Speaking of propranolol what about sildenafil there was a recent paper regarding sildenafil improving Alzheimer's risk. that might be a similar mechanism
My lan tested blood ketones is 28. Typically my urine test is 30 to 40. Dom didn't really spec out what is too high to not spike an insulin increase? I have stage 4, and I am doing everything I can to keep ketones present as a fuel. But I want my glucose/insulin low to try to starve the cancer. Thoughts? Is 28 too far up? If so how would I regulate down? It's all diet induced
I don’t have a clue but replying to offer support and maybe one comment will encourage someone else. If stage 4 some type of disease/cancer maybe an oncologist might know better.
CR works in mice and other lab organisms yes, but it's strongly indicated that it's not very effective in long lived mammals. (for reasons having to do with differences in evolutionary adaptation) Since the ketogenic diet in many ways emulate the fasted/CR state, how do we know it translates to humans? Why can't someone look at the epigenetics in humans on a ketogenic diet in an RCT trial for example? We need more of that type of data and not yet another mouse study.
Interesting. Right at the edge of my understanding. Chris Palmer is also talking about mitochondrial biogenesis resulting from ketogenic diet improving mental health disorders. I never had my blood levels measured, but I would like to know if it any kind of weight gain/bulking on a ketogenic diet would result in those same deleterious effects as having too many ketones via exogenous sources, and are those deleterious effect (especially feeding cancer cells with the extra energy) are on par with having a carb-rich diet or not.
Re: people who appear carb tolerant bc their A12 remains low. I heard researcher suggest that this may be bc the pancreas is pumping out more and more insulin to keep blood sugar “normal”, but eventually this may exhaust the pancreas. Would HOMA-IR to measure insulin reveal this effect? If A1c is low but insulin is high, maybe we’re not really carb tolerant?
Your point is exactly why someone with a A1C below six must must test for fasting insulin level A1C may be 5.5 but the pancreas is providing a high level of insulin to maintain that level of glucose To be tested Fasting glucose level Fasting insulin level Preferably with a 24-hour fast
Doc you’re taking into the null area of that condenser microphone. That kind of microphone typically has three patterns Omni. Figure 8. Cardiod. You should speak into the side of the microphone.
In which study? Many studies I've seen use a ton of seed oils, 30%+ calories from polyunsaturated fat (and most of that linoleic), that'll induce heart damage every time if you run the experiment long enough. It's like running a low fat diet study but feeding them mainly table sugar, very academically dishonest.
Dr. Dom, my Superhero.
Most information interview on D'agostino I've watched.
Dom is the best!
Work fridge right?
Best every podcast I see today! Thank you
Amazing content but low volume audio
Very appreciated
Speaking of propranolol what about sildenafil there was a recent paper regarding sildenafil improving Alzheimer's risk. that might be a similar mechanism
My lan tested blood ketones is 28. Typically my urine test is 30 to 40. Dom didn't really spec out what is too high to not spike an insulin increase? I have stage 4, and I am doing everything I can to keep ketones present as a fuel. But I want my glucose/insulin low to try to starve the cancer. Thoughts? Is 28 too far up? If so how would I regulate down? It's all diet induced
I don’t have a clue but replying to offer support and maybe one comment will encourage someone else.
If stage 4 some type of disease/cancer maybe an oncologist might know better.
Wonderful discussion
CR works in mice and other lab organisms yes, but it's strongly indicated that it's not very effective in long lived mammals. (for reasons having to do with differences in evolutionary adaptation)
Since the ketogenic diet in many ways emulate the fasted/CR state, how do we know it translates to humans? Why can't someone look at the epigenetics in humans on a ketogenic diet in an RCT trial for example? We need more of that type of data and not yet another mouse study.
Interesting. Right at the edge of my understanding. Chris Palmer is also talking about mitochondrial biogenesis resulting from ketogenic diet improving mental health disorders. I never had my blood levels measured, but I would like to know if it any kind of weight gain/bulking on a ketogenic diet would result in those same deleterious effects as having too many ketones via exogenous sources, and are those deleterious effect (especially feeding cancer cells with the extra energy) are on par with having a carb-rich diet or not.
What's the name of the supplement mentioned for sleep?
Fenny bute
Please have an experiment on how to improve intelligence of keto with grade 1 to grade 12
Re: people who appear carb tolerant bc their A12 remains low. I heard researcher suggest that this may be bc the pancreas is pumping out more and more insulin to keep blood sugar “normal”, but eventually this may exhaust the pancreas. Would HOMA-IR to measure insulin reveal this effect? If A1c is low but insulin is high, maybe we’re not really carb tolerant?
Your point is exactly why someone with a A1C below six must must test for fasting insulin level
A1C may be 5.5 but the pancreas is providing a high level of insulin to maintain that level of glucose
To be tested
Fasting glucose level
Fasting insulin level
Preferably with a 24-hour fast
Doc you’re taking into the null area of that condenser microphone. That kind of microphone typically has three patterns Omni. Figure 8. Cardiod. You should speak into the side of the microphone.
What is the effects of keto to memory and learning
Doesn’t alcohol stop ketone production? You said it lowers glucose?
Volume is kind of low
Why does one study show damaged heart mitochondria and fibrosis with ketosis?
In which study? Many studies I've seen use a ton of seed oils, 30%+ calories from polyunsaturated fat (and most of that linoleic), that'll induce heart damage every time if you run the experiment long enough. It's like running a low fat diet study but feeding them mainly table sugar, very academically dishonest.
maybe give the link to the study instead of trolling
Nascent for sure
Your presentations are way too long. Why don’t you just say what needs to be said?