CRISPR-Cas9 ("Mr. Sandman" Parody) | A Capella Science
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- เผยแพร่เมื่อ 10 ก.พ. 2025
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"MAKING OF" PRODUCTION TUTORIAL: • CRISPR-Cas9: Productio...
CRISPR PLAYLIST: • Genetic Engineering Wi...
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----LYRICS----
READ LYRICS HERE: timblais.bandc...
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![[UNCUT] ขยี้ "อลิส" ปม "คลิปลับแตงโม" เปิดชื่อคนพยายามแฮก "มือถือแตงโม" I คนดังนั่งเคลียร์I 10ก.พ.68](http://i.ytimg.com/vi/_RPLEIi5Sz8/mqdefault.jpg)
This is simultaneously the hottest track about a genome-editor, the best cover of Mr. Sandman, *and* one of the top 3 best genre fusions. Serious s-tier stuff here.
And a acapella so good that at points I forgot there were no instruments
Typo it’s SSS tier
You could say, he Crisr Cas9'd the fuck out of it.
S+++ tier if you want my opinion bud , bcs this is actually a big brain time song Ngl
overwhelms me
I've been assigned the task of writing a CRISPR-Cas9 song for the youngest visitors at the museum where I work. Naturally I googled "CRISPR song" just to see if there was anything else out there.
I'm handing in my letter of resignation tomorrow.
LMAO
Maybe Tim could help you.
@@annesmith9642 I've actually just finished the song. Thankfully it's in Swedish, so nobody here will ever know just how awful it turned out. 🤣
@@sebastianflavet2531 I'd love to hear it.
@@annesmith9642 th-cam.com/video/p7u7mxSRKDo/w-d-xo.htmlsi=OKgSOJXlU69glvqy
This has got to be the nerdiest thing I've ever seen.
I love it.
i agree I. LOVE. IT.
You stole my coment from my head
This is the essence of my personality
i might as well reply when this somehow has 3 comments
7 years later and I'm back to realize: this still might best the best music video on youtube (myy opinion)
I've only watched this 4 times so far. It hasn't been enough. I
☺️☺️☺️
only 4 times, i must have watched it like 40-50 times within the first 3 months, and by this post :P
Physics Girl Let me remind you “I’m so alone”
@@hellspawn3200 Hah, rookie numbers
you should've dated terry davis
A student just sent me this song and oh my lordt the effort that must've gone into making this.... mindblowing I am IMPRESSED
"incite a scene" in place of cytosine is some amazing wordplay
Rip guanine
"that one Nazarene" is a great turn of phrase too.
it really would in cytosine
"Outside our power and inside us all" is also a great line
@@betapi1726 and uracil lol (edit: i think those are the only bases used in both DNA and RNA; guanine is only dna and uracil is only rna)
Now that the discovery of CRISPR-Cas9 has been awarded the Nobel Prize, this video should get revitalized and shared all over again!
Tim should have been invited to the Nobel ceremony to perform for the King of Sweden. Command performance, dude!
This one just keeps modifying itself into something stronger. Poetic, that!
acapellascience stop being so amazing, you make us mere mortals feel inadequate
This is some good musix for mah ears and brain
In a way it reminds me of Tom Lehrer's _"Clementine"_. It's fun to try and identify the different musical styles as they go past.
Your vids keep getting better and better, but the better they get the longer i think your dead or cant afford to make videos anymore.
+Kristopher Kohlmeier Au contraire, the more affordable this process becomes, the longer I take to do things right :P
I first discovered this song when I was 13 or 14. Back then I had no bio knowledge, and basically only listened to this song for the epic harmonies. However many years later, I am now a college student learning about CRISPR in my gen ed bio class, so I came back to this song to see if I understood it any more. The result is me going wildly back and forth between understanding and being even more confused than I already was. A recreation of me watching this:
"Encoding for a specific protein" - oh yeah, cuz the RNA guide's really easy to program, I bet it searches out specific sequences that make proteins, yeah this makes kind of sense
"Make a few snips at this coded locus" - yeah yeah yeah i'm actually understanding this!
"You work so well inside a streptococcus" - aaaaaand you lost me
I'm sure you'll get there, Molly.
Haha, you'll get there. The cas9 that was developed into the gene editing tool was from Streptococcus pyrogens and it works beautifully inside the bacteria to target and kill the bacteriophage trying to infect it.
All I know is streptococcus is a bacteria that causes strep
I'm 14 right now
Afaik the theory behind how CRISPR works is based on observations of how the S. Pyogenes microbe does it naturally
This might be the best one you've made yet… and I'm not just saying that because I helped on it! :)
When amazing people work together, amazing things happen.
Then ask for credit in the video description. I usually don't hate on youtubers, even propagandists, but you mate are the exception. You arrogance makes me cringe everytime.
@@hfyaer he is credited in the video description. It says there: JOE HANSON, right after --- End Screen Links --- which, by the way, brings up the fact that he is also credited at the end of the video, too. Verbally, in fact
@@hfyaer You can't judge people off their usernames man. He's got a channel that teaches science. He's not trying to act smarter than anyone else, it's just the name of a video series ran by PBS. Lol.
@@els_near lol
the first time I heard this was my freshman year of highschool. I am now 22 and this song gets stuck in my head on the regular. Absolutely love Acapellascience! Thank you!!
Epic!
So epic! Hey Derek, you should come visit your Alma Mater, Queen's University sometime.
Veritasium WTF!
Veritasium iq
Veritasium 8
Veritasium indeed
I come back to these virtuoso creations again and again. Really some of the best videos on TH-cam, they never get old.
You won me entirely with the Aladdin mash-up in 1:58. The thing is that not only the scientific part of the video is really well explained, but the artistic part is outstanding. ¡Olé!
A call-ahead to a video I haven't made yet :P
Crespo!!!!!!! :D
what aladdin song?
Friend Like Me. Apparently is was a reference to the now released "Whole New Worlds"
Crespo nos tienes que decir qué canales ves, que si son todos como este flipo!
Dayum man, you're unique
Mad scientists unite !
Thanks DirtyBiology for bringing me here ! Make sure to check out his channel if you understand French !
Damn... Dirtybiology, Veritasium and It's Okay To be smart in the comment section, and I didn't know that video ? I feel so late x)
DirtyBiology is ~300,000 enough?
salut dirty biology
Tu devrais en faire la promotion sur ta chaîne pour les les francophones qui ne le connaîtraient pas ^_^ (ou alors tu l'as fait et j'ai pas capté)
**well I was just sayin that he should present him in his french channel..
Holy cow, HOLY COW, it actually makes me mad to think about the fact that this video ONLY has 1.3 M views, with the insane amount of time and effort that went onto making it, from making the lyrics to recording every single little panel of the dozen that appear, it's crazy, Tim you're insanely talented. This video truly deserves at least 10 M views.
Definitely
Just you wait.
Very true
There should be awards for people like you.
I watched this when it first came out, when I was still in high school, and I loved it but didn’t understand it at all. Now I’m a Neuroscience PhD student currently learning about CRISPR and I finally fully get it!! It’s been so fun to watch over the years of my science training 😄
Hi from Barcelona
Corinne, congrats for your Neuro PhD🎉
so many comments like this and it's so wholesome😭 i'm in my first year of uni studying bio so i like, vaguely understand it but not all the small references. can't wait to finally fully understand it one day :D
My best friend and I literally had this memorized in high school freshman biology and I’m back for the memories.
Wow. This song has so many layers of information in it, that it's in a league of its own.
I honestly don't know how this song doesn't have a billion views yet.
This song assisted my through my whole studies, from bachelor til masters now :) Chapeau!
HE RHYMED "AND CYTOSINE" WITH "INCITE A SCENE" PURE GENIUS
Wow that was MENTAL ! I can't begin to imagine the amount of work put into this... Brilliant job ! :)
I'm really glad you mentionned the ethical part of it as well, at some point around the middle of the song I was worried this would be a complete promotion of gene editing without any warning !... Nicely done, keep up the good work !
I was confident the ethical aspect would come up. Eminemium is pretty preachy^^
Responsability comes once you're a science guy, yo !
I'm glad Gattaca got mentioned too, a few seconds after I thought of it ^_^
Luckily for you, you don't need to imagine it! Go to acapellascience2 to watch the making of it!
Not gonna lie, this is by far the best video on the internet when it comes to explaining the CRISPR/Cas system. It explains everything in a catchy hot manner. even future possibilities and ethical problems.
OMG THIS IS THE MOST AWESOME THING I'VE EVER SEEN!!!!
*BRAAAAAAAAAVOOOOOOOOOOOOOOOOOO*
Seriously, that 2:58 part is absolutely SUPERHUMAN
CoriSparks the only part of the sing I cannot learn
It carries the sounds of "help, my computer died."
I think I've watched this like 10 times now and I'm still bewildered at how accurate and super entertaining this is.
Wow that was delicious on so many levels. Well done man, you are an amazing entertainerd.
Thanks man! I definitely owe you for prompting me to understand barbershop.
The barbershop part was beautiful! I wish you would have done the whole song in that style in stead of the more common beat-box a capella style.
You missed an e, JK.
Ooooh of COURSE you've seen each other's videos. You're both stellar musicians! Small internet world, right? Consider a collaboration?
So normally the science parodies that Mister Teacher shows us in class are just a bit of fun that someone with a passion for science made but this one's a masterpiece and must have taken who-knows-how-long to make. So good that I went out of my way to go watch it outside of the classroom, very nice job!!
I hope you brought it back in to share.
I maybe only listened this about 280 times.
Relatable
Ha I beat u
Edit:281
Not enough
Only 280 times? Sheesh.
Those are rookie numbers, boy.
I just *love* the arrangement, lyrics and acapella aside
The original to electro-swing, jazz to a full orchestra
GAAHH I adore this
WHAOOOOOOO I just smiled throughout this whole thing. SO COOL!!
This comment smells like knowledge.
R.Instro That's probably because it still has brains on it.
Alexis Rainbow Queen Ahhh, that would explain it. ^_~
In case you don't want to use the link, here's the lyrics:
CRISPR-Cas9
Bring me a gene
Encoding for a specific protein
Make a few snips at this coded locus
You work so well inside a streptococcus
Cas9
I'm so alone
Without your scissors in my chromosome
Cut me up and do it clean
CRISPR-Cas9 bring me a gene
CRISPR-Cas9
Keep me a gene
A viral sequence you've already seen
Chopped into bits and stored as genomic
With clustered repeats
That are palindromic
Cas9
Bind with this code
Use it to target infections of old
Immunized like a vaccine
CRISPR-Cas9 keep me a gene
CRISPR-Cas9
Cut me a gene
With a precision that I've never seen
Unzip a strand and interrogate it
Seek out your sequence until you locate it
Cas9
Lock into place
And do your job as endonuclease
Chop just like a guillotine
CRISPR-Cas9 cut me a gene
Snip snap!
CRISPR-Cas9
CRISPR-Cas9
CRISPR-Cas9
Bring me a gene
By commandeering my repair routine
A strand to match your severed location
For some homologous recombination
Cas9
Cheap and precise
Rewriting genomes from microbes to mice
And soon the humble human being
CRISPR-Cas9 bring me a gene
CRISPR-Cas9
Give us a gene
Give us a miracle like that one Nazarene
‘Cause giving the lame their legs and the blind their sight is
In view for dystrophy and retinitis
But CRISPR-Cas9
What if you fall
Outside our power and inside us all
That really could incite a scene
When this terrible wonderful power unsettling
Opens the door to unethically meddle
Is ev’ry congenital malady bettered
Sufficient to warrant genetics unfettered
To modify man in the manner of Gattaca
Raise up a mammoth or make a rattata
Dramatical medical means to eradicate aging
Or cancer or make a fanatic
A mass epidemic a weapon nefarious
Single mosquito to wipe out malaria
Send in a viral infection to ferry a
Cure to the cells of an HIV carrier
Freed of disease as we're free to uncover
What nature and accident failed to discover
And free to be other than
All that we ever have been
CRISPR-Cas9
CRISPR-Cas9
Oh CRISPR-Cas9
Bring us a gene
You wondrous ribonucleoprotein
You have the power to vanquish or save us
Who would have thought that the microbe that gave us
Cas9
S. pyogenes
The source of strep and flesh-eating disease
Housed this marvellous machine
Full of uses great and obscene
CRISPR-Cas9 bring us
Please don't sting us
Cas9 bring us a gene
With adenine
And thiamine
Incite a scene
Cas9 bring us a gene!
zelda64rules thank you, kind cyber citizen
You're welcome.
zelda64rules Relevant nitpick: third to last line is "and thymine" not "and thiamine" they are very different compounds and although their pronunciation might be similar they should be distinct.
@@charliegoodwin8651 Nope, but you got the joke so you get half points anyway.
no way, you are amazing thank you
Holy crap, your videos are all scientifically and lyrically and musically impressive, and this one is all those things, but the musical arrangement in this one particularly stands out! Absolutely incredible work, I can't get enough of it. Thank you for making these, I'm breaking into writing science parodies myself (medical, specifically) and you're a huge inspiration!
Am I only one that this song gives “theme for positively crazy, lovable and powerful character that eventually becomes the most dangerous antagonist” vibe?
"With adenine and thymine incite a scene" - The background patterns A T and C!
Also nice pun there
This must surely be one of the greatest things on TH-cam
This video was a complete knockout!! I showed it to my friend PAM but she thought it was a bit off-target.
I want to "like" your comment two times... maybe more. lol
I saw what you did there. :D
"...and do your job as endonuclease..." Oh I love the rhymes in this song!
Guys, help me out. How do I say "It's 3am and I'm lying in my bed almost crying because I love science and I love a capella harmony and this is the best thing I've ever seen and you are so so talented and amazing and I would also perhaps maybe like to marry you, hi" in the least creepy, preferably at least semi-normal, and most decent way possible?
I'm a linguistics major but right now I'm at a loss for words. I think my brain inadvertently just turned into mashed potatoes.
There's no non-creepy way to do that. But if you like linguistics, I highly recommend Tom Scott: th-cam.com/video/2qT8ZYewYEY/w-d-xo.html
acapellascience oh my goodness, I didn't think you'd actually see my comment. I- sorry. Honestly, sorry. I was just really tired and fangirling about science and over how amazing your videos are, I found your channel just two days ago. Again, sorry. Now that I reread that comment in the morning I do agree that it does sound extremely creepy. What I meant to say was, you're very talented, keep up the good work. Science is awesome.
Sorry.
/facepalms and digs a hole in the ground to live in forever because I can never face anyone ever again/
acapellascience Haha I've seen worse comments, don't worry, I think Jozie is just a huge fan :) You are hella talented, dude :)
Jozie Charles Haha I'm so sorry! :) That was meant to be playful but I don't think it came across. I forgot that inflections don't come across in text form. Really, I'm not creeped out at all! Just glad to have a fan. Cheers!
I'm always jokingly deadpan in real life; I have to remember that if you don't actually know me it probably just comes off mean. #sorry
This is the theme song of today (7.10.2020) when _Emmanuelle Charpentierin_ and _Jennifer A. Doudnan_ got their Nobel prize in chemistry announced. Congrats for both of them!
That is really awesome!!! What a perfect opportunity for it to be shared.
Seven years and this bop still lives in my head rent free, and I still return to it every now and again. Love your work!
Over three years later, this is still arguably The Best Thing on TH-cam.
Seven years in, still no contest
@@q-tuber7034 no, there are some close competitors (evo-devo, the molecular shape of you, leukocyte, nanobot, entropic time) so basically... this guy is the GOAT :D
Why doesn't this have millions of views?
I wonder that every day.
Every day there are more persons ignoring more things..... Only a few understand and enjoy. Knowledge is elitizing
It does now! :D
It does now
well, it has about 1 million now!
Oh my lord, this changed my life. We are your biggest fans. Please continue with your sensational work! This was so fantastic. From Lynbrook High School's Period 4 Science Research Class.
Sam Cohen Glad to be of use!
The amount of editing that went into this is mindblowing...
Tim Blais you are great!!!!!
As a biologist I celebrate your good work. I start hearing just one song and I became a huge fan of you.
Keep doing this and thank you to be in this planet with us, is better with you here. 😁👍😘
"adenine and thymine incite a scene"
I see whAT you did there, younG mUsiCian.
I don’t understand it
@@danieltigas9771 incite a scene sound like "and cytosine" which is another nucleotide base
Wasn’t it thymine?
Edit: It was “Adenine and Thymine”. I checked the lyrics.
Edit 2: “Incite a scene” is supposed to be “and cytosine”. I’m an idiot.
@@acetuberjason6730 there are 4 bases, in RNA uracil replaces thymine
@@kevinaugustsson2202 Ok thanks
Never mind the frontiers of gene editing. This video pushes the frontiers of video editing!
My 9 year old won't go to sleep without watching one of your videos, and he especially loves this song and Molecular Shape of You. It amazing how talented you are to make such incredible songs.
This one is so dense in references, musical jokes, scientific insiders and other witty shenanigans that Im concerned we'll have a singularity here...
Oh my goodness - I'm not kidding when I say I got goosebumps three separate times when watching this for the first time! Somehow when I thought it couldn't get any better at each section, it did??
I can't imagine how long this took and I'm not a biology student - but as a music person, the amount of musical territory covered and insane harmonies going on is really astounding. This really is a masterpiece to be proud of 🥹
Three years ago I answered correctly a serial application exam (its a weird translation but it works) question because of this song, and that helped me to get into uni. Now, studying genetics, the crispr was mentioned, so im listening to this banger again
This song plays all day long in my mind since I first heard it each time we discuss genomic editing in my major XD
This has been stuck in my head all day! I have been singing it to my lab friends! Thank you so much for writing this and for all the work you put in to put into making this video!
Crispr scares me, but it's still awe inspiring what we could do with it.
Some people wake up and choose violence. You woke up and chose masterpiece
Made especially for nerds and geeks like me. This man has so much talent. Thank you for inventing this.
Absolutely incredible as always. Still can't understand why your channel hasn't blown up more.
Body: tired and ready to go to sleep
Brain: CRISPR -Cas9 bring me a gene DUH DUH DUH DUH
"With adenine and thymine *n' cytosine* "
You are just the best, and I love you
I'm a Middle School Science teacher and I love you. Patreon supported!
WOAAAH! I heard the audio preview version of this and loved it, but being hearing-impaired I couldn't appreciate the full magical beauty of it. Now I've seen the video (and the accompanying subtitled lyrics, yay!) I can unleash my full-on awe. Spectacular job!
Hell's bells, that's a lot of Tims! It's so evident that an enormous amount of work and talent goes into these! Well done.
This is a masterpiece of a really professional niveau. For creating this as a single person deserves all my respect!
I got a CAS-9 ad on this video, and I don't think I've ever been happier to see an ad before.
An appropriately epic song for an epic scientific breakthrough :D Brilliant as always!
oh my god, i get freaking CHILLS at the part that starts at 2:30
this is definitely my favorite version of this song hands down - and this is my favorite song to begin with.
I am still so in love with this song... and presentation... and young kids absolutely love you all....
Are you watching any of his live or production streams? They are wonderful.
As a biochemist and a musician, you took my heart and made me laugh like a baby. My most sincere gratitude.
I... there are no words. I mean, I've seen some good stuff on TH-cam and some of it was on your channel(s), but that.... that actually made me tear up. My jaw was on the floor and salt water was coming out of my eyeballs. Dare I say that was better than bohemian gravity. And let it me known that I have memorized that song and sing it at work. I just... wow dude. Props to you. Well done sir, well done.
You seem like you have many words.
I tear up also when I get about halfway through. It’s a combo of my passion for musicianship / vocalizing (many forms) and my passion for medical biology, as well as probably also my autism.
"You have the power to vanquish or save us." Subtle Harry Potter reference!
I must have watched this hundreds of time already and never noticed that you hold up scissors at 0:32. How did I miss that?
_When you're beginning to feel like a Rap God and a Rap Scientist at the same time:_ 2:58 - 3:22
This is truly something special
Mate I just wanna say that I'm no scientist at all, I'm a musician, but I don't if people realize : Not only from what I get from the comments section you seems to know you shit extremely well in many scientific fields, but you are a total vocal harmonies brainiac!!! My dear Lord that was something! :O
I like the scratchy noise at the beginning, simulating an old record.
Ok, this is way beyond nice. This is ridiculous... This is brilliant musically, textually and graphically (Art Deco Voronoi, anyone?). Also the molecular shape of you contains some of the best explanatory animations of electron clouds I've seen to date. Extremey well done! I'm eagerly awaiting your next project and well on my way through your portfolio enjoying myself immensely. I would be mortified of making a mistake, if I were you, but given the detail and the broad knowledge displayed I guess there is a team behind this for fact checking? Cudo's to all.. Way to make nerdy science cool and even mainstream.
Most underrated TH-cam content. Keep up the good work!
Best version of this song I've ever heard
It's 2021 from 3b1b channel and your job is just.... insanely gorgeous!!!!!
The sheer depth and intensity of production here is incredible. You've earned yourself a subscriber today!
It's 1:30am I'm in front of a screen full of incomprehensible gibberish and your video's on cause, yeah, it's that time of night - video starts with an ad for CRISPR something and I just roll with it - took over a minute to realize this was the ad, not your video. Thanks for making late night logic programming a bit saner.
You hoping for CRISPR to win the Nobel so you could release this during the announcement, weren't you? Oh well...
That would have been nice, I'll admit.. But no, this was just the best idea I had so I made it :P
When I work in the Doudna lab, I will show this to her because this was absolutely terrific!!!
The Batman Are you actually going to be working in the Doudna lab?
I REALLY HOPE SO AND I THINK I HAVE A PRETTY GOOD SHOT AT IT!! I'm an undergrad at Cal and she taught Bio 1A last semester, so, normally, I fangirled and went to office hours regularly and still do now that I'm in the second half of the Bio series.. I asked her what bio/chem classes undergrads in her lab complete before beginning to work in her lab and I mentioned I was interested, so by the end of this semester I'll have an answer because I'll be done with both sequences. She signed my notebook and we even took a selfie!!
The Batman HOLY CRAP that is amazing. I get to see her speak later this month and I'm also fan-girling super hard. She's a superstar
Who is the GOD that edits your videos???? That kind of sync of all those individual tracks is black magic to us mortals ^^'
I believe Tim did it all.
This hits so damn hard... not only is it incredibly informational but it's also just musically magnificent.
4:13 I can't tell if "incite a scene" was a typo or the smartest DNA pun I've ever heard.
It's clearly the latter.
That was awesome, I can't stop talking about your channel to other science geeks.
Man, you deserve success.
They'll have to create a new award. It shall be called the Timmy.
4 years and a Nobel later, still amazing !
I worked my ass off for 4 months to assemble Cas9-RNPs in-vivo but the dear Mr. Cas9 just wouldn't perform as asked. Thank you for lightening my mood and keeping the entire lab motivated :)
Congrats for the Nobel Prize 2020
I still come to this video every once and awhile. I really think this is one the best ones you've ever done!!
As a musicialyish squid, this song is AMAZING. I mean the arrangement is absolutely stellar. AND THERE'S SCIENCE TOO! AND IT'S ACAPELLA! This is like a perfect storm of awesome. And not the slang term awesome, the *absolutely amazing euphoric awe-inspiring kind of awesome.*
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What are the odds that the two of us both like A Capella Science AND ImpulseSV and TangoTek?
YES AND WHAT ABOUT THE VIDEO EDITING SKILLS
I forgot to mention the video editing. Amazing. So, you are basically amazing at: singing, arranging, audio editing and mixing (sounds great), video editing (wow), acting, memorizing, knowing about science, writing lyrics. You are perfection!
You really nailed it! Fantastic job
i know its now almost 2 years old and hasnt as much views as the rest of your videos, but i still think this is the best video you made so far. they way the lyrics correspond with the music and evolve and recombine and escalate is pure art!
This song is hotter than ever in 2020! It would be the perfect song played at the Nobelprize Award Ceremony, honouring Emmanuelle Charpentier and Jennifer A. Doudna for the discovery of CRISPR-Cas9. 😍
This is actually one of the best put together science song I've ever heard!