How Medications Get Absorbed By Your Body

MEDICAL ANIMATION TRANSCRIPT: Medication absorption is the movement of a drug from its site of administration into the blood. Oral drugs enter the stomach where they either dissolve and pass through the cell membranes of epithelial cells lining the stomach or travel undissolved through the stomach to the small intestine, which is the most common site of absorption. Here, drugs dissolve and pass through the intestinal wall. Oral drugs then travel through the portal venous system to the liver, where they undergo the first pass effect. During this process, the liver metabolizes some of the drug, either inactivating it or excreting it into bile for elimination from the body. The remaining amount of active drug leaves the liver and reaches general circulation and target organs. If a drug is administered via intravenous injection, it passes directly into the bloodstream, thus bypassing absorption in the GI tract. If administered through intramuscular or subcutaneous injection, the drug enters either muscle or subcutaneous tissue, where it passes through gaps between cells into capillary walls and then into general circulation or target organs, also bypassing absorption in the GI tract. Bioavailability is the net amount of a dose of a drug that is actually absorbed into the bloodstream. The bioavailability of oral drugs is less than 100% because of the first pass effect of the liver. In contrast, the bioavailability of IV drugs is 100% because they are not exposed to the first pass effect of the liver. Different drug formulations alter bioavailability, because they are not absorbed at the same rate or to the same extent. For example, tablets dissolve at varying rates. Enteric coated drugs dissolve in the small intestine, not the stomach. Because gastric emptying time differs between individuals, absorption times also vary. Sustained release formulas contain tiny spheres that dissolve at different rates, resulting in a steady drug release throughout the day, but also resulting in variable absorption. Some factors affecting drug absorption are the rate of dissolution. Drugs that dissolve faster are absorbed faster. Surface area, since the lining of the small intestine has more surface area than the lining of the stomach, most drugs are absorbed faster in the small intestine. Blood flow, the greater the concentration gradient between the drug-filled stomach and the rapidly flowing drug-free blood, the faster the absorption. Lipid solubility, highly lipid soluble drugs pass through the phospholipids in the cell membrane more easily than drugs of low lipid solubility. And PH partitioning, absorption is faster when the difference between the PH at the site of administration and the PH of the plasma attracts more drug molecules to ionize in the plasma. ♪ [music] ♪
#MedicationAbsorption #DrugAbsorption #DrugMetabolism
ANM11011

[@adamdumsday]

I don’t know if the makers of this video will ever read this, but these videos are absolutely fantastic. Some audiences are curious, some are in the medical field wanting to clarify something, some take medications and want the background.
Well done and keep making these 😀.

[@emmanuelolayimika5459]

I agree with you. The explanation is so simple and clear.

[@sowhitney]

well daid

[@AZKhan-ft2bc]

I have my maths exam tomorrow but this was important

[@MuhammadAli-ns4pb]

You prepare math and do not waste your time

[@hanafeelpn8154]

​@@MuhammadAli-ns4pb the comment was last year but you're right

[@tryvichethify]

I don’t know if the makers of this video will ever read this, but these videos are absolutely fantastic. Some audiences are curious, some are in the medical field wanting to clarify something, some take medications and want the background.

[@crystalgirlgaming8429]

Stolen comment.

[@coolpanda7132]

better than my medical college professor

[@shantanupandey2752]

Lagta to nahi hai laude ke to med college me hai

[@yytyyy5329]

Overused comment

[@sudarsanaraopitta4939]

always

[@LifeIsArt3908]

Better than any teacher 0:52 0:54

[@flowerflower8242]

Lol. Thank you

[@Brancaalice]

Body is so intelligent, it knows where everything we need and deliver them to the right site. It a secret intelligence that works with great synergy. Each part doing their job well.

[@landi777]

God is an awesome designer!!!

[@heirloomcategory5673]

​@@landi777 How's life in Africa?

[@charnitawalker9493]

Was looking for a simple explanation and learned so much more. Excellent job! Please keep making these videos!

[@SmartPracticeSuccess]

This is such a good video!
I was just recently diagnosed with MS and have started taking an MS medication via subcutaneous injection. It’s my first maintenance subcutaneous injection and I was seeking further details on exactly how it disseminates into the rest of my body as opposed to an oral or intravenous medication. Very helpful!

[@jeslinemwansakanchule2842]

The most beautiful illustrative video I've ever seen

[@Algebrainiac]

I wish you could do a video on antidepressant withdrawal syndrome!! That would be awesome

[@mathsquared121]

You provide very interesting information related to our body with animation making it more understandable 😉 thank you nucleus medical media.

[@AhmadAs-t8b]

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second season

[@storminnormin4651]

Fascinating 💊

[@Jakesullyy]

i am currently taking ATT T.B medicines ... and this is most valuable and most knowledgeable video for me ❤🎉😊 thank you !

[@Brianbassey]

World class explanation...4th year medical student here

[@OnilPitigala]

This video helped with my exhibition a lot

[@OceanSwimmer]

These videos should be required viewing for High School students.
Everyone should understand these concepts.

[@wolfdenranjeet]

Far better than my pharmacy classes
2007

[@codedaily365]

as always loved it. Make a video on how brain targeted drugs work eg: ADHD, antidepressant etc

[@BaoTran-ls7oy]

Great video. Hats of to the production team for such an informative and well designed animation!

[@robnewman6101]

Understanding our bodies in the Future.

[@xenstence]

dont do drugs kids

[@CloudHub99]

Unless prescribed by a doctor

[@Shapeshifter-of-Names]

Yep

[@SangenRai-ru2sz]

Condo

[@ASUFAN-]

"Drugs are bad,mkay" 😅

[@Proto07MGYT]

Why is this comment so funny 💀💀

[@brandongarcia1994]

I'm on meds rn so I need to see how it travels after a shot education indeed!!

[@mamenggaluh8897]

after taking medications by having diarrhea i was curious of how the meds work.
now i feel powered, buffed and stronger than ever after taking the meds

[@shiningalpha_]

Same😢

[@rasmokey4]

Fantastic explation for the Laymen!

[@Panacea9]

Even patterns you picked up on your own early on you don't recognize the same. They can be glared over and go unnoticed at the time until it is out of your system.
You can look at every instance later in memory and find those same patterns again and wonder why they went unnoticed because they can seem obvious to you again.

[@userAl9893]

I absolutely love modern medicine

[@luissingh4722]

Very informative for a Registered Nursing student. As I'm now trying to understand pharmacology

[@rafaelstabile2387]

Great content! Just missed sublingual adminstration but I guess it's almost the same as every non oral ROA

[@waelfadlallah8939]

Great animation ❤

[@Vilas-qh8ri]

This channel content and animation is really very good keep it forwarded and more❤

[@zakiagul-zt4bp]

I am going in medical college next year... I hope these videos will help me through out my journey...👍🦅😊

[@Riyansasemita-vn2xj]

Amazing,thanks

[@septianhung4565]

Keep making amazing videos 👍👍👍

[@SudeepAdhikari0611]

Thanks to Whole Nucleus Medical Team ❤

[@robertceliberti7175]

Very interesting. Wish I had a video like this in high school biology when I was young..

[@landi777]

Awesome video! GOD IS AN AWESOME DESIGNER!!!

[@DeBlauweOlifant]

How does it know which organ to target?

[@FitLifeJourney102]

5:00 amazing 😮😮😮

[@OmhashemGebril-vx2ly]

Good job many thanks 😅😅😅😅😅😅😅❤❤❤❤❤❤❤❤❤❤❤❤❤

[@lerossolas1057]

Very good animation from a soon pharmacist💊

[@manojkumawat7006]

Best explanation, I request you to explain complete pharmacokinetics ❤❤

[@jaybee608]

We needed to know this!👍👍

[@joyguruvlog6095]

Excellent video of Medical Sciences 😃😃 I am a medical aspirant 😃 and it's a very good video and informative for biology students😌

[@TheTechCguy]

Ahh, yes. How the body absorbs the GOOD drugs! 😆😎👍💊

[@magretangel5242]

Thank you 🙏🙏🙏 Can you also make video about Benzos!

[@PunjahariKharat]

This is good channel for education😈

[@allthings77oo]

Digestive system look after the basic necessity of the human body

[@mrjamesmonkey]

You missed sublingual meds but that's the only thing I votive find in this video but other than that great video

[@imhritan1722]

Really too much informative...🙏❤️

[@djstarrjunkie]

Question: What happens with the route of medication IF you don't have a gallbladder?

[@chaoticmind04]

I was also wondering this too. I got my gallbladder removed July 2020

[@taylorembach8559]

She forgot to add in how liquid form by mouth gets absorbed

[@lumartipudan]

Excellente❤

[@asifalithaheem5390]

How external stuck effects brain and there function nucleus please make videos ❤

[@asifalithaheem5390]

How injury effects body parts like testicles eyes please make videos

[@Alsab786]

Superb Presentation!

[@Kratos....]

So theres an on going war through my circulatory system

[@viesjunkyard]

nice pfp you got there

[@blinknazira2571]

How about the "plastic"cover drug?

[@okonh0wp]

graphics are awesome

[@PAWA_IYKE]

Very educative

[@Duricas]

How does a medication _know_ to target its intended organ?

[@chaoticmind04]

I was always wondering this too. What happens if the medication needs to go to the brain? Example antidepressants and antipsychotics

[@justkorbii3180]

I was JUST thinking this

[@tinanewrozi7667]

@@chaoticmind04they are manufactured as “more fat soluble” drugs so they get absorbed less throughout the body and more in the brain since brain is just fat and fat soluble things can easily pass through their very strict membranes, also to add on that blood flow to brain is very rich too. This might not be 100% accurate but i think its this way i’m a med student

[@chaoticmind04]

@@tinanewrozi7667 thank you for the explanation I appreciate it 😁

[@Codduct]

Fascinating

[@mohammedal-hammadi5085]

I love this channel! Thank you for your great efforts

[@gideonosei5631]

Thank You

[@faisalazam358]

Brilliant

[@jayalakshmijayalakshmi9092]

Thank you 🙏very very helpful Video 😊 to NEET aspirant ☺.

[@Ishwarya865]

Insightful

[@asifalithaheem5390]

Hi nucleus my wish is make the video about diabetic retinopathy

[@Young_giants]

Love the content ❤❤

[@cybo_vampire9145]

Me who wants to start HRT watching this video because I want to know which form of estrogen administration will be the most effective

[@youtub-q1b]

Thanks ❤❤❤

[@aminaelidrissisospedra4943]

locura i love this video

[@anirudhv2997]

How did people first knew this?

[@carehub3729]

Is this video can be used for other youtube channel by some edit???

[@indranildas5101]

Amezing wow 😲🎉

[@rustomabdulrhman6326]

amazing

[@worldhealth86]

Nice Information ❤

[@bisum1790]

For oral administration, does the drugs go back to liver from circulation after completing pharmacological action ??

[@theodoraethelnaadoduahammo5625]

awesome

[@eileenlocke7877]

I allways wondered

[@Drzein22]

Awesome

[@Dandelion_flight]

Stomach can absorb things? I thought it is only for digestion?

[@saro5463]

Imagine if some of red cells got into the tube

[@ethanjohnson995]

nothing would happen

[@sulaimonramon7622]

Just wow

[@josephsesay5662]

Just like Chemical kinetics

[@kevinjones4142]

Does taking powder like (BCs) hit you faster than a pill like Tylenol

[@Ayushpatil0701]

Cool ! 👀

[@user-ss7jf1lm1n]

Что такое уколы и таблетка????????????????????????????????????????????????????????????

[@eileenlocke7877]

Clever

[@celestinez9406]

Does it also apply to Vitamin supplements?

[@brandonfarfan1978]

Wow!😃

[@sudarsanaraopitta4939]

I am curious

[@OlisaPrice-qq1wm]

Cool cool

[@Rahul-en3cl]

YAAR IN SABKI HINDI VIDEOS NHI MIL SAKTI 🤔🤔🥺❤

[@sharinaross1865]

Imagine being a medical student.

[@77D777]

What about under your tounge?

[@Cloudy9-10]

I have lexapro

[@rakeshvelpula6804]

👍 👌

[@KyleRevives]

i really hope i didnt destroy my liver taking so much tylenol and ibuprofen :C the effects of repressed csa suck. vote for no statute of limitations on any form of it imo.

[@piyushpathak1186]

Me watching it with 102°F fever

[@PranavPatil-k6j]

Me 103°F 🤒

[@dannyrichards-nb9sh]

❤❤❤

[@A_person.who_is.most_at_peace]

ঈশ্বরের ক্ষমতা আমার সঙ্গে আছে কোন মেডিসিন লাগবে না বন্ধু