Darienne Myers (UCSF): A Mouse Model to Understand Lupus

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Dr. Darienne Myers investigates the molecular mechanisms of lupus using a mouse model.
Lupus is a disease in which the immune system becomes erroneously activated and attacks a patient’s own tissues. Using a mouse model of lupus called Rasgrp1, Dr. Darienne Myers investigates the molecular mechanisms of this autoimmune disease. Specifically, she asks how the immune system knows when to mount a response. She discovers increased levels of mTOR (Target of Rapamycin) signaling and protein translation in the Rasgrp1 mouse’s T cells, which contributes to the lupus-like disease displayed by the animal.
This talk is part of the Young Scientist Seminars, a video series produced that features young scientists giving talks about their research and discoveries.
Speaker Biography:
Darienne Myers received her Bachelor’s Degree in Biology from Amherst College. After this, she worked as a research assistant in Dr. Fred Alt’s lab in Boston, MA, where she first became excited by Immunology research. Darienne then pursued a Ph.D. in Biomedical Sciences with a focus in Immunology at the University of California, San Francisco (UCSF). There, she studied how signaling pathways in T cells are tightly controlled to prevent these T cells from attacking and damaging our own healthy tissues. Darienne is also interested in science communication and writes scripts for Youreka Science, a company that produces educational whiteboard videos. In her free time, Darienne enjoys cooking, traveling, and takes boxing classes.

[@angelgabrielcaviedesjoya9368]

Thank you for your work, this really made me understand the mechanisms behind autoimmune diseases

[@aimeequaifes175]

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[@angelgabrielcaviedesjoya9368]

@@aimeequaifes175 🤦

[@JohnSmith-lf5xm]

Get to know a little more about how the Immune system works is always interesting. Thank you.

[@atacorbillel]

Thank you lady Myers

[@roosefamily6746]

Awesome job Darienne!

[@hraqhraq]

2:19 buzzle piece fit. This is not actually what happen. Of course one of the early things to affinity of molecules is fit, and sometimes it is induced fit, but what really matters is actually the Hydrogen Bonding and the Pi Bonding between molecules that need to find each other for an immunogenic recognition. You could have a perfect fit of 2 molecules but they have amino acids, sugars or lipids with zero bonding capability, then you will never have a binding and consequently immunogenicity.

[@platzandersonne2198]

Do You know the work of Niels Ryberg Finsen ?

[@sashikantaparida9763]

Awesome

[@tactileslut]

Holy vocal fry.