Lec 22 Amine Synthesis

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  • เผยแพร่เมื่อ 21 ธ.ค. 2024

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  • @bradwolfe3124
    @bradwolfe3124 3 ปีที่แล้ว +35

    You get a sense of how much he genuinely enjoys talking about chemistry. Definitely keeps my attention. The fact that this is free to watch on TH-cam is great, definitely deserves more views.

    • @Skunkhunt_42
      @Skunkhunt_42 3 ปีที่แล้ว +2

      Id pay for it

    • @waltersobchak7275
      @waltersobchak7275 2 ปีที่แล้ว +3

      Definitely. Fair to say I like this guy

    • @noname-80lbs
      @noname-80lbs 2 ปีที่แล้ว

      @@Skunkhunt_42 well in fact if you wanna go deep in this info you got to pay I I'm not talking about that phenethylamines Dr his wife and their vast work in the field both chemistry and detailed biochemistry I am referring to modern research you will find PDF files on sale Dr surgin provides 2 approaches to MDMA one piperonal and isosafrol piperonal from piperine and isosafrol eugenol

    • @Skunkhunt_42
      @Skunkhunt_42 2 ปีที่แล้ว

      @@noname-80lbs not sure what your saying. But for academic publications behind paywalls - there's scihub and libgen for that

    • @noname-80lbs
      @noname-80lbs 2 ปีที่แล้ว +1

      @@Skunkhunt_42 RHODIUM.....THE HIVE....are good for research
      I´ll check out your info, thanks
      anyway I have more than enough papers
      I´d be making experiments for a while till needing more data

  • @DIGITALVHS
    @DIGITALVHS 4 ปีที่แล้ว +64

    I'd love to have an orgo chem lecture where we go to erowid and talk about Alexander Shulgin's work

    • @gratefuldoge8598
      @gratefuldoge8598 ปีที่แล้ว +4

      I need that Rhodium / Trout sideclass

    • @DIGITALVHS
      @DIGITALVHS ปีที่แล้ว +7

      @@gratefuldoge8598 guest lectures from Strike

    • @triple_gem_shining
      @triple_gem_shining ปีที่แล้ว

      🤦‍♂️😅

    • @uraninite8151
      @uraninite8151 ปีที่แล้ว

      My dreams😂. Also interested in modern alternatives to the ones presented on those websites/archives. Apparently they are quite outdated?

  • @clovenbeast5183
    @clovenbeast5183 3 ปีที่แล้ว +13

    I just bought PiHKAL and TiHKAL because of the references I've been seeing to so many years and they are great books

  • @togoth1
    @togoth1 2 ปีที่แล้ว +20

    little note - methamphetamine is not present in adderal. Just standard amphetamine (L and D mix)

    • @bigboss9817
      @bigboss9817 2 ปีที่แล้ว +3

      and thats why adderal sucks. you dont want the L type.

    • @monke3552
      @monke3552 2 ปีที่แล้ว +2

      @@bigboss9817 Its a 3-1 ratio of d and l isomers, so it's still mostly Dextroamphetamine. Besides, L is not useless, it still has activity.

    • @Kirt44
      @Kirt44 ปีที่แล้ว

      I know that if you want meth you make pervitin that is essentially the original meth amphetamine

    • @syzygy4365
      @syzygy4365 ปีที่แล้ว +2

      Thank you for this. I get so sad when people compare these two. I know amphetamine never made me want to steal from others, hallucinate, or chase someone down with a meat clever. I just like to study, work, and take care of my family. 😥

    • @Kirt44
      @Kirt44 ปีที่แล้ว +1

      ​@@syzygy4365 and methamphetamine will also not make u behave in this way /
      If you ever do or did these things you mention it is you and your true self that makes you do it becouse there is something wrong whit you! Stimulants can only stimulate any and every feeling or state of mind that you already are in /has in you from the start

  • @toreschanke4086
    @toreschanke4086 2 ปีที่แล้ว +5

    Although I already know that kind of chemistry, It's greatly entertaining to see a charismatic teacher that has this kind of enthusiasm combined with knowledge and experience in this field!

  • @shepardsinsequence
    @shepardsinsequence ปีที่แล้ว +2

    24:32 beautifully explains how cyanide messes with the electron transporters in the mitochondria

  • @kagamer21
    @kagamer21 ปีที่แล้ว +2

    Your love for chemistry is so engaging! I really appreciate the energy you brought to this lecture :)

  • @clovenbeast5183
    @clovenbeast5183 3 ปีที่แล้ว +6

    I'll be 40 this month and I've been going to that site since I was like 18 17 maybe

  • @pakman422
    @pakman422 2 ปีที่แล้ว +2

    Forget about regular money this is GOLD🏆💰

    • @Kirt44
      @Kirt44 ปีที่แล้ว

      TRUE !
      This info, this knowlegde , and understanding of this is gold! you can even make it into kilos of gold if you do this reaction, then you sell the product you get from it for gold 🎉

  • @triple_gem_shining
    @triple_gem_shining ปีที่แล้ว

    Love the enthusiasm. I hope i have teachers like you in the future. And thanks for freely uploading such great knowledge

  • @charleschidsey6192
    @charleschidsey6192 2 ปีที่แล้ว +3

    Dr. Van Vranken,
    Thank you for “showing us the money”.

  • @aryanprivilege9651
    @aryanprivilege9651 3 ปีที่แล้ว +14

    Looking up organometallic rxns, I stumbled here. Like a fortunate student who finds gold like this. these are the teachers you need, those with passion about the subject.
    Can feel the interest & he $hows irl relevane! Learning & teaching can be the symbiotic reaction if both are the CATALYSTS! No matter how you got here, let the love of curiosity & chemistry take hold. Coof Please?!? Thank you sir, great teachers are the True Heroes!

  • @heroacross
    @heroacross 2 ปีที่แล้ว +2

    I hope that I get into this university, so that I can take your courses.

    • @noname-80lbs
      @noname-80lbs 2 ปีที่แล้ว +1

      I am afraid going to school will never be so good on the other hand you can spend two years of Laboratory practice and you won't even finish with pikcal

  • @chemicalaffair.
    @chemicalaffair. ปีที่แล้ว

    that's the kind of chemistry teacher i would have liked to have back in school!

  • @WuDDuP-eh7ie
    @WuDDuP-eh7ie 4 ปีที่แล้ว +3

    Ive been looking for real in debt discussions on chemicals. Thank you so much 🕉💚✨

  • @triple_gem_shining
    @triple_gem_shining ปีที่แล้ว

    Even though im only at the stage to take ochem 1 I understood a lot ! And i learned a lot too! Thank you!!!

    • @triple_gem_shining
      @triple_gem_shining ปีที่แล้ว

      I wrote down everything for future reference as well!!

  • @dimascuwk1362
    @dimascuwk1362 3 ปีที่แล้ว +2

    You are the best, thanks dad ❤️

  • @flaplaya
    @flaplaya ปีที่แล้ว

    You know your stuff on sub. PEA's sounds like experience no doubt. Awesome lecture I will relisten a few dozen times. Alex Shulgin is looking down from psychedelic heaven happily 😊

  • @samarmstrong6341
    @samarmstrong6341 ปีที่แล้ว

    Your videos are really awesome and professional

  • @bikeyogi16
    @bikeyogi16 2 ปีที่แล้ว

    hey david! would you please provide a link for the amazing background-music

  • @chadwik4000
    @chadwik4000 3 ปีที่แล้ว +1

    Does anyone remember JLF Poisonous Non-Consummables?
    I totally had forgot about EROWID!

    • @Skunkhunt_42
      @Skunkhunt_42 3 ปีที่แล้ว +1

      I got a copy 🙂 i cherish it greatly

    • @larryjarvis8294
      @larryjarvis8294 2 ปีที่แล้ว +1

      Sure do! What fun that was

  • @everythingexplained3226
    @everythingexplained3226 8 หลายเดือนก่อน

    I remember Nichols saying most phenethylamines can be reduced with Sodium borohydride and ethanol, instead of LiAlHydride an ether. Much more safe and cheap

    • @PsychChemistryEase
      @PsychChemistryEase 7 วันที่ผ่านมา

      Yeah you need a catalyst tho.. also you will find it cleaves halogens from the 4 position.

  • @markdunstan8277
    @markdunstan8277 ปีที่แล้ว

    Brilliant this is love them

  • @yusefsadik8730
    @yusefsadik8730 4 หลายเดือนก่อน

    MONEY!!! hahaha, absolute awesome video sir

  • @metri0n
    @metri0n ปีที่แล้ว +1

    Adderall is not methamphetamine... It's an amphetamine salt combo. Usually Dextroamphetamine and racemic amphetamine.

  • @ppmaks668
    @ppmaks668 2 ปีที่แล้ว +3

    methylphenidate is not an ampheramine neither an amine its a completly different drug group

    • @Kirt44
      @Kirt44 ปีที่แล้ว

      And so what methylphenidate is relevant to the synthesis and its a farmakologic and neuro toxic similar compound , the molecule structure probably Even is close to each other,
      Analogs

  • @_macrophage
    @_macrophage ปีที่แล้ว +1

    I think you have "Serenity" wrong.. That looks like 3,6-dimethoxy-4methylamphetamine. DOM is 2,5 dimethoxy. Adderall is a mix of dl-amphetamine salts or pure d-amp in Dexerdrine.

  • @SuperYTPmaster
    @SuperYTPmaster ปีที่แล้ว +2

    Nope. Adderall is dextro and levoamphetamine, not methamphetamine.

  • @mrx2062
    @mrx2062 3 ปีที่แล้ว +1

    DCC is practically not useful, because of tedious work-up. There should be more practical ways to make that amide. Better a reaction, which does not produce quantitative amounts of waste from the DCC reagent to make such a simple amine. If really DCC is needed, better use EDCI instead for easier work-up. A direct amidation may be achieved by reductive amination.

  • @nilnik2673
    @nilnik2673 2 ปีที่แล้ว

    What's the instrument in the background?

  • @hampoop35andywhitlock49
    @hampoop35andywhitlock49 2 ปีที่แล้ว +2

    So have you heard of kava or kratom? I’m trying to make a patch. A patch that slowly absorbs over days, instead of taking grams capped up or in powder

    • @toreschanke4086
      @toreschanke4086 2 ปีที่แล้ว +1

      The biosynthesis of the active compounds would probably be interesting to you then.. But, I remember the challenge and fun of growing Salvia divinorum back in the 1990'.And, exploring a psychedelic plant, before it was common knowledge. Of course the way the plants made salvinorin A, and isolating the compound was very intriguing. It wasn't even like now, that everything can be looked up on the web - and even have a Wikipedia article that covers much of it. But I still wish I could grow those plants that you mention. I remember when I tried to grow as many plants with special properties as possible. I think it's a thing that I'll have to try again! (Even though I live in a challenging climate for many species).

  • @koenjanssen5838
    @koenjanssen5838 3 ปีที่แล้ว

    David i tought LiAlH4 did not reduce alkenes, whatsup with that?

    • @strife3084
      @strife3084 3 ปีที่แล้ว +1

      It doesn't reduce whats called "simple Alkenes". i.e. ethene, methane, propene etc. these are all phenyl substituted Alkenes. huge difference in reactivity.

    • @jorgejimenez4325
      @jorgejimenez4325 ปีที่แล้ว

      Really electrophilic alkenes (like nitroalkenes) can be reduced

  • @rendhy_8864
    @rendhy_8864 2 ปีที่แล้ว +1

    Can you tell me the ingredients and how to make it, I really want to know. Isn't it legal for science, because I don't circulate it. please tell me, for anyone of you in the comments column who knows the ingredients and how to mix it,🙏🙏 meth and MDMA🙏🙏

    • @noname-80lbs
      @noname-80lbs 2 ปีที่แล้ว +1

      I´m affraid it´s a little bit more complicated man.

    • @rendhy_8864
      @rendhy_8864 2 ปีที่แล้ว

      @@bigboss9817 I'm from Indonesia, can you tell me about that?

    • @rendhy_8864
      @rendhy_8864 2 ปีที่แล้ว

      @@noname-80lbs I'm from Indonesia, can you tell me about that?

    • @noname-80lbs
      @noname-80lbs 2 ปีที่แล้ว

      @@rendhy_8864 I dont know much about the subject but the book the teacher mentioned. let me check out one thing

    • @rendhy_8864
      @rendhy_8864 2 ปีที่แล้ว

      @@noname-80lbs can you help me so I can get the material guide book and how to make it, I'm from Indonesia,

  • @rudymelo880
    @rudymelo880 2 ปีที่แล้ว +1

    Adderall is not methamphetamine. Its just amphetamine

  • @chadwik4000
    @chadwik4000 3 ปีที่แล้ว

    DOC was a real whopper it looked like, in Pihkal

  • @mubsz
    @mubsz 2 ปีที่แล้ว

    turn up the music i can hear u

  • @CmdrJameson007
    @CmdrJameson007 ปีที่แล้ว

    Chem 51C : Discover Mash Josh Soni Jordan Jag

  • @salimsopari
    @salimsopari 2 ปีที่แล้ว

    does anyone know how to make 2cb?

  • @triple_gem_shining
    @triple_gem_shining 2 ปีที่แล้ว +3

    Hamilton's gotta be lurking in these comments somewhere

  • @polinaknoroz5523
    @polinaknoroz5523 ปีที่แล้ว

    Anyone noticed the Indian background music 🎵

  • @stephenjacks8196
    @stephenjacks8196 4 ปีที่แล้ว

    She put an axe in his head but they're still in love.

    • @BushyHairedStranger
      @BushyHairedStranger 3 ปีที่แล้ว +2

      “She put an axe in his head but they’re still in love”-Stephen Jacks
      Please explain.

    • @stephenjacks8196
      @stephenjacks8196 2 ปีที่แล้ว

      The Shulgins had a fight. But they buried the hatchet.

    • @ericami5642
      @ericami5642 ปีที่แล้ว

      I think your confusing people

  • @jhoughjr1
    @jhoughjr1 11 หลายเดือนก่อน

    Id expect a teacher to know meth and addetal are not the same thing