Case study: Dose individualisation of Tobramycin

[@qiaoxili2685]

This work is fantastic, especially for that interface calculating the best dosing regime automatically. Thank you for your sharing!.

[@gerdmikus3898]

Well done, thank you very much, that’s exactly what we need to individualise drug treatment because we can do better than „one dose fits all“

[@abdu170]

Thank you!

[@rustygear9370]

Very informative
I went to the case study pages and tried to go step by step, everything went fine till the fourth chapter where dose individualization requires R studio
I've installed every library (including of course lixoftConnectors) but it seems than "simulx" command no longer works (I'm using monolix suite 2023 R1), so all the following steps regarding iterative dosing regimen adaptation no longer work and give me the same error (simulx command not working). How can I do it with updated libraries and monolix suite (your case study looks like it was done with monolix 2019)
Thank you in advance

[@MonolixSuite]

Glad you found the case study useful! And sorry, we are still in the process of updating the case study for the new version, which should be done in the next few weeks. In the meantime, if you already have lixoftConnectors installed, you just need to install RsSimulx from CRAN (cran.r-project.org/web/packages/RsSimulx/index.html). The simulx() function moved to RsSimulx since the case study was published. You can now also call Simulx directly from the lixoftConnectors package (simulx.lixoft.com/simulx-api/), though the syntax is different than that shown in the case study.

[@rustygear9370]

@@MonolixSuite Thank you for your quick answer
I got it to work through the first step, but now I have an issue with the readDatamlx function, it seems that it no longer take a project file as an argument. Eventhough I loaded the "Rsmlx" library where it is defined, it says that "project = project.file" argument is ignored. How can I access a covariate in a project file with the new setup ?

[@MonolixSuite]

@@rustygear9370 You now need to pass in the data file directly. So you can use something like this:
d

[@rustygear9370]

@@MonolixSuite
I tried this approach with no success. The readDatamlx function returns "error in strsplit(header, ",") : non-character argument" .
I think it's related to the way readDatamlx parses the data passed to it. I even tried to pass data the same way mentionned in the readDatamlx Help, as a double vector, named tobramycinPk but get the same error.
Here's my code, which I tried after the one you suggested:
headerTypes = c(as.character("id"), as.character("time"), "observation", "amount", "eventid", "contcov", "contcov", "catcov", "contcov")
tobramycinPk

[@MonolixSuite]

@@rustygear9370 you need to name the list items so that readDatamlx knows how to interpret them, like you've done with dataFile you also need to do with headerTypes, like this:
tobramycinPk