FACS OFF! Autonomous & High Throughput Single Cell Cloning

B-cell cloning is an industry standard method for reliable and reproducible production of monoclonal antibodies (mAb). A typical journey in mAb development involves B cells isolation prior to screening. For years, FACS has been the method of choice for semi-automated seeding of single cells into microwell plates. However, this method suffers from low throughput due to inherent difficulties to automate start up, calibration, sample/target exchange processes. Furthermore, FACS is labour-intensive as it requires continuous presence of skilled operator to monitor and troubleshoot the process. Hence, the need of an alternative approach that addresses the aforementioned shortcomings that are: throughput, clonability, and high operating costs.
In this webinar, we present how cellenONE HT, an image-based single cell isolation platform, is fully automated using Green Button Go Scheduler so that it operates continuously without the need for an operator, effectively enabling 24/7 unattended single cell plating from one or multiple samples.
Speakers 🗣️
🎤 Mathieu Bennet, CTO, Cellenion
Mathieu leads the product development at Cellenion where the emerging need of researchers and scientists to automate single cell workflows is translated into solutions such as the cellenONE HT. Before joining Cellenion 6 years ago, he graduated with a PhD on microfluidic devices from the University of Edinburgh (UK) and spent 7 years on the biophysical study of biomaterials at the MPIKG in Potsdam (Germany).
🎤 Dustin Whitson, Applications Consulting Scientist, Biosero
Dustin Whitson is an Applications Consulting Scientist at Biosero where he works with scientists from labs around the world to design solutions for automating science. He has spent the last 6 years specializing in delivering automation into the lab setting with applications experience at Biosero and Hamilton Robotics.
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Biosero, Inc. develops automation solutions to help laboratories make better decisions in less time, using more data. Our integration services match laboratory automation to your science, overseeing implementation from start to finish. Coupled with Biosero Green Button Go® software, we create a cohesive technology ecosystem that accelerates operations and increases productivity. On its own, Green Button Go software is an end-to-end laboratory management solution that integrates with business process automation to keep workflows and operations moving in life science, biotechnology, pharmaceutical, and diagnostic research.
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