ไม่สามารถเล่นวิดีโอนี้
ขออภัยในความไม่สะดวก
Making Cubane (without handles)
ฝัง
- เผยแพร่เมื่อ 17 ส.ค. 2024
- Here's the real cube, with nothing attached. You're welcome.
Support my channel with patreon:
/ chemiolis
Cubane methyl ester synth starting with UV step: doi.org/10.103...
Methyl ester to diacid: doi.org/10.101...
2-Mercaptopyridine N-oxide sodium salt purification: doi.org/10.100...
Diacid to Cubane: doi.org/10.103...
_______________________________
0:00 - 0:25 Intro
0:26 - 2:06 Photoreaction to decahedron
2:07 - 3:45 Cubane dicarboxylic acid
3:46 - 5:27 Dimethyl 1,4-cubanedicarboxylate
5:28 - 7:09 Back to the diacid
7:10 - 8:25 Acid chloride
8:26 - 15:40 Decarboxylation to Cubane
![Making [2.2.2]Cryptand: A Chemical Prison](http://i.ytimg.com/vi/qqr9U47jx7o/mqdefault.jpg)
![Making [2.2.2]Cryptand: A Chemical Prison](/img/tr.png)
![Making [1.1.1]Propellane](/img/n.gif)
NMR analysis of my Cubane and some precursors can be seen in this video: th-cam.com/video/m08fbrhQqnE/w-d-xo.html
can you make some better cubane
Ok but WHAT ABOUT OCTANITROCUBANE HUH
Octanitrocubane rightfully belongs to you by name alone, certainly sounds like a job for explosions and fire !!
either way I hope this doesn't discourage you from your own cubane synthesis, your videos are extremely entertaining and charming and I eagerly await your cubane !!
Master the cube then talk smack
@ExtrationsAndIre
I wanna see some Hydrogen Per Peroxide.
HOOOH.
That should be lively.
That's nothing, make octazacubane
It's harder in Australia because they have to do everything upside down
nobody is considering this very important factor
@@Nosirrbro whatdayatalkinabout
Probably something to do with poisonous spiders too.
*crying in symmetries*
Ahhhhh see now it makes sense
I think you have the most varied collection of stir bars among all the chemistry youtubers.
I like the one that looks like a big old almond.
I know, right? I saw the triangle one and though that would be great for lifting solids off the bottom of a beaker or whatever instead of just grinding them against the glass.
I wonder what he does with it
I think we are in dire need of a stir bar tier list..
Watching E&F and watching this is like the difference between watching a Let's Play and watching a walkthrough. Both are still technically playing the same game, but one is somebody trying to figure it out on their own having never experienced it fully before and the other is somebody who's just showing the process of the game being beaten, having played the game already or knowing how to do it properly.
With E&F it's the journey and the fact he's trying to do it with the worst equipment possible that makes it great.
I was just going to say, this guy seems to have no equipment or monetary limitations
Another big difference is that these videos are dry as the Sahara, whereas Tom's are entertaining even to a non-chemist.
Both are great 😊
@@davidemelia6296 I am a non-chemist and still love these, especially with his top tier dry humor.
He's just rubbing it in now...poor E&F
Stop, stop! He's already dead!
I still don’t know who this guy is that this cubane competition appears to be coming from
@@eliasdilles8550 a crazy aussie
The crazy ozzy is doing his cube synth full otc. So it’s kind of not the same thing.
@@eliasdilles8550 Comes from here: th-cam.com/video/ney-qTU3m4I/w-d-xo.html
Excellent work, way to take hobby chemistry beyond its common limitations!
So.... When do you plan to make it? 😃
@@BackYardScience2000 I don't for now, since I'd need a UV reactor and whole bunch of other stuff. Besides, why copy what's already been done! Maybe someday though...cubyl isocyanide and cubanethiol are both pretty enticing, lol!
What could be another milestone for hobby chemistry after cubane?
@@kemster9495 Maybe tetrahedrane? It's essentially cubane but with triangles, and a few derivatives of it have been synthesized.
this man has a whole chemical warehouse at his disposal goddamn
I wonder if all of these chemistry youtubers are some kind of professors or something and if not where do they get their chemicals from? Where I live the government wants your ass for even ordering a little too much Acetone.
If you set up a one-man company, the big name suppliers don't really care who you are
@@georgejanzen774they don’t care since if you studied chemistry and have a company you’re allowed to have them. Now it’s only about the money
@@georgejanzen774 True but usually you have to fill out a form in which you have to state what you will do with it and if you order a suspicious combination of chemicals they will report you to the government. Say you're buying toluene and some sort of nitrating agent for something totally harmless, they're gonna think you're making trinitrotoluene and come for you.
Didn't do it with pool chemicals
crazy shit dude this is def some of the top youtube chemistry content
Top tier of the top'est of tiers!
It's great seeing the mechanisms drawn out, really top-notch chemistry. Maybe you can squeeze and ACS paper out of this!
Now that you have the cube, would you be willing to try to make fluorinated cube and trap an electron in it?
I dont know much about chemistry, but that sounds sophisticated to pull off. It sounds so posh w/o it probably being it lol
That would violate the "Freedom for electrons" act.He has no right to do that
I don't know what you are taking about but it sounds a bit like using a fulferene to trap an atom
@@gameDev-ih7cj It's pretty simple (at least in theory), incorporate a free electron into the positive area in the middle of the molecule caused by the polar carbon-fluorine bonds of cubic C8F8
Or there's the one where you replace all eight Hydrogen atoms with a Nitro group each, making C⁸N⁸O¹⁶, Octanitrocubane.
Which is what I assume E&F is working towards.
Cubebros it's happening!
Congrats on getting cubane finally (awaiting that NMR tho lol). Any idea what the internal volume of cubane's cavity is? I assume it's very small but I wonder if it's large enough to host maybe a proton or something. I did my doctoral work on supramolecular host-guest chemistry, so cavities always catch my eye :)
Octafluorocubane can trap an electron inside!
the NMR: |
@@Chemiolisehe, “naughty electrons go in the C U B E C A G E”
Where does this proton go?
That's right, IT GOES IN THE CUBE HOLE!
@@Tea_N_Crumpets lmao I'm telling yall, yall sleep on host-guest chemistry. Baller subfield, plus jokes all day long
congratulations mate, this is one hell of an achievement!
the last step was particularly interesting, in that it's a Barton decarboxylation modified by using light as the radical initiator rather than AIBN
Eaton and Pettit's original methods predate Barton by nearly 20 years, but are more accessible to amateurs as they used t-butyl hydroperoxide, which can be homebrewed with relative ease (sodium pyrithione is generally much harder to find for amateurs)
now this mans gotta do Octanitrocubane just to really show that aussie whos boss
I very much enjoy Tom's videos but Chemiolis' vids, in my mind, are more educational. It's also been interesting to watch a chemist who is not phased by yellow.
Finally, Kurt Cubane
@@Flesh_Wizard 👍
Never clicked faster on a chemolis vid
how will australians ever recover???
Gonna nitrate it?
^ Asking the important questions. 💯
I can hear Tom(Explosion&Fire) screaming in the background
lel
sad cubane noises
wow this channel is on FIRE with these back-to-back cubane syntheses
Oh this is going to be the most exciting and interesting NMR ever
Definitely one of the best chemistry channels on youtube
Now do it again, in a shack, random things from the hardware store, and a PhD thesis do lol. Tbh all I learned from all chemistry vids is yellow is bad and tar means you messed up
I swear to god - all organic chemistry turns yellow at some point.
Hot take: yellow is just a low concentration of tar
@@kpunkt98 well yes. Turning yellow when expected is good. Randomly turning yellow no
@@hukaman88 i would love to agree, but ideologically i have to insist that yellow can't exist outside of a tar-context
Tbf in my Chemistry red is the bad colour ;)
@@kpunkt98 Yellow leads to brown which leads to black which leads to tar. It's a tale as old of time.
@@shitfuckmcgee8611 your feeble skills are no match for the power of tar!
he s better than most chemistry ytubers
He also has more equipment, so it might not be the fairest comparison. Still very skilled
Still doesn’t have the same entertainment factor as Ex&F, but this is channel is great for chemistry
@@TheSpacePerson nile(color)
@@TheSpacePerson The equipment is not that much better, I think purity of basic reagents is what really sets him apart. Of course he also handles the equipment very well (PhD level)
He might not be subject to the same restrictions on reagents. NileRed is in Canada and I'm in the US. I end up needing to make more reagents than I straight up by because I either lack access to the stuff, or it's straight up illegal for me to buy it. This varies greatly depending on where you live and where you can and can't ship stuff to.
I respect you so much for being part of advocating for good science. Honest props.
7:10 Thank you so much for explaining what atoms go where in the reaction!
Quality stuff. Reminds me how much I loved my rotary evaporator though.
Summarising this procedure:
1: Dissolve solid.
2: Distill away solvent
3: Return to step 1
I like your words, magic man.
This is just rubbing salt on Tom's wounds lol
now is the time for octanitrocubane
I'm currently finishing my bachelor chemistry and I'm looking forward to my master years. I forsure want to make cubane! It's like an absolute must for me!! I will 100% go to my promotors with some ideas for cubane derivates. Just look at the structure right?????
Excellent vid.
Fantastic. 👍👍
The difference between Chemiolis and E&F is: one is pre apocalypse and the other very post apocalypse chemistry. 🤣🤣
Incredible, seriously cool to see video proof and I can't wait to see the NMR results. Would have been better if you did it in a rusty fridge though... :P
How do you release these videos so consistently? It's like you do chemistry 35 hours a day.
what NEETdom does to a chemist
I do, I'm locked in my lab forced to do chemistry and produce videos
@@Chemiolis can you thank your guard for that lol? love the vids
@@Chemiolis can I join the dungeon lab?
Meanwhile Nilered:" Today, I wanna make Benzoic acid. I will upload a new video in 6 months because it take a lobg time a make this content."
おめでとう。解析が楽しみです
Just found out cubane doesn't crystallize in the cubic system - what a disappointment 😞
Too bad, it theoretically should be as strong as diamond!
This is when you're lvl 99 and go back to the earlier chemistry bosses.
I look forward to seeing a NMR with a single peak.
ffs, thanks Tom. the TH-cam algorithm is gonna be force-feeding me Cubane for yonks now
The contrast between doing chemistry in a crack shed and a proper lab with a few 10k dollars of equipment is very noticable to say the least.
where in this vid is $10ks worth of equipment? it's just glassware and a hot plate/mantle lol
@@thtasrjjgsfuny nah a good vacuum pump alone costs a fortune.
the glasware shown in this vid might be not too expensive(500+ or so) but when you have such equipment you clearly have more lying around and its easily worth 10k
think about fumehood etc aswel
@@Moritz___ Let's not even start talking about the price of Chemiolis' insanely pure reagents.
@@Moritz___ a few $10k is really stretching it, we can't even see all the things he has and where he got it from. Besides that he showed already it is not a 'real' bought fumehood but made. All the equip in the vids is what everyone can get. Only some of the chems not. The difference is mostly just presentation and how someone invests money. Tom could have easily built a fumehood too, but doesn't
king . pure king whit the chem flask man . big up to u
This guy made a youtube channel just to flex all of his different shapes of magnetic stirring bars
Props to you for the work on the product and the work on the video too.
Bro killed Ex&F and is now T-posing on his body😅
Wrong kind of T-something 🙂
Think the thing you're thinking of rhymes with T-lagging 🙂
Very cool! Not to take away from this synthesis but I think some commenters also need to remember also that these precursors were not from Bunnings :)
Isnt it possible to react the cubane dicarboxylic acid with NaOH and CaO (a decarboxylation reaction )to directly get cubane. Someone please explain
This guy's a JCB with all the scooping he's doing...
The chem gods have spoken and you have been blessed. All hail the King of Cubane!
so glad you degassed!
Very nice! Does the cubane has any smell?
Sweet aromatic, in an artificial not-pleasant way
@@Chemiolis misread that as aromantic for a moment.
Super excellent!!
Come on, you can't just make ONC (octanitrocubane) now??
Please do it, nobody has ever done that in front of a camera!
I mean you just have done the hard part!(making cubane)
It's not so sensitive and you can make it in small amounts and test it!
(Thanks again and Waiting for NMR)
Lol you think obtaining cubane is the hard part? Think again
@@raffaeledivora9517 8 times nitration sounds like hell on earth
I would consider it in the future, but atm the synth is not possible for me
@@raffaeledivora9517 yup!
Looks like I made a mistake about that cause I read somewhere that with nitric acid and other things you can make the stuff(not so easily, but possible 🤷)
But actually that's not important, I really want to see its explosion 😂😅
@@Chemiolis That's awesome!
I think you absolutely have to do it :)
You say can't cause the nitration is so hard to do or cause it's dangerous or what?!
Hypercubane when?
Thanks!
To purify salt, just turn it into salt, disdolve in water, wash with DCM all garbage. Then acidify, dissolve in DCM, and wash eith water.
If you run a column, play with polarity of eluent to get good separation.
Oh, no! Tom! Scooped again!
lol the smell of evaporating a liter of mercapto purine rofl
I gotta ask what your background is? You're so good! Have you published any papers? Do you do this for work? Where did you study?
Alexander Hamilton about to spit bars in these comments
I wanna see someone make it with stuff from the pool cleaning aisle 😂
How about octonitrocubane?
Surely your TH-cam money can get you a sonicator.
Love the work!!
#SHORTPATHVACUUMDISTILLATION
Congratulations, Good Job!
I love starting with a Schlong flask.
I’d like to see some complex uranium chemistry. Nothing agency-list worthy, but I remember seeing one vid on periodic videos years ago they were working on something that looked like one U atom sandwiched in between two crowns. Looked pretty cool similar to how cubane is a neat looking molecule.
What colors would Chlorocubane, Iodocubane or Bromocubane display?
White
Bro, success! Congrats
Omg you're making me wanna learn chemistry!
Now do the Nile red thing and synthesize from only urine.
I'm gonna need you to hold your product in a vial and dab and then send it to E&F
I like your funny words magic man
Finally. Pure bocks.
A glorious day for all cube kind
Poor Aussi lad must be siting infront his PC watching this and crying his soul out
I'll be honest with you: I don't care about cubane synthesis if it's not done on a shed under the aussie sun shinning through the ozone hole
soon
8:15 you connected the short path distillation apparatus the wrong way to the water 😂
next week: here are 3 other quick and easy methods you can use to make cubane at home
what about then taking the C-H and going through reaction series to attach ammonium groups in place of the H+. Then Nitrating that product?
Far more involved than inorganic options...but I'd be interested to see what the resulting products properties were.
Pff lame,
Now do it in shed, with hardware store ingredients and in 40C heat.
You know THE PROPER WAY
Jk, Great work, *sad E&F noises*
What's with the N->O bond in the mercaptopyridine?
It represents a dative bond, where both the 2 electrons in the bond are coming from the nitrogen. you could alternatively represent it as a N-O bond with N bearing a positive charge and O a negative charge.
Well that's fuking goooooooo
do crystallography with it i wanna see what is looks like mirco and etc
This man could easily become a real life walter white with his chemistry skills
my brother in christ any chemist can make meth, most meth producers barely finished highschool.
Which software do you use for drawing chemical structures and mechanisms?
i love cubes
So whats it good for?
Now do it with Bunnings supplies only
wow just wow
Time to nitrate it?
isnt cubane explosive?
Now it's time to make DODECAHEDRANE!
Extractions&Ire: OH YOU!!1
How is oxigen diluted in water and what does tge nitrogen does to get it out
I wonder if Cubane based pharmaceutical drugs are the same
Like amphetamine but Cubans instead of benzene
MethamphetCubane ... f****** when? 🤘🏻😎
Well, it's a little bit cheating because Cheliolis uses a newly published and different UV process, that makes the whole s**t a lot more reliable. And he also doesn't do it over months in a shed partially with cooking utensils.... 😀
Nice work
Hiii!! Just wondering, how do you know you actually got cubane? And, follow up question, could you actually get to see the cube in say, an electron microscope?
I don't know jack about chemistry, but I heard thio and mercaptan... this process must have stunk like hell!
Would be super cool if you could make IBX or even the Dess-Martin periodinane. I’ve always been fascinated by that compound.
I made it in the cat video :)
@@Chemiolis the catnip one? Really?