Management of Mycobacterium Abscessus Infections: The Rise of a Superbug
ฝัง
- เผยแพร่เมื่อ 15 ก.ย. 2024
- Infections caused by Mycobacterium abscessus appear to be increasing in frequency among the immunocompromised population and are challenging to treat. Antibiotic options in these cases are scarce, prologued therapy is required and new options are needed. We will discuss this important topic with experts in the field.
Topics discussed:
- Define M. abscessus as an opportunistic pathoge
The intrinsic phenotypic characteristics of M. abscessus, including resistance to common antimicrobials
- Treatment approaches and rationale for these strategies
Guests:
- Kelly Dooley, MD. PhD, MPH. Professor of Medicine, Johns Hopkins University and Editor of AAC
- Charles L. Daley, MD, Professor and Chief of the Division of Mycobacterial and Respiratory Infections. National Jewish Health
- Thomas Dick, PhD. Professor, Center for Discovery and Innovation, Hackensack Meridian Health
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Extremely informative discussion. Thank you all for your expert options and views. Very helpful for patients.
Very informative as a patient. Thank-you
Can all species of mycobacterium hide inside macrophages ( but not form digestive vacuoles) to ellude the immune system? Thanks and I know I'm going to like this video!
It would be interesting if specific bacteriophages could to be used to reduce the quantity of mycobaterium in vivo.
14 yrs ago I was hospitalized with mycobacterium absesses in my lungs. at same time BOOP was diagnosed.I was very ill. fortunately it was nonTB. I have COPD. Female 79 yro. at present have chronic cough .phlem. my pulmonary dr has always informed me my mycobacterium could actiivate at any time. I have had billateral pneumonia. and become sepsis. so many hospitalization. so its doormat for now but scans in past show nodules. scar tissue. sarcodosis. thank you. Angela
If D-amino acids built with low emission isotopes that suffer transmutation, could be infused in vivo, perhaps the rate of modifications resulting from said transmutation could disable bacterial proteins / enzymes in a sufficient way in order to work as an antibiotic class without any means to develop resistance against. But it would be very expensive and with a short shelf life.
Palindromic regions of bacteria could be targets for restriction enzymes produced by and isolated from other bacteria, but how could they cross the outer membranes is a problem.
I was initially diagnosed with M abscessus, later updated to M xenopi in my lungs in 2020. After 13 months of oral antibiotics, it seems to be gone. My question is for all mycobacterium. Is anyone addressing possible modifications to the water system? This could be individual filtration/treatments or changes to public water treatment. It’s scary to hear of how resistant the strains are becoming, especially if you have already been treated. I would love to find some modifications to my water system to reduce or eliminate future infection. It also seems that patients receiving treatment could benefit too.
Hi which antibiotics were you on that completely eliminated M. Absessus?
@@IppylengI would like to know as well