I m a practising doctor in India…your videos are very insightful…in our country people pay from their pocket for treatment.all the more it’s so important to know about specific test to be advised…thanks again
It will not be fair not to say thank you for your videos. You simply hit the nail on the head. When I want to know if I have got the best of my test books, I simply come here and if I want to read a new topic that seems scary, I simply come here first. Thanks medicosis perfectionalis team!
Thank you! Your videos are very helpful and informative. I'm writing my Master Thesis, and the theme is Rheumatoid Arthritis, and your videos helped me a lot to understand the topic.
Patient with arthritis....ANA, RF, anti Ccp negative but ESR 77 and crp 7.9 (normal is up to 0.8)... the question: how we do interpret the degree to which ESR/CRP is elevated? What is mild? Moderate? Very high elevation? in the non -specific markers? At what level can you NOT disregard them and must pursue investigation? Obviously no other obvious acute explanation is present to explain (i.e. infection).
Great educational videos. How about ANA 1:80. SSA 1:8 and screening is speckled but all other antibodies are negative? SLE or SS or MCTD? Your answer will be highly appreciated
Hi Sir, i have elevated rheumatoid factor, but negative anti ccp. I have joint, stiff pains on feet & hands. How i can check if i have RA? My rheumatologist did not order a ANA test for me. Tks!
Is it that no single blood test confirms a diagnosis, or is it that if you have Sm + dsDNA autoantibodies you have confirmed lupus? I don't see how you have both. These vids are great!
Can you elaborate, please? What do you mean by “both”? Both antibodies? Or do you mean “you can’t have it both ways because it’s self-contradicting.”? Let me know!
After going back over it, I wasn't properly contextualizing it. Didn't connect the dsDNA and Sm activity confirming Lupus as being already within the context of having matching symptoms. I saw "you can't confirm with one test" and then "if test says X, you 100% have it" and didn't realize the test saying you have X is within a medical context of already having good reason to check for it based on presentation
I have CRP 2.11 and RA + , suffering with SI join , right knee pain . Consulted rheumatologist and she said I do not have arthritis. I still continue to have pain almost from 5months now, suggest what should I do
Thank you very much for your high quality lectures. May God bless your project. I regularly struggle with biostatistics and I tried follow each step of your explanation (1:54 to 7:17). Still some points are unclear to me. In the sensitivity part you explained that FN + TN = 1. But aren't FN and TN independant from each other? For example if a company introduces a newer Corona test kit with higher specifity (meaning higher TN) the amount if FN might stay the same. So FN and TN do not directly influence each other. For me rather TP + FN = 1would make more sense. But maybe I am wrong and could not digest the topic well. I would be very grateful for any clarification.
You right he made a mistake there , the sensitivity is a measure of how well a test can correctly identify individuals who have the condition so that's mean it mesure TP , so a negative result rules out with high certainty the presence of the condition (TN) , so in conclusion if a test is 100% sensitive that's means it detect 100% of TP then if it's negative then that's automatically means it's TN ( of course all of this is theoretically) that's why it's used to rule out a condition
Same gose for specificty test , we change it to FP+ TN=1 so the higher the specificty the higher the TN , so if the test is positive it means that with high degree of certainty the patient have the condition
What am I looking at if tests are comming back neg but have conditions that can be related to autoimmune have physical symptoms of autoimmune and visual markers?
@@MedicosisPerfectionalis sorry im not a professional. Joint pain stiffness redness edema fatigue bouts lethargy rash sun sensitivity mottled skin reynauds ect. And im not sure if this is part of it too still looking into it.periods where the inflammation in the finger joints and knuckles clear up on and off right after taking a round of prednisone there is hypopigmentation in the shape of the inflammation and swelling. Sorry so long thank you for replying to me.
@@MedicosisPerfectionalis yes.october the 1st. But I know nothing about him. Patients reviews are mixed and my choices are limited so I have to make it count. Just trying to learn what I can and do as much as I can on my part to help find an answer. I don't want the risk to be swept under the rug for lack of understanding and knowledge.
@@MedicosisPerfectionalis sorry if I have inconvenienced you. Figured since you have such great videos you could help me figure out a direction. It looks like a duck walks like a duck but so far the blood tests are saying it isn't a duck lol. Very confusing.
What about a male in 30s who has many lupus symptoms like facial rash, rashes in the sun, protein in urine in the past, headaches, fevers, night sweats, tremors, digestive issues, anxiety, etc and has Ana 1:640 and false positive Lyme test and all other blood tests including sm and dsdna are normal. If this guy said Dr I think I have lupus would he be correct in assuming or would he be an idiot?? 🤣 asking for a friend.
cANCA is positive in granulomatosis with polyangiitis. But please remember...No single blood test can confirm the diagnosis of these autoimmune diseases.
Your messaging about what constitutes a positive ANA test is confusing and inconsistent. At 8:40 you say that a positive is anything "HIGHER THAN 1:80" but then seven seconds later you say that positive is "1:80 OR MORE." Is 1:80 positive or not?
In fact I think the titer should be defined as the highest dilution which is capable of producing a positive test. So that ANA (1:80) means 1:40, 1:10, 1:4, 1:2 is positive, while 1:160 is negative, I think and I learnt.
ok, this was 2 years ago... but he means HIGHER DILUTION. The titer corresponds to the highest dilution factor that still yields a positive reading. The dilution factor is a measure of how much a solution has been diluted. So, the greater the level of antibodies in a sample, the higher your dilution factor should be to wash them out.
@@mawadamarei2703 I get that. But the issue is that the way he phrased it, he both INCLUDES and EXCLUDES 1:80 as a positive ANA. 1:80 is either positive or it's not. Which is it?
man im in my fifith year of medical school and no professor ever explained as well as you do.
Thank you 😊
I m a practising doctor in India…your videos are very insightful…in our country people pay from their pocket for treatment.all the more it’s so important to know about specific test to be advised…thanks again
It's my pleasure!
It will not be fair not to say thank you for your videos. You simply hit the nail on the head. When I want to know if I have got the best of my test books, I simply come here and if I want to read a new topic that seems scary, I simply come here first.
Thanks medicosis perfectionalis team!
I appreciate you so much!
Thank you! Your videos are very helpful and informative. I'm writing my Master Thesis, and the theme is Rheumatoid Arthritis, and your videos helped me a lot to understand the topic.
That’s awesome 👏
Thank you so much 😊
Good luck to you!
loving this series so far
Awesome 😎
Thank you soooo much for these videos!!!! Preparing for my finals rn and I am so happy I found this channel, you're amazing!!!
My pleasure!
you are very good i wish you are shining somewhere now as the most brilliant doctor in the building
Thank you 😊
Patient with arthritis....ANA, RF, anti Ccp negative but ESR 77 and crp 7.9 (normal is up to 0.8)... the question: how we do interpret the degree to which ESR/CRP is elevated? What is mild? Moderate? Very high elevation? in the non -specific markers? At what level can you NOT disregard them and must pursue investigation? Obviously no other obvious acute explanation is present to explain (i.e. infection).
finals next week.. so happy i came across this
Thank you so much 😊
Can you please help me by sharing?
You sir.... Are a legend.
Thank you 🙏
Love it❤, great job.
I will share the link with my colleagues
I appreciate you so much, Rawa!
Your videos are insightful.
Thank you!
7:11 dr house says its never lupus, thats why he stashes his drugs there.
Correct... 💯
if a specific test come back negative, what can we conclude ?
You should speak on seronegative lupus!
Great educational videos. How about ANA 1:80. SSA 1:8 and screening is speckled but all other antibodies are negative? SLE or SS or MCTD? Your answer will be highly appreciated
Dude I love you! Best videos tο revise rheumatology.
Thank you so much 😊
WoW !! I love Gastroenterology playlist!! If you would just do it . emmmm😍
Thank you 🙏
Thanks
Welcome!
Ive reqd on the Internet that sensitivity is the true positive rate and specificity is the true negative rate not the other way around
Thank you ♥
You're welcome 😊
As always brilliant
Thank you!
Hi Sir, i have elevated rheumatoid factor, but negative anti ccp. I have joint, stiff pains on feet & hands. How i can check if i have RA? My rheumatologist did not order a ANA test for me. Tks!
Is it that no single blood test confirms a diagnosis, or is it that if you have Sm + dsDNA autoantibodies you have confirmed lupus? I don't see how you have both.
These vids are great!
Can you elaborate, please?
What do you mean by “both”?
Both antibodies? Or do you mean “you can’t have it both ways because it’s self-contradicting.”?
Let me know!
After going back over it, I wasn't properly contextualizing it. Didn't connect the dsDNA and Sm activity confirming Lupus as being already within the context of having matching symptoms. I saw "you can't confirm with one test" and then "if test says X, you 100% have it" and didn't realize the test saying you have X is within a medical context of already having good reason to check for it based on presentation
I have CRP 2.11 and RA + , suffering with SI join , right knee pain . Consulted rheumatologist and she said I do not have arthritis. I still continue to have pain almost from 5months now, suggest what should I do
You need to see a Rheumatologist regularly and I’m sure they’ll suggest drugs ASAP
Thank you very much for your high quality lectures. May God bless your project.
I regularly struggle with biostatistics and I tried follow each step of your explanation (1:54 to 7:17).
Still some points are unclear to me.
In the sensitivity part you explained that FN + TN = 1. But aren't FN and TN independant from each other? For example if a company introduces a newer Corona test kit with higher specifity (meaning higher TN) the amount if FN might stay the same. So FN and TN do not directly influence each other.
For me rather TP + FN = 1would make more sense.
But maybe I am wrong and could not digest the topic well.
I would be very grateful for any clarification.
You right he made a mistake there , the sensitivity is a measure of how well a test can correctly identify individuals who have the condition so that's mean it mesure TP , so a negative result rules out with high certainty the presence of the condition (TN) , so in conclusion if a test is 100% sensitive that's means it detect 100% of TP then if it's negative then that's automatically means it's TN ( of course all of this is theoretically) that's why it's used to rule out a condition
Same gose for specificty test , we change it to FP+ TN=1 so the higher the specificty the higher the TN , so if the test is positive it means that with high degree of certainty the patient have the condition
Thank you very much :)
My pleasure 😇
Hi, I came to see your videos recently. Outstanding! Could please post some videos related to Next generation sequencing ?
Thank youuu 🥺❤
My pleasure!
Thanks this is so helpful
My pleasure 😇
Helpful
Thanks 🙏
Infectious disesse please and nuerology
I will try
That would be good. I got Zika and immediately started having neurological symptoms
What am I looking at if tests are comming back neg but have conditions that can be related to autoimmune have physical symptoms of autoimmune and visual markers?
What do you mean by visual markers?
@@MedicosisPerfectionalis sorry im not a professional. Joint pain stiffness redness edema fatigue bouts lethargy rash sun sensitivity mottled skin reynauds ect. And im not sure if this is part of it too still looking into it.periods where the inflammation in the finger joints and knuckles clear up on and off right after taking a round of prednisone there is hypopigmentation in the shape of the inflammation and swelling. Sorry so long thank you for replying to me.
Are you following up with a rheumatologist?
@@MedicosisPerfectionalis yes.october the 1st. But I know nothing about him. Patients reviews are mixed and my choices are limited so I have to make it count. Just trying to learn what I can and do as much as I can on my part to help find an answer. I don't want the risk to be swept under the rug for lack of understanding and knowledge.
@@MedicosisPerfectionalis sorry if I have inconvenienced you. Figured since you have such great videos you could help me figure out a direction. It looks like a duck walks like a duck but so far the blood tests are saying it isn't a duck lol. Very confusing.
Well done 👏👏👏
Thank you 😊
outstanding
Thanks 🙏
Thanks alot
Neurology please
Coming
❤️❤️
:)
Nice
Thanks!
❤❤❤❤❤❤
I appreciate you!
❤
:)
What about a male in 30s who has many lupus symptoms like facial rash, rashes in the sun, protein in urine in the past, headaches, fevers, night sweats, tremors, digestive issues, anxiety, etc and has Ana 1:640 and false positive Lyme test and all other blood tests including sm and dsdna are normal. If this guy said Dr I think I have lupus would he be correct in assuming or would he be an idiot?? 🤣 asking for a friend.
Also has joint pain and parent has RA.
👏🏻❤️🙏🏻
🙏🙏🙏
If my test came back cANCA positive then it's likely that I have one of the vasculitides....
cANCA is positive in granulomatosis with polyangiitis.
But please remember...No single blood test can confirm the diagnosis of these autoimmune diseases.
That's why I'll get a referral to z rheumatologist to see. The neurologist was no help
Your messaging about what constitutes a positive ANA test is confusing and inconsistent. At 8:40 you say that a positive is anything "HIGHER THAN 1:80" but then seven seconds later you say that positive is "1:80 OR MORE." Is 1:80 positive or not?
In fact I think the titer should be defined as the highest dilution which is capable of producing a positive test. So that ANA (1:80) means 1:40, 1:10, 1:4, 1:2 is positive, while 1:160 is negative, I think and I learnt.
@@MingeulE no. 1:160 is a positive
ok, this was 2 years ago... but he means HIGHER DILUTION. The titer corresponds to the highest dilution factor that still yields a positive reading. The dilution factor is a measure of how much a solution has been diluted. So, the greater the level of antibodies in a sample, the higher your dilution factor should be to wash them out.
@@mawadamarei2703 I get that. But the issue is that the way he phrased it, he both INCLUDES and EXCLUDES 1:80 as a positive ANA. 1:80 is either positive or it's not. Which is it?
Hell ya.coool
Indeed!
Why cant they climb a tree? LOL
:)
❤
:)