HADES TEMPLE - DAMAGE CAP (4.2 Bi) - CAPRICORN SHURA - CRATERIS SUIKYO

If you have:
Sufficient Defense Pierce (over 1300, ideally). Equip the Cosmo mixer, Cosmo with an inscription.
The Heavens and Earth Cosmo to boost Defense Pierce.
With all these in place, you should be able to "break" the boss's defense.
Tips for Shura:
You also need a speed above 600 to outspeed Shura; you might consider using the Cosmo Decelerator for this.