My friend who had stage 3 ovarian cancer is HRD negative. She been standard treated (chemo, surgery and chemo). Is Niraparib is suitable for her as maintenance therapy? Is there any other available therapy for her? She is in Ottawa.
Hello as far as I know, the PARP inhibitors are only currently approved for use in BRCA 1 & 2 mutations or HRD status after frontline treatment. The PARP inhibitor Lynparza has been used in trials on women who are not BRCA or HRD, with some success…but to my knowledge, it is not approved for use in this population. I wonder if Avastin infusions every 3 weeks for as long as it can be tolerated would be a good choice for her?
Thank you for your comment and we're sorry to hear about your friend. The fastest way for us to answer those questions would be for her to book in a Precision Second Opinion ➡ www.ctoam.com/consultation
I am a young Italian patient and I am pursuing the second degree in biological sciences with cellular and molecular address. I have high grade 3 stage serous ovarian cancer with brca1 mutation. I am on olaparib and for now I am fine, I am NED, but due to the studies I do I know many things and I am terrified by the recurrence of disease. I would like to add durvalumab to my therapy but in Italy it is not prescribed. How can I do it? I would like some extra chances, I don’t want to end up in hospice so young to wait for death for months. Could you help me? Thank you so much
Thank you for your comment, Darlene - we are sorry to hear about your situation. It is all too common. You are welcome to book in a Precision Second Opinion with me. Just visit this page to book ➡ www.ctoam.com/consultation
Why is it always first line treatment, what about the rest of us who have bern fighting this horrid disease for yrs. We need new treatment to help us to. We need new treatment to help us survive. This is so unfair for. I’m BRCA1. Nothing is working anymore. I need new treatment but can’t get anything because it’s always for frontline. Again so unfair, so the rest of us have to die because there’s no new treatment for the rest of us because we aren't frontline.
Agreed Tony! I do think that these studies eventually filter out to the recurrent OC population, and maybe that will be the case for this new combination therapy that has been so promising for Frontline treatment. It seems like for recurrent OC (for BRCA one and two negative gals), the only option is eternal Avastin, which you eventually have to stop suddenly because of unacceptable protein levels, or recurrence… Then face the rebound aspects of this drug. Good luck, and keep the faith!
I'm brca positive on both chemos said 3 chemos surgery n be 3 chemos soon then be put on a yr yr med pray for me no reoccurrence I also had hipec heated chemo too in sugery
My friend who had stage 3 ovarian cancer is HRD negative. She been standard treated (chemo, surgery and chemo). Is Niraparib is suitable for her as maintenance therapy? Is there any other available therapy for her? She is in Ottawa.
Hello as far as I know, the PARP inhibitors are only currently approved for use in BRCA 1 & 2 mutations or HRD status after frontline treatment. The PARP inhibitor Lynparza has been used in trials on women who are not BRCA or HRD, with some success…but to my knowledge, it is not approved for use in this population. I wonder if Avastin infusions every 3 weeks for as long as it can be tolerated would be a good choice for her?
Thank you for your comment and we're sorry to hear about your friend. The fastest way for us to answer those questions would be for her to book in a Precision Second Opinion ➡ www.ctoam.com/consultation
I am a young Italian patient and I am pursuing the second degree in biological sciences with cellular and molecular address. I have high grade 3 stage serous ovarian cancer with brca1 mutation. I am on olaparib and for now I am fine, I am NED, but due to the studies I do I know many things and I am terrified by the recurrence of disease. I would like to add durvalumab to my therapy but in Italy it is not prescribed. How can I do it? I would like some extra chances, I don’t want to end up in hospice so young to wait for death for months. Could you help me? Thank you so much
Thank you for your comment, Darlene - we are sorry to hear about your situation. It is all too common. You are welcome to book in a Precision Second Opinion with me. Just visit this page to book ➡ www.ctoam.com/consultation
Why is it always first line treatment, what about the rest of us who have bern fighting this horrid disease for yrs. We need new treatment to help us to. We need new treatment to help us survive. This is so unfair for. I’m BRCA1. Nothing is working anymore. I need new treatment but can’t get anything because it’s always for frontline. Again so unfair, so the rest of us have to die because there’s no new treatment for the rest of us because we aren't frontline.
Agreed Tony! I do think that these studies eventually filter out to the recurrent OC population, and maybe that will be the case for this new combination therapy that has been so promising for Frontline treatment. It seems like for recurrent OC (for BRCA one and two negative gals), the only option is eternal Avastin, which you eventually have to stop suddenly because of unacceptable protein levels, or recurrence… Then face the rebound aspects of this drug. Good luck, and keep the faith!
I'm brca positive on both chemos said 3 chemos surgery n be 3 chemos soon then be put on a yr yr med pray for me no reoccurrence I also had hipec heated chemo too in sugery
2 yr med after
Thank you, this applies to me. I will share with my oncologist.
Happy to hear this video helped you. And yes, we encourage you to share it with your oncologist and treatment team - the proof is in the science.