Great explanation, and loved how you mention that flushing is a sign of higher acetaldehyde levels triggering catecholamine release, which also implies that cyp2e1will be employed, increasing ROS
Great video, now I understand why it can be so difficult to lose weight when drinking, and how alcohol consumption can lead to major excess calories in the diet.
I think we’re also missing another key. I read somewhere else that if we have Candida it can turn sugar and carbs into alcohol because that’s it’s main food source, another reason why we can’t lose weight.
Hey JJ thanks very much for the succint and descriptive lecture. Would you mind referencing where you draw your data from? It would be helpful for those of us needing to cite the information beyond your TH-cam video. Thanks in advance!
I turn blue when I exercise, have since I was very young, i didn't start drinking until I was 32, got a book about whiskey making and I tried one (hate beer smell, so never drank it) anyway, after drinking one shot, 1st time, I got dizzy, but my hand eye coordination improved. Second time a few days later, I didn't get as woozy, but felt like I could breathe easier and hand eye coordination improved. Thinking improved too. I stopped drinking for a few years, had wine once in a while, but got some the other day, whiskey, and suddenly there was this feeling of breathing easier, and sweating. I usually sweat very little. I crave bread, wheat bread. Am I riboflavin deficient?
9:15 The average drink contains 14 grams of alcohol, NOT 7 grams. 12 ounces of 5% abv beer contains 0.6 ounces or 17.74ml of alcohol, weighing 14.19 grams (0.8g of alcohol per ml). A 167 lb male consuming 1 beer over 1 hour will have a BAC of 0.013%, NOT 0.0%. If you drink one drink per hour, you will not remain sober.
I think it's mainly to do with osmoregulation... Water is the universal solvent.. and alcohol readily dissolves in water.. so to compensate the concentration water moves towards alcohol.. so alcohol draws out water from our body cells.. that's why we get dehydrated...
Another stellar video, and thank you for mentioning zinc, but the other enzyme, ALDH, is Mo dependent, which happens to be one of the most deficient minerals in the body. Since minerals are the spark plugs of life, I hope you continue to mention the mineral cofactors bc understanding the mineral matrix is where we can move the needle to better health. Meanwhile, we can break the chains of our dependency on big pharma that have single handily destroyed the health of our population as they run and control our government hospitals FDA and all medical schools as the trillion-dollar drug cartels are a criminal family; with unlimited power and money...
Okay, but ... like ... when does it become something that you can absorb calories from? How does it effect blood sugar? Is metabolism not the word i'm looking for?
Metabolism is biology-speak for converting chemical energy from one form to another. Acetyl CoA, the last molecule mentioned in the video, which should quite readily feed into the Krebs cycle (taking place within the mitochondria) - but there is a problem . . . there is too much NADH around, and through Le Chatlier's principles, it will run the reaction the other way meaning the Kreb's cycle is thwarted. Where does all of the NADH come from? Alcohol metabolism, technically catabolism, goes from ethanol to acetaldehyde (eventually to acetate to acetyl CoA). In the first and second reaction there, two enzymes are doing the work, alcohol dehydrogenase and acetaldehyde dehydrogenase. The name "dehydrogenase" is a dead give away that we are doing an oxidation reaction, and in electrochemistry, if something is oxidized, something else must be reduced; here NAD+ is reduced to NADH. The trouble starts with the excess of NADH (we actually run out of NAD+ to reduce), and a reduced molecule means "satiety or a fed state" in the cellular respiration world, signaling to the hepatocytes that no further energy is needed in the body. This inhibits to processes conducted in the liver that provide sustenance for the rest of the body: B oxidation and gluconeogenesis. What is worse is that the high [NADH] starts another process: fatty acid synthesis leading to a fatty liver (not good). The high [NADH] has another consequence, it inhibits isocitrate dehydrogenase and alpha-ketoglutarate in the Kreb's cycle. Metabolically this is equivalent to a pile up of products. Remember the Acetyl CoA product? To deal with all of that acetyl CoA, the body will make ketones (to keep the brain fed) and lacate which lower blood pH inducing metabolic acidosis - again, majorly not good. Does that help?
YESSSSSSSSSSSSSS...... thank you for teaching me how to get right proper drunk...... or I mean teaching me about what I am doing when I chug my next case.
That acetate ion is like dissolved acetic acid flowing around the blood... no wonder why i can smell the stink of vinegar after having a few beers or wines...
Hi Sean. Ethanol itself can cause vasodilation, which also causes some flushing in some individuals (regardless of whether they have an ALDH-2 deficiency). Hope that helps!
GREATEST EDUCATIONAL MEDICINE CHANNEL OF ALL TIME
Great explanation, and loved how you mention that flushing is a sign of higher acetaldehyde levels triggering catecholamine release, which also implies that cyp2e1will be employed, increasing ROS
excellent, clear understanding of the process, shame our lecturers cannot do the same as you. thank you so much for sorting these pathways out
I'm a french speaking student and it was crystal clear, thank you so much! Much better than the stuff we have in our textbooks here (in France).
So helpful! Thank you for breaking this down concisely!
Thank you so much! You made it super clear and easy to understand. Very helpful!!!!
Thanku sir great ,,,,material bahout help full h sir dekte hi samj aa gya h
Watching when buzzed 🥂😄
Pretty nicely explained and helpful. It made me understand a lesson I just couldn't grasp. So thank you sensei.
Great video, now I understand why it can be so difficult to lose weight when drinking, and how alcohol consumption can lead to major excess calories in the diet.
Hey John! Thanks for the comment! Glad you found it informative :)
I think we’re also missing another key. I read somewhere else that if we have Candida it can turn sugar and carbs into alcohol because that’s it’s main food source, another reason why we can’t lose weight.
The idea is to include the calories from alcohol as part of your daily caloric intake so you don’t over consume making the body store carbs and fats.
I chugged Heineken beer to this video on an empty stomach, I feel great right now!
thi is so funny
Among acetaldehyde and acetic acid which is responsible for alcoholic effects like confusion,dare, unbalanced body etc
Idky but I like learning when I'm drunk
😂
As do I
Excellent! Thank you for the breakdown
amazing!! thanku for the xplanation
Hey JJ thanks very much for the succint and descriptive lecture. Would you mind referencing where you draw your data from? It would be helpful for those of us needing to cite the information beyond your TH-cam video. Thanks in advance!
Agreed! That would have been super helpful
Mateo Farfan Just Google it and tons of medical articles will pop up, from which you can cite.
Fantastic explanation of this proces!! Thank you!!! Excited to see how my exam goes tomorrow… 🥴😄
Thank you so much. You explained it so well and understandable which i wish my professors did
Finally a good description. Thank you :)
Awesome explanation
great presentation. thansk.
Hi where does the H+ come from when NAD+ is reduced to NADH. Could you please explain this to me! Also your videos are amazing xxx
Greatttt video!!!! Ur amazing!!!!!
The NASM course I’m taking says first pass metabolism happens in the gastric muscosa of the stomach lining?
I turn blue when I exercise, have since I was very young, i didn't start drinking until I was 32, got a book about whiskey making and I tried one (hate beer smell, so never drank it) anyway, after drinking one shot, 1st time, I got dizzy, but my hand eye coordination improved. Second time a few days later, I didn't get as woozy, but felt like I could breathe easier and hand eye coordination improved. Thinking improved too. I stopped drinking for a few years, had wine once in a while, but got some the other day, whiskey, and suddenly there was this feeling of breathing easier, and sweating. I usually sweat very little. I crave bread, wheat bread. Am I riboflavin deficient?
9:15 The average drink contains 14 grams of alcohol, NOT 7 grams. 12 ounces of 5% abv beer contains 0.6 ounces or 17.74ml of alcohol, weighing 14.19 grams (0.8g of alcohol per ml).
A 167 lb male consuming 1 beer over 1 hour will have a BAC of 0.013%, NOT 0.0%.
If you drink one drink per hour, you will not remain sober.
His point was the entire metabolic process from CYP 450 together with ADH yields 7 grams an hour not the drink per se
Do you gain energy after consuming alcohol?
Psychological energy, or Caloric energy?
@@alloypaulson7520 Caloric.
@@tibormalinsky8751 You actually do, about 7 food calories per gram of ethanol.
Great video.
Wow thanks so much❤
Please say actually one more time.
Just messing with you, but thanks for painting such a clear picture of alcohol metabolism! :)
Why do we get dehydrated when we drink too much alcohol?
Google Play alcohol inhibits ADH, a hormone that helps the kidney put water back into the blood, so we lose more water than normal to the bladder.
@@Sveccha93 Thanks 😊
I think it's mainly to do with osmoregulation... Water is the universal solvent.. and alcohol readily dissolves in water.. so to compensate the concentration water moves towards alcohol.. so alcohol draws out water from our body cells.. that's why we get dehydrated...
Another stellar video, and thank you for mentioning zinc, but the other enzyme, ALDH, is Mo dependent, which happens to be one of the most deficient minerals in the body. Since minerals are the spark plugs of life, I hope you continue to mention the mineral cofactors bc understanding the mineral matrix is where we can move the needle to better health. Meanwhile, we can break the chains of our dependency on big pharma that have single handily destroyed the health of our population as they run and control our government hospitals FDA and all medical schools as the trillion-dollar drug cartels are a criminal family; with unlimited power and money...
Amazing!
what will happen the excess amout of acetyl coa and nadh
Perfect thank you
you killed it
Okay, but ... like ... when does it become something that you can absorb calories from? How does it effect blood sugar? Is metabolism not the word i'm looking for?
Metabolism is biology-speak for converting chemical energy from one form to another.
Acetyl CoA, the last molecule mentioned in the video, which should quite readily feed into the Krebs cycle (taking place within the mitochondria) - but there is a problem . . . there is too much NADH around, and through Le Chatlier's principles, it will run the reaction the other way meaning the Kreb's cycle is thwarted.
Where does all of the NADH come from? Alcohol metabolism, technically catabolism, goes from ethanol to acetaldehyde (eventually to acetate to acetyl CoA). In the first and second reaction there, two enzymes are doing the work, alcohol dehydrogenase and acetaldehyde dehydrogenase. The name "dehydrogenase" is a dead give away that we are doing an oxidation reaction, and in electrochemistry, if something is oxidized, something else must be reduced; here NAD+ is reduced to NADH. The trouble starts with the excess of NADH (we actually run out of NAD+ to reduce), and a reduced molecule means "satiety or a fed state" in the cellular respiration world, signaling to the hepatocytes that no further energy is needed in the body.
This inhibits to processes conducted in the liver that provide sustenance for the rest of the body: B oxidation and gluconeogenesis. What is worse is that the high [NADH] starts another process: fatty acid synthesis leading to a fatty liver (not good). The high [NADH] has another consequence, it inhibits isocitrate dehydrogenase and alpha-ketoglutarate in the Kreb's cycle. Metabolically this is equivalent to a pile up of products. Remember the Acetyl CoA product? To deal with all of that acetyl CoA, the body will make ketones (to keep the brain fed) and lacate which lower blood pH inducing metabolic acidosis - again, majorly not good.
Does that help?
I suggest the author edit the subtitles, they're off.
YESSSSSSSSSSSSSS...... thank you for teaching me how to get right proper drunk...... or I mean teaching me about what I am doing when I chug my next case.
Canadian impaired driving law does not recognize any of this science.
That acetate ion is like dissolved acetic acid flowing around the blood... no wonder why i can smell the stink of vinegar after having a few beers or wines...
Isn't very little ethanol met in first pass metabolism?
Wow it so go
Go on
🍺
Watching when too drunk (too much acetaldehyde rn)
What is CoA....
coenzyme A
I get very red when I drink and yet I’m not asian.
Hi Sean. Ethanol itself can cause vasodilation, which also causes some flushing in some individuals (regardless of whether they have an ALDH-2 deficiency). Hope that helps!
All lies
Thank you so much