Deadly Strychnine - Periodic Table of Videos
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- เผยแพร่เมื่อ 25 มิ.ย. 2024
- Discussing Strychnine, a famous poison and an "Everest" of synthetic chemistry.
Featuring Rob Stockman and Martyn Poliakoff.
Very Fast Death Factor: • Very Fast Death Factor...
Frog Poison: • Frog Poison - Periodic...
Calcium ions are 2+
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The 2nd part of the video when he explains the progression and achievements of organic chemistry is awesome.
Agreed!
+Szilágyi Szabolcs My jaw dropped several times at that part. First, a 28 step synthesis is absolutely insane to carry out and second, managing to increase the yield of a synthesis by a factor of 100 000 is nothing else than amazing!
+Szilágyi Szabolcs
Oh yes it absolutly was, +Periodic Videos, we need more on this topic!!
evilcam I agree 140% !
This is really fascinating to me. I'd be really curious to know how many steps (& what yield) that the actual plant needs to do this & how each one evolved.
I'd also like to know if any insects, or larger organisms, have managed to adapt to process the toxic stuff, enabling their consumption of the plant.
"What happened to the professor?"
"I'm the professor"
Hilarious!
"I'll tell you after you finish your tea"
True chemistry geek: You can tell what something tastes like by looking at the molecule.
what i want to know is how they found that out... they mustve at some point gotten a bunch to sample poisonous materials and make a note of their flavour beforr being overcome by symptons xD
+slendy9600 i would imagine you can see how the molecule can show you what parts of the tongue will register it? maybe?
+tyler111762 He says in the video what triggers it. Every molecule with this particular node, edge or corner will taste this way.
+dangerouslytalented to extend it further: Hydroxyl groups often taste sweet, acidic compunds taste sour and alkaline stuff mostly tastes kinda soapy. Salts (ionic compounds) taste, well, salty, and glutamates (MSG for example) taste hearty/umami.
Undead Gaddafi
NNEEEEEUUUURRRRRRDDD@!!!!!!!!!!!!
As someone who plans on taking a PhD in organic chemistry, this video pleased me greatly.
100% agree 7 years on
"Although we have made a few natural products over the years which were really quite potent"
Lit, my guy.
I want more of these! As an organic chemistry student I think this is fascinating.
If the decimal points are all correct, Macmillan's is actually 100,000 times more efficient than the original process, not just 10,000.
More toxicology-based chem videos please! This is great
i just wanted to say that after discovering this youtube channel i was, for several days, rendered incapable of accomplishing anything other than feverishly starting the next video as quickly as the last one ended. you fine folk have created a wonderful resource for advancing public interest in one of the most (if not the absolute) important scientific fields, and in a way that engages audiences and is understandable as well as enjoyable for anyone from a student in prmary school, to a seasoned researcher. a big thank you to the periodic videos team. please keep releasing new material as long as physically possible, and beyond.
I collect antique bottles (primarily antique poison and medicine bottles). One of my favorites is a "Fraser's Tablet Company Chocolate coated Iron, Arsenic, and Strychnine" medicine bottle from the late 1800's.
+MrRandysh Lol, I just Google searched the bottle (to see if I could find anything else on it) and I found a "Worthpoint" webpage on the same exact bottle I bought. Apparently there aren't very many around.
What ailments was it supposed to cure?
Very cool.
@@africanelectron751 Excellent, make mine a double!
@James Sloan Obviously the sales guy spruiking the stuff wasn't converted!
"My PhD students over the years...have made a few rather potent products..." There's another video right there! :-D
Has anyone done a study about the stereotype that professors are typically, absent-minded?
But who would do the study, if not the very absent-minded professors themselves? Maybe the lack of such a study is the proof it's true.
Huh? What were we talking about?
+TAOFLEDERMAUS Wtf jeff you're like in every channel I go.
+TAOFLEDERMAUS The professor of strange ballistics.
man you are everywhere
Very interesting! Always nice to see that organic chemists are still making breakthrough in synthetic chemistry!
Greetings from Strasbourg University!
I'd like to see a video about Ferric ferrocyanide
+theslimeylimey Me too. We have some in the lab and don’t know much about it.
+ryan22370 It is used for example as an antidote for Thallium and radioactive Ceasium poisoning :)
+theslimeylimey it's used as an intense green blue pigment (I have some in my paint kit) often called prussian blue or iron blue :)
As somebody else mentioned it can also be used a treatment for radioactive poisoning and heavy metal poisoning and is considered an important medicine.
I'd be great if the professor was to do a video on it
Id rather see a video about Azadoazide Azide
+LHommeDeCave
:0 you want to see something explode
Strychnine was an important and effective heart medicine even in the 20th century. When we cleaned out my late grandparents' old house, a box of my grandfather's strychnine pills from 1930s was found. If my memory is correct, each pill contained 1/30th of a grain of strychnine.
Is "a grain" an accurate unit of measurement? It should be milligrams or micrograms. But I know medicine has changed (improved) a lot.
@@WinterReflections yes, it was an accurate measurement back in the day. One english grain is equivalent to 65 mg
A chemist that wanted to poison his wife... I suspect that marrying a chemist is one of the most dangerous things one can ever do.
+Leopoldo Aranha Probably less risky than marriying a chemists wife^^.
+Leopoldo Aranha well yeah. marrying a former chemistry student (a failed one) is deadly enough. seriously my first three semesters i learned nothing but what kills you how^^ (well i learned a lot more but i learned a lot about toxic substances)
Sus
Well if you've seen breaking bad...
In the old pharmacy I worked at in my youth they had little narrow tubes full of little stacks of seven small white tablets. They were strychnine tablets sold way back when to poison mice. We had lots of interesting leftovers like that tucked away in the back rooms.
I bet u took 4 thinking they were opiods
"Allthough we have made a few... natural products over the years *cough*... which, er which are really quiete potent".
haha, best part of the video. that made me laugh
@@lorenzo42p Tastes like....Heroin.
It was phenethylamines.
Can we get more videos with Rob in them ? I really enjoy the videos he is in !
Interesting. Didn't know much about strychnine.
organic chemistry, or as it is usually known, wizardry
Thank you for making these great videos
what a great teacher! his passion is obvious. thanks for making the vid.
Fantastic video! Arguably one of the best PT videos.
I love when the proff tells stories
love the videos you guys upload. please don't stop!
Loving everything about chemistry and technology.Cheers 😊
Great Video! I really enjoyed the end about total synthesis, great for someone pursuing Ochem.
Have they done a video on ATP? As a former Biology student, I would find a detailed description of ATP quite interesting.
I would think a former biology student wouldn't need a detailed description of ATP.
@@iliakorvigo7341 The chemistry of ATP is frequently abstracted away, not talking about the chemistry in depth like a chemist on Periodic Videos would
Strychnine was used by a professional runner for the first Olympic marathon in St. Louis. He didnt win the race. At the end of the race he was severely sick, dehydrated, and even delusional.
this video is awesome !!
You should do more of these.
Love this ,brilliantly explained.
Best story i ever heard about it was that Woodward, at some frustrating point in his attempt to synthesise it, was reputed to have said "we'll either make it or I'll take it".
Liked it all, really enjoyed the part detailing the history of improvements in the synthesis process. Thumbs up :)
Some folks like water, some folks like wine...
Wizmut I love The Sonics.
Featuring my old organic chemistry professor - Philip Magnus! That guy is a genius.
high security containment system lol 5:20
Brilliant, thanks for the excellent explanation.
You should do a video about the most complex molecules that the Nottingham crew have made.
Makes sense that it takes bitter, since we evolved to distinguish poison from food thousands of years ago.
i'm so glad for your existence it makes my life a lot less boring i love your videos keep sharing your knowledge i will be watching :)
Thanks for a new video :) Really interesting.
Love your stories!!!!
Very interesting thanks for the information
That is a fantastic video. I am a neuroscientist, and I've never heard or read a more clear elucidation of chemistry than this one. - "In truth, it is just atoms and the void."
Vanderwal is a great name when you work with this kind of stuff =D Kinda funny.
The force is strong in this one
Absolutely amazing, the 1000 fold improvement on total synthesis in 55 years.. The attention to detail here on the chemical of the day has my vote as number one science channel on the web. Brilliance. Anyone feel like guessing the starting material? And no cheating! My first guess would be Tryptamine.
very cool story about the synthesis, I'm so lucky to know about this youtube channel!
Dear lab scientist,
EVERY substance CAN BE toxic; it is just a question of DOSE. Queue my usual remark about Philippus Theophrastus Aureolus Bombastus von Hohenheim (a.k.a. Paracelsus) who lived 500 years ago and coined the following phrase:
*The dose makes the poison.*
I read: Daily Strychnine
+Haiiry Cake So...I'm not supposed to sprinkle it in my coffee? uh-oh
+Haiiry Cake Back in the day it was pretty much it. Silly Victorian people.
+Haiiry Cake
If you're a drug dealer who hates their customers, it could very well be.
+Haiiry Cake DAILY DOSE
I need my daily dosage of this
One of my favourite songs is Strychnine by The Sonics.
Rob Stockman is a very clear speaker. Well done Sir!
I'm having withdrawals from so few videos lately, I've watched every one on the playlist multiple times and many on the related channels as well.
Love you guys, don't ever stop!
A slight correction: because of its effects on the receptors strychnine IS a PNS stimulant, so it is a marginally effective as an athletic enhancer, muscles contract more forcefully. The problem is that the theraputic index is razor sharp. A report from a student that suffered a mild intoxication while using it as a stimulant attest to its effects at slightly supra-theraputic doses, even after he sedated himself with bromide.
Very interesting video, especially the second part ! I was wondering though what were the uses of Strychnine, apart from the use as a pesticide ?
like the way this guy explains things.. very interesting.
i was accidentally poisoned with that 29 years old .... i survived. *IT WAS THE MOST PAINFUL EXPERIENCE OF MY LIFE* and i was hospitalized for months. had to learn how to walk without a walker talk without a stutter i was paralyzed for 2 weeks at first in the icu BUT could feel every thing. they had to "re-position me" and i couldn't be touched without screaming. this was almost 2 years ago to date.
NOW- *PTSD* *short term memory loss* *need a new heart valve*
*i don't know what it tastes like* it was thru iv ... i cant remember tasting anything but then again i was slowly shivering turning to stone throwing up stomach bile, drinking massive amounts of water, and begging the er doctors to save me. i wasnt even aware it was strychnine until weeks later.
How does the plant make such a complex chemical compound.
Complexity is in no way linked to Biological or non-biological origin. Also strychnine is not very complex. It’s only slightly more complex than sugar. I can think of hundreds of chemicals that are produced by plants that are far more complex
@@blueisnotgreen7258 if you're talking about proteins, those are directly made via code (DNA) so they don't count. Considering that, would your opinion be different?
Very interesting video. I wish that, as a norm, when discussing poisons, information on detection and antidotes was available.
What a nice coinkydink.. I listened to the Sonics song Strychnine just about an hour ago!.
"Some folks like water, some folks like wine, but I like the taste of straight strychnine"
This is awesome! I want to hear more about the rock stars of organic chemistry
You talk about it looking beautiful, which it is. I feel the same about cyclopropane and cyclobutane, any chance of a video on these two? Keep up the great work! Simon, RA @ Lboro Uni, Aero & Auto Eng
Wow great vid, thanks Bro x
If you're a strychnine fan, you should read the tale of John R. Kizer, a local alleged serial killer, who used strychnine as his weapon of choice. Eventually, when found out, he used it on himself. His story can be found online.
woah. thank you.
He should use snatoms instead of those stick molecule things
+apenasmeucanal Yes, and it would only cost $168 to make this molecule using those.
Well he could use molymods
+apenasmeucanal If I understand correctly, there is no Nitrogen available yet, only C,H,O.
+Tijn van Boekel there isn't
+apenasmeucanal you cannot make these rings with snatoms. they'd be intuitive for the very simplest of organic molecules, but even for the basic building blocks of life you need a more powerful visualisation tool that can actually model double bonds.
If they haven't already got a video about mercuric sulphide (cinnabar) and alchemy, I'd like to see that. If they've already done that & I just didn't know, my second idea is about either benzene or sodium polyacrylate.
Make a video on Tetrahydrocannabinol
Don't forget about nearly-deadly Strycheight!! ;)
Or strychten
pnkflyd66 that's just overkill
Fantastic video. One thing I feel sometimes is missing though is any discussion about actual use cases in the modern world of the chemicals being discussed. For instance, the synthesis of the chemical was carried on in the '90s and into the modern day, but what was the incentive for doing that? Simply to refine a process that could be applied to other chemicals of a similar kind or is there a industrial application to be had from being able to make Strychnine on a 'mass' scale?
Fascinating!
Thanks for video! Could you please explain in more detail how the spectroscopy works and how you can detect complex molecule structure using by using it.
Be a delightfully if this process will be shown and explained on the example.
Thank you
Is there an antidote or something to negate the deadly affects once it enters the bloodstream?
I don't think so. But at least you could be put in sedation with a mechanical ventilator until the toxin washes out your body.
Collective synthesis of natural products by means of organocascade catalysis is the name of the mcmillian paper if you are interested, though i needed to use an institutional access to get hold of it
fantastic video :)
Been in the lab before! Awesome place, I just need nottingham to give me that offer now
Please produce some videos on the instruments used in chemical analysis and how chemical structure is deduced. It would also be interesting to see something on named reactions.
I ACTUALLY have an old antique medicine bottle, never opened, that contains strychnine! Including arsenic! They're 100 chocolate-coated tablets. Iron (1 grain), arsenous acid (1/50 grain), and strychnine sulphate (1/60 grain). Parke-Davis Drug Company. I wish I had a picture. Too bad you can't put pics in comments. It's crazy that I found a bottle of strychnine (with arsenic) containing "medicine". Awesome video!
Please more videos with Rob :)
I would love to see more videos about interesting molecules. NH3 really need one ;-)
Lovely video as always... though I find sound-levels very low :-)
Oh professor, how we've missed you!
As far as I know, strychnine doesn't prevent muscle contraction, it prevents the relaxing
Which gives way eventually to flaccid paralysis.
This reminds me. Google "1904 Olympic Marathon" if you wanna have a good laugh.
Very Interesting, But what happened to the Ricin Video ?
Fascinating
Really great video, but did I miss the question of whether any positive uses had been found for strychnine?
Just thought of something, could you guys do a video at some point about how to determine a molecule's structure?
Especially the "old-fashioned" way that the they had to use back in the day (since that one probably is less complex to understand).
Speaking about rat poison, it would be cool to see a video about Warfarin. An interesting piece of historical trivia is that the discoverer, Frank Schofield, was both a veterinarian and a major figure in the liberation of Korea from the Japanese Empire (a story most Ontario Veterinary College graduates have heard several times).
9:54 - 100,000 times more efficient, not 10,000.
Two new syntheses of strychnine were very recently published which consist of 10 steps with a 14% yield and 8 steps with a 10% overall yield! Exciting stuff. Beemelmanns et al, July 29 2015, in The Chemical Record
My Favorite poison! Thank you PV :)
Can you do a video on metallic nanoparticles, and surface plasmon resonance?
How about a similar video going over the structure and info on witch hazel?
"Gut-to-blood-barrier". I missed that one on my Biology exams.
Blood-Gut Barrier Scientists identify a barrier in mice between the intestine and its blood supply, and suggest how Salmonella sneaks through it. Nov 12, 2015 RUTough it. Nov 12, 2015 RUTH WILLIAMS
The gut-blood barrier permeability - A new marker in cardiovascular and metabolic diseases Medical Hypotheses 98 · January 2017 Interesting, huh?
Never heard of it and I aced those classes. Only one to ace anatomy
Well it depends on if the competitor is taking it then it enhances performance.
It is beautiful and thank you i am a huge fan of Agatha Christie and so it's fascinating to learn how it looks and how exactly how it works
Very awesome
Please make a video about ferrochelatase. Our course is using it to learn protein structure and function.
0:31 also used in Duff beer, but not anymore. Didn’t you hear on CNN last night!?
Don't want to be picky but it's Ca2+
Otherwise nice video as always, unbelievable structure there and the achievements in it's synthesis are stunning :)