Residue Conservation Score in a Multiple Alignment

Video Description
In this video, we discuss different theories of estimating residue conservation in a multiple alignment. Starting from Shannon entropy we show how this score expresses the sequence variation at different alignment columns of a multiple alignment. We discuss the limitations of conservation score and depict how a simple normalization approach scales this score within the range of 0 to 1 to depict residue conservation. We further depict the use to two online tools: Protein Variability Server and Scorecons to estimate sequence variation using a multiple alignment input.
Link for the video on Pairwise Local Alignment
• Local and Global Seque...
Link for the video on Pairwise Global Alignment
• Pairwise Global Alignm...
Link for the video on Multiple Sequence Alignment
• Multiple Sequence Alig...