am often left 'scratching my head' at the disparity of opinions between clinicians or researchers when the Science is supposed to be the same between all of them. Gerontology and anti-aging research is so fascinating.
It's not a total loss if these two supplements don't work. We still have autophagy from fasting for dealing with senescent cells. There is also exercise which is the other way of naturally boosting autophagy.
Quercitin has been recommented to get rid of the spike protein injected into your veins or as a prophlyactic against catching the virus or an early intervention. I've never, ever heard of taking it for longevity, but I still eat an apple every day.
re At 12 minutes... Delighted that you said one of my life-guiding wisdoms---Mr Perry, my high-school physics teacher, had us do an experiment each week and report it, by stating results AND CONCLUSION. I myself urge reasonable as separate from the merely rational. For example, I do not believe there are witches---so the premise is wrong, even when a witch-trial case appears solid.
I read your quercetin document. It is great!!!!!!! But I have one question: if you give a SMALL MOUSE 2000 mg of Quercetin that will obviously have a more dramatic effect than 2000mg would have on a big human body. So we can not even consider the study where the mice got 2000 mg to draw any conclusion for humans. What am I missing here??
I’ve been taking Quercetin to help control uric acid as David Perlmutter suggested and it seems to work as good as allopurinol, I never knew about these other potential benefits.
Really, this quercetin is one of the most powerful supplements I have ever researched. Check my free newsletter, I give inside my research on tis supplement. what you said supports my findings
I followed the same paper trail that you did and came to the same conclusions although you went further with regards to quercetin. I am about to view your next video. I sent a request to the IPT. I don't expect a response.
Thanks Riman. I go crazy with these scientists posting they take something and 5 minutes later changing their mind and then changing it again. Then they put those little irritant disclaimers. This is not medical advice. Go and try to make money somewhere else.
Yes, listen I'm just like you. I'm too confused and then try to clarify by research and thinking. This is why I don't cooperate with supplement companies, because I think it will reduce the clarity of my videos, hurting the very purpose of trying to alleviate confusion instead of causing one.
Good video but a bit of a tease as to why the study was flawed. I suspect bioavaialability has much to do with it.Curcumin is another good senolytic, and that as huge absorbtion issues. Fisetin, though is not just a senolytic, which is where Stansfield was unwise - the length and breadth of the studies on fisetin are remarkable.
I've published a free concise report on quercetin after 6 months of research with 300+ studies, at:
www.WellnessMessiah.com/Gift
This is the follow-up video: th-cam.com/video/DfZc4zbrPds/w-d-xo.html
Both 🙂👍
😊u
I'd say feel free to analyse the data that is available at this time.
HMMMM, anyone else smelling raw fish: ITP's Dr. MILLER SOUNDING LIKE Fauci or one of his Orian minions has touched him. Forget their rapid about Face. Quercetin has saved countless lives and shied off
C19 i'lls and wows now, all of a sudden it no l ok nger works .
PLEASE !
I doubt you could, ...or we should, wait until 2032....
When they will publish a study showing the opposite 😁
I have a friend who is 92 years old. His leg was swollen and painful. He was using a cane. I bought him a bottle of Quercetin and told him to take one at night and one in the morning. I saw him 2 weeks later and he said, “I feel like I’m 35 again!” That is better than a study on mice!
If I was Brad Stanfield's age I wouldn't take fisetin either. But I am 71. I take 2,400 mg in 1 dose 3 days in a row monthly. I take it with fat, usually olive oil and piperine because it is hard to absorb. When I first started 2 years ago I felt distinctly different on the days that I took it. I believe I was killing a lot of senescent cells. I do not have as much of a reaction now as I believe the senescent cells are now under control. Ironically I use Brad's discount code when I buy it. Personally I don't have time to wait for a published study when I can see results myself.
Very interesting experience. It definitely sounds like something happening in your body. if only senescent cells would indicate their own demise, we should not have waited for other human studies to be sure what happens inside
May I ask, what differences have you seen since starting Fisetin? In particular changes to joint health, skin and hair, if any. Also where do you get your piperine. Thanks in advance.
Very interesting keep me posted bro
Piperine is extracted from black pepper. You might/should be able to get all your peperine requirements from simply using ground black pepper! @@g.......g
How much piperine do you take with Fisetin? I am taking 100mg Fisetin everyday now, maybe I should just take it like the way you do.
I’ve said it before and I’ll say it again-YOU HAVE THE BEST BRAIN OUT THERE IN THE THE LONGEVITY FIELD ! Thank you so much for figuring this stuff out and sharing it with us. I love you.
Hi Joan you make me blush again. I'm just a cog in the system of information, trying to make sense of it all (of things that sometimes seemingly make no sense) :)
@@WellnessMessiah You are more than just a cog. I hope you don’t lose your humility and goodness as they are far important than intelligence. Every now and then I see this childlike funny little boy in you. I bet you were the most adorable little boy ! Im old enough to be your grandmother-if you ever need a grandmother-I’d like to adopt you 😊. I pray your wife is improving. Considering all you’ve been through and are still going through it’s amazing to me that you can still maintain your focus so well. God bless you 🙏🏻❤️
thing is you would have to have the best brain in the field to know he had the best brain in the field, lol, im wondering if he might actually be the worst brain in the field. GENERALLY ANYONE WHO USES CAPS TO MAKE A POINT IS REALLY A MORON
I’m 75. I take Quercetin daily.
@@Keep-on-ok sooo? is it working?
Impressed with your approach to addressing this topic logically without any individual disparagement. Appreciate you helping people find their way to the truth.
Hi Mike, sometimes humans, the more we are alike (e.g. me and Brad) the more we try to hurt one another. It's really stupid, I think anyone has their own values, contributes and we're all in this together. I age, you age, and Brad ages. Trying to cause pain to others because they are similar doesn't help much.
@@WellnessMessiah you don't think it's at least a little pompous call yourself the wellness messiah?
It's worth noting that Brad is pretty young. Him deciding to wait for further research is pretty reasonable. If he were 50, 60, I imagine his risk calculus would be different.
Make sense Coyork. I'm 36 and that's exactly what I do.
So far this is the interpretation of the study this is what we know. th-cam.com/video/DfZc4zbrPds/w-d-xo.html
Even though he’s young it appears he would rather just shift to supplements that work.
@@johna5484 exactly, and based on science, not "interpretation"
@@johna5484You obviously don't understand what's going on here. Bloviating BS seems to be what people like to do these days. The whole point is He's young and not old and old is when toxic buildups accumulate
I have approximately over 60 supplements and drugs including fisetin, quercetin, nmn, resveratrol and spermidine. What i found according to my experience is that nmn has strong results. Fisetin is also effective in increasing oxygen tolerance throughout the body. In fact all of the five longevity supplements do have a positive effects. Remember i m not referring to any lab results, i am all about what i felt or experienced on my own.
Thank you for sharing. Would you object explaining the "increasing oxygen tolerance throughout the body" benefit?
Perhaps you could do a google search on spermidine absorption, it is not absorbed by the gut. Liposomal spermidine might be a solution I would guess.
Its pretty well established that resveratrol doesn't promote longevity and nmn, although increases NAD in the bloodstream, does not increase NAD in tissues, thus severely limiting what positive benefits it could have. Once again, it doesn't do much for increasing longevity.
@@nukenfry
Agree with you👍 Thanks for speaking out on this issue - with FACTS!
@@WellnessMessiah well, apparently they DID object to sharing proof of their claim about fisitin's ' increasing oxygen tolerance throughout the body'
(someone explain to me please, what that statement even means)😅
And... TADA!
No answer to your request.
... And therein lies your answer. 😊
That was a lot of work putting these interviews and studies together… thank you for shedding light on fisetin / quercetin … I’m going to keep taking it for now 🤷🏼♀️
Hi Lucy, you're very kind. I think this story is the epitome of confusion in our community.
Ho Lucy - should I do data interpretation now or wait for the full study?
@@WellnessMessiah as someone mentioned you should do both :)
@@WellnessMessiah I would love to follow as it unfolds. Is both asking too much ? 😀
@@lucycooper55 no :)
I think Brad also states he’s around 30 or 35 so it doesn’t make sense for him to take them personally since senescent cells do not build up until older. Age matters.
Hi could be. In the videos I showed addressing specifically fisetin+quercetin, he didn't mention that at all. But he might have mentioned that in following videos that are not around fisetin-quercetin.
@@WellnessMessiah he does take decisions based on his age, I think I remember him saying, for example, that he will not take NAC until he's 45. Regarding Fisetin, I don't recall him talking about his age
@@giovannidominoniWhat's his reasoning for not taking NAC before 45? Want to find out cause I'm 21 and I dose 600-900 mgs almost daily
@@TudorIrimescu I don’t remember… Anyway, it’s in the video about the five supplements that he recommends. It’s easy to find it if you search for it in TH-cam.
@@giovannidominoni
He promotes collagen, which is bs. Don't pay attention to him.
Thanks Rimon, I was very disappointed and confused over Brad Stansfield’s decission on Fisetin and Quercetin although on balance decided to continue my own regime. So hearing your take on it I agree strongly that accurate data interpretation is vital on which we can all base our personal approach to supplementation
These work for me, I'm 148 years old and still going!!!
Cool - You will live long enough until the full study will come out....!
148 yrs ?
You lucky youngster! I'm 242 years old...
I'll race you to 200!
Remember to double the dose when you hit 150 years. You'll thank me when you break 200
You made a HUGE mistake in your illustration of Fisetin and Quercetin similarities and differences (18:46). There's a big red circle around the catechol adduct on quercetin, implying that it's an important difference vs. fisetin. It's not. The two hydroxyls are on the 3' and 4' carbons of the "B" ring of BOTH molecules. Simply put, the catechol moiety (B ring) is covalently bonded to the #2 carbon of the "C" ring on BOTH molecules by a sigma covalent bond which can freely rotate. The graphic you chose minus carbon numbering make them LOOK different on that B ring. They're not. Both graphics (minus carbon numbering) are correct. The only difference between fisetin and quercetin is a hydroxyl on the quercetin carbon 5 of the "A" ring. That renders it slightly more hydrophilic, but not much. The B-ring moiety on both molecules are identical.
No doubt that data interpretation is important along with scientific replicability. All data should be submitted to independent examination(there is far too little of this!). Apart from the effects of Fisetin & Quercetin, IMO the best way to get rid of senescent cells is to do 24 hr, fasts, which I do every weekend. This promotes effective autophagy & as a 79 year old, it is most likely I have a plethora of senescent cells. Maybe autophagy using the body's own processes is more effective than adding exogenous molecules through supplementation, I have lists of foods that supply Fisetin & Quercetin & I try to eat these as much as possible as well. Congrats on your thorough analysis of the science. As for Stanfield, I find him to be somewhat impulsive in drawing conclusions.
Agree
Dr. Stanfield is very cautious about spending for supplements that have doubtful effect. Quercetin and fisetin may require large doses that would be waste and reduce our budget for the more important ones.
And what are the most important ones ?
@@PedroGonzalez-me1qb Lots of things, but melatonin is among them.
Quercetin and fisetin are not expensive, especially when used episodically; cost is not an issue.
And whether or not they eliminate senescent cells is not the only issue. They have many other benefits.
Re fisetin, see: "Fisetin: A Dietary Antioxidant for Health Promotion" on pubmed.
It is dumb to rule out fisetin just b/c it may have failed at ONE thing (expunging senescent cells) in ONE study. But then, Stanfield is none too bright.
Dr Fraud Stanfield 💩
I bought his supplements and ended up admitted to the hospital. He is a Fraudster. Beware 🛑 ⚠️ ⛔️
@@PedroGonzalez-me1qb Stanfield cherry picks and makes arbitrary conclusions, always.😊
@@PedroGonzalez-me1qbMagnesium, Creatine, D3 (low sunlight seasons,), Taurine
Thanks for the video. As for Dr Stanfield, his channel was really helpful at first. Then all of a sudden he became pessimistic and negative about everything, to the point I didn't feel his channel was useful anymore. Glad I found yours!
Amen. Dr Stanfield's channel has become very random, misleading and political shooting gallery dressed as "science"
I think his feud with David Sinclair has wounded him
Great video 10/10. Keep pushing out content of this quality and your subscriber count my double.
Brad Stanfield has been caught out on the Vitamin E (tocopherols vs tocotrienol) debate using similar illogical arguments. It's starting to look like a pattern.
Hi. I am continually amazed by your insights into studies done by other researchers, and how you often find significant issues being overlooked. Well done!
Hi Rimon, you videos are great! With the Quercetin intermittent hit and run, alternate days for 3 days exposure, how frequently should we do this please? Weekly, monthly or what time intervals are best in your opinion please? Thank you
Fisetin does work for me. I tested by applying it on my right hand and use left hand as control. My age is about twice Brad's.
You applied it by placing it into a cream or lotion?
@@KatSchlitz Yes. it only works for old people, I'm pretty sure.
@@weiminyang7206 And you noticed... what? Fewer age spots? Better turgor?
Quercetin has other benefits aside acting as senolytic. It tackles nad+ depletion from a different angle of that taken by NR or NMN by affecting cd38 levels and act as attenuator. So that alone is a good reason to take this supplement. The claim is that in high dosage it also could operate as a senolytic and was shown to act as sirt6 activator.
Nice to meet you, Yuval
It's also a powerful antihistamine.
Quercetin is also a Zinc ionosphore - helps transport zinc into cells
YES. Many other benefits. This thing of rejecting a substance because it failed in ONE study of ONE action is just ridiculous. But that's the kind of thing that I expect from Stanfield, sadly.
Dr. Kirkland's observations in the video regarding the lack of senescent cell markers leads me to wonder:
1.How are the senescent cells themselves detected...and characterized? Does one detection methodology fit all senescent cells?
2.Are there degrees of senescence?
3.Can senescent cells definitely NOT be resuscitated? If not, why not?
4.Can senescent cells be typed by origin, i.e., used as organ early warning indicators in their own right?
5. Are there common and predictable epigenetic markers for senescent cells, or are they all unhappy in their own way?
Declaring senescent cells themselves the problem seems analogous to a mechanic discovering metal in an oil pan and installing a magnet in the oil filter as a "solution." Some bearing is in trouble.
Good questions. I can tell you that in longevity research senescent state is 100% recognized once you look at the cell. It's irreversible on principle (albeit they can become cancerous. Low chance of that happening.).
But when we try to see the accumulation of MANY cells, we need markers cells that show different markers. This is where we're unsure. What Kirkland addressed.
Dr Stansfields stand on quercetin was probably based on that research (Kirkland, perhaps) showed that fisetin was more effective than quercetin.
So, if fisetin doesn't work, the weaker quercetin wouldn't work either.
This is just my guess.
That quercetin works better together with that cancer pharmaceutical might indicate that senolytics work better in combinations. Such as quercetin and fisetin together, perhaps.
If Fisetin, does not work, how is it “more potent” than anything else? If it’s not potent?
Since it is likely that senolytic cells start accumulating above the age of 50, it is not a big risk to younger people to delay the taking of anti-senolytics compounds until further evidence.
Also, there are researchers that hypothesize a delicate balance between senolytic cells and cancer cells that is not yet understood.
Brad is too rigid and swayed by every latest study, no matter what it says. He will be changing his mind when the next study says the exact opposite. The fact is that fisetin is proven many times over to be effective.
Spot on.
My son is autistic and I’ll go he if Stanfieid isn’t also autistic.
He’s far to conservative for my liking and places waaaaay to much emphasis on studies, as if studies are 100%.
Imo studies should be one of the more important factors in deciding which supplement to take and they shouldn’t always have the same emphasis in every situation, for every supplement.
These kinds of attitudes are common for autistics, especially autistic drs, they’re extremely inflexible in their thinking and cling to rules and studies to calm their anxiety about uncertainty.
Also stanfield is young and healthy, I’m not, I don’t have the luxury of being so cautious, I’ve been sick for 4 years and my autistic dr, whose alot like Stanfieid
Has done very little to attenuate my condition- hence why I’m here.
I like this guys insights, but the aesthetic on the channel is insufferable, like some unbearable PowerPoint conference at work.
That's what I would expect from people that follow the evidence, though. I'd be more worried if he didn't change his mind if more evidence comes to light.
@@ingramdw1 not when it’s back and forth, back and forth, though. He’s blown by every wind, it seems. Interpreting the studies properly is important, as we both know. I think the Fisetin video he just wrote off Fisetin when the study didn’t even say whether the Fisetin was taken with food or not. If it wasn’t taken with food, then it wouldn’t be absorbed well at all, and that changes the entire results.
But Brad just made up his mind about it based on that.
Proven where? The more I look into studies the less I believe "longevity community" hypes. More often than not either studies are deeply flowed or interpretations are taken to absurd. Sometimes both. And let's not even go into ridiculousness of looking at some half-assed study done on worms and flies showing that something might work and extrapolating that into "I must stuff my mouth with a bunch of shady pills to live longer". The quackery masquerading as science is rampant in "longevity community".
@@alterego157 I agree with much of what you said.
But it sounds like your taking it to the extreme and being cynical , there is a lot of exciting cutting edge science coming out of this space, if your saying there isn’t, then your definitely a cynic.
I mean you can’t argue with some of the results from prominent longevity personalities, also there’s a tonne of formerly - very sick people who’ve been sick for a really long time and have exhausted all options through specialists and gps, once they discover sone supplements in the longevity community there lives turn around for the first time in years.
I’m one of those people, I could barely get off the couch after work and was struggling to even get to work most days, I had dementia like symptoms and had one illness after the next, now after developing my own stack my life has completely turned around, I have enough energy to go to the gym 3 times a week and am now looking to increase that too. Not to mention all my blood work has improved and I no longer need blood pressure medications.
So this is compelling evidence for me too. And yes I was already growing my own food and doing keto, I.f. Before I discovered the longevity community, I was doing everything the drs suggested and more and still wasn’t getting results.
I do apreciate your angle and interperetations very much so. it is of the essence to keep this community (and any other community for that matter ) properly and accuratly informed. i feel your coments and findings are genuine and sincere and that helps a lot. ive learned a lot from you. please go on.
You're very kind Nikola
I was ready to not like your video but your honest and open manner converted me into a subscriber. I do like Dr. Brad although I certainly do have differences of opinion from him in certain areas. I also credit Dr. Sinclair for getting me interested in longevity to begin with although I question his motives sometimes after the debacle with Resveratrol where his studies seem to have been found flawed while his company made over $700 million from selling it to GSK who then shut it down once it didn't look like they could profit from it.
Thank David, in my opinion, confusing contradicting information prevents us from sticking with habits. I view that as damaging if not based on solid science. Better to stick to what you're certain about and wait until the data is out. I have the privilege of seeing results with clients, to make me more certain that interpret data correctly.
I like clear logic, different molecules & unpublished, enough. I am on Quercetin started today (side effect it fixes exercise rhinitis and I exercise daily, no more runny itchy nose is awesome). Will play with dose/frequency. subbed.
There are a variety of positive reasons to take Quercetin and perhaps Fisetin aside from senescence - incidentally assisting longevity.
Unless testing a specific pathogen, most test mice, worms, etc. are NOT exposed to various viral, bacterial or fungal infections.
Zinc is VERY valuable to strengthen the immune system and resist viral infection, but unassisted zinc has trouble.
Quercetin appears to be a zinc ionophore, assisting more zinc cations to cross the plasma membrane.
In a way, you have confirmed Dr. Brad's conclusion. If the information/data does not show efficacy of the compound the default should be to NOT take the supplements. Too many people in this community are too quick to get on the next supplement, the next drug, the next go to product. There are not enough studies or proof of the efficacy of these supplements, so every professional should be advising their community to be careful, and only take that which science and studies have proven with a statistical confidence. You should be an advocate for science and proven studies and the interpretation of those studies by the scientists who are associated with those studies.
I got a totally different understanding from the video. I understood that when taking fisetin supplements, the total amount amount taken per kg of body weight is very important. If enough is not taken, then one will not experience the longevity benefits of fisetin, it will only kill senescent cells at the correct dosage as related to body weight.
@@kianleyon6613how much per kg?
Stanfield just makes contrarian headlines to generate clicks. Then he cherry picks data/studies to support the video title.
I've unsubscribed from him recently. Particularly when he singled out one of my comments in his IF video and then misrepresented the study i cited to him.
Yup. I totally understand why Sinclair blocked him
he is in Confirmatory bias
Bingo!!
What’s the ideal frequency for taking these? I’ve seen some reports that taking these infrequently was a better approach. A couple times per week for Quercetin and as little as one or two per month for Fisetin. I can’t remember where I saw this but Rimon if not for you I’d be taking too much Resveratrol daily until I saw your video so I thought you might have insight into quercetin and fisetin frequency.
As I will show more research on these in the next episodes, possibly you can make up your own mind. Remember we don't have a ton of data on the perfect doses right now, but close.
@@WellnessMessiah Thanks Rimon. Understood, I are an engineer and appreciate the way you approach these from not just your scientific profession but also an engineering mindset. You also gave me some additional insight that being 43 and healthy/fit (and told I look a lot younger), maybe senolytics should be the least of my focus now but for a once a month dosage? Always interested in your feedback and your next video with more of this research.
@@TomLe79 Cool to meet more intelligent people like you. see you, I think the next episode this Saturday
@@WellnessMessiah Thanks Rimon, I’m looking forward to it. And hope your wife is doing well. I’ve been keeping you both in my prayers.
I'm glad your channel exists
Thank you! I have been a big fan of quercetin and have tried fisetin. I think the research is young and since these compounds are widely distributed in nature. They seem to be well tolerated. I don't think it hurts to err on the side of taking them.
I like Brad Stanfield and he does very good work analyzing the various studies out there - better than most by far. Lots of people jump on the longevity hypewagon and ride it as far as they can citing mice data and seriously flawed human studies. So, my question would be where is the long term, human studies (properly conducted) that show that either fisetin or quercetin provide senolytic benefits? I don't think there are any and that's what Brad says most often. If there isn't solid science around it he's not going to recommend it. He almost always says that it's your choice and if it works for you do it as long as there are no harmful or long term side effects. Mice data is only "interesting" at best. There are an almost uncountable number of tests on mice with various interventions that yielded no result in humans. There's still questions about the bioavailability of fisetin and quercetin in the first place when taken orally.
So, let's not misquote Brad here. He says this is why HE stopped taking it. He didn't say you should stop taking it nor did he say it's ineffective. What he did say is that from what he sees of the science, there just isn't enough evidence yet to say it's truly effective. I tend to agree and want to limit my supplement stack to those things that we know are effective instead of making the pharma and supplement companies rich. Also, let's be honest and build in a little "bias interpretation" into our opinions. Brad has nothing to gain from recommending or discouraging the use of certain supplements and drugs. Sinclair and the rest of them often do since they have built a business around selling them.
Show me some unequivocal proof and science that this stuff works and I'm all in. Until then, it remains "interesting" to me.
well put!
Hi, I didn't misquote him. I put the exact segments of him, speaking and said what is my understanding (which I said, could be wrong). I will add that I do like Brad channel, as I said.
Sometimes humans, the more we are alike (e.g. me and Brad) the more we try to hurt one another. It's really stupid, I think anyone has their own values, contributes and we're all in this together. I age, you age, and Brad ages. Trying to cause pain to others because they are similar doesn't help much.
we are Biohacker, you not, you can waiting for .....
@@WellnessMessiah It's all good. I appreciate the efforts of everyone who's trying to earnestly and honestly help us all understand to extend lifespan and healthspan. The biggest problem I think we (people in general) face today is that there just haven't been enough good studies yet to tell us what supplements are ideal AND the mechanisms by which they work. Even with the enormous amount of research being done into lifespan and healthspan it's shocking how little we really know and how much is changing. Remember the resveratrol hype? Sinclair made a fortune on that molecule and now there are new studies showing that is doesn't do what he claimed it would - that it was a lab error related to the dye used. It might even have some detrimental effects. Someone here commented to the effect that Brad changes his mind on things a lot. GOOD! that's not him, that's a result of the test results being published that tell us new things. We should all be changing our minds regularly on this issue as new data becomes available.
Yes, indeed he just argued that this is why HE stopped taking it. He didn't say you should stop taking it nor did he say it's ineffective.
However, it should be clear to you that your are following an idol. You model him as a saint, kind of. He is running a channel, meaning he is trying to build trust in what he is saying,, and with that and his title comes authority.. AND responsibility. In such a channel, there is no "neutral zone". He himself was removing that.
Furthermore, he is not just telling it, he is preaching it. Trying to appear as important as it can get. Body language, intonation, just look at it. IT IS DISGUSTING. Boy, that's not serious, honest communication.
I got his channel recommended by others ...and found a clown, who wants to be important, and has no clue about the things he is talking about.
I am happy for once somebody said the word that many peoples think, it’s very frustrating for the consumers to receive contredit confirmation on product he invest and use for a certain time and moneys, thank you.
Yes, listen I'm just like you. I'm too confused and then try to clarify by research and thinking.
This is why I don't cooperate with supplement companies, because I think it will reduce the clarity of my videos, hurting the very purpose of trying to alleviate confusion instead of causing one.
Brad is driven by peer reviewed studies that are well designed. Sure he can change his mind, but that’s what you are supposed to do in light of new evidence.
I appreciate when we hold each other accountable for accurate scientific conclusions…especially in this rapidly developing field of longevity. Thank you for being additive to this process!
Great background information! As there are no risks found (yet?) taking Quercetin/ Fisitin other than spending money on a possibly useless drug, I will take it and wait for more data.
Yes, as you said, in situations where we have limited data, sometimes taking things that are unlikely to cause harm yet don't have absolutely 100% proven benefits, make sense nevertheless as aging is a much greater risk factor.And a certain one.
oooops. My jaws dropped... You are doing great work. Thank you!!! It is this kind of work that makes your channel so trustworthy. You are a genius :))
...so they claim to made a study in 2018, Stanfield talks about it in 2021 \ 2022, and in 2023 it is still not published ???
Serious academic research works differently (I am trained as a natural scientist, in biology). In a world where publishing is everything, not to publish for 5y means that the persons doing the study long left the organization, and the studies were not at all clear. Also, they refer to a Fisetin hydrogen sulfide study... Interesting part, this hydrogen sulfide. Probably it was a study about provoked senescence.
....and Mr. Stanfield is just a clown. His way of thinking, as revealed in this affair regarding the relation of fisetin and quercetin, has structural deficits and he should not feel entitled to give any recommendation, not even express his opinion on YT. That was not just a small mis-take. He has absolutely no clue about biochemistry.
@@RandomGuy-qg9xf they started at age 20months (@15:40), and they live maybe 28..34 mo... so it is +8 to +14, roughly a year.
I correct. study finished in 2019 etc etc
@@RandomGuy-qg9xf why not scientific? It is done in many studies. In some studies they start even later in their life. And no, it does NOT start a age 0. check out the few moments around 15:40. They start giving the substance at age 20 mo.
(ps. the scientific principle is : ceteris paribus, as long as everything (!) is controlled, it is fine. Now, that institute makes a huge mistake regarding that, but i will not spoil Rimons next episode :)
My jaws dropped as well. When I said "am I turning blind or what" I indeed thought I was to blame for not finding the study :) Thanks for the compliments, you're very kind.
And I'm a physicist working with medical data and I'd say one can still publish an inconclusive study. Maybe not on Elsevier, but on your own website, but publish it somehow nonetheless. More than once my team published such studies, it's a way to say "don't try my target because you'll hit a dead end or, if you try, change the study design". I think the only reason a study cannot be published is if there is a design flaw that nobody caught until the study was finished. Now, there's the small matter of the money this study consumed, but that's another problem.
This is my favorite longevity channel!
Thank you :)
Great video Ramon. You are a brilliant guy. Thank you. Your channel should grow into one of the most followed on the internet in the field of longevity.
I'm 50 yrs old had covid twice thought I was gonna die. Started taking queceritin and been around several people really sick and I haven't been sick with anything g for at least a year I think it works at keeping me from getting sick
Thank you - check the survey in my community tab. your advice helps a lot!
I have not gotten sick either with Quercetin.
Is this something u take forever or take breaks?
Hi Rimon, it’s important to note that no clinical guideline suggests using Quercetin or Fisetin. We don’t have any robust human data showing benefit for either molecules, plus the Interventions Testing Program found NO BENEFIT for mice who took Fisetin.
I’d much prefer to focus on diet, exercise, sleep, and the occasional supplement that has proven benefits such as creatine.
✌️
Hi Brad thanks for the response! I invite you to make a response video, which could benefit your followers greatly. It's a very interesting discussion and it will get proper attention.
Dr Brad changes his mind all the time. I only watch his channel because he is eye candy. 😍
Rimon, thanks for your work. With regards to Dr. Stanfield, I stopped following him awhile ago as I believe he is more interested in click bait than actual analysis. I have confidence in your data interpretation so please continue the great work. Any update on your wife’s condition?
Hi, thank you for asking. Well, she's at home and it's not easy. We're doing oxygen chambers almost every day, I estimate at least 6 more months of intense recovery and then slow and gradual over a period of 1-2 years.
@@WellnessMessiah the good news is there is light at the end of the tunnel. Good luck to you both.
I generally trust Dr Stanfield. However, his fundraising to finance his own Rapamycin study gives me concern. Any such study is probably beyond his capability (no insult to him). Such a study is a huge undertaking requiring expertise in many advanced fields including statistics. Does he have that depth?
So, is the fundraising on the up and up? I question it.
Whether on not Fisetin or Quercetin help clear senescent cells, each has other things that they may do that may beneficial, and neither has been shown to have any downside other than price. I personally take Quercetin for it's effect on mast cells and allergies. Here is another video related to Fisetin and effects that it may have against cancer: th-cam.com/video/7ppEtPi_ZHE/w-d-xo.html
Hi!
Big fan here in Brazil.
Regarding your couse, how the content is delivered?
It is video lessons, pdf material, zoom meetings, telegram groups?
I am willing to join but could not find this piece of information in the subscription page.
Thank you!
Hi, video lessons in a collaboration mode (Alex and me), pdf, and excels with breakdowns
@@WellnessMessiah how many hours of video lessons?
Enjoyed this take on the issue. Keep it up. Really appreciated your approach.
What about grape seed extract which is reported as a good senolitic ? Great Work Rimon.🎉
HI I haven't researched it enough. I'm not sure it was extensively researched for senolytic activity as fisetin and quercetin, so it's difficult to make data interpretation.
@@WellnessMessiah How much fisetin and quercitin should I take?
Rimon:
In your experience is it normal for a study (being run by ITP?) in 2018 still NOT being published in 2023?
Is it due to the study only being started in 2018 and not being completed until recently? If so, how could the 'experts' on fisetin / quercetin risk their credibility by commenting on an incomplete study before it is published?
If the target of fisetin / quercetin is removing/recycling senescent cells (in all their varieties), how effective are each of the various types of fasting (8/16, OMAD, 3 day water fast, 7 day water fast) when compared with the two supplements noted?
HI Ken, I think they only started the study in 2018. The issue is even if the ITP completes t the study - then they work on publishing previous studies, a waiting list kinda thing. They are slow, so it is normal. As to whether the researcher comes out with their findings 2 years prior to the data... that's up to you to decide.
HI Rimon: I agree with your line of reasoning. Could you please explain how in research they measure autophagy or senescent cell death amount?
Hi there, autophagy could only be measured locally, by tissue sampling. Senescent celll death, it depends on the study. So far this is the interpretation of the study this is what we know.
So far this is the interpretation of the study this is what we know. th-cam.com/video/DfZc4zbrPds/w-d-xo.html
LE produces Senolytic Activator, I don't have it yet, but I want it, the fisetin and quercetin are in phytosomes, stabilized with galactomannan fiber gel etc. to get it past the stomach and the phytosomes get it into the bloodstream. 3/week is all they recommend.
Great video and very insightful as always 😊 thank you.
I am continuing to take it because I know that it works
Thank you for all your hard work.
Thank you and happy new year, full of youth and love
For someone who attacks other doctors because there is no data to support taking nmn only to turn around to have an opinion based on no data is all I need to know about him.
Man, it takes one week or less to write and publish the study once you have all data! That's because you already have the framework for what you're going to do. You set a target, you design the study, you gather and adapt your tools, you start gathering data while making adjustments to your tools and, by the time you close the study, you already have 80% of the paper. Everything else after that is statistics and letter picking from the keyboard. And, one more point, you hurry up because you don't want other teams who are working on the same subject, to have their studies published before you. The only reason you don't publish your study is if your resident statistician was already dead at the start of the study and you can't guarantee that the sampling stage/process was correct.
Not always
Any chance you could get an interview with the head or a researcher at the ITP? Would be interesting if you’d ask all those questions directly to the people working on those studies.
Could be Dan, my understanding Miller is not the "head" but one of the heads. Whatever he says, I want to see the full data first.
@@WellnessMessiah Totally agree, would definitely be interesting to see. Awesome work on the video you did, great as always! :)
I am confused about the comment about losing our only arsenal of defense against senescent cell buildup. Not only are there alternatives, there are free alternatives. Mankind has been fasting for thousands of years. Although not popular with the masses, we have know since the early part of the 20th century about clinical proof of caloric restriction with optimal nutrition. Among the many approaches to finding longevity, caloric restriction (CR) has received a lot of attention in the last few years. The first evidence indicating the benefits of CR date back to the 1930s in studies conducted by Clive McKay, an American biochemist and gerontologist. Most people myself included would love nothing more than to be able to pills as a first line defense against aging.
Hi Michael, I didn't refer to habits as much as external agents (supplements) and nothing innate. Apologize for the confusion. Obviously, a strong immune system will be able to clear them as well, depending on what you mean by "tools".
@@WellnessMessiah Thank!
How about cold showers
I'm going to start taking Fisetin a few days a month as I'm in my mid 40s now. There are brands formulated to be much more bioavailable and that seems the route to go. The same goes for Quercetin, which I've bought in bulk powder but haven't taken because it tastes awful. I'll get a more absorbable form in a pill instead.
Great work. Really like what you’ve done so far to present every angles of information:-)
From my experience you must beware of fisetin and dosage if you've any kind of degenerative condition. I've noticed when I take it in high doses the pain is greater where I have the condition and subsides when I stop taking it. Maybe it's doing what it does on the senescent cells or maybe its just me but I'm wary of fisetin.
Yes it makes sense! Thanks for sharing
Curcumin is ALSO a serious senolytic - why is everyone ignoring it? I know it's not easily bioavailable, but there are solutions for that, e.g., Longvida's preparation.
Well Brad also says Vitamin d3 800iu are enough..so much about his credibility
Good point!
Careful about this, there are studies that show that supplementation of D3 in large doses can crete problems in the long term. What Brad is saying (I think) is that is better to eat more fat fish and reduce D3 supplementation, rather than taking only large doses of D3 through supplements
Giovanni Dominoni you are right about the nutrition but then you need to explain it every time ..D3 800iu is like Zero.. if you eat a Hering per day you got it all covered
So happy to know such a masterful researcher as yourself, my brilliant internet buddy!!!
how often do you take Fisetin/Quercetin combination? Every month, 90 days??
I still take Fisetin and Quercetin and my wife also. We take a week break, and then continue with these supplements. We also take NMN, and NR plus AKG from ProHealth Longevity.❤
Thank you for you in-depth and analytical description of the study, I will continue to take fisetin and quercetin and NMN.
Nice to meet you here. I've published a free report on quercetin in a few days after 6 months of research with 300+ studies, into short at www.Wellnessmessiah.com/gift
@@WellnessMessiah Thank you, I will check it out
Thank u for this so much! Very logical and clear !
thank you, you're very kind
Is only 100 mg of Resveratrol doing me any good. Is it to low. I also do take Quinoline.
Brad should look into the research from Life Extension who has introduced compounds that allows for body to actually absorb them.
Most if not all of these compounds aren't absorbed as capsules. You would likely need to get expensive shots to make them work and even then, the absorption issues are still there.
That’s hilarious. Research from the manufacturer lol 😂
We've always known from the advice of the elderly that there was an effect of eating an apple with(quercetin) or without the skin, so the bottom line in my opinion is don't listen to studies that try to distract you from reality ! It is healthier to eat a whole apple than to peel it. So that effect cannot be removed by a study that has not been published!
Hi Kim, episode 3 will be on Quercetin. It's quite fascinating, powerful stuff that could help the elderly.
Knowledge is dimensional. Not linear. Finding your way requires intuition and listening to internal inspiration and external authority findings.
We might ask;
What was the mineral balance of the people/ beings studied?
Who funded the study?
How much should we question the orthodoxy ?
In my estimation any study needs to be questioned, as we do not know the motivations of those doing the study. Science is about ready to change exponentially over the next five years, put on your seatbelt.
There are currently are no precise biomarkers for measuring senescent cells
Let Brad stop taking all the supplements what he has consumed so far. He can then use the money for his rapamycin study. Unfortunately his fundraising efforts for this are not moving forward 🤷
Brad Stanfield has a lot more videos that have lot of almost believable misinformation and sensationalism and debate based on no data, bad data, or just professional jealousy against other researches. So refreshing to see you take him out on this piece of sensational misinformation on bad data politely.
Let's hope that he will take it as "politely" which was my honest intention. He may not!
@@WellnessMessiah if he does not I guess as you said at the very least this will raise some more awareness for our community! 😁
Love that you question and breakdown these video
Nice to meet you Gina, see you in the next episode of this controvercy
Another great video, Rimon! I also like Brad Stanfield quite a bit, in fact I added creatine and collagen peptides to my supplement routine based on his videos. However, like anyone, he's not perfect and sometimes gets it wrong. I find his videos about why he stopped taking things less convincing than his other ones which are usually really good. Like his resveratrol video which you replied to earlier.
Here with fisetin and quercetin is another example of how he incorrectly interprets data. And his reasoning for why he stopped taking quercetin is particularly bad - it's a different molecule than fisetin to begin with. But setting its senolytic properties aside, it is an iron chelater, which is critical because excess iron hurts your health and longevity, is a zinc transporter, which is important because zinc needs to cross into cells to help your immune system, and it is a sirt6 modulator, meaning it stimulates or represses sirt6 activity depending on the circumstances. So deciding whether to take quercetin based on how its senolytic properties compare to fisetin seems ill reasoned.
And fisetin has good things going for it besides its ability to eradicate senescent cells. To do that you need to to the high dose pulse protocol that Dr. Kirkland is testing. But low dose may induce cells to clean themselves by eliminating old or damaged organelles or other proteins and reduce senescent cell toxins in the system. So you can't even judge fisetin on its ability to reduce senescent cells alone, you have to consider everything.
Regardless of Stanfield's videos, I take both fisetin (liposomal form) and quercetin (phytosome). An unexpected result of the fisetin is my skin softening and becoming smoother. Anecdotal of course, but I was very surprised this happened after adding fisetin to my supplements. And when I looked into it out of curiosity it turns out there is some evidence for it improving skin health. Go figure!
To sum up, I think Brad Stanfield is a big asset to the longevity community, especially given he's on the side of allowing NMN to be sold even though he doesn't use it, but like all of us, you can't just take his word on anything uncritically without validating his reasoning and conclusions.
Hi Jason I'm impressed with your knowledge about quercetin. indeed it seems like an iron chelator.
And it's activity on SIRT-6 changes - just like you said. I myself haven't completely grasped how this powerful molecule works. I'm going again over some studies.
How did you know it's fisetin and not quercetin lead to smoother skin if you take both?
@@WellnessMessiah I had been taking quercetin phytosome for a long time before beginning liposomal fisetin. The skin changes coincided with starting fisetin.
I also noticed similar skin benefits when starting hyaluronic acid, by the way.
Again, anecdotal and clearly not scientific, just reporting my personal experience.
One other thing, since you recently made your video on synergy between foods and supplements, there is evidence that quercetin has synergy with curcumin.
Hi! Do you mind sharing the brand/dosage/frequency of the fisetin and quercetin you take. thanks in advance!
@@g.......g I take Renue by Science's LIPO Fisetin and Thorne's Quercenase quercetin phytosome with bromelain.
@@jasonbromano Do you take the recommended dose (on bottle) everyday? Once a week... or some other frequency? Has there been any perceptible improvements in joint health for you (if you had an issue with the joints to begin with).
The study he based his decision on was one without a lipid but only water.
If no oil is included the fisefin and quercetin may not have absorbed at all??
By the way, THANK YOU for your work. Means a lot.
Sorry Brad, as a practicing physician, does what most busy clinical physicians do. Doesn’t read papers, at best they read the abstracts and perhaps the bottom line of the conclusion. These are the good Doctors! I had a local GP who confessed, he never read “articles” he was a qualified doctor! To my point Brad is a master at the shortcut conclusion, hence his frequent change of “personal” practice. He seems to have upped his game, reacting to a single statement on a paper yet to be written. My real point is that all study papers are written to be published, in doing so they need to satisfy the peer review, to do so they often need to “massage” the abstract and conclusions to pass peer review, sometimes to a point where they don’t match there own study data. Of course this assumes that a study like this wasn’t set up to fail by design. Usual tricks: inappropriate and low P study population, under dosing, short duration. Inappropriate markers and peculiar statistical categories. Perhaps the best is “adjusted for cofounders” without identifying what the cofounders were or how they were weighted.
Final note Dr Kirkland is perhaps the most experienced researcher into senolytics we have, while that doesn’t make him correct, his informed understanding of senolytic research is discounted at your peril.
Doctors aren’t supposed to read individual papers - there are committees that read the latest evidence and summarise it into guidelines and that’s the safest and best practice - perhaps understand the mechanics of the profession before you judge
@@heyyou9839 Having spent decades in hospital medicine, I think I have some insight. If your point is that medical practitioners operate as a consensus, a collective and therefore should only conduct interventions from defensible positions, I can agree with you. However as medical journals are filled with individual peer reviewed papers and well as meta analysis and multiple paper review articles, your suggestion that doctors shouldn’t read individual papers is faintly ridiculous.
A lot of scientists build their whole careers and obtain millions in grant research dollars on flawed theories. When their research eventually produces data that disagrees with their theory they either never report it or throw it out.
I like your humorous use of music... i.e. "another one bites the dust"... I've always thought that it be apropos for your name to sung for the intros to your podcasts... ...in the style of "dream on"...
I wonder why Dr Stanfield would want to take such supplements now, when he is so young. Maybe better to take these things when he is older and the evidence for their effectiveness is more affirmitive. There are other compounds, such as NMN that Dr Stanfield doesn't personally take, but Dr Sinclair does. And I find Dr Stanfield's nay-saying around such compounds, the perfect antidote to the possibility of a blind obedience that could be displayed by some consumers, who could be influenced by Dr Sinclair's superstar status. As a potential consumer myself, monitoring the identity of the supplements that both of the Doctor's agree have undeniable, (evidence based), efficacy, will go some way for me making the right choices and not wasting so much money. Dr Stanfield is a General Practitioner in his country of New Zealand and presumably has to satisfy the governing body of his own profession there and presumably his own conscience, that he doesn't make poor recommendations to his own patients in particular and his You Tube audience in general. Dr Sinclair on the other hand is outside that sphere, in the world of academic research. Longevity researchers like himself, can turn around in the long-run and say, 'hey, evidence doesn't support our premises or early research after all', or vice versa, because this field of Longevity research is still so young. Personally, I am often left 'scratching my head' at the disparity of opinions between clinicians or researchers when the Science is supposed to be the same between all of them. Gerontology and anti-aging research is so fascinating.
It's not a total loss if these two supplements don't work. We still have autophagy from fasting for dealing with senescent cells. There is also exercise which is the other way of naturally boosting autophagy.
Excellent analysis as always and very helpful. I just wish it could be more concise and less repetitive.
Noted!
Quercitin has been recommented to get rid of the spike protein injected into your veins or as a prophlyactic against catching the virus or an early intervention. I've never, ever heard of taking it for longevity, but I still eat an apple every day.
re At 12 minutes... Delighted that you said one of my life-guiding wisdoms---Mr Perry, my high-school physics teacher, had us do an experiment each week and report it, by stating results AND CONCLUSION. I myself urge reasonable as separate from the merely rational. For example, I do not believe there are witches---so the premise is wrong, even when a witch-trial case appears solid.
Thankyou for your information. But I am still confuse.🙈
What about the Mayo protocol that does Fisetin loading 3 days a month?
I read your quercetin document. It is great!!!!!!! But I have one question: if you give a SMALL MOUSE 2000 mg of Quercetin that will obviously have a more dramatic effect than 2000mg would have on a big human body.
So we can not even consider the study where the mice got 2000 mg to draw any conclusion for humans.
What am I missing here??
I’ve been taking Quercetin to help control uric acid as David Perlmutter suggested and it seems to work as good as allopurinol, I never knew about these other potential benefits.
Really, this quercetin is one of the most powerful supplements I have ever researched. Check my free newsletter, I give inside my research on tis supplement. what you said supports my findings
I followed the same paper trail that you did and came to the same conclusions although you went further with regards to quercetin. I am about to view your next video. I sent a request to the IPT. I don't expect a response.
What brands do you guys go with for fisetin and quercetin?
Thanks Riman. I go crazy with these scientists posting they take something and 5 minutes later changing their mind and then changing it again. Then they put those little irritant disclaimers. This is not medical advice. Go and try to make money somewhere else.
Yes, listen I'm just like you. I'm too confused and then try to clarify by research and thinking.
This is why I don't cooperate with supplement companies, because I think it will reduce the clarity of my videos, hurting the very purpose of trying to alleviate confusion instead of causing one.
@@WellnessMessiah You do a great job man. Keep. It going. X
Dr. Brad is too young to worry about SC. I'm in my 60s and based mostly on Dr Kirkland's work i will continue periodic fisetin use. Low toxicity.
How often is periodic?
I can get quercetin over the counter. I am happy to give fisetin a pass. NMN doesn't interest me. There are other options available
Good video but a bit of a tease as to why the study was flawed. I suspect bioavaialability has much to do with it.Curcumin is another good senolytic, and that as huge absorbtion issues. Fisetin, though is not just a senolytic, which is where Stansfield was unwise - the length and breadth of the studies on fisetin are remarkable.
I take Fisetin and Quercetin along with NMN and my NAD + is up to 44.5 and my CD 38 is going down