Sliding filament theory explains how muscles contract at a cellular level. Learn more and test yourself with our quizzes here: www.teachpe.com/anatomy-physi...
@@paramanandbalara3602 Thanks man for your information 😊... I've passed out but I'll keep it in mind for my current first year physiology lectures on NMJ and during tricky exams
I feel your pain, but did you know that you can make the video play more slowly? If you click on the gear shaped icon under the video, it will give you a choice of speeds to play at. You can also turn on closed captions, and turn the voice off if you wish.
Can someone explain this to Me If we strap our hand to a machine which helps us move our hand move in and out and we let loose of it then how is it moving because we aren't sending neuro signals meaning the sites of bonding are still closed how is the muscle still contracting then??????
@@ahadzx8875 I think you are correct, and multiple sarcomeres are then stacked and connected one after another within the myofibrils, as far as I know so far.
The myosin motor domain is what's doing the ATP hydrolysis. Myosin with no ATP bound is locked to the actin filament. ATP binds the myosin head, causes conformational change in both the head and lever arm, releasing the head from the filament and swinging it forward. ATP is hydrolyzed into ADP + Pi, which causes another conformational change in the head, increasing its affinity for actin, causing it to bind to the actin filament again, this time forward from where it was at the beginning. Pi is released, which causes the lever arm to return to its original position, pulling on the actin filament as it does so. ADP is then released, and another ATP binds the myosin head to release it and start the cycle over.
There at the end..my muscles are not able to relax back. It's hell. On any activity when I finally get loose (usually in water floating and stretching) it takes only a few minutes and i get super tight again. I had t9t10 damage in spinal. Got one leg paralyzed but I was, am able to get that leg working after 3.5 years. My muscles in legs an glute are so tight, but I get them loose with hours of work and water..yet to feel them get so tight I can't walk after 100 yards. My Drs are clueless and really don't give a dam..
Ca 2+ not Ca +. Acetylcholine = uh see - tul or uh-see-tl. Named after the acetyl groups in Chemistry. Not ass-e-til. Excellent illustrations + a few corrections in the voiceover = perfect.
2hr lecture in 2minutes! Thank you💞
How did it go ?
@@W.Incognito lmfaoooo
So much info condensed in a digestible formulation! Thanks
That's call crystal clear explanation 🔥🔥
Keep in mind that acetylcholine do not enter in the sarcomere , it remains at neuromuscular junction or motor end plate.
SOURCE - NCERT
@@paramanandbalara3602 Thanks man for your information 😊... I've passed out but I'll keep it in mind for my current first year physiology lectures on NMJ and during tricky exams
@@paramanandbalara3602Yes
Just helped me out for my exam . Amazing explanation 👍
Thank you very much to make a video on this vary topic..It was indeed very helpful ❤️
Extremely well explained and illustrated. Is there a complementary video for eccentric contraction?
Really really helpful. Clear cut visualization. Thanks alot. Stay blesséd💕
Toughest concept made easy 😊 thank you 😇
Explained very well thank you very much now my concepts are clear
Glad it helped
Thanks you clear my confusion...
Actin is basically crowd-surfing on myosin. Thank you for explaining! I could not understand my professor's lecture at all.
Thanks 😊 that lady is crystal clear 😊
Thank you for this video
Very, very helpful
I literally watched this video to prep for the upcoming Biology test tomorrow...
Same...
Same here
@@langrisvaude9298 Hiiii jungkook 😁
How are you?
Mine is in 45 minutes :)
Crystal clear explanation 👏
Smooth explaination.
satisfied😊
So easy and well explained
I know right
Very well understood....🙏🙏🙏
Shes really not Trynna catch her breath going hella fast🤦🏽♂️
Slow the video down
you can change playback speed
Brilliant. Nature is brilliant. Wiser than whole humanity combined will ever be.
Thank you! Very helpful
Thanks a lot for explanation.
Very good explanation 🙂
Thank you for this
Veryy clearly explained..good✌️
R u a medical student?
Thank you so much for this
So amazing my 2 hours lectures explain in 2 minute
Soooo clear!!
This video would be very good for revision
Great Video
Great video, still super confused though im gonna have to watch a few times lol
thank you so much!
Brilliant amazing spectacular 🥰
Interesting video
i now really understood thank you
thank you so much ❤️
A long lesson withing few minutes 😍 Thank you so much❤️
Can you please explain slowly. because of This is fast for beginers 🤗
I feel your pain, but did you know that you can make the video play more slowly? If you click on the gear shaped icon under the video, it will give you a choice of speeds to play at. You can also turn on closed captions, and turn the voice off if you wish.
Can someone explain this to Me
If we strap our hand to a machine which helps us move our hand move in and out and we let loose of it then how is it moving because we aren't sending neuro signals meaning the sites of bonding are still closed how is the muscle still contracting then??????
im going to nail this exam
thank you sooo much
I was always that ATP break before cross bridge formation or after crossbridge formation...now it's crystal clear..
Thank you😌😊
Mjhay sarcomere samjh n araha kya hai
@@user-rd7nn5dh8m area between two Z lines
@@SaraAli-cg3qj so technically sliding filament actually occurs in sacromere right?
@@ahadzx8875 I think you are correct, and multiple sarcomeres are then stacked and connected one after another within the myofibrils, as far as I know so far.
We talking about all types of muscle in the body or specific muscles, like heart muscle. Asking because Troponin is found in the muscles of the heart.
Thank u sooo much 🥰🥰
Nice explanation but little bit it is fast . Please slow your speed of explanation.
Otherwise it is the best one ✅
Who else revising the day before 🙏 🔥🔥🔥
Thanks
Thank You! :)
This 2 minute video was a 3.5 hour lecture in the Army's ICU course.
Thank you
Nice lecture
How does the myosin head pull the actin inwards? Is there some conformational change in a protein leading to shortening or something?
The myosin motor domain is what's doing the ATP hydrolysis. Myosin with no ATP bound is locked to the actin filament. ATP binds the myosin head, causes conformational change in both the head and lever arm, releasing the head from the filament and swinging it forward. ATP is hydrolyzed into ADP + Pi, which causes another conformational change in the head, increasing its affinity for actin, causing it to bind to the actin filament again, this time forward from where it was at the beginning. Pi is released, which causes the lever arm to return to its original position, pulling on the actin filament as it does so. ADP is then released, and another ATP binds the myosin head to release it and start the cycle over.
Oscar winning legend ❤❤❤❤❤❤
Amazing
Thank you!
Well explain
धन्यवाद माऊली🙏
Thanks 👍
loved it
Perfectly condensed love it
Thank you! It was the toughest one I have done but worth the effort. Wish I had time to do many more.
Mam from where atp molecule bind to myosin during relaxation of muscle mam
Ty
Does magnesium have a role in this?
Nice yrr maja aagaya 👍
good job
Thanks
Bro.
This topic is fucked up LOL, by far the hardest 😅
0:53
Acetilcolina o calcio?
Good
I never get the atp part
Any personal training students here?😂🤣😂
Sorry this vid was really slow; try 2x speed
Much better
Finally!! Peace ✌
Thnqq
0:58 wrong spelling, "acetylcholine", not "acetylecholine".
Better very little slowly......
👌👌💛
The myosin looks so cute
2:00 Ca2+
It's ca+2
Thank you! I peeped that and scrolled to see if anyone corrected her in the comments...
There at the end..my muscles are not able to relax back. It's hell. On any activity when I finally get loose (usually in water floating and stretching) it takes only a few minutes and i get super tight again. I had t9t10 damage in spinal. Got one leg paralyzed but I was, am able to get that leg working after 3.5 years. My muscles in legs an glute are so tight, but I get them loose with hours of work and water..yet to feel them get so tight I can't walk after 100 yards. My Drs are clueless and really don't give a dam..
That sounds horrible Chas. Hopefully the Drs will figure out a solution for you soon. Wishing you all the best, stay strong.
❤️
Ca 2+ not Ca +. Acetylcholine = uh see - tul or uh-see-tl. Named after the acetyl groups in Chemistry. Not ass-e-til. Excellent illustrations + a few corrections in the voiceover = perfect.
best
💖
I don't understand a little bit.
من طرف استاذ احمد على 👍
What I was imagining seems to be completely wrong. 😂
ACTUALLY i THINK you'll find it's Ca TWO PLUS, not Ca PLUS. i think lol
holy cow
Kon kon meenakshi mam k batane prr aya h yha 🥰
cap!
Not sucko but saRco.
Isse mera kya fayeda mei tho commerce student hu🗿
Who all saw this video in 1.75 speed
What d hell just happened
I knew this video was going to be ratchet :D get it? I'll see myself out...
*IDK WHO MADE THIS BUT IT WAS ALL WORTH THAN 3HR LECTURES* 🥹🫶🏻❤️