75 hours of online pharmacology video for NEET/USMLE/FMGE/PLAB by Dr.Ranjan Kumar Patel at www.pharmle.com Integration is the current need of the hour and that is what PHARMLE gives you. PHARMLE integrates pharmacology with all preclinical as well and clinical subjects. Get your extra edge today by joining PHARMLE.
Best and awesome presentation and i dnt unerstand why ppl dislike video and looks like its a professional grudge or else i cant find any reason to dislike this one ....
Positive free water clearance-water remaining in the lumen of thick ascending limb and DCT.. too much water reachinv collecting duct is reabsorbed causing negative free water clearance.. carbonic anhydrase inhibitor cause inhibition of sodium and water reabsorption, sodium drags water to TAL and gets reabsorbed ultimately causing increase in positive FWC.. loop diuretics by decreasing reabsorption of sodium decrease FWC. Thiazides also decrease FWC. Loop Diuretics decrease sodium in medulla causing decrease in medullary osmolarity and preventing water reabsorption, and thus decrease negative FWC so they decrease both positive and negative FWC Loop decrease both positive and negative FWC Thiazide decrease positive FWC CAI increase positive FWC
With respect, To be honest, This video is very complicated in the aspects of Physiology. Its a concept spoiler which is not good for USMLE. Its title should be Pharmacology aspect of Free water clearance. Free water clearance is - How much pure water is being excreted. if Urine Osm = 300msom/kg (270-290) Free water clearance is = 0, as no pure water is lost from Plasma. If Urine osmolarity >>300 mosm/kg, it means Urine had lost water, which is a negative Free water clearance - It Happens when Circulating ADH/AVP is Increased. If Urine Osm is
Pramvir Rathee Well i am a pharmacology teacher and my aim in this video was to make clear how drugs affect free water clearance. I hope you get the point, that this is not a physiology video.
Thiazide affects only the symports present in the distal convoluted tubules involved with absorption of solutes .. so it abolishes positive free water clearance. It has no action on the loops . Loops are responsible primarily for maintaining the corticomedullary gradient. This gradient drives water out of the thin descending limb and the collecting duct due to increased osmolarity... Thus thiazides have no action in negative free water clearance.
Bikashraj Paul For diuretic effect we need solute to be present in the lumen. Drugs with negative free water clearance have more solute in lumen and are more effective diuretics.
Sir if drugs with negative free water clearance are better diuretics then Thiazide diuretics should have more efficacy as compared to Loop diuretics ( beacause Loop diuretics decrease negative free water clearance ) but we know tht Loop diuretics have higher efficacy.
Carbonic anhydrase inhibitors act in the proximal tubule. In this part of nephron there is iso osmotic absorption of water. So neither positive nor negative free water clearance.
Most of the solutes that reaches the loop and distal tubules are reabsorbed .. so there isn't an increase in negative free water clearance. Hope this clears your doubt
When body is in water surplus state body removed excess water and if it is salt and water deprived..there is negative free water clearance. Primarily regulated by ADH
75 hours of online pharmacology video for NEET/USMLE/FMGE/PLAB by Dr.Ranjan Kumar Patel at
www.pharmle.com
Integration is the current need of the hour and that is what PHARMLE gives you.
PHARMLE integrates pharmacology with all preclinical as well and clinical subjects.
Get your extra edge today by joining PHARMLE.
Oh my goodness. This was super duper awesome. i didnt knew this concept in my entire MBBS. Thanska a lot
Same 😂
Best and awesome presentation and i dnt unerstand why ppl dislike video and looks like its a professional grudge or else i cant find any reason to dislike this one ....
Dr.G.Bhanu Prakash Thanks a lot dear for your kind words
Crystal clear teaching, no time wasting.
Jitna mushkil tha usse bhi zyada easy way me bataya aapne sir, thank you very much sir😊
Never understood this concept before ...thank u sir
Perfect sir,......esa best explain action kisi ne nahi diya...👍🏻👍🏻🙂
Thanks sir..... Koti koti pranam
Best explanation out of all the difficult concepts I've ever studied. 🤯🤯 This emoji depicts my state after watching this lecture.
Oh my god. That was the perfect explaination. Thank you very much sir.
Very well explained.Thank you so much sir..
This was excellent! You will not regret watching this at all!!
Very simple to understand video. Thank you
thank you so much sir...u explained in simple manner so that the concept of free water clearance is clear to me now...
It's a really awesome video sir. It made me easy to understand this topic..
This is an awesome video, delivering the concept in a spectacular way . ❤️
Thank u sir u have cleared all my doubts abouts diuretics
Thanku so much sir really clear my concept 🙏🙏🙏🙏
Woow , the best explanation about Free water clearance in TH-cam ♥️♥️
Thank you 👍🙏🏻
Thank you 👍🙏🏻
Thank you 👍🙏🏻
Beautiful explaination, crispy clarity :)
Girish Kiran Thanks dear
Thank you so much sir for clear this topic 😊
Awesome lecture sir 👌👌👌
Thank you so much sir... I get a clear concept of free water clearance and effects of diuretics on it... Thank you so much sir...
SAURABH KUMAR Welcome dear. God bless you 😊❤️
@@RanjanKumarPatel sir, I love your accent and your explanation really very pleasing.
great video.
but the thin ascending limb is not permeable to water, it only has passive reabsorption of ions/solutes
Thank u very much guruji.... Superb
PERFECT
I wasted 2 hr reading K.D tripathi and still did not got it .Sir explained the concept in just 5 min .thank you sir
Wow u make it so easy
Positive free water clearance-water remaining in the lumen of thick ascending limb and DCT.. too much water reachinv collecting duct is reabsorbed causing negative free water clearance.. carbonic anhydrase inhibitor cause inhibition of sodium and water reabsorption, sodium drags water to TAL and gets reabsorbed ultimately causing increase in positive FWC.. loop diuretics by decreasing reabsorption of sodium decrease FWC. Thiazides also decrease FWC. Loop Diuretics decrease sodium in medulla causing decrease in medullary osmolarity and preventing water reabsorption, and thus decrease negative FWC so they decrease both positive and negative FWC
Loop decrease both positive and negative FWC
Thiazide decrease positive FWC
CAI increase positive FWC
Crystal clear sir. Thank you
Keep uploadin more Sir
Your teaching is really good.all concept is clear.plz make video lecture on other pharmacological topic also.
Sir why we can not say negative free water clearance occurs for the water which is reabsorbed from thin descending loop of Henle ?
Thank u so much sir
Thankyou sir you are best 😊😊👍
well explanation sir
👍👍👍
I got lucky tday🤩 thanks sir... Rising from the ashes
excellant sir..keep it up
vijay mendhe Thanks dear 😊
Amazing 👌
Thin ascending limb also absorbs NA cl
Thank you Sir! ❤️
Sir available on play store ur app sir
Sir I cant get the feel of the basic formula of
Free water clearance =volume of urine -osmotic clearance
Amazing!!!
Thank u soo much sir
dipali das Welcome dear 😊👍🏻
Thanku sir
Welcome dear Sourabh 😊👍🏻
Thank you sir
Sir what will be the effect of CA inhibitor on negative free water clearance?
Thank you so much sir😊
With respect, To be honest, This video is very complicated in the aspects of Physiology. Its a concept spoiler which is not good for USMLE. Its title should be Pharmacology aspect of Free water clearance. Free water clearance is - How much pure water is being excreted. if Urine Osm = 300msom/kg (270-290) Free water clearance is = 0, as no pure water is lost from Plasma. If Urine osmolarity >>300 mosm/kg, it means Urine had lost water, which is a negative Free water clearance - It Happens when Circulating ADH/AVP is Increased. If Urine Osm is
Pramvir Rathee Well i am a pharmacology teacher and my aim in this video was to make clear how drugs affect free water clearance. I hope you get the point, that this is not a physiology video.
Ranjan Kumar Patel Yes Sir, Thats an awesome approach in pharmacological aspects.
In case of Negative water Clearence,
When water is reabsorbing under the influence of ADH,how & why plasma Osmolarity increases?
Please explain it
why thiazide no effect in negative free water clearance
Thiazide affects only the symports present in the distal convoluted tubules involved with absorption of solutes .. so it abolishes positive free water clearance. It has no action on the loops . Loops are responsible primarily for maintaining the corticomedullary gradient. This gradient drives water out of the thin descending limb and the collecting duct due to increased osmolarity...
Thus thiazides have no action in negative free water clearance.
@@OneTouchPharmacology U got a subscriber
What is its clinical significance?
Bikashraj Paul For diuretic effect we need solute to be present in the lumen. Drugs with negative free water clearance have more solute in lumen and are more effective diuretics.
@@RanjanKumarPatel ok clear now😊
Sir if drugs with negative free water clearance are better diuretics then Thiazide diuretics should have more efficacy as compared to Loop diuretics ( beacause Loop diuretics decrease negative free water clearance ) but we know tht Loop diuretics have higher efficacy.
Sir then Why Carbonic Anhydrase inhibitors doesn't increase Negative free water clearance as after Loop urine will go to Collecting duct ?
Carbonic anhydrase inhibitors act in the proximal tubule. In this part of nephron there is iso osmotic absorption of water. So neither positive nor negative free water clearance.
Most of the solutes that reaches the loop and distal tubules are reabsorbed .. so there isn't an increase in negative free water clearance. Hope this clears your doubt
thank u
What is the significance of free water clearnace
When body is in water surplus state body removed excess water and if it is salt and water deprived..there is negative free water clearance. Primarily regulated by ADH
Either you are wrong or KDT is wrong.
Confusing approach
Thank you so much sir
Thank you sir
Thnk u soo much sir