Catherine Drennan (MIT/HHMI) Part 1: Introduction to Metalloproteins
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- เผยแพร่เมื่อ 8 มิ.ย. 2024
- www.ibiology.org/biochemistry...
Lecture Overview:
Dr. Drennan begins her lecture by explaining what metalloproteins are and how the inclusion of a metal in the protein structure results in amazingly reactive proteins. She describes techniques, such as X-ray crystallography and electron microscopy, which her group uses to get "snapshots" of metalloproteins in action. These "snapshots" allow them to better understand how metalloproteins function in many critical biological reactions.
In Part 2, Drennan focuses on experiments her lab has done to understand the mechanism of action of ribonucleotide reductase (RNR), a key enzyme required for DNA synthesis and repair and, consequently, cell viability. By taking "snapshots" of bacterial RNR, Drennan and her colleagues deciphered how changes in the structure of RNR regulated its activity. Interestingly, the structure of bacterial RNR appears to differ from that of human RNR suggesting a possible new target for antibiotics.
In the last part of her talk, Drennan explains how cobalt based metalloproteins allow acetogenic bacteria to live on CO2. This group of bacteria convert more than 10 billion tons of CO2 to acetate each year and scientists are interested in understanding and using these metalloproteins to remove CO2 from the atmosphere. Structures determined by Drennan's lab have provided information on the mechanism of action of these important enzymes.
Speaker Bio:
Cathy Drennan is a Professor of Chemistry and Biology at the Massachusetts Institute of Technology and a Professor and Investigator of the Howard Hughes Medical Institute. She studied chemistry as an undergraduate at Vassar College, received her PhD in biological chemistry from the University of Michigan, was a post-doc at the California Institute of Technology and in 1999, Drennan joined the faculty at MIT. Her lab uses X-ray crystallography and other techniques to study the structure and function of metalloproteins.
Drennan is also very involved in efforts to make chemistry education more exciting for students; perhaps due, in part, to time she spent as a high school science and drama teacher after college. Drennan helps to train graduate student teaching assistants and to develop free resources for educators. She has been recognized with several awards for excellence in undergraduate teaching, as well as her outstanding research. - วิทยาศาสตร์และเทคโนโลยี
The PERFECT amount of technical detail. Thank you to iBiology and the presenters for these lectures! Thank you for putting them up on TH-cam.
best teacher in iBiology I've seen so far. At first I found her enthusiasm a tad childish, but it definitely helped me to pay more attention. Kudos for you!
This is a brilliant presentation. Perfect for my exam.I did pass my chemistry exams last year thanks to her and her collegue's lectures. I would have neve rthought I would one day get an MIT level education!
Chronically underviewed
Thank you for explaining it so well.
Fantastic lecture/talk. She has an excellent way of explaining things.
Wow! This is very interesting, never heard it this way explained in a very clear way. Thank you!
Very nice presentation!
Thank you for more wonderful explanation
Really great lecture; thank you!
brilliant. such a great lecture!
3.35 just realised the stoichiometric coefficients for photosynthesis are the number of the beast
🤣🤣🤣🤣 Don't eat your plastic forks.
I love proteins too. Especially ones with metals as ligands and co-factors. Please proceed!
thank you for this video!!
This was so cool. Does anyone know if there have been major advances in production of metalloproteins?
Very interesting
7:30 Mention of ketosis! Yes!
Interesting, tks
Name and explain 2 biophysical techniques which are used to get oxidation-state of iron in metallo-proteins.?
please help me can anyone will ans the ques @iBiology
Would trypsin be deemed a metaloprotein? It is basically inactive without chromium 3+
same with insulin: no amino acid absorption
w/o Cr3+
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You forgot selenium!
Human standards matching ET basics. Progress indeed.
Good lecture but why is it called chemestry when phisics are always involved?
One reason: In physics, configurations are easily reversed and the composition of particles is not changed. In chemistry, the substances are changed in composition during a chemical reaction...
Why is martin wearing shorts in a lab?
You don't need long pants or a lab coat if you're not working with toxic stuff.
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Wow she is gorgeous and smart wowa wee wa
IH8 when someone wastes my attention telling me what they're going to do instead of just doing it.
DON'T PRIME ME !!
That's the way essays are written.
I don't like that too, but you've got to admit, she did a good job in relaying the material to us..
unnaturally low voice, sounds weird
Have no absolutely the same perception to your sensation sorry