Sir, can you please tell us the cut-off for the value of ki67 to be considered as highly proliferative tumor? Also can you mention (maybe in a separate video) where ki67 is implicated in the cell's signaling cascade and why is it considered as the index of proliferation
Ki67 index cut-off is variable and depends upon the tumour itself... In case of a relatively benign tumour, increased Ki67 levels indicate poorer prognosis, so the respective cutoff score will also be less for a benign tumour... For example, Ki67 cutoff will be relatively higher for Burkitt's than will be for say BCC
Ki67 is a nuclear protein expressed in late G1, S, G2 stage and undergoes ubiquitination late in M phase... Almost nil in G0 and early G1... So it is obviously implied that high levels of Ki67 means a higher rate of cellular division.
@@RouxEnYHepaticoJejunostomy thank you so much, that question was in my mind for a long time which you crisply clarified. Thank you for reading my post and for the prompt very enjoyable response.
Thank you so much sir for so many efforts you are putting in for us🥺❤️❤️ Jai Shri Krishna Radhe Radhe 🙏🏻🙏🏻 Sir one request plz make videos on Endometrial Cervical and ovarian cancers🙏🏻🙏🏻
Thank you sir
Simplest explanation ever seen..
Thank u so much sir..❤
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Thank you sir ❤️❤️❤️❤️
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Thank you sir,sir please take one session on ovarian and testicular tumours,it is very confusing
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Thankyou sir❤
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Sir please inicet more topics per day
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Sir can we have some video regardin rbc disorder wbc disorder and platelet disorder like lymphona leucemias bernard soulier wiskot etc
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Sir, can you please tell us the cut-off for the value of ki67 to be considered as highly proliferative tumor? Also can you mention (maybe in a separate video) where ki67 is implicated in the cell's signaling cascade and why is it considered as the index of proliferation
Ki67 index cut-off is variable and depends upon the tumour itself... In case of a relatively benign tumour, increased Ki67 levels indicate poorer prognosis, so the respective cutoff score will also be less for a benign tumour... For example, Ki67 cutoff will be relatively higher for Burkitt's than will be for say BCC
But mostly it's like... More than 20% high grade, 10-20% intermediate grade and so on
Ki67 is a nuclear protein expressed in late G1, S, G2 stage and undergoes ubiquitination late in M phase... Almost nil in G0 and early G1... So it is obviously implied that high levels of Ki67 means a higher rate of cellular division.
@@RouxEnYHepaticoJejunostomy thank you so much, that question was in my mind for a long time which you crisply clarified. Thank you for reading my post and for the prompt very enjoyable response.
@@RouxEnYHepaticoJejunostomy maybe i can refer to you whenever i have more doubts 😊
Thank you so much sir for so many efforts you are putting in for us🥺❤️❤️ Jai Shri Krishna Radhe Radhe 🙏🏻🙏🏻 Sir one request plz make videos on Endometrial Cervical and ovarian cancers🙏🏻🙏🏻
🕉❤️🙏
Thank you sir