I’ve listened to so many lectures explaining this concept that my professor expects me to learn from reading the text with no lecture material. Between this and the MIT open source lectures, It finally makes sense and I’m a post-baccalaureate student with a 4.0 GPA. Thank you for sharing these lectures publicly for those of us with useless instructors,
Hey, just wanted to let you know that I'm an AP Biology Student, and this video really clarifies as I'm studying for the AP Exams! I really appreciate it man, and I wish I had someone like you who is so open to office hours. In my class I'm able to understand most stuff with the exception of this topic, but from 50% knowledge of this stuff, I can gladly conclude that I've gone up to 80% knowledge of this stuff. If that even makes sense lol! Thanks Professor!
My molecular biology class basically taught crossing over as a normal process of prophase in meiosis i.e. happens with each event. However, you say it is rare. How rare of an event is it considering it is a mechanism which contributes to variation among progeny, further increasing their potential of fitness?
Yes, crossing over is a normal process in meiosis, but what the video tries to say is that depending on the distance between genes, that's how likely it will be for them to be part of that crossing over proces. If there is a short distance between let's say 2 genes, they have less probability to be part of the crossing over process. I may be wrong, but that is the conclusion this video gave me.
If I cross a domestic mouse to a wild mouse the pups are f1 hybrids. If I take those pups and do a sibling to sibling cross to produce f2 then what would those f2 pups be called? Are they still wild hybrids? Are they wild recombinant? I read something that suggested they might be called an intercross. But I'm not sure. Any thoughts?
Chrm number one and fourteen bit is confusing. Are you talking about the Alleles or the chromosomes themselves? Because the gametes must necessarily have both chromosomes 1 and 14.
@@thomasmennella5501 Thank you so much. I can't stress on how your videos have been helpful. Everything is well explained. If you have any research papers that you've co-authored, I would love to read them. And also, I would like to know the text book you've been using because I tried searching and couldn't find it. Thank you once again.
Some images are borrowed and used from other sources but the vast majority of the figures as well as the organization of the material come from Pierce. It’s very fair to say that this series of lectures is “built around” that text. Also, it’s by far the best text for undergraduate genetics, imho
The 30 map units is the correct answer. The "perceived" recombination frequency (28%) is less than 30 because double crossovers have likely occurred. As two genes get further and further away form one another, not only do you get single crossovers, but you can get double crossovers as well, which would revert the alleles to their original configuration. So the 28% you "see" is due to 2% of the total of 30% recombinations doing a double crossover and they are not picked up as crossovers (even though they WERE crossovers, but they occurred TWICE and canceled each other out). When you analyze two genes that are closer together, you get a truer representation of what's actually occurring because double crossovers are rare and don't artificially reduce the recombination frequency.
english isn't even my first language and I actually understood everything! this is amazing, thank you
I’ve listened to so many lectures explaining this concept that my professor expects me to learn from reading the text with no lecture material. Between this and the MIT open source lectures, It finally makes sense and I’m a post-baccalaureate student with a 4.0 GPA. Thank you for sharing these lectures publicly for those of us with useless instructors,
This playlist is exactly what I was looking for, THANK YOU SO MUCH!!
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I love how you broke down the book and explain it so well.. thank you ... it finally clicks after reading my book and watching you ....
Thank you so much, I love that you take your time really explaining topics so it’s easier to follow along, thanks again!
Hey, just wanted to let you know that I'm an AP Biology Student, and this video really clarifies as I'm studying for the AP Exams! I really appreciate it man, and I wish I had someone like you who is so open to office hours. In my class I'm able to understand most stuff with the exception of this topic, but from 50% knowledge of this stuff, I can gladly conclude that I've gone up to 80% knowledge of this stuff. If that even makes sense lol!
Thanks Professor!
Dude, you are my effing hero. My teacher should learn to teach like you! Thank you, Sir! ♥
My molecular biology class basically taught crossing over as a normal process of prophase in meiosis i.e. happens with each event. However, you say it is rare. How rare of an event is it considering it is a mechanism which contributes to variation among progeny, further increasing their potential of fitness?
Yes, crossing over is a normal process in meiosis, but what the video tries to say is that depending on the distance between genes, that's how likely it will be for them to be part of that crossing over proces. If there is a short distance between let's say 2 genes, they have less probability to be part of the crossing over process. I may be wrong, but that is the conclusion this video gave me.
@@andresflorez497 Yes, that's true about the distance of genes. Maybe I just misunderstood what the video was saying
If I cross a domestic mouse to a wild mouse the pups are f1 hybrids. If I take those pups and do a sibling to sibling cross to produce f2 then what would those f2 pups be called? Are they still wild hybrids? Are they wild recombinant? I read something that suggested they might be called an intercross. But I'm not sure. Any thoughts?
this is crystal clear thank you
Really really helpful! Thanks a lot!
Chrm number one and fourteen bit is confusing. Are you talking about the Alleles or the chromosomes themselves? Because the gametes must necessarily have both chromosomes 1 and 14.
Sır Can you please answer this?
''Differences between genetically linked genes vs physically linked genes?''
@@thomasmennella5501 thanks a lot sir. You are the best.
Hey. At @9:43 , what do you mean by we get fewer of the recombinant ones than the original ones. I am kinda confused here.
@@thomasmennella5501 Thank you so much. I can't stress on how your videos have been helpful. Everything is well explained. If you have any research papers that you've co-authored, I would love to read them. And also, I would like to know the text book you've been using because I tried searching and couldn't find it. Thank you once again.
Where can I buy that textbook 📕
For this Genetics course, I use Ben Pierce’s Genetics, a Conceptual Approach. You can find very good used copies on most major online retail outlets.
@@thomasmennella5501 thank you so much 😊
@@thomasmennella5501 are all your lectures on Genetics coming from this particular book? I would like to follow along.
Some images are borrowed and used from other sources but the vast majority of the figures as well as the organization of the material come from Pierce. It’s very fair to say that this series of lectures is “built around” that text. Also, it’s by far the best text for undergraduate genetics, imho
really helpful
you explain so well! thank you
can you also do deletion mapping? thanks
it was awesome man...
Perfect
Why did we split in half exactly?
@@thomasmennella5501 actually I meant the 84% into 42%, but I now understand. Thank you though!
please, Can I get this PowerPoint?
Is it the genes that are linked or the chromosomes 😅?
Unironically based
1:01:00 blue
56:50 a 28 turns into a 30....
The 30 map units is the correct answer. The "perceived" recombination frequency (28%) is less than 30 because double crossovers have likely occurred. As two genes get further and further away form one another, not only do you get single crossovers, but you can get double crossovers as well, which would revert the alleles to their original configuration. So the 28% you "see" is due to 2% of the total of 30% recombinations doing a double crossover and they are not picked up as crossovers (even though they WERE crossovers, but they occurred TWICE and canceled each other out). When you analyze two genes that are closer together, you get a truer representation of what's actually occurring because double crossovers are rare and don't artificially reduce the recombination frequency.
@@marylynnelamantia2798 I was wondering the same question. Thank you for this explanation