This is encouraging research! I would not describe mood and motivation suppression as a primary symptom of ME however. The people I know within the ME community are amongst the most motivated I have ever known. We are not lacking motivation to do things, just the physical ability to do them! We must not confuse ME with depression, that has caused too much damage already. Thank you for this research!
Can't answer for others but a lack of motivation has not been part of my experience. When a person does work-arounds like standing against a sink to balance while carefully washing each part of the body, that requires motivation. When a person brings an outdoor activity like potting plants indoors--that's motivation. When a person continues to cook healthy food, breaking up tasks over several days--that's motivation. And so it goes. We feel like crap but don't give up. We feel like medicine gave up on us--until recently. Now there's a spark of hope!
I too have so much motivation and desperately want and desire to do many many things. Depressed people don’t won’t to do things, and many lack desire. Stupid psychologists need to wake up and get the fact than ME/CFS mood is the opposite of depression. The only time people get depression is because we are locked into a body that constantly punishes us for ‘pushing through’. And after being stuck in this state some people could well end up depressed from lack of relief. I’m lucky I only have moments of despair. but I’m not depressed. Idiotic closed minded psychologists and psychiatrists need to face the fact that their behaviour has caused undue distress to a group of people who are physically ill. They also stole our funding and altered data to save face (PACE trial fraud) all at ME/CFS patients expense. There actually needs to be a government inquiry into the mistreatment of patients. Or a decent investigative journalistic exposé in how the medical insurance industry benefited from declining claims. (Note the infamous lying research psychiatrist Simon Weasley is linked to the insurance industry.) Only then will the world wake up that we have suffered many years more that we should have because of the greedy close minded psychological community.
I agree. Mood problems and lack of motivation seem to be stunningly rare in most ME populations. Which does make me wonder about the cohort selection. I hope SEID wasn't used in preference to ICC.
I think he means the drowsiness and sluginess you experience that go with the other flulike sensations during a relapse or for healthy people with a common fever. There’s a difference between feeling demotivated and depressed because of an illness or being a demotivated or depressed person.
Cheers for this, I've been looking for "how to diagnose chronic fatigue syndrome symptoms" for a while now, and I think this has helped. Have you ever come across - Diyadelyn Ziyily Idea - (Have a quick look on google cant remember the place now )? It is a smashing one of a kind guide for getting rid of chronic fatigue syndrome (CFS - Also known as myalgic encephalomyelitis or ME) minus the normal expense. Ive heard some pretty good things about it and my friend got great success with it.
Make me well and see how motivated I am. At issue is that my motivation isn't seen by others who wonder why I don't "come out to play" any longer. Although I'm ambulatory for awhile, I'm sure my neighbors who see me in my electric wheelchair while going down to the mailbox think that I'm not trying very hard. I'm an amateur photographer with 60 years behind the camera who can't go out to photograph. But, I'm motivated to study my craft for part of every day. I'm a recreational bicyclist who rode between 6 and 8 thousand miles every year when well. I've sold all of my cycling gear, but I'm still motivated by the sport and support my wife who still rides. Just make me well. Help me get out of bed and out of my house. I've had M.E. for 17 years, but I still dream of showing you...all of you how motivated I am.
These webinars keep getting more and more interesting. I had the good fortune to see Dr. Younger speak after his first year of research and found it fascinating. This webinar takes it to the next level. So many correlations to what we go through daily. Of particular interest was his premise for cooling the brain by cooling the blood going up to it seems to be a simple way to overcome the blood/brain barrier in a non-pharmaceutical way. Of course it will need further study to ensure that it doesn't mess up any other parts of the brain, but innovative none-the-less. And I think the science behind his specialty programming of MRIs will benefit far more than the ME/CFS community. But hurry, Dr. Younger. I'm getting old.
Diagnosed in 2010. It took years before I understood my ME/cfs, and still its a mystery to me. One moment things go a bit better, and in seconds you get ill and have to lay down for the rest of the day. And people think you're acting 😒😒😒 I also have fibromyalgia. Sometimes my brain hurts, I can feel the pain without a doubt. ADVICE: fresh air and very light exercises in fresh air are very important, also healthy food. Limit your time in front of the screen because it can give you brain fatigue (!!!). When in the shower: take also a COLD shower, also over the head. Stay away from toxic people. Look for real love in the Name of God, compassion and HUGHS 💕! BE AWARE: people with Chronic Childhood Trauma can have inflammation in the brain, so you've to work on that too.
Brilliant. Thank you so much for this research. I feel emphatically you are going in the right direction. As a housebound sufferer of 30 years, as well as the fatigue, brain fog some muscle weakness, general malaise and complete lack of motivation to do evenbasic things like taking a shower,. are a major major part of my existence. Sometimes ,I can't even be bothered to eat, unless I'm really hungry. I'm so grateful that at long last, research on the devastation that is ME, CFS seems to be heading in the right direction!Thank you again, Dr.!!!
@@paul2019monte Hi. Sue. Thanks for that. Many on here don,t believe that. ,,malaise,, can be a component of CFS.!! What the HELL do they think CFS is!!!!? If the brain is sufficiently affected, of COURSE it,s going to be one of the symptoms,. In some of the people, some of the time.!!!
my wife was just diagnosed with M.E shes 29, we have a 7 year old, i'm scared af and want to know about the progression of the disease. It takes a toll on you, especially when you're the guy who fixes everything, and seeing my wife deteriorate away
I'm so sorry to hear about your wife, as much as possible encourage her to rest more than she ever thought she could. I've only seen improvements from going off of work and having my husband take on house work, it's terrible but we're determined to have me get better so this isn't life long. Sending you hope!
@@harperevelyn81 curious if mushrooms would work.. it creates new neurological connections like 100’s even if a only a few stick that’s a few more neural connections that could rewire the brain to correct a lot of the subconscious things
@@Matt-su5wp I've been curious about that as well. I'm seeing a lot of improvement taking 40-60 mg of cbd, eating an anti inflammatory whole foods based diet, taking melatonin and thc to sleep, and basically doing very very very little to avoid crashes. It's hard to develop a recovery treatment plan with so little medical knowledge, but I've found Raeline's CFS/ME recovery youtube channel really helpful.
Thank you for this research! also for explaining in a way we can understand, it makes so much sense to me, I was diagnosed 34 years ago with ME but believed It started over 42 years ago! At times when I was very sick trying to explain how I felt like my brain was boiling , that it wasn't just a headache!! the looks that I had & was also told that wasn't possible! Thank you for making me realise I haven't been making anything up! You have given me some hope back!! when I had totally given up on there ever being a cure in my lifetime!!
I swear I had this as a kid. Whether or not I actually had CFS or just experience life in a similar was is something I cannot say, but I absolutely feel for all of you. Don't give up! I was super motivated, slept 10-12 hours a day, constantly falling asleep in class, couldn't sit still due to pain throughout my spine and terrible brain fog. I'm good now, which makes me think I didn't have CFS, but I know how many of you are feeling. I especially know what it's like to cycle through countless doctors and for them to have absolutely no clue what is going on and to basically outright say it's in your head. If it is brain inflammation, perhaps it is in the head though XD
I have burning pain in my spinal column whenever I have done too much either mental or physical. Takes day or two of rest and heat on spine to recover. have had ME/cfs for 33yrs .
I know where the cause of the spinal cord pain comes from. In 1980 before MRI’s I had a Mylogram if my spine with contrast dye, I was allergic to iodine had a bracelet on my wrist saying I was allergic to iodine, did not know dye had iodine. After the outpatient procedure I was in pain and felt paralyzed I was put in hospital for several days and they put me on tilt table to try and remove as much of the iodine as possible. After 6 months pain went away completely and never felt pain again until I had come down with ME/CFS in 1988. Never had the burning pain again until I would try to push what I was doing and stayed up longer than I should. For the last 20 years it is the symptom that tells me oh you have done it again. Also comes with migraine headache which I had never had before ME/CFS.
Personally, I take aspirin and use ice on my head, I've only had a few times of spinal inflammation in my 25 years but brain inflammation almost daily.
This is the most exciting research I have seen. It is exciting to see the convergence with research from other groups and with different measurements within your own group, and the specificity between diseases/injuries. It feels like when patients with MS first got confirmation years ago about demyelination with neural scans - real evidence, as well as giving real direction for further research. I hope you get the federal funding you deserve. This is a big breakthrough.
Fantastic work, Jarred 🙂 I knew you were measuring brain temperature, but didn't know you could identify the concentration/amount of specific substances (e.g. lactate) in different parts of the brain. Can't wait to see what the next 5 or 10 years bring!
Is there any concern that the neuro-inflammation seen in ME/CFS is due to important processes (e.g. combatting a persistent pathogen) and treatments designed to tamp it down (medications, cooling, vagus nerve stimulation) would interfere with that process without addressing the true underlying cause?
I have wondered that....if my brain inflammation is due to my body trying to fight off borrelia burdorferi....Lyme...and therefor we need to address the Lyme first?
@ Kyle. It's funny you should say that. While I personally try to avoid sugar, (a known inflammatory agent), I HAVE discovered that when I drink very VERY cold water (I put ice and water into a blender to make a plain water slurpee), to purposefully create "brain freeze", IT HELPS HEADACHES. I've been doing that for a while now and yes, it hurts really badly while I'm having brain freeze. BUT after that pain subsides, , it seems to help the headache/migraine. When I saw this video it sort of confirmed why it works. I had been trying to cool my brain by putting ice packs on the outside of my head, and it never worked. I've had ME/CFS since 2013. I send out hope to all who are dealing with these mysterious brain conditions.
@@svenlundergard1 Hello your born with fibromyalgia so you've had it since birth.......... It gets worse with bad lifestyle the pain gets worse all over the body...... Keeping your gut healthy healing leaky gut is key to controlling pain but not a cure just pain management....
What about the gut? Anti inflammatory drugs are terrible in the gut :( so many of us can not have these drugs. Some people’s pain levels are off the charts and nobody should have to suffer! However it’s fantastic that your looking into diagnosis and medication. Please keep up. Your amazing work, some of us are a decade or 2 into this disease, others have had many bouts throuout their lives and some never get better :(((( many can with much intervention! And some people can not get better.
Re the MRI.. it does require an injection of dye. I have had 3 months of severe brain inflammation , had both CAT scan and MRI, but refused the dye infusion due to chemical allergy. Neither imaging showed any problems in spite of much pain and inflammation. I was told that the dye would have revealed any infection in the brain. Without it, the scam was inadequate. So I’m wondering if the scans shown here were done with or without the dye infusion. Thank you for an excellent video.
Does it matter if the patient is motivated or depressed? The disease is real, regardless.I hope clinical research grows exponentially. So many people who are suffering and the medical system abandoned them.its inspiring to see these studies being done. I hope treatments come in my lifetime.
Manual lymph drainage will cool me down pretty quick. It also removes inflammation. It has turned my life around even though it is needed regularly as the inflammation returns or continues.
@@dayamix13 it is a specific treatment. A light form of massage, about the weight of a dime. There are massage therapists that specialize in this treatment. I am lucky enough to have my wife that went for training. I need it pretty regularly but it is slowly improving all of my symptoms. I also quit all my medications for my kidneys and my kidneys have actually improved since I quit the drugs that harm kidneys. Kidney drugs that harm kidneys is a ridiculous approach. Good luck
@@SAVETHEKIDS-bn5zo look you lunatic. I don't have fibre myalgia... I have Myalgic encephalomyelitis which is inflammation of the brain. The manual lymph drainage reduces the inflammation. Just sit back and be a victim instead of trying new understandings. In the end, there is little research and if you want to rely on doctors that dismiss the injury and ignore toxicity, you do whatever you want. For the others that are willing to try a technique to improve, this is for them. People like you are really part of the problem when you shoot down people trying to offer insight into improvements. Ignorance is no excuse. Maybe do some research or try the treatment for the 80 bucks. It is not a cure but alleviates symptoms. Keep being a victim. You seem to really embrace it.
@@mikesawatsky9161 Wow you don't even have a brain cell..... Your on a video about fibromyalgia and don't have the disease... I knew you didn't have fibromyalgia by your comment.... Saying their is no cure for fibromyalgia isn't playing the victim you jerk it's living in reality you should try it some time instead of living in la la Land you must think pigs fly... Your a know it all that knows nothing it's actually because of people like you that these solutions to serious health problems is delayed your not a scientist you don't even have fibromyalgia you can't make this stuff up
I had a terrible case of interstitial cystitis leading to complete bladder removal. My bladder was full of Hunners ulcers. After this surgery, I was free from CFS for about a year and a half. Then, it came back ! I’ve been suffering since 1987.
I was diagnosed in 2006, and having learned about new discoveries by researchers through TH-cam, I’m hopeful that we’ll see a reasonable treatment in my lifetime.
I’m grateful to all those researching in the area of ME. Younger’s is fascinating research, and I hope that there will be follow up to this. I can envisage brain inflammation being caused by a viral trigger, but what about people with ME that was not caused by a viral trigger?
This is a conundrum we all need sorted by proper diagnostics. But in the usa enteroviral testing is not accessible, nor is a SPECT as explained by Byron Hyde’s work. No way to know without the right tests…
Have you looked at the enzyme lactate dehydrogenase that interconverts lactate and pyruvate? I consistently tested low on this enzyme - 60-70% of normal.
This is really reassuring and gives hope. I had an MRI to rule in/out MS, MS and tumours were ruled out however the consultant neurologist said there were unexplained shadows. Ive heard others with ME have had the same. Could some of our inflammation be shown in this way?
It’s definitely brain inflammation- my husband is 95% bedridden with horrid over sensory brain pain daily- sound , light stings his brain for hours until he passes out the only thing that helps a bit is Ativan- He cannot even tolerate a MRI it’s just too load even with ear protection-
23 years it's been for me...so what caused the inflation in the first place? I don't believe one isms voemrn with it UNLESS something infiltrated one of my parents bodies. That means somebody put it in the ecosystem. I keep my home at 60 degrees and I don't get any relief. I don't eat sugar or any processed foods nor have I ever. I've always had multi filtered or distilled water from the time of birth to this very day. I am completely tolerance to any kind of pain medication yet I have only taken 3 pills in my entire life so there is no way I could have built a tolerance. Something flipped off in my system any furtherInto my thyroid system or anyting else that would cause such utter and completed exhaustion. I've always had a organic non-gmo produce grown by our family in our own yard any type of fertilizer was homemade buy composting. Only grass fed, non antibiotic meets which was little.
Did the funding come for the scanning? 5 years on - this was released while I was in the depths of despair trying to work out what was happening to my 18 year old, she is still recovering, I havent. An actual test to pick up MECFS, and to be believed, would make so much difference.
My father has had this for many years and bo doctor has been able to even come up with a diagnosis never mind any help for it. He notices it worse in the morning and it gets better as the day goes on. It flares up when he eats any kind of tomato sauce.
This is interesting and building on other presentations elsewhere. I'm curious that such clear delineations between cohorts can be seen given (as per the response in the Q&A at the end) the patients cohort is very able at 60% of normal. If I was at that level I would be be regarding my presentation as being 'in remission'. I understand the problems wrt to severely ill patients being unable to use the required equipment but I ponder it might be useful, when or if this study is extended, to use patients more like me who have been housebound many decades, have lower functionality (less than 30% of normal), conform to the ICC definition of the disease but with help can, on rare occasions, make their way out of the home, especially for projects which show such promise as this. I'm guessing if the considerably healthier patient cohort can show the results that they do then having an even tighter and more representative cohort could narrow things down even further?
Very interesting. I gotta wonder if inflamed guts could result in brain inflammation. From things like sugar, flour, high glycemic or processed foods, etc. Or viruses of course or candida or mold. And btw y'all, I hear CBD is a great anti-inflammatory. I do believe what we eat ends up in the brain (otherwise how would the brain get nutrition). For me, grains and bread especially make me inflamed for sure. I felt way better and had way more energy when I was off them.
Dr John Chia has been publishing in the Journal of Clinical Pathology this for decades, often caused by Enterovirus B. Currently awaiting development of Enterovirus Antiviral
I didn't hear anything about the basal ganglia being involved. Isn't that the area that controls movement? My main malfunction is abnormal movements: parosysmal dyskinesia/dystonia which I have to take Dilantin, klonopin, and Baclofen to keep it under control, with Ativan on hand for breakthroughs. Is this area not seen as inflammed also? I also have the usual ME/CFS symptoms, but my pain is minimal. I am wondering if it's because I take dextromethorafan for my chronic cough. Thank you, Dr. Younger, for your work. God bless you!!
A great step forward. Thank you for your work and for publishing this research. It is so important for hope to keep being rekindled. Robert Phair presented the metabolic trap findings at the Open Medicine Foundation. Could there be targeted gene therapy to the IDO1 gene, or simply breaking the immune response by the body by forcing inflammation to down regulate and allow the release of the trap to happen.
NSAIDs are effective, but kidneys can't tolerate them forever. If a kidney-safe, liver-safe NSAID can be developed that is tolerated for indefinitely long periods of time (i.e., potentially for a lifetime), that will be ground breaking.
Son Of Hibbs I know a gut surgeon who said they give Losec medication to patients that can’t eat for periods while on NSAIDS . He said it stops the ulcers forming
Dr. Younger, Thank You so much for your helpful research. Could you please let us know which botanicals helped better than the placebos in your study. I use essential oils when doing Reiki Treatments, and I would like to know if there is a botanical or specific essential oil that would help in reducing inflammation both for my clients and myself. May your work and journey be blessed!
For the past year I have been micro dosing with psilocybin once a week. At these small doses no psychoactive effects are felt. The active components of these mushrooms have significant anti inflammatory, anti viral and pain relief properties as well as remarkable effects on neural activity. My M.E symptoms continue to decrease in severity. I feel like the quagmire of brain fog I have been wading in the last 3 years is finally lifting. My crashes are far less severe and far less frequent. My body pain no longer constant, my sight is less frequently disturbed, my tinnitus no longer a daily occurrence, the vertigo is now a warning sign not a constant, the eruption of cold sores are now rare not consistent
Not sure what type of medicine he is thinking of to reduce brain inflammation, but I would like to mention that PREDNISONE and similar meds actually exasperate LYME symptoms (one of which is ME/CFS). So it would have to be a drug that does not act in the same way and result in the terrible relapse of Lyme folks. Excited about this work. Prayers you find answers!!
I too, appreciate your work on ME/CFS, but I am wondering, why did you have to quit working on ME/CFS, and started working on Fibromyalgia instead? Is that because Fibro has an ICD code, but "TPTB" won't give us one? In how many cases of ME have you seen abnormal movement disorders?
Look at Epstein-Barre virus research. EBV stays in your immune B cells, hides itself so immune system can't get rid of completely, so in times of physical or mental stress it reactivates and takes advantage of your lowered resistance replcating itself over and over again overwhelming your system.
I am concerned about the cost of new medications. Also, the symptoms of COVID-19 "Long Haulers" are strikingly similar to ME/CFS. It would be interesting if the the scans are similar.
there needs to be a place in the country where patients can get scanned for pay out of pocket. I would spend my own money to get this scan to confirm this diagnosis. I do indeed feel like my brain is on fire.
Wow, thankyou thankyou thankyou, I am filled with gratitude that work on finding a treatment is getting so close it give me hope that I 1day may be able to enjoy my life properly once again 🙏🤔🤩😍 wonderful reaserch
When I told my doctor that I feel like my brain is hot and swollen, he told me if that were the case I’d be dead by now but I could feel the heat with my hand at the base of my skull… dismissed
My skull cap is heating up dramatically and has a far higher temperature than the rest of my body. I am not having a fever. Can this be due to brain inflammation in ME CFS which I have been suffering from for many years?
Hi, we can not give medical advice or make any diagnosis. Dr. Younger's research indicates that those who suffer from ME/CFS run hotter than a non-afflicted person. Have you read Cort Johnson's article about micro-circulation? www.healthrising.org/blog/2018/12/04/capillaries-microcirculation-chronic-fatigue-syndrome-me-cfs/
Davide Pattibiomed yes, it’s regulated and Jared is a research (PhD) doctor, not a medical doctor (MD) which means he’s not able to work with patients outside of the research lab.
Hello YO YO, yes I say the exact same thing and I do get irritable when the brain inflammation and noise and light sensitivity is happening. It is a frustrating feeling to cope with anytime when I need to do clerical or computer work. Almost impossible. And so, I am training myself to NOT push thru because that will make my brain worse and a bigger crash the next day. Interestingly your ID name being YO YO. I wonder if you choose that bcuz you feel like one? I am a yo yo with my bedtime and energy levels. Get energy after 9 pm then stay up too late doing catch up jobs I could not get done all day bcuz of fatigue, lack of focus and going in circles due to short term memory issues. Really bad pattern for healing. Working on circadian rhythm. How about you? Any of these symptoms?
@@lauragott2122 Hi! I’ve got a similar pattern to you. It’s the weirdest thing. I’m lousy all day. Slightly better in the afternoon, when I try to get outside for some fresh air. Evening is the best time, physically and mentally. When I discovered this I was delighted that there was at least a bit I could do but I wasn’t going to bed until about 3am. I started taking an antihistamine at bedtime to try to increase sleep and bring my bedtime forward. I’ve got it to about midnight now and my evening energy now starts at about 4pm. Noticing the evening peak made a big difference though - previously it was as if I was fighting against the brain fog and lethargy all day and by evening I was exhausted; now I try to go with the flow. How are you getting on?
@@JoButterwick Hello Dream Dancer, Thank you for responding to my comments.. That is interesting about the histamine. I'll watch Dr. Osborne's talk on histamine sensitivity. May be something I can do like you. Thank you so much for the feedback! BTW, my energy has been much better during Lenten session now that we are fasting wth one meal per day. I've noticed it b4 also. I think just digestion can drain your energy, not to mention good sensitivities! I think I've got all my down now, I hope. No gluten or grains, no nightshades. Skin is very gradually healing. Thanks for sharing!
@@lauragott2122 I’m so glad to hear that you are on the road to recovery. I mainly follow RUN-DMC for long Covid. He is a fellow sufferer who has collected lots of info and interviews various experts. Thanks for the idea about fasting, I’ll give it a try. Stay safe x
@@JoButterwick Hello again Dream Dancer, Thank you for the reference. Is he on You Tube or other? My CFS is not from Covid, I have high titers to EBV. I know, however, that the Covid long haulers are quite similar to the classic ME/CFS sufferer and that many things can cause CFS e.g. Lyme and other infections, so it makes sense there would be CFS from Covid too. I think this all has to do with our particular immune systems and how they respond differently than other people who get sick but don't stay sick. The microbiome is different in everyone. But glyphosate I feel is a big player in causing these modern chronic diseases by ruining our gut linings and let's viruses, mold, toxins and bad bacteria into our blood stream. So much to research!
I listened to another video of a woman who found that when she took a warm shower it would trigger her Cronic Fatigue Syndrome so maybe if they took cold showers it would at least help reduced possible events in their day that might trigger CFS.
I have always felt like I have brain inflammation. I can’t explain it but I was diagnosed with hemicranium continuia (spelling?) a couple years ago. At that time I felt like my brain had a temperature (that’s the only way I know how to explain it) I also had a terrible headache in my right temporal area. I was given Indocin which immediately stops my headache. When I take it I feel Like it helps the inflammation. I also have mild CFS. I had mononucleosis when I was 20 and since then I have never felt like myself. I’ve also been diagnosed with fibromyalgia . I’ve also noticed that when I take the Indocin it helps my fibromyalgia pain.?? I know about the side effects of Indocin but the difference in the way I feel when I take it make it worthwhile to me to take it. My brain feels better. ?? Is this possible? Is the Indocin helping the inflammation in my brain? Thank you so much for your research on this awful disease. There are so many of us that need help !
What's a plausible explanation for why disrupted sleep would be evolutionarily advantageous in the same way as other "sickness behavior" symptoms appear to be? And if there are symptoms in a condition like ME/CFS that would certainly have ensured someone's demise on the Serengeti, can we be so sure that *any* are evolutionarily adaptive? (We can't just pick and choose can we?)
I Have Very High level’s of Fatigue & inflammation levels it’s hard now been given me Brain fog in the beginning Forgetting & my Concentration/ grammar has been getting worse I live in New York Area Where can I seek out a Doctor that can Help me?? Please Help. Thank You.
Clara Sutton. What do you mean by. ,,motivation decrease,, ,,why is this discussed, ,?? As an ME sufferer of 30 years, as well as fatigue, dizziness, brain fog, etc, lack of motivation on !y part to do AnYTHiNG is a major factor in my daily existence. Even when I have sufficient energy to say, have a shower, I never want to do it. Not much of anything. And I believe this is common to a large percentage of ME CFS sufferers.
@@susantomis6556 I mean, depression involves a motivation decrease ( not wanting to), whereas ME/CFS involves wanting to do more, but not being able to do so. The will is not gone, just the ability.
@@ciarasutton5203 I think if you listen very carefully to the ,,lecture,,above, the Dr. talks about increased levels of certain chemicals in ME ,CFS patients. One of which is choline, increased levels are seen in what he seems the ,,sickness response,, area of the brain. Resulting in malaise and motivation decrease. I don't think you can possibly say ,,Me,, CFS. Is about wanting to do things, but being unable,, as a blanket diagnosis. As a 30 year sufferer myself, I have ,and still do, experienced both of these states, on a more or less continual basis!!! Sometimes, extreme frustration because I'm unable to do what I want to. Other times ,total malaise and lack of any sort of motivation to do anything of anything. ME ,CFS is as individual to the sufferers as the sufferers are themselves. Although of course we all suffer from the same basic pathology , ie. Chronic fatigue, mental fog, loss of concentration, and sometimes mild depression brought on by the condition itself. I hope this clarifies things for you. And thanks anyway for your reply.
To be able to measure brain inflammation is a huge step. But what about the cause? Can't the inflammation (chronic) be the result of low perfusion? How does it look like in other patients with brain fog? E.g. Fibromyalgia (dividing them in 2 sub-groups, with or without SFN), POTS (dividing them in 3 sub-groups: with SFN and adrenergic or muscarinic autoantibodies, with SFN and w/o aabs, w/o SFN and aabs), and maybe other POTS causing diseases as Lupus or Lyme
The cause for me was the microwave oven. This may sound unbelievable: the internet states that the use is harmless or that the danger is cancer or a reduction in vitamins. The first consequences were: pain in the neck, fatigue, sore throat, depression, ..... After 3 months without a microwave oven these symptoms disappeared. Consequences are greater the closer the microwave oven is to you: if the oven is right next to your dining table, for example. If you bring this to your members' attention, those who wish can give it a try and let you know about their experiences. Everyone can now participate in the study! People will not think much of CFS. Organs are not damaged. It looks more like an internal strangulation. I don't know if that can be found. The muscles tense under the influence of microwaves (microwave), Hence the pain and the intestines are too tense, which makes digestion poor and too few vitamins are absorbed. In the throat one has pain due to the tensioning of the muscles there. Be careful not to cure other diseases with fatigue for CFS.
Stop repeating this, I doubt it’s that simple and everyone is different in response to electromagnetic energy and toxicities. Do you really need to blast this “theory” on every sight? glad it worked for you but this is not a one size fits all issue.
Dear, now the cause of Chronic Fatigue Syndrome is found: radiation of microwaveoven. To stop you have to eliminate the oven out of the house. The plug out of electricity net because the oven has also radiation when it is not in use.And out of the house because the oven has a high voltage capacitor. The distance between an oven and a person is very important.After a 2 weeks without microwaves health becomes better.
This gives me hope. I thank all the doctors trying to genuinly help and cure this awful disease from the bottom of my heart..
This is encouraging research! I would not describe mood and motivation suppression as a primary symptom of ME however. The people I know within the ME community are amongst the most motivated I have ever known. We are not lacking motivation to do things, just the physical ability to do them! We must not confuse ME with depression, that has caused too much damage already. Thank you for this research!
Can't answer for others but a lack of motivation has not been part of my experience. When a person does work-arounds like standing against a sink to balance while carefully washing each part of the body, that requires motivation. When a person brings an outdoor activity like potting plants indoors--that's motivation. When a person continues to cook healthy food, breaking up tasks over several days--that's motivation. And so it goes. We feel like crap but don't give up. We feel like medicine gave up on us--until recently. Now there's a spark of hope!
I too have so much motivation and desperately want and desire to do many many things. Depressed people don’t won’t to do things, and many lack desire.
Stupid psychologists need to wake up and get the fact than ME/CFS mood is the opposite of depression. The only time people get depression is because we are locked into a body that constantly punishes us for ‘pushing through’.
And after being stuck in this state some people could well end up depressed from lack of relief.
I’m lucky I only have moments of despair. but I’m not depressed.
Idiotic closed minded psychologists and psychiatrists need to face the fact that their behaviour has caused undue distress to a group of people who are physically ill. They also stole our funding and altered data to save face (PACE trial fraud) all at ME/CFS patients expense.
There actually needs to be a government inquiry into the mistreatment of patients. Or a decent investigative journalistic exposé in how the medical insurance industry benefited from declining claims. (Note the infamous lying research psychiatrist Simon Weasley is linked to the insurance industry.)
Only then will the world wake up that we have suffered many years more that we should have because of the greedy close minded psychological community.
I agree. Mood problems and lack of motivation seem to be stunningly rare in most ME populations. Which does make me wonder about the cohort selection. I hope SEID wasn't used in preference to ICC.
I think he means the drowsiness and sluginess you experience that go with the other flulike sensations during a relapse or for healthy people with a common fever. There’s a difference between feeling demotivated and depressed because of an illness or being a demotivated or depressed person.
Mariëlle de Vries yes I think you are correct. I wondered if Jarred Younger meant that
Thank you so much for this research!!! It gives me hope that I'm not going to rot in bed for the rest of my life.. I really appreciate it.
Cheers for this, I've been looking for "how to diagnose chronic fatigue syndrome symptoms" for a while now, and I think this has helped. Have you ever come across - Diyadelyn Ziyily Idea - (Have a quick look on google cant remember the place now )?
It is a smashing one of a kind guide for getting rid of chronic fatigue syndrome (CFS - Also known as myalgic encephalomyelitis or ME) minus the normal expense. Ive heard some pretty good things about it and my friend got great success with it.
@@alexvidu4517 Spammer
try taking a cool shower, not freezing showers but cool showers.
Me too cuz I have been in bed for 7 yrs.
I'm too bad. Any real news by now?? Sorry, can't even research myself. Thank you:))
Make me well and see how motivated I am. At issue is that my motivation isn't seen by others who wonder why I don't "come out to play" any longer. Although I'm ambulatory for awhile, I'm sure my neighbors who see me in my electric wheelchair while going down to the mailbox think that I'm not trying very hard. I'm an amateur photographer with 60 years behind the camera who can't go out to photograph. But, I'm motivated to study my craft for part of every day. I'm a recreational bicyclist who rode between 6 and 8 thousand miles every year when well. I've sold all of my cycling gear, but I'm still motivated by the sport and support my wife who still rides. Just make me well. Help me get out of bed and out of my house. I've had M.E. for 17 years, but I still dream of showing you...all of you how motivated I am.
These webinars keep getting more and more interesting. I had the good fortune to see Dr. Younger speak after his first year of research and found it fascinating. This webinar takes it to the next level. So many correlations to what we go through daily. Of particular interest was his premise for cooling the brain by cooling the blood going up to it seems to be a simple way to overcome the blood/brain barrier in a non-pharmaceutical way. Of course it will need further study to ensure that it doesn't mess up any other parts of the brain, but innovative none-the-less. And I think the science behind his specialty programming of MRIs will benefit far more than the ME/CFS community. But hurry, Dr. Younger. I'm getting old.
Diagnosed in 2010. It took years before I understood my ME/cfs, and still its a mystery to me. One moment things go a bit better, and in seconds you get ill and have to lay down for the rest of the day. And people think you're acting 😒😒😒 I also have fibromyalgia. Sometimes my brain hurts, I can feel the pain without a doubt. ADVICE: fresh air and very light exercises in fresh air are very important, also healthy food. Limit your time in front of the screen because it can give you brain fatigue (!!!). When in the shower: take also a COLD shower, also over the head. Stay away from toxic people. Look for real love in the Name of God, compassion and HUGHS 💕! BE AWARE: people with Chronic Childhood Trauma can have inflammation in the brain, so you've to work on that too.
Thank you ❤
All the best to you x
I feel inflammation everywhere in the body, and very strongly in the head too.
Brilliant. Thank you so much for this research. I feel emphatically you are going in the right direction. As a housebound sufferer of 30 years, as well as the fatigue, brain fog some muscle weakness, general malaise and complete lack of motivation to do evenbasic things like taking a shower,. are a major major part of my existence. Sometimes ,I can't even be bothered to eat, unless I'm really hungry. I'm so grateful that at long last, research on the devastation that is ME, CFS seems to be heading in the right direction!Thank you again, Dr.!!!
PS. And I am not particularly depressed, either. So lack of motivation is not born of depression. Not in my case, anyway.
@@susantomis6556 same here
@@paul2019monte Hi. Sue. Thanks for that. Many on here don,t believe that. ,,malaise,, can be a component of CFS.!! What the HELL do they think CFS is!!!!? If the brain is sufficiently affected, of COURSE it,s going to be one of the symptoms,. In some of the people, some of the time.!!!
@@susantomis6556 people that haven't experienced it have no idea😪
@@paul2019monte Amen!! Merry Xmas, Sue.
my wife was just diagnosed with M.E shes 29, we have a 7 year old, i'm scared af and want to know about the progression of the disease. It takes a toll on you, especially when you're the guy who fixes everything, and seeing my wife deteriorate away
I'm so sorry to hear about your wife, as much as possible encourage her to rest more than she ever thought she could. I've only seen improvements from going off of work and having my husband take on house work, it's terrible but we're determined to have me get better so this isn't life long. Sending you hope!
@@harperevelyn81 curious if mushrooms would work.. it creates new neurological connections like 100’s even if a only a few stick that’s a few more neural connections that could rewire the brain to correct a lot of the subconscious things
@@Matt-su5wp I've been curious about that as well. I'm seeing a lot of improvement taking 40-60 mg of cbd, eating an anti inflammatory whole foods based diet, taking melatonin and thc to sleep, and basically doing very very very little to avoid crashes. It's hard to develop a recovery treatment plan with so little medical knowledge, but I've found Raeline's CFS/ME recovery youtube channel really helpful.
Hi, look up Raelan Agle, she has loads of success stories from people who've fully recovered.
Thanks! I will look her up.
Thank you for this research! also for explaining in a way we can understand, it makes so much sense to me, I was diagnosed 34 years ago with ME but believed It started over 42 years ago! At times when I was very sick trying to explain how I felt like my brain was boiling , that it wasn't just a headache!! the looks that I had & was also told that wasn't possible! Thank you for making me realise I haven't been making anything up! You have given me some hope back!! when I had totally given up on there ever being a cure in my lifetime!!
I swear I had this as a kid. Whether or not I actually had CFS or just experience life in a similar was is something I cannot say, but I absolutely feel for all of you. Don't give up!
I was super motivated, slept 10-12 hours a day, constantly falling asleep in class, couldn't sit still due to pain throughout my spine and terrible brain fog. I'm good now, which makes me think I didn't have CFS, but I know how many of you are feeling. I especially know what it's like to cycle through countless doctors and for them to have absolutely no clue what is going on and to basically outright say it's in your head.
If it is brain inflammation, perhaps it is in the head though XD
It would be a miracle to be able to go outside and have a normal life.
True
Yes, people take for granted this wonderful gift of just being able to go out for a walk or meet a friend and socialise.
🤲🏻 So true
Hang in there , i know your pain ! One day you will go outside
Yes this fits my experience with ME Also inflammation not only in brain but also spinal cord. Now for what to do about the inflammation?
I have burning pain in my spinal column whenever I have done too much either mental or physical. Takes day or two of rest and heat on spine to recover. have had ME/cfs for 33yrs .
take cool showers, or just run cool water over your head in the sink
@@beverlycrawford7859 take cool showers, or run cool water over your head.
I know where the cause of the spinal cord pain comes from. In 1980 before MRI’s I had a Mylogram if my spine with contrast dye, I was allergic to iodine had a bracelet on my wrist saying I was allergic to iodine, did not know dye had iodine. After the outpatient procedure I was in pain and felt paralyzed I was put in hospital for several days and they put me on tilt table to try and remove as much of the iodine as possible. After 6 months pain went away completely and never felt pain again until I had come down with ME/CFS in 1988. Never had the burning pain again until I would try to push what I was doing and stayed up longer than I should. For the last 20 years it is the symptom that tells me oh you have done it again. Also comes with migraine headache which I had never had before ME/CFS.
Personally, I take aspirin and use ice on my head, I've only had a few times of spinal inflammation in my 25 years but brain inflammation almost daily.
This is the most exciting research I have seen. It is exciting to see the convergence with research from other groups and with different measurements within your own group, and the specificity between diseases/injuries. It feels like when patients with MS first got confirmation years ago about demyelination with neural scans - real evidence, as well as giving real direction for further research. I hope you get the federal funding you deserve. This is a big breakthrough.
thankyou for your work,have suffered with this since 1999
Thanks so much for research..I am tired of feeling crappy for 8 years as I know many others are too
Thank you so much, Jarred. What should we do without you? God bless you. 🙏🌹❤️
Fantastic work, Jarred 🙂 I knew you were measuring brain temperature, but didn't know you could identify the concentration/amount of specific substances (e.g. lactate) in different parts of the brain. Can't wait to see what the next 5 or 10 years bring!
I won't last 5 years. 😕
@@melloyellow5598 Lucky you!!!
Is there any concern that the neuro-inflammation seen in ME/CFS is due to important processes (e.g. combatting a persistent pathogen) and treatments designed to tamp it down (medications, cooling, vagus nerve stimulation) would interfere with that process without addressing the true underlying cause?
That is a good question!
I have wondered that....if my brain inflammation is due to my body trying to fight off borrelia burdorferi....Lyme...and therefor we need to address the Lyme first?
So we need to cool our brain? Ok, BRB. Headed to 7/11 for a few slurpees.
@ Kyle. It's funny you should say that. While I personally try to avoid sugar, (a known inflammatory agent), I HAVE discovered that when I drink very VERY cold water (I put ice and water into a blender to make a plain water slurpee), to purposefully create "brain freeze", IT HELPS HEADACHES. I've been doing that for a while now and yes, it hurts really badly while I'm having brain freeze. BUT after that pain subsides, , it seems to help the headache/migraine. When I saw this video it sort of confirmed why it works. I had been trying to cool my brain by putting ice packs on the outside of my head, and it never worked. I've had ME/CFS since 2013. I send out hope to all who are dealing with these mysterious brain conditions.
@@svenlundergard1 Hello your born with fibromyalgia so you've had it since birth.......... It gets worse with bad lifestyle the pain gets worse all over the body...... Keeping your gut healthy healing leaky gut is key to controlling pain but not a cure just pain management....
@@svenlundergard1 has cold water helped u with ME CFS?
Take cool showers too!
@@c8rich416 just had a vanilla milkshake
What about the gut? Anti inflammatory drugs are terrible in the gut :( so many of us can not have these drugs. Some people’s pain levels are off the charts and nobody should have to suffer! However it’s fantastic that your looking into diagnosis and medication. Please keep up. Your amazing work, some of us are a decade or 2 into this disease, others have had many bouts throuout their lives and some never get better :(((( many can with much intervention! And some people can not get better.
Re the MRI.. it does require an injection of dye. I have had 3 months of severe brain inflammation , had both CAT scan and MRI, but refused the dye infusion due to chemical allergy. Neither imaging showed any problems in spite of much pain and inflammation. I was told that the dye would have revealed any infection in the brain. Without it, the scam was inadequate. So I’m wondering if the scans shown here were done with or without the dye infusion.
Thank you for an excellent video.
Hello, how have you healed your brain inflammation?
I have really impaired brain function most days. I really hope medication from this research can be developed it's really hard some days to deal with.
This is so encouraging. Thank you for your work!
Does it matter if the patient is motivated or depressed? The disease is real, regardless.I hope clinical research grows exponentially. So many people who are suffering and the medical system abandoned them.its inspiring to see these studies being done. I hope treatments come in my lifetime.
What were the 2 botanicals that helped with the inflammation? This video is 2 years old.
Thanks so much for figuring this out !
Based as hell my dude
Manual lymph drainage will cool me down pretty quick. It also removes inflammation. It has turned my life around even though it is needed regularly as the inflammation returns or continues.
Mike Sawatsky how do you do it?
@@dayamix13 it is a specific treatment. A light form of massage, about the weight of a dime. There are massage therapists that specialize in this treatment. I am lucky enough to have my wife that went for training. I need it pretty regularly but it is slowly improving all of my symptoms. I also quit all my medications for my kidneys and my kidneys have actually improved since I quit the drugs that harm kidneys. Kidney drugs that harm kidneys is a ridiculous approach. Good luck
You don't know what your talking about their is no solution for fibromyalgia you don't have it if massage is your cure what a dingbat
@@SAVETHEKIDS-bn5zo look you lunatic. I don't have fibre myalgia... I have Myalgic encephalomyelitis which is inflammation of the brain. The manual lymph drainage reduces the inflammation. Just sit back and be a victim instead of trying new understandings. In the end, there is little research and if you want to rely on doctors that dismiss the injury and ignore toxicity, you do whatever you want. For the others that are willing to try a technique to improve, this is for them. People like you are really part of the problem when you shoot down people trying to offer insight into improvements. Ignorance is no excuse. Maybe do some research or try the treatment for the 80 bucks. It is not a cure but alleviates symptoms. Keep being a victim. You seem to really embrace it.
@@mikesawatsky9161 Wow you don't even have a brain cell..... Your on a video about fibromyalgia and don't have the disease... I knew you didn't have fibromyalgia by your comment.... Saying their is no cure for fibromyalgia isn't playing the victim you jerk it's living in reality you should try it some time instead of living in la la Land you must think pigs fly... Your a know it all that knows nothing it's actually because of people like you that these solutions to serious health problems is delayed your not a scientist you don't even have fibromyalgia you can't make this stuff up
I had a terrible case of interstitial cystitis leading to complete bladder removal. My bladder was full of Hunners ulcers. After this surgery, I was free from CFS for about a year and a half. Then, it came back ! I’ve been suffering since 1987.
Younger's research is about the only research presently ongoing which is actually promising to the true nature of this condition.
Dr. Younger, you are a Godsent❤️.
Thank you! Praying for a cure!!! 🙏🏽🙏🏽🙏🏽
Thank you for this valuable research!
I was diagnosed in 2006, and having learned about new discoveries by researchers through TH-cam, I’m hopeful that we’ll see a reasonable treatment in my lifetime.
I’m grateful to all those researching in the area of ME. Younger’s is fascinating research, and I hope that there will be follow up to this. I can envisage brain inflammation being caused by a viral trigger, but what about people with ME that was not caused by a viral trigger?
This is a conundrum we all need sorted by proper diagnostics. But in the usa enteroviral testing is not accessible, nor is a SPECT as explained by Byron Hyde’s work. No way to know without the right tests…
Have you looked at the enzyme lactate dehydrogenase that interconverts lactate and pyruvate? I consistently tested low on this enzyme - 60-70% of normal.
This is really reassuring and gives hope. I had an MRI to rule in/out MS, MS and tumours were ruled out however the consultant neurologist said there were unexplained shadows. Ive heard others with ME have had the same. Could some of our inflammation be shown in this way?
It’s definitely brain inflammation- my husband is 95% bedridden with horrid over sensory brain pain daily- sound , light stings his brain for hours until he passes out the only thing that helps a bit is Ativan- He cannot even tolerate a MRI it’s just too load even with ear protection-
My heart goes out to him xxxx
Brain pain ? Terrible headache .
23 years it's been for me...so what caused the inflation in the first place? I don't believe one isms voemrn with it UNLESS something infiltrated one of my parents bodies. That means somebody put it in the ecosystem.
I keep my home at 60 degrees and I don't get any relief. I don't eat sugar or any processed foods nor have I ever. I've always had multi filtered or distilled water from the time of birth to this very day. I am completely tolerance to any kind of pain medication yet I have only taken 3 pills in my entire life so there is no way I could have built a tolerance. Something flipped off in my system any furtherInto my thyroid system or anyting else that would cause such utter and completed exhaustion.
I've always had a organic non-gmo produce grown by our family in our own yard any type of fertilizer was homemade buy composting. Only grass fed, non antibiotic meets which was little.
This has been really helpful. Thank you so much.
I would like to know how you get local mass spectra from a brain MRI? Also how do you get Thermograms of Brain sections?
Did the funding come for the scanning? 5 years on - this was released while I was in the depths of despair trying to work out what was happening to my 18 year old, she is still recovering, I havent. An actual test to pick up MECFS, and to be believed, would make so much difference.
does anybody have white coating on tongue & ME / CFS ? Could candida TOXINS be responsible for this all ?
My father has had this for many years and bo doctor has been able to even come up with a diagnosis never mind any help for it. He notices it worse in the morning and it gets better as the day goes on. It flares up when he eats any kind of tomato sauce.
Dr. Younger’s research is ::so:: fascinating. Thanks so much for sharing this ❤️
How can I volunteer for clinical trials?
This is interesting and building on other presentations elsewhere. I'm curious that such clear delineations between cohorts can be seen given (as per the response in the Q&A at the end) the patients cohort is very able at 60% of normal. If I was at that level I would be be regarding my presentation as being 'in remission'. I understand the problems wrt to severely ill patients being unable to use the required equipment but I ponder it might be useful, when or if this study is extended, to use patients more like me who have been housebound many decades, have lower functionality (less than 30% of normal), conform to the ICC definition of the disease but with help can, on rare occasions, make their way out of the home, especially for projects which show such promise as this. I'm guessing if the considerably healthier patient cohort can show the results that they do then having an even tighter and more representative cohort could narrow things down even further?
Very interesting. I gotta wonder if inflamed guts could result in brain inflammation. From things like sugar, flour, high glycemic or processed foods, etc. Or viruses of course or candida or mold. And btw y'all, I hear CBD is a great anti-inflammatory. I do believe what we eat ends up in the brain (otherwise how would the brain get nutrition). For me, grains and bread especially make me inflamed for sure. I felt way better and had way more energy when I was off them.
what foods do you eat and whats CBD?
Dr John Chia has been publishing in the Journal of Clinical Pathology this for decades, often caused by Enterovirus B. Currently awaiting development of Enterovirus Antiviral
I didn't hear anything about the basal ganglia being involved. Isn't that the area that controls movement? My main malfunction is abnormal movements: parosysmal dyskinesia/dystonia which I have to take Dilantin, klonopin, and Baclofen to keep it under control, with Ativan on hand for breakthroughs. Is this area not seen as inflammed also? I also have the usual ME/CFS symptoms, but my pain is minimal. I am wondering if it's because I take dextromethorafan for my chronic cough. Thank you, Dr. Younger, for your work. God bless you!!
A great step forward. Thank you for your work and for publishing this research. It is so important for hope to keep being rekindled. Robert Phair presented the metabolic trap findings at the Open Medicine Foundation. Could there be targeted gene therapy to the IDO1 gene, or simply breaking the immune response by the body by forcing inflammation to down regulate and allow the release of the trap to happen.
Thank you for your question. We received a lot of questions during the webinar, as well, and Dr. Younger was able to address them directly.
NSAIDs are effective, but kidneys can't tolerate them forever. If a kidney-safe, liver-safe NSAID can be developed that is tolerated for indefinitely long periods of time (i.e., potentially for a lifetime), that will be ground breaking.
Doc Atheist?!! Really cool alias. Love it. I have no faith in MD's either. 👍😅
@@azalea1404 In part, that's why I became one: so I could take care of myself. At least, I know what the MDs are thinking, because I am one, too.
Neither do stomachs- ulcers/gastritis.
Son Of Hibbs I know a gut surgeon who said they give Losec medication to patients that can’t eat for periods while on NSAIDS . He said it stops the ulcers forming
They can mess up some peoples's gut and digestive system so natural approaches with not severe side effects I think are worth considering
Dr. Younger, Thank You so much for your helpful research. Could you please let us know which botanicals helped better than the placebos in your study. I use essential oils when doing Reiki Treatments, and I would like to know if there is a botanical or specific essential oil that would help in reducing inflammation both for my clients and myself. May your work and journey be blessed!
For the past year I have been micro dosing with psilocybin once a week. At these small doses no psychoactive effects are felt. The active components of these mushrooms have significant anti inflammatory, anti viral and pain relief properties as well as remarkable effects on neural activity.
My M.E symptoms continue to decrease in severity. I feel like the quagmire of brain fog I have been wading in the last 3 years is finally lifting. My crashes are far less severe and far less frequent. My body pain no longer constant, my sight is less frequently disturbed, my tinnitus no longer a daily occurrence, the vertigo is now a warning sign not a constant, the eruption of cold sores are now rare not consistent
Not sure what type of medicine he is thinking of to reduce brain inflammation, but I would like to mention that PREDNISONE and similar meds actually exasperate LYME symptoms (one of which is ME/CFS). So it would have to be a drug that does not act in the same way and result in the terrible relapse of Lyme folks. Excited about this work. Prayers you find answers!!
Thank you for these studies!
Would the logical next step be to see if these results are reliable when extrapolated onto a larger sample?
I would love to participate in one of these studies!!
Is there any follow up to this please?
Dr. Younger, when will you be able to make a video on the blood draws you did for 21 days?
I too, appreciate your work on ME/CFS, but I am wondering, why did you have to quit working on ME/CFS, and started working on Fibromyalgia instead? Is that because Fibro has an ICD code, but "TPTB" won't give us one? In how many cases of ME have you seen abnormal movement disorders?
Acetylcholine is synthesised from Acetyl-CoA and Choline. Isn't that interesting? Can high choline also mean that there aren't enough Acetyl-CoA?
Why would the brain have neuro inflammation after a viral infection has resolved?
And that is the million dollar question.
Look at Epstein-Barre virus research. EBV stays in your immune B cells, hides itself so immune system can't get rid of completely, so in times of physical or mental stress it reactivates and takes advantage of your lowered resistance replcating itself over and over again overwhelming your system.
I am concerned about the cost of new medications. Also, the symptoms of COVID-19 "Long Haulers" are strikingly similar to ME/CFS. It would be interesting if the the scans are similar.
This information has to be available to all doctors in the world, how do we do that?
there needs to be a place in the country where patients can get scanned for pay out of pocket. I would spend my own money to get this scan to confirm this diagnosis. I do indeed feel like my brain is on fire.
Would love to hear his thoughts about Arachnoiditis and neuroinflammation.
What type of MRI machine for the inside the brain is used in 2020?
This is 2 years old, very interesting👍
Is there drugs to reduce neuroinflammation yet? Ive tried LDN and didnt help unfortunately.
Wow, thankyou thankyou thankyou, I am filled with gratitude that work on finding a treatment is getting so close it give me hope that I 1day may be able to enjoy my life properly once again 🙏🤔🤩😍 wonderful reaserch
This is great information! Thanks!
Maybe speculate on known drugs that could be tried off label?
How reproducible are the results? I want to see this being reproduced as soon as possible...
14:07 - 14:59 why is there negative levels of lactate in the graph (on the right)?
When I told my doctor that I feel like my brain is hot and swollen, he told me if that were the case I’d be dead by now but I could feel the heat with my hand at the base of my skull… dismissed
My skull cap is heating up dramatically and has a far higher temperature than the rest of my body. I am not having a fever. Can this be due to brain inflammation in ME CFS which I have been suffering from for many years?
Hi, we can not give medical advice or make any diagnosis. Dr. Younger's research indicates that those who suffer from ME/CFS run hotter than a non-afflicted person. Have you read Cort Johnson's article about micro-circulation?
www.healthrising.org/blog/2018/12/04/capillaries-microcirculation-chronic-fatigue-syndrome-me-cfs/
@@SolveME I am wondering, why can you not give medical advice? is this a regulated by your US law?
Davide Pattibiomed yes, it’s regulated and Jared is a research (PhD) doctor, not a medical doctor (MD) which means he’s not able to work with patients outside of the research lab.
@@SolveME thank you.
Any trials like this in Ireland as I have always believed this condition is related to the brain .
Any more info on the botanicals that work??
Brahmi Ashwagandha Jatamansi
Luteolin
I KEEP SAYING ITS LIKE MY BRAIN IS ON FIRE! ANYONE HAVE BEHAVIOUR CHANGES?
Hello YO YO, yes I say the exact same thing and I do get irritable when the brain inflammation and noise and light sensitivity is happening. It is a frustrating feeling to cope with anytime when I need to do clerical or computer work. Almost impossible. And so, I am training myself to NOT push thru because that will make my brain worse and a bigger crash the next day. Interestingly your ID name being YO YO. I wonder if you choose that bcuz you feel like one? I am a yo yo with my bedtime and energy levels. Get energy after 9 pm then stay up too late doing catch up jobs I could not get done all day bcuz of fatigue, lack of focus and going in circles due to short term memory issues. Really bad pattern for healing. Working on circadian rhythm.
How about you? Any of these symptoms?
@@lauragott2122 Hi! I’ve got a similar pattern to you. It’s the weirdest thing. I’m lousy all day. Slightly better in the afternoon, when I try to get outside for some fresh air. Evening is the best time, physically and mentally. When I discovered this I was delighted that there was at least a bit I could do but I wasn’t going to bed until about 3am. I started taking an antihistamine at bedtime to try to increase sleep and bring my bedtime forward. I’ve got it to about midnight now and my evening energy now starts at about 4pm. Noticing the evening peak made a big difference though - previously it was as if I was fighting against the brain fog and lethargy all day and by evening I was exhausted; now I try to go with the flow. How are you getting on?
@@JoButterwick
Hello Dream Dancer,
Thank you for responding to my comments.. That is interesting about the histamine. I'll watch Dr. Osborne's talk on histamine sensitivity. May be something I can do like you. Thank you so much for the feedback! BTW, my energy has been much better during Lenten session now that we are fasting wth one meal per day. I've noticed it b4 also. I think just digestion can drain your energy, not to mention good sensitivities! I think I've got all my down now, I hope. No gluten or grains, no nightshades. Skin is very gradually healing. Thanks for sharing!
@@lauragott2122 I’m so glad to hear that you are on the road to recovery. I mainly follow RUN-DMC for long Covid. He is a fellow sufferer who has collected lots of info and interviews various experts. Thanks for the idea about fasting, I’ll give it a try. Stay safe x
@@JoButterwick Hello again Dream Dancer,
Thank you for the reference. Is he on You Tube or other? My CFS is not from Covid, I have high titers to EBV. I know, however, that the Covid long haulers are quite similar to the classic ME/CFS sufferer and that many things can cause CFS e.g. Lyme and other infections, so it makes sense there would be CFS from Covid too. I think this all has to do with our particular immune systems and how they respond differently than other people who get sick but don't stay sick. The microbiome is different in everyone. But glyphosate I feel is a big player in causing these modern chronic diseases by ruining our gut linings and let's viruses, mold, toxins and bad bacteria into our blood stream. So much to research!
I'm wondering how much dextromethorphan you would have to take it or low level to maybe help your brain.
600 mg - 1200 mg
I listened to another video of a woman who found that when she took a warm shower it would trigger her Cronic Fatigue Syndrome so maybe if they took cold showers it would at least help reduced possible events in their day that might trigger CFS.
I have always felt like I have brain inflammation. I can’t explain it but I was diagnosed with hemicranium continuia (spelling?) a couple years ago. At that time I felt like my brain had a temperature (that’s the only way I know how to explain it) I also had a terrible headache in my right temporal area. I was given Indocin which immediately stops my headache. When I take it I feel Like it helps the inflammation. I also have mild CFS.
I had mononucleosis when I was 20 and since then I have never felt like myself. I’ve also been diagnosed with fibromyalgia . I’ve also noticed that when I take the Indocin it helps my fibromyalgia pain.?? I know about the side effects of Indocin but the difference in the way I feel when I take it make it worthwhile to me to take it. My brain feels better. ?? Is this possible? Is the Indocin helping the inflammation in my brain? Thank you so much for your research on this awful disease. There are so many of us that need help !
What's a plausible explanation for why disrupted sleep would be evolutionarily advantageous in the same way as other "sickness behavior" symptoms appear to be? And if there are symptoms in a condition like ME/CFS that would certainly have ensured someone's demise on the Serengeti, can we be so sure that *any* are evolutionarily adaptive? (We can't just pick and choose can we?)
I Have Very High level’s of Fatigue & inflammation levels it’s hard now been given me Brain fog in the beginning Forgetting & my Concentration/ grammar has been getting worse I live in New York Area Where can I seek out a Doctor that can Help me?? Please Help. Thank You.
Dr Derek Enlander in NYC
what do we do when we are in a flair
Eat raw fruits vegetables clean water systemic enzymez... Healing leaky gut is key not a cure but pain management....
Motivation decrease? Why is this discussed? This does not seem consistent with other definitions of ME/CFS.
Clara Sutton. What do you mean by. ,,motivation decrease,, ,,why is this discussed, ,?? As an ME sufferer of 30 years, as well as fatigue, dizziness, brain fog, etc, lack of motivation on !y part to do AnYTHiNG is a major factor in my daily existence. Even when I have sufficient energy to say, have a shower, I never want to do it. Not much of anything. And I believe this is common to a large percentage of ME CFS sufferers.
PS It is a major factor in our daily lives. I have to force myself to eat, sometimes!!
@@susantomis6556 I mean, depression involves a motivation decrease ( not wanting to), whereas ME/CFS involves wanting to do more, but not being able to do so. The will is not gone, just the ability.
@@ciarasutton5203 I understa
@@ciarasutton5203 I think if you listen very carefully to the ,,lecture,,above, the Dr. talks about increased levels of certain chemicals in ME ,CFS patients. One of which is choline, increased levels are seen in what he seems the ,,sickness response,, area of the brain. Resulting in malaise and motivation decrease. I don't think you can possibly say ,,Me,, CFS. Is about wanting to do things, but being unable,, as a blanket diagnosis. As a 30 year sufferer myself, I have ,and still do, experienced both of these states, on a more or less continual basis!!! Sometimes, extreme frustration because I'm unable to do what I want to. Other times ,total malaise and lack of any sort of motivation to do anything of anything. ME ,CFS is as individual to the sufferers as the sufferers are themselves. Although of course we all suffer from the same basic pathology , ie. Chronic fatigue, mental fog, loss of concentration, and sometimes mild depression brought on by the condition itself. I hope this clarifies things for you. And thanks anyway for your reply.
How Do we contribute cash towards Research?... :)
I'm thrilled to see this. How do we get involved in the next study?
How do i volunteer for the next study?
interesting what you say about the brain overheating because i'm forever having to put my head in a bowl of cold water
Me sniffing the cold air in the freezer department of the grocery store. 😜
I would love to be in these studies!
Any news since 2 years?? 😐
To be able to measure brain inflammation is a huge step.
But what about the cause? Can't the inflammation (chronic) be the result of low perfusion?
How does it look like in other patients with brain fog? E.g. Fibromyalgia (dividing them in 2 sub-groups, with or without SFN), POTS (dividing them in 3 sub-groups: with SFN and adrenergic or muscarinic autoantibodies, with SFN and w/o aabs, w/o SFN and aabs), and maybe other POTS causing diseases as Lupus or Lyme
From what I can gather - SOME peptides help us & fasting!!... :)
Give me a break every other person had an opinion are you a scientist? Do you work with scientists everyday at the university....
what do you mean?
17:45 Please stop peddling this this nonsense about ME being to do with a lack of motivation. It isn't.
Also they talk about low pain tolerance, that is B.S. also.
The cause for me was the microwave oven. This may sound unbelievable: the internet states that the use is harmless or that the danger is cancer or a reduction in vitamins.
The first consequences were: pain in the neck, fatigue, sore throat, depression, .....
After 3 months without a microwave oven these symptoms disappeared.
Consequences are greater the closer the microwave oven is to you: if the oven is right next to your dining table, for example.
If you bring this to your members' attention, those who wish can give it a try and let you know about their experiences. Everyone can now participate in the study!
People will not think much of CFS. Organs are not damaged. It looks more like an internal strangulation.
I don't know if that can be found. The muscles tense under the influence of microwaves (microwave), Hence the pain and the intestines are too tense, which makes digestion poor and too few vitamins are absorbed. In the throat one has pain due to the tensioning of the muscles there. Be careful not to cure other diseases with fatigue for CFS.
Stop repeating this, I doubt it’s that simple and everyone is different in response to electromagnetic energy and toxicities. Do you really need to blast this “theory” on every sight? glad it worked for you but this is not a one size fits all issue.
I don't own or use a microwave 🙄 so.... You're wrong
❤❤
Oh cripes whos happy housebound..our minds.are normal...people with a cold are miserable
Maybe he wants to help... Or maybe he just want a share in the new drug and make tons of money... lol
For most researchers the possibility of new profitable drugs are what brings the grant and investor funds in
Tons of money is given to research every year billions or more..... The scientists are saying it's the glial cells in the central nervous system....
Dear, now the cause of Chronic Fatigue Syndrome is found: radiation of microwaveoven.
To stop you have to eliminate the oven out of the house.
The plug out of electricity net because the oven has also radiation when it is not in use.And out of the house because the oven has a high voltage capacitor.
The distance between an oven and a person is very important.After a 2 weeks without microwaves health becomes better.