halfway through nursing pharm semester and I am finally beginning to understand pharmacokinetics SOLELY due to your videos and lectures. thank you SO MUCH!
You have helped so much with the videos you are posting. Finally I can understand what my pharmacy book describes in a more complicated way. Thank you!
Just a note, at 4:57 you mistakenly said that tylenol forms a "Non-toxic" metabolite. Its byproduct is NAPQI (N-acetyl-p-benzoquinone imine), which is toxic. You stated correctly in a previous video that acetaminophen is an example of a drug that goes from non-toxic to toxic so I'm sure this was just a slip-up. Just wanted to put an FYI for anyone that might not have seen the previous video. Thanks for the videos!
But he said that 95% of acetaminophen is converted to non toxic metabolite which is true though he didnt mention about the remaining 5% toxic metabolite NAPQI ( which he should have done) otherwise his statement is correct but incomplete
I get what happens in second pass metabolism but I need a more zoomed out view of what that means compared to first pass. First pass made a lot of sense to me but I'm a little lost in the weeds for second pass
Thanks For the Great Explanation , but what about the Drug Having The O group after it has been oxidized by CYP 450 in Phase 1 , does that count by default as part of the Drug when it undergoes Phase 2 ? Thanks :)
This video was very well explained, so easy to follow and understand in such a short time. Excellent video.
Love. Love , Love!!!!
You've saved me from a slow pharmacokinetic DEATH!!!
halfway through nursing pharm semester and I am finally beginning to understand pharmacokinetics SOLELY due to your videos and lectures. thank you SO MUCH!
you are a good teacher...thanks for helping alot of people out there.
double likes to all your lectures so far! all on point!
You have helped so much with the videos you are posting. Finally I can understand what my pharmacy book describes in a more complicated way. Thank you!
"Areo Saffarzadeh
Cardiothoracic Surgery Resident at Yale-New Haven Hospital"
You are the next Christina Yang
Excellent,detailed & to the point.
Thank you so much for such a wonderful & informative video...🎉
Perfect amount of info for me. Really helped make sense of concepts for a graduate nursing student. Thanks.
You're getting me through medical school! Thank you!
love your videos!!!!
they are absolutely fantastic!!!!! :D thank you for making them!!! they are really a life savor for my exam study :D
Just a note, at 4:57 you mistakenly said that tylenol forms a "Non-toxic" metabolite. Its byproduct is NAPQI (N-acetyl-p-benzoquinone imine), which is toxic. You stated correctly in a previous video that acetaminophen is an example of a drug that goes from non-toxic to toxic so I'm sure this was just a slip-up. Just wanted to put an FYI for anyone that might not have seen the previous video. Thanks for the videos!
But he said that 95% of acetaminophen is converted to non toxic metabolite which is true though he didnt mention about the remaining 5% toxic metabolite NAPQI ( which he should have done) otherwise his statement is correct but incomplete
Man you are good at exsplaning this crap. Thank you so much you have really help me. God bless you.
thank you is an understatement........pharmacology just got easier
Your videos are amazing - Thanks for making difficult concepts easy to understand!
These videos are just perfect and so helpful, thank you!
Sir , your videos are just awesome 👏🏻 and thankyou a lot 😊😊
thankyou for the awesome lecture. your method of teaching made the concept easy to grasp~
Thank you it really helped me get the basics of pharmacology. God bless you
Thanks again for making pharmacology understandable!
Wouldn't the enzyme be N-Acyl transferase because of the sulfur molecule linking the CoA to the acetyl group?
I cannot thank you enough! You really saved me!
Thank you! you are an excellent teacher!
Thanks, your videos are great, did too much daydreaming in my lectures ;)
Your videos are great. Thank you so much.
I get what happens in second pass metabolism but I need a more zoomed out view of what that means compared to first pass. First pass made a lot of sense to me but I'm a little lost in the weeds for second pass
where is non-p450 explanation I can't find it?
Caffeine is metabolized by CYP1A1/2, which also happen to be induced by smoking.
Fantastic video!!
thank you very very much.....
it's like you've saved me from death
thank you again and waiting for clinical pk videos
Thanks For the Great Explanation , but what about the Drug Having The O group after it has been oxidized by CYP 450 in Phase 1 , does that count by default as part of the Drug when it undergoes Phase 2 ? Thanks :)
Phase 2 metabolism could happen to the drug directly or after phase 1 reaction.. The nucleophile like OH or SH or NH should be existed..
You're very good! Do you have biochem videos? :)
Is it supposed to be CYP2C8 or CYP2C9?
great lecture!
Excellent stuff ! thank you
Excellent!
Thank you, thank you, thank you!!!!
Thank you soo much! This is really helpful! :)
Thumbs up for people making things simple :)
THANK YOU VERY MUCH !!
make more videos please
Awesome!
Thank you so much
thanks for the help.
awesome!
thank you so much ^-^
very good
Thanks. But you said nothing about type 1 and type 2.
4:11
phase 2 reactions need high energy requirement....
hello..can you please elaborate what is glutathione conjugation because i need it in my report tommorow,..
cooooool
Not sure if it is really simple and easy or I am not understanding lol
Thanks anyway :)
Thanks !! XD
Slick
U method of teaching is too gd