I'm a human biologist and a lot of my colleagues are currently volunteering to conduct diagnostic tests. For our laboratory, it is not entirely clear yet if we will join but I'll make a video about my experience if we are enrolled! Looking forward to Ninja Nerd Science's video!
Joining the fight in a few days! First we'll get a hands-on training. I'll be in the pipetting team. 200.000 samples still need evaluation at Ghent Uni hospital alone. 9 times 96-well plates per shift (4h), with a team of 5 people...and this is only prior prepping to the RT-qPCR tests, which are done by a qPCR biotech lab in our nearest biotech park...
Pumudu Nilmanthi my understanding of it is that it can be a number of things but multiple organ failure seems to be common, not directly lack of oxygen. The inability to breathe can be ameliorated using mechanical ventilation but when you start having to add dialysis and several other things on top of it the prognosis tends to not be good.
Thank you Zach. You really know how to teach! Although I am not in the medical or science field like most of your followers, you present information in a way even I can understand. Stay safe. Keep doing this wonderful work.
Can you please do a video explaining serum chemistry results (what increased/ decreased values represent, which organ systems they represent/ etc)? That would help me tremendously!!
Incredible videos! Slight correction to the RT-qPCR protocol. The "light" signal comes from a fourth component that you didn't mention: "probes." These probes are short DNA sequences that have a fluorescent "tag" on them that only fluoresces when they bind to a target sequence. In this case, the target sequence would be a small region of the SARC-CoV-2 genome that is between the primer binding sites. If target viral DNA is present the number of bound, fluorescing probes will increase exponentially over PCR cycles and once a certain threshold of fluorescence is crossed we'd classify the sample as positive for the virus.
I would like to know why higher metabolic rate and activity(physical) levels seems to correlate so highly to the severity of illness in COVID-19 patients. I suspect it has to do with the interaction of the spikes on the virus and the ACE2 receptors. If the nature of the bond was purely chemical, then increase in temperature caused by fever should increase the number and quantity of the bonds attaching the spikes to the receptors thereby speeding up the infection process and making it more efficient. We know that chemical reactions double for every 10ºC. The febrile response in humans and other higher level vertebrates would be counter indicated if that were the case. By indirect reasoning, the process must be more of a physical process similar to docking the Lunar Excursion Module (LEM)(see 1969). Such a process would be greatly hindered by turbulence from movement caused by metabolic activity (jump shots, slam dunks, jogging etc) and increase in body temperature. Temperature is essentially the measurement of how much molecules vibrate. This increase vibration in bacteria can be observed under high magnification microscopy. In short, younger people have higher metabolism and a more active lifestyle, reference for example the perpetual motion machines that are children. Older people, those with restricted mobility, and other conditions keeping them bedridden will have these miniature LEM vehicles docking and boarding 24 -7. The more active amongst us are would only have the LEMs docking in our sleeping hours. This may explain why when I have had the flu, I always feel worse in the morning but if I suck it up and head to work, I feel much better and especially if I go to my lunchtime fitness class.(target heart rate baby!). If the process were predominantly chemical bonding in nature, I would expect the infection to expand radially and exponentially from the first point of infection like a bacteria in a petry dish. CT scans of the lungs show the diagnostic ground glass opacity(GGO) texture which to my eye mimics the three dimensional patterns observed in other systems I have studied. Looks to me to be fractal suggesting a random likelihood for any ACE2 receptor to be engaged by the virus. This would be another line of reasoning suggesting that a mechanical process is at play rather than chemical. The implication goes to treatment suggesting the worst thing to do is rest in bed.
Thanks for these wonderful videos sir. I owe you so much. Love You So Much. Because of you, I can able to understand these medical research papers despite an engineering background. Excellent teaching.
Huge thanks ,after watching all the videos that you putted on it as a medical student I have more confidence of that I can help in case I was needed since you explained all the steps to deal with this patients, so glad you guys make all this available for us, been reading articles and researches about it but never as smooth as how you present it , all blessing
I'm still a little confused by the diagnostic process and how SARS-COV2 is differentiated from other viruses. Almost all viruses present with antibody production, RNA+DNA and objective/subjective signs of infection- so how specifically are they told apart when a patient presents with all/some of these symptoms? My other concern is- are full respiratory viral panels being done before diagnosing patients with suspected COVID-19?
Smart question . Apparently there is little information about how they developed the primers for pcr test - these primers have to be so unique to the novel covid19 for the diagnosis to be reliable - The Chinese took lung fluid from 9 patients and they extracted out particles they assumed was the virus - this is unfortunately how science is conducted these days. No validation , no confirmation and no solid peer review process - and we have smart people like zach that goes along what he reads on google without proper critical thinking - brave new world indeed !
In Russian there is a saying "arms grow from the right place" when describing a person who is doing everything very well. Both the explanation and the straight lines on the board are incredible! (I have never seen such long rulers, so the Master Ninja Nerd must have very good skills of drawing straight lines as well). Brilliant work, many many thanks!
I love your lessons, you know what they remind me off? Tony Buzan Mind Maps, in other words the best way to retain and learn. Fantastic, if only you could replica yourself so there could be more teachers just like you everywhere!
Thank you for your covid-19 teaching method, so informative and easy to understand, my father passed on August 6 from pneumonia due to covid 19 at St.Jude Hospital in Fullerton, we had no idea on how to deal with his condition being quarantined at home, and only able to speak to doctor and nurses over phone and facetime, that we self educated with your youtube course . I understood when hospital staff would call to give me his daily updates, in fact, I would ask additional questions that they were stunned that I knew so much detail, certainly thanks to you! God bless you Zach!
it would be great if you could highlight at the end which "tools" can/should be "best" used at what stage of COVID19: i.e. early, mid, late, recovery, relapse.
I am integrating and developing a memory for your method of explanation now, at first it was a bit faster for me, especially the American ascent and sometimes you pronounce the words a little bit faster, but my subconscious is getting used to it now, i am loving it... Thank Zack and Team. Again, Please Please We Need More Videos In The Molecular Biology Section Please Please, I just Realized you do have some ideas in Molecular Biology, would great if you do some videos on some basic molecular assays techniques... THANK YOU AGAIN. WE OWE YOU AND THE TEAM ALOT I am a STUDENT of Medical Biochemistry and Molecular Biology
It is a rare gift to have the ability to clearly and concisely communicate one's knowledge in a lecture despite the high level of education and knowledge behind it. Keep up the good work, you have the gift. Your efforts are inspiring and far more reaching than you may expect. I look forward to your next presentation.
I thought they dropped the febrile benchmark for COVID-19? Something like 95% had fever over 99.5 F or something like that? Important since it's one of the first symptoms, definitely the most monitored first vital for this outbreak.
Just one correction for the IgG IgM test. The strips are not coated with capture antibodies but with SARS antigen that trap SARS speciifc antibodies if the patient has them. Coated Anti-IgG or anti-IgM them will bind to the SARS specific antibodies if present. The key is which antigens are used to coat as this will determine the specificity of the test. The use of capture antibodies would be useful for a point of care SARS detection test. Great videos and keep up the great work.
When does increased heart rate (not presented as a symptom in this video) happen in the COVID-19 infection timeline and what causes it? I have noted this in every infection I have had since 1974 for influenza, norovirus, meningitis, gastrointestinal infections (montezuma's revenge). For influenza, I have personally measured the increase in resting heart rate occurring 5 to 7 days before first symptoms (headache, fever). In COVID-19, if this tachycardic response occurs prior to other symptoms (pre-symptomatic) or in individuals who are truly asymptomatic, this may provide a simple diagnostic tool to signal people they should self-isolate and quarantine till the symptom stops or other symptoms more specific to COVID-19 present. This would essentially self-remove anyone who has contracted the virus from general circulation before they are infectious (to a statistically significant amount) and take away our major challenges in slowing the spread, namely asymptomatic/nonsymptomatic spreaders, insufficient quantity of tests, testing facilities and personal in the form of testers, testing machines and contact tracers. We will always be 4 or 5 days behind the virus unless we can find a way to diagnose potential cases before they present. Its kind of like cancer, if you can catch it during the pre-Cancer or early stages, your success rate for a cure is high!
I disagree with your meaning about first patient. He can have infection, but IgM cant be so fast, because theyare starting to produse in 5-7 days time. So first patient can have an infection, but he does not have any imunity.
Zach, aren’t S Proteins present in many viral infections, like Influenza A/B, or rhinovirus? I’m just trying to figure out the rate of false positives with performing only serology and not combining it with RT-PCR.
Don Herbert my understanding is that a lot of rapid tests give false positives for any kind of coronavirus being present, but I'm not sure of RT-PCR with respect to this subject. Just thought it might add something, since a lot of testing is not done by RT-PCR but the rapid testing kits that have much lower specificity to SARS-Cov-2.
Good day doc. I have a question, If the person had a recent viral infection of any type, would that person be positive in RAPID TESTING and RT-PCR test?
It’s more of a statistical answer couple with the fact that this is a novel virus our bodies haven’t ever had a chance to build an immunity against/for yet
Top! I love your videos ... I just think you should add subtitles in Portuguese, Spanish ... because we from other countries suffer with automatic subtitles from TH-cam ... very bad ... I think the reach of your videos would increase a lot in the countries of latin america ... i'm from brazil ...
Would it be possible to add hypoxia if occurring, anaerobic metabolism and lactic acidosis when discussing acid base balance in future presentations and/or updates. Thank you!
Beautifully explained lectures on all topics including this one on diagnostics! Would like to know the name and academic qualifications of this talented young man! God Bless Him!
haha he didnt mentione the fluorescent directly he left that open, but its okay, because not everyone will use the exact fluorescent and also i think he left out the use of probe to track the viral dna within the pool.. but its okay, not do dive too much into molecular biology... By the way he's done a great job
Hey Ninja nerd, love your content! Any way you could show a view of your drawings at the beginning of your videos so we can see the entire board? I like to screen shot your nice art and follow along taking notes while I watch but often is hard to get a good picture of the whole board. Thanks for the awesome videos!
Lymphocytes ever used for viral serology process instead of macrophages (which works more competently with neutrophils but with bacteria n particulates)?
I wish you could make a video to explain the process of infection of the coronavirus once inside the body and what it does to all the organs, please pleaaaaaase
Recently my wife attend the COVID19 Testing centre. She was presenting with stomach pain and diarrhea both identified by the clinic as potential signs of COVID19. These were not mentioned in you presentation. Can you help me understand the absence
I am eager to join the choir of the enthusiasts of your lectures! You make many things clear and logical, however, I have some difficulty with your usage of the term PCR sensitivity (9:10). I'd expect it means the lowest amount of RNA or virions possible to detect with this method, but then it would not be expressed in % and it would be very low. Should it mean how efficient this test is as a sieve catching out infected people from the studied population? But then shouldn't 70% mean that for any two to three patients properly diagnosed as COVID2 - positive, there would be one person undectected as carrier of this virus? I do not suppose you would just call such efficiency good. So what is precisely the meaning of this 70% sensitivity value?
Are the IgG and IgM the same proteins produce from other diseases such as Waldenstrom macroglobulinemia? If so, can the Rapid test be used on people with other diseases like WM?
Excellent - wonderful- I will have to review again but Wow understandable- very helpful as i help family members with COVID - thanks - very helpful as I talk to the Docs - thanks
Hey Ninja Nerd! I am a Veterinary Technician not working with pets (kitty and Pooch) so much any more. I forgot how many similarities there in human and animal medicine. Enjoyed the refresher course Looking forward to more!!!( FYI for all that did not know scary Asymptomatic carriers are all over the animal kingdom we have gotten to close to the undomesticated ones🙀)
I’m not a doctor, but I listened to the whole thing. Amazing!!! I have a question. If passed immunity is passed on by the IgG antibody, can the mother pass the immunity on to her child?
Truly a natural teacher. A gift to all
Naaa, he's more of a Snowden of the biochemistry
I never went to Med School but the content on this channel is incredible.
So true bro
.
th-cam.com/video/VdisJbcSguc/w-d-xo.html
Best teacher in TH-cam 👌🇩🇿💯
Best teacher in the world!! 🥳🇫🇮
DrBeen is good too
@@-1nterruption-960 link please 😊
@@thaisvictoriamatias377 You don't have any courses on your channel 🤔😑
Your explanations make it look super easy! You’re the best!
Zach, thank you for your amazing content. You are the only reason I started my own channel.
u r a excellent teacher
I'm a human biologist and a lot of my colleagues are currently volunteering to conduct diagnostic tests. For our laboratory, it is not entirely clear yet if we will join but I'll make a video about my experience if we are enrolled! Looking forward to Ninja Nerd Science's video!
Joining the fight in a few days! First we'll get a hands-on training. I'll be in the pipetting team. 200.000 samples still need evaluation at Ghent Uni hospital alone. 9 times 96-well plates per shift (4h), with a team of 5 people...and this is only prior prepping to the RT-qPCR tests, which are done by a qPCR biotech lab in our nearest biotech park...
Life Lab Learner so is the main reason for a covid patient’s death is the inability of respiration? Is it because the lungs are filled with fluid?
Pumudu Nilmanthi my understanding of it is that it can be a number of things but multiple organ failure seems to be common, not directly lack of oxygen. The inability to breathe can be ameliorated using mechanical ventilation but when you start having to add dialysis and several other things on top of it the prognosis tends to not be good.
I would add a O2 Saturation check. It would help determine the health of the Respiratory system
He did at 22:43
Wtf do you think Spo2 is?
Thank you Zach. You really know how to teach! Although I am not in the medical or science field like most of your followers, you present information in a way even I can understand. Stay safe. Keep doing this wonderful work.
I love his videos, new to me but becoming a daily go to
Can you please do a video explaining serum chemistry results (what increased/ decreased values represent, which organ systems they represent/ etc)? That would help me tremendously!!
Shoutout to camera men! patiently listening and focusing the best frame! :)
Incredible videos! Slight correction to the RT-qPCR protocol. The "light" signal comes from a fourth component that you didn't mention: "probes." These probes are short DNA sequences that have a fluorescent "tag" on them that only fluoresces when they bind to a target sequence. In this case, the target sequence would be a small region of the SARC-CoV-2 genome that is between the primer binding sites. If target viral DNA is present the number of bound, fluorescing probes will increase exponentially over PCR cycles and once a certain threshold of fluorescence is crossed we'd classify the sample as positive for the virus.
I would like to know why higher metabolic rate and activity(physical) levels seems to correlate so highly to the severity of illness in COVID-19 patients. I suspect it has to do with the interaction of the spikes on the virus and the ACE2 receptors. If the nature of the bond was purely chemical, then increase in temperature caused by fever should increase the number and quantity of the bonds attaching the spikes to the receptors thereby speeding up the infection process and making it more efficient. We know that chemical reactions double for every 10ºC. The febrile response in humans and other higher level vertebrates would be counter indicated if that were the case. By indirect reasoning, the process must be more of a physical process similar to docking the Lunar Excursion Module (LEM)(see 1969). Such a process would be greatly hindered by turbulence from movement caused by metabolic activity (jump shots, slam dunks, jogging etc) and increase in body temperature. Temperature is essentially the measurement of how much molecules vibrate. This increase vibration in bacteria can be observed under high magnification microscopy. In short, younger people have higher metabolism and a more active lifestyle, reference for example the perpetual motion machines that are children. Older people, those with restricted mobility, and other conditions keeping them bedridden will have these miniature LEM vehicles docking and boarding 24 -7. The more active amongst us are would only have the LEMs docking in our sleeping hours. This may explain why when I have had the flu, I always feel worse in the morning but if I suck it up and head to work, I feel much better and especially if I go to my lunchtime fitness class.(target heart rate baby!). If the process were predominantly chemical bonding in nature, I would expect the infection to expand radially and exponentially from the first point of infection like a bacteria in a petry dish. CT scans of the lungs show the diagnostic ground glass opacity(GGO) texture which to my eye mimics the three dimensional patterns observed in other systems I have studied. Looks to me to be fractal suggesting a random likelihood for any ACE2 receptor to be engaged by the virus. This would be another line of reasoning suggesting that a mechanical process is at play rather than chemical. The implication goes to treatment suggesting the worst thing to do is rest in bed.
It doesnt, thats complete bullshit. Higher metabolic rate and covid severity have no correlation.
Its an idiotic notion
Thanks for these wonderful videos sir. I owe you so much. Love You So Much. Because of you, I can able to understand these medical research papers despite an engineering background. Excellent teaching.
Huge thanks ,after watching all the videos that you putted on it as a medical student I have more confidence of that I can help in case I was needed since you explained all the steps to deal with this patients, so glad you guys make all this available for us, been reading articles and researches about it but never as smooth as how you present it , all blessing
I'm still a little confused by the diagnostic process and how SARS-COV2 is differentiated from other viruses. Almost all viruses present with antibody production, RNA+DNA and objective/subjective signs of infection- so how specifically are they told apart when a patient presents with all/some of these symptoms? My other concern is- are full respiratory viral panels being done before diagnosing patients with suspected COVID-19?
This is the question I wanted answered and why I searched out this video.
Smart question . Apparently there is little information about how they developed the primers for pcr test - these primers have to be so unique to the novel covid19 for the diagnosis to be reliable -
The Chinese took lung fluid from 9 patients and they extracted out particles they assumed was the virus - this is unfortunately how science is conducted these days. No validation , no confirmation and no solid peer review process - and we have smart people like zach that goes along what he reads on google without proper critical thinking - brave new world indeed !
In Russian there is a saying "arms grow from the right place" when describing a person who is doing everything very well. Both the explanation and the straight lines on the board are incredible! (I have never seen such long rulers, so the Master Ninja Nerd must have very good skills of drawing straight lines as well). Brilliant work, many many thanks!
6:43: asks a rhetorical question.
"Well, I'm glad you asked"
Thanks for your education team.
I love your lessons, you know what they remind me off? Tony Buzan Mind Maps, in other words the best way to retain and learn. Fantastic, if only you could replica yourself so there could be more teachers just like you everywhere!
Thank you Zach. You are a gift to the medical community.
You are absolutely a saviour....hats off to you and a big thank you for sharing...
Thank you for your covid-19 teaching method, so informative and easy to understand, my father passed on August 6 from pneumonia due to covid 19 at St.Jude Hospital in Fullerton, we had no idea on how to deal with his condition being quarantined at home, and only able to speak to doctor and nurses over phone and facetime, that we self educated with your youtube course . I understood when hospital staff would call to give me his daily updates, in fact, I would ask additional questions that they were stunned that I knew so much detail, certainly thanks to you! God bless you Zach!
Ninja everytime I watch your videos I feel smart 🤓 thanks
Thank you for your great teaching videos. I give also the link of your channel to my undergraduating students. You make really good job.
Rhonchi in the Bronchi, Crackles in the Back, Wheezes in Lateral.
it would be great if you could highlight at the end which "tools" can/should be "best" used at what stage of COVID19: i.e. early, mid, late, recovery, relapse.
Love your Videos !! You have helped me pass every class.
Please make a video about covid-19 treatment and what drugs are used ,their actions ....big fan from India😍😘
his videos helps me when I took my ASCP exam in 2018❤
This is my exam to pass
Thanks Broski from morocco , i am glad i find out you'r channel few weeks ago , it feeds the science nerd inside of me hahahahha
Thank you for everything
From Algeria
oh wow great to see another algerian who follows this channel! :D
🇩🇿💯🤣
Amazing ..ton of info in 40 min
.
I am integrating and developing a memory for your method of explanation now, at first it was a bit faster for me, especially the American ascent and sometimes you pronounce the words a little bit faster, but my subconscious is getting used to it now, i am loving it... Thank Zack and Team.
Again, Please Please We Need More Videos In The Molecular Biology Section Please Please, I just Realized you do have some ideas in Molecular Biology, would great if you do some videos on some basic molecular assays techniques... THANK YOU AGAIN. WE OWE YOU AND THE TEAM ALOT
I am a STUDENT of Medical Biochemistry and Molecular Biology
It is a rare gift to have the ability to clearly and concisely communicate one's knowledge in a lecture despite the high level of education and knowledge behind it. Keep up the good work, you have the gift. Your efforts are inspiring and far more reaching than you may expect. I look forward to your next presentation.
Thank you again Zach!!!
I thought they dropped the febrile benchmark for COVID-19? Something like 95% had fever over 99.5 F or something like that? Important since it's one of the first symptoms, definitely the most monitored first vital for this outbreak.
Natural teacher! Thank you
Respect from INDIA 🇮🇳
Just one correction for the IgG IgM test. The strips are not coated with capture antibodies but with SARS antigen that trap SARS speciifc antibodies if the patient has them. Coated Anti-IgG or anti-IgM them will bind to the SARS specific antibodies if present. The key is which antigens are used to coat as this will determine the specificity of the test. The use of capture antibodies would be useful for a point of care SARS detection test. Great videos and keep up the great work.
Couldn't find link to pooling method.
This guy is an amazing teacher
you really ROCK . I guess this is the most usefull video about COVID 19 diagnosis on youtube and it's very simplified, thank you very much
Thank you very much, easy to understand.
You are an amazing teacher !!!
Your videos are just amazing
You are helping e learn so much about my lung disease. Thank you
Thanks a lot, mate.
When does increased heart rate (not presented as a symptom in this video) happen in the COVID-19 infection timeline and what causes it? I have noted this in every infection I have had since 1974 for influenza, norovirus, meningitis, gastrointestinal infections (montezuma's revenge). For influenza, I have personally measured the increase in resting heart rate occurring 5 to 7 days before first symptoms (headache, fever). In COVID-19, if this tachycardic response occurs prior to other symptoms (pre-symptomatic) or in individuals who are truly asymptomatic, this may provide a simple diagnostic tool to signal people they should self-isolate and quarantine till the symptom stops or other symptoms more specific to COVID-19 present. This would essentially self-remove anyone who has contracted the virus from general circulation before they are infectious (to a statistically significant amount) and take away our major challenges in slowing the spread, namely asymptomatic/nonsymptomatic spreaders, insufficient quantity of tests, testing facilities and personal in the form of testers, testing machines and contact tracers. We will always be 4 or 5 days behind the virus unless we can find a way to diagnose potential cases before they present. Its kind of like cancer, if you can catch it during the pre-Cancer or early stages, your success rate for a cure is high!
Great job......some people are so smart. Thanks
Thank u for such amazing content!!
I disagree with your meaning about first patient. He can have infection, but IgM cant be so fast, because theyare starting to produse in 5-7 days time. So first patient can have an infection, but he does not have any imunity.
sceptical? or your dont know COVID-19 can be reactivated on "recovered patients"
Beautifully comprehensive. Thanks.
I ?
Thanks for teaching.
Great video. Very helpful and simplified.
👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻
He is best of best good teacher
Great work! I look forward to your next talk.
Just wow , thanks a lot 🌷
Zach, aren’t S Proteins present in many viral infections, like Influenza A/B, or rhinovirus? I’m just trying to figure out the rate of false positives with performing only serology and not combining it with RT-PCR.
Don Herbert my understanding is that a lot of rapid tests give false positives for any kind of coronavirus being present, but I'm not sure of RT-PCR with respect to this subject. Just thought it might add something, since a lot of testing is not done by RT-PCR but the rapid testing kits that have much lower specificity to SARS-Cov-2.
BEST CHANNEL IN TH-cam
Good day doc. I have a question,
If the person had a recent viral infection of any type, would that person be positive in RAPID TESTING and RT-PCR test?
thank you very much..
Amazing and engaging lecturer
Amazing lectures! So brief yet so fully explanatory!! He'll probably be a big help for me through my med school:))
Can anyone please explain how spreading ratio of COVID-19 thats 1:3 is calculated
th-cam.com/video/YRfwZcLeOm4/w-d-xo.html
It’s more of a statistical answer couple with the fact that this is a novel virus our bodies haven’t ever had a chance to build an immunity against/for yet
Thanks for keeping us upto date regarding Covid-19.
Love,
Ninja Nerd 🙂
Top!
I love your videos ... I just think you should add subtitles in Portuguese, Spanish ... because we from other countries suffer with automatic subtitles from TH-cam ... very bad ... I think the reach of your videos would increase a lot in the countries of latin america ... i'm from brazil ...
Excellent brother. You are genius. Very very helpful.
You’re a great teacher man! This content is very useful to review topics from med school and keep myself updated, thank u!
This stuff inspires me to do medicine
Zach!!! Only Zach!! 🥺🥺❤️❤️
Thank you 😊
Excellent teaching!
You’re an amazing teacher! Thank you very much for the impact you’re making in our lives as medical students 👍👍🙏🏻
Would it be possible to add hypoxia if occurring, anaerobic metabolism and lactic acidosis when discussing acid base balance in future presentations and/or updates. Thank you!
Beautifully explained lectures on all topics including this one on diagnostics!
Would like to know the name and academic qualifications of this talented young man! God Bless Him!
very good lecture.... clear concepts
thank you, ur lecture helps a lot in understanding my studies for my research
Mind doing another COVID update video? I feel like a lot has happened since April
Super job Zach, quite amazed at your precision in speed method,thanks
Just like to know why they say that serology is unreliable
SYBR gold fluorescent dye will intercalate with the dsDNA as it’s formed with the tan polymerase during the PCR.
haha he didnt mentione the fluorescent directly he left that open, but its okay, because not everyone will use the exact fluorescent and also i think he left out the use of probe to track the viral dna within the pool.. but its okay, not do dive too much into molecular biology... By the way he's done a great job
This is so informative and refreshing.
super clear and well structured material - well done , your future will be great
U r the best boss
Hey Ninja nerd, love your content! Any way you could show a view of your drawings at the beginning of your videos so we can see the entire board? I like to screen shot your nice art and follow along taking notes while I watch but often is hard to get a good picture of the whole board. Thanks for the awesome videos!
Lymphocytes ever used for viral serology process instead of macrophages (which works more competently with neutrophils but with bacteria n particulates)?
You're a beast man. Look like you could be a massive linebacker
I wish you could make a video to explain the process of infection of the coronavirus once inside the body and what it does to all the organs, please pleaaaaaase
Love your work!!
Recently my wife attend the COVID19 Testing centre. She was presenting with stomach pain and diarrhea both identified by the clinic as potential signs of COVID19. These were not mentioned in you presentation. Can you help me understand the absence
After watching Zach's videos I am now conferred with the title, M. D. and a certified Microbiologist 👍👍👍
You're a Great Teacher, dude!👍
I think you should use high megapixel camera 📸📸
I am eager to join the choir of the enthusiasts of your lectures! You make many things clear and logical, however, I have some difficulty with your usage of the term PCR sensitivity (9:10). I'd expect it means the lowest amount of RNA or virions possible to detect with this method, but then it would not be expressed in % and it would be very low. Should it mean how efficient this test is as a sieve catching out infected people from the studied population? But then shouldn't 70% mean that for any two to three patients properly diagnosed as COVID2 - positive, there would be one person undectected as carrier of this virus? I do not suppose you would just call such efficiency good. So what is precisely the meaning of this 70% sensitivity value?
Can you do a lecture of neuroexam with rationale please? I learned a lot from you.thank you
You are a true genius. Keep it up
Are the IgG and IgM the same proteins produce from other diseases such as Waldenstrom macroglobulinemia? If so, can the Rapid test be used on people with other diseases like WM?
Excellent - wonderful- I will have to review again but Wow understandable- very helpful as i help family members with COVID - thanks - very helpful as I talk to the Docs - thanks
good job .great job
Hey Ninja Nerd! I am a Veterinary Technician not working with pets (kitty and Pooch) so much any more. I forgot how many similarities there in human and animal medicine. Enjoyed the refresher course Looking forward to more!!!( FYI for all that did not know scary Asymptomatic carriers are all over the animal kingdom we have gotten to close to the undomesticated ones🙀)
Can anyone explain how rt pcr technique helps to detetct the virus specifically? Video-8:35 .
I’m not a doctor, but I listened to the whole thing. Amazing!!! I have a question. If passed immunity is passed on by the IgG antibody, can the mother pass the immunity on to her child?