Dissecting the role of T-cell receptors in T-cell large granular lymphocytic leukemias

Presented by Utpal Davé, MD, Associate Professor of Medicine, Associate Professor of Microbiology and Immunology, Indiana University School of Medicine
The etiology of T-LGL (T-cell large granular lymphocytic leukemias) and its accompanying autoimmune disease manifestations are mostly unknown. With the help of Cellecta’s sequencing technologies, we investigated the most abundant TCR clonotypes in a T-LGLL patient with severe neutropenia. Further analysis of the CDR3 region (VDJdb server) identified putative antigens recognized by the expanded clonotypes, allowing us to devise a model for the onset and development of T-LGL.