Lol honestly that is my bad 😅 I should have made my own graphics with chlorine instead of bromine but the ones I found looks so clean I couldn't help it
It doesn't work like that with super long acting benzos or phenobarbital. The high is still like 20 hours, and yes with phenobarbital it's half life is like 20 days, you are not feeling the phenobarbital for 20 days more like 10 to 12 hours yet you will test postive for weeks after it wears off.
I've made this, definitely don't try taking it since a lot of the dosage information is incorrect and it's got a half life of something like 37 DAYS. I wasn't back to normal for nearly a month, my wife still brings it up occasionally...
@lagrangiankid378 if you aren't going to listen to the SERIOUS AND EMPHATIC warnings to not do this, I would not recommend starting with something so large as 200mg. With a halflife of over a month, you would not process out all of the chlorobutanol for 5-8 months, with 6mg remaining at 5 months and finally reducing to >1mg at 8 months. I will not provide a suggested dosing amount as I am not a pharmacist not do I want to encourage anyone to attempt this, but anyone stupid enough to do this needs to be aware that a half-life time is the time to half the original dosage and should plan accordingly. You will be in a highly suggestive state for at least a month, you will have a bad time and you will make regrettable actions.
@@jacobbrown7367 200 mg is not that large of a dose for something with this level of psychoactivity. For comparison chloral hydrate is dosed at 500 to 1000 mg. The OP of this thread ingested a gram or so if I remeber correctly and this lead to overdosing. And (unlike you) I know precisely what the elimination half-life is (which by the way usually refers to blood levels, not to the total amount in the body). And by the way 37 days is the half-life as measured in vitro at a pH of 7.4, terminal elimination half life in vivo in healthy human subjects is reported to be only 10.3 days (C Tung et al., Biopharm Drug Dispos 1982). I have quite some free time as I'm currently taking a vacation so there's plenty of time to recover and this self experimentation won't have any significant consequence. I know what I'm doing and I'm highly prepared, experienced and equipped. I just asked some anecdotal dosage information as there is little or no human data on this obscure and very old CNS depressant.
You always take it a step further, I thought it would be just chloroform initially when I saw the title!👍 Btw, 1:52 the sep funnel is slowly dropping down, which is an alarming sign that accident could happen at some point.
I like to make every video a surprise that only rewards you if you actually take the time to watch to the end. I think its fun and a nice little way to foster continued interest (jury is still out on whether it'll work lol) And yeah I actually noticed the same thing.. I think its a "settling" due to the weight of such a large sep funnel on such a tiny ring stand. I did leave it overnight once or twice and it never failed, but it is still not ideal by any means. Think I'll probably bolt some bars to the inside of my fume hood for greater flexibility but also to support some of these heavier objects.
@@integral_chemistry I made a custom-made lattice inside my fume hood just to accommodate different clamps, I find setting up the clamp and stand every time quite annoying, stands are also prone to tip over which I am not a big fan of.
@DangerousLab thats exactly what I want to do, honestly I might have gotten the idea from one of your videos. Where did you source the metal bars you used for the scaffold?
you're thinking of sodium pentathol and it doesn't make you tell the truth you can even confess to things that never happened so it's worthless for interrogation,there was once a case where the police went looking for bodies a person claimed they buried in central park NY and there were never any bodies they just implanted the memory.
These types of hypnotic sedatives would likely render the person a deadhead and rather irritable as well similar to the first generation antihistamine like phenergan - horrible in large doses and even worse in even medium ones.
I love this video. I enjoy how your videos go step by step and not too many technical terms. Would you consider doing a video on SLU PP 332 in a pill form instead of as an injection?
Considering how readily available the chemistry is id would not be surprised that this is actively used in bioweapon attacks, dirty little tricks indeed.
Hm so maybe I wasn't using too much.. this stuff is just STRONGLY pigmented. As a side note I made para red as well and I want to try using it as a fabric dye, but I read that in order for the dye to be permanent it needs to be coupled with phenol or aniline. You know anything about this?
@@integral_chemistry Yes, azo violet is a fairly rich dye. The reference to phenols and amines refers to the coupling process itself and does not indicate an additional work step for fixation. I have to admit that the last time I dealt with textile dyeing was in my senior year - that was over 30 years ago. So here is a translated text from one of my school encyclopedias at the time: Developmental coloration: In contrast to direct dyes, developing dyes are created on the fiber. They are often azo dyes. Two components are required for their production, namely an aromatic as a coupling component and an aromatic diazonium salt. The coupling component is dissolved in a basic, aqueous medium. The fibers, which are mostly cellulose fibers, are soaked with it and then dried. They are then treated with the diazonium salt solution. The coupling reaction that creates the dye therefore takes place on the fiber. Like the vat dyes, the developing dyes are not water-soluble and therefore very wash-fast. Naphtol AS (3-hydroxy-2-naphthoic acid anilide), a derivative of naphthalene, is often used as the coupling component, which is why it is also referred to as naphtol-AS dyes. For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.
@@integral_chemistry The mention of phenols and amines does not mean an additional work step, but rather the well-known coupling reaction itself, which must take place directly on the textile and thus leads to a wash-fast color. For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.
@@integral_chemistry The concentration of the developer solutions influences the color depth of the dyed textile. Here are instructions for dyeing with Para-Red: Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B. Following these instructions (I dug out my notes that are over 30 years old) we dyed T-shirts in our senior year of high school chemistry class (of course the amounts of the solutions were adjusted accordingly). The instructions are probably universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.
Will it base-eliminate to the 1,1-dichloro, 2,2-dimethyl oxirane? Chlorines being about the same size as methyl groups...lipophilic! Then...slowly...interesting.
Thanks! I did wrap up the azo violet a few weeks ago, but I've just been too busy to do the voice recording and editing. Likely have it out within the next week or so. BTW I read that azo violet gives a color change with ammonium similar to the blue color change with magnesium. Would you happen to know anything about that?
@@integral_chemistry No, but I will try it out and report about it. Ammonium often is a disturbing ion in analytics, so it has to be driven out beforehand by boiling the test substance with sodium hydroxide solution.
I doubt it would be using this route, and I can't find any literature about it. May indeed be possible by another route, but fluoroform is really hard to work with (boils at like -80 degrees) and deprotonation wouldn't work due to the extreme electronegativity of fluorine. Also thank you very much! I was worried people wouldn't care much for this vid
An influencial German chemistry creator brought about my ban, because I dared to point out his mistakes publicly. 🙄 Feel free to ask the platform if they can reverse it. I am not overly optimistic about that.
Yeah youtube is not a particularly flexible platform.. and this guy doesn't sound very scientific. As scientists we are supposed to relish in and rely on other people out there with the knowledge to point out our mistakes. Can't imagine how boring science would be if I knew everything about everything and nobody out there knew enough to challenge me..
@@integral_chemistry The creators on this platform are mostly not interested in scientific discourse, but rather in being soldiers of fortune and cultivating vanity. Accordingly, openness to criticism is weak. People like us, who see mistakes not as a personal flaw but as an opportunity to grow professionally, are the exception here.
@@experimental_chemistry I have noticed that to be the case unfortunately. It is to the point that I've had several commenters on here surprised by how open I've been to their critique because they've come to expect hostility and defensiveness. Its honestly quite sad considering how valuable an open discourse could be in the TH-cam chemistry community..
Is it possible that the dichlorocarbene reacts to form tetrachloroethylene? That might explain why there’s still so much chloride even after completion.
That is definitely possible, honestly probable. I'm convinced there are definitely multiple side reactions going on here, not least because after the formation of the deprotonated version of the chlorobutanol, there a big chance that free oxygen just displaces a chlorine and closes in a ring with the adjacent carbon
Am I the only one that thinks the diagram at 4:00 describing the reaction looks like one guy puking and another guy with expolsive diarrhea followed by two crosses (presumably on the graves of the previous two guys)? Just what the heck is going on in this reaction???
hmm thats a good question. Honestly I think this is one of those types of drugs that it isn't really possible to become physically addicted to, but if there was something that had the same effect as an amphetamine for an entire month yeah you'd probably be addicted after a single dose.
@integral_chemistry addiction=/= physical dependence. If you have sedatives constantly in your system for even a week or two (such as benzodiazepines, alcohol, sleeping pills, etc) you will have mild withdrawal after stopping. I bet if you dosed this compound you would sober up in a day or two, not because the drug cleared your system, but because your receptors downregulated to compensate for the drug. When you do actually clear the drug I bet you would feel WD after that single dose.
They just haven't eaten before. It's loveliness smell is too nasty to consume, but to make that joke more fun, the question would have to be, "excuse me, does this cloth smell like chloroform?"
Yeah thats what I figured. I honestly am not sure if your body can even oxidize it at all, I think I read somewhere that it is metabolized by glucuronidation or sulphation, and then eliminated renally.
@@integral_chemistry I wonder if it could worsen liver or kidney function if there is already a reduced function of those organs. With its half life, I wonder if it could cause a stead and long term decrease in renal function for someone that has CKD and does not know it.
@@user-nu8in3ey8cif it’s that hydrophobic, probably not. Kidneys typically filter out H2O soluble compounds, that’s why the CYP enzymes and glucoronidation exists. I bet there is some reactive intermediate from depletion of glutathione from glucoronidation pathway saturation.
Some time ago i worked in a factory that (next to other stuff) made this bloody stuff in the tons range Gave us all sorts of problems with the centrifuge and discoloration and quality control Edit: The reason you can't find any literature about the reaction mecanism is, that the mecanism is not fully understood yet. I searched for it for the better part of a year and could only obtain some information on side products and reaction conditions Never again but very nice video once again
@@Aaron-zu3xn it would put you in a state of feeling dead for a month and change which sounds like something a necromancer would do to get close enough to the other side to talk to it lol
There's a paper out there that even describes terminal self-harm from ingesting mouthwash that contained chlorobutanol. Whether or not the incident was concomitant with other ingested substances due to the past behavior of the poor soul could be debated but it isn't seen as an anti-fungal, antibacterial additive in personal care products anymore.
Thank you so much! And yeah it got worse the more I read about it. Interestingly enough in my research I came across what is absolutely the most horrifying chemical I've ever heard of: EA-3167. It has the same effect as datura or extremely high dose Benadryl but with a psychoactive peak of 10 days instead of a few hours..
@@integral_chemistry Why do I get the feeling that EA-3167 got some research done on it by a certain 3 letter agency here in the states? They had a period where if it caused hallucinations or removed you from reality they figured they might be able to use it as a weapon of war. (Spoiler Alert: Not really, no.)
@@integral_chemistryI cannot begin to fathom how terrible this would be. I sitting here after the video thinking it would be like being on Ambien for a month... I thought about how bad my ketamine treatment experiences lasting that long. Not I'm sitting here trying to comprehend datura for a month.. absolutely wild stuff. Thank you so much for the videos and comments.
For anyone wondering, the effect is literally as having a flu without the pain and fever. You just get enormously letargic and dysphoric and fall asleep very easily. I imagine even hitting your head really hard is more recreational. The taste is like menthol flavoured sand.
Literally. There's some scary ones out there, this one is in the same area as benadryl where it's such a miserable experience they don't bother regulating it
Idk how accurate this is but I´ve heard that Adolf Von Baeyer synthesized barbituric acid from human urine and apple juice, to make sodium thiopental? Maybe this is something you could try and make a video about. Definitely gives the opportunity for some good video titles; "Making anesthesia from apple juice and pee" 😂
Huh I've never heard of that before but definitely worth looking into. I know you can make barbituric acid from malonic acid (which does occur in apples) and urea (which is definitely in pee lol). I'll have to check it out and see if its feasible
sounds fun, let's watch this video before it gets shadow banned by youtube. Love your stuff bro keep up the good work, i know TH-cam can be a cruel mistress sometimes.
@Apoptosis: Since this platform is ghosting all answers to my answering comments (accept for the ones from the creator himself, but even my own), I have to answer your question as a new comment: Never heard about the interfering properties of ammonium ions on detection of Mg with azo violet, so I tried it out immediately: no blue colorlack was formed nor did any other color change happen (except to yellow if the test solution is too acidic). Did you use distilled water to dissolve the ammonium salt? Azo violet is so sensitive on magnesium that it will even detect the traces present in tap water. Indeed ammonium often is an interfereing ion in analytics so it has to be boiled off as ammonia with sodium hydroxide beforehand then. But in this case it doesn't cause any problems. But there's one thing to take into account with this dye: the alkaline violet solution is sensitive to air. It becomes a brown liquid lost its indicator properties when standing open for a longer time. This can be prevented by adding a little ascorbic acid - and preparing the solution freshly everytime when needed.
Thank you very much for checking and letting me know! Also I don't have any idea why it keeps hiding your comments, I almost want to ask youtube support on Twitter why that might happen. In any case I hadn't tried the ammonium ion test yet (only read about it on Wikipedia). I also didn't realize until working with it just how EXTREMELY sensitive it is to magnesium ions. It's to the point that when diluted in a sufficient quantity of tap water it is certainly more blue than violet, and when I added 2M magnesium sulfate to a freshly-prepared alkaline sample of azo violet, I got a thick blue precipitate.. which I can't remember whether or not you mentioned in your video. The intensity of the colors with this one are actually such that it's hard to get good footage, and in all honesty I might just be using to much of the azo dye. This stuff seems like a little goes quite a long way
You could easily further purify the chlorbutanol through sublimation. Mix it well with some calcium chloride in a beaker to further dehydrate, then heat from the bottom and crystallize on top on the exterior surface of a round bottom flask filled with ice water.
Is this a common method for recrystallizing compounds that sublimate? I’m not far along in my chem education but it seems like that would cause a bit of loss.
I’m sure acetone on its own could be a sedative just based on how nasty it smells. It might end up being a one time use kind of thing but I don’t know. I’m not a chemist.
So I tried this back in 2017. I ate some, and despite its flavor, didn't puke. It was like plastic cloves amd didn't knock me out at all. It was a waste of chloroform, albeit the science was cool. You did it way better than myself, and you were right to not eat it. Think headache ❤
The smell becoming overwhelming and gross is probably due to how our scent receptors oxidize aromatic compounds, something about them becoming overloaded or the accumulation of side-products of oxidation forming complex molecules with other organics (from your tissues - hence the cancer/degenerative disease risk from many volatiles) that also get processed but register as rancid or acrid due to similarity with rotting meat or spoiled fruit smells.
Huh.. to be completely honest I've never considered that explanation before but it does make perfect sense. Also would explain possibly why the more reactive molecules (like pyridine) just smell bad instantly from the get-go
I was expecting this to be a synthesis of chloral hydrate. I remember hearing about 20 years ago that it's a very easy synthesis. Requiring you to just bubble chlorine gas through I think ethanol. Which sounds suspect and comes from the same source that claimed you can separate ether from hexane by mixing it with water and draining off the bottom water layer. But it's got me wondering how easy/hard the actual synthesis of chloral hydrate is. It would be a real treat if you could cover this one. If legally possible.
Hmm ill definitely look into it. I'm pretty sure legally that would be fine, lately the big concern is not getting stuff removed by youtube's AI. Lots of things like that get auto-flagged
Could that be used on an unsuspecting date? I'm just asking for my friend. Not for me for my friend. Would my date...uh I mean my friends date know what happened afterwards? Just asking for my friend. Not for me. Hehehe . Could I... uh I mean my friend get in serious trouble for that? Just asking. Hehehe 😃👋
@Apoptosis: By the way: if you have entered the same email address on your channel's AboutMe page as the one you used to set up your channel, I would strongly advise you to change your contact address as soon as possible. Otherwise, the risk of your channel being hijacked is high.
Oh yeah I had considered that possibility. I didn't use that email to set up the account, but for security reasons I'm considering setting up a third email just to be safe.. I always underestimate the willingness of bored idiots to hack into people's accounts just to make their lives miserable
Runaway haloforms are NO joke. I was doing one in an erlenmeyer flask and lost control of it. It sprayed hot bleach into my face and managed to get into my eyes, clouding my corneas for the rest of the evening. Instead of going to the ER, I went to sleep. Next morning I woke up fine. That was my last haloform
Glad to hear you were fine, that sounds terrifying.. You aren't kidding though, the sheer heat these type of reaction generate are honestly shocking and you really have to get it as cold as you possibly can (and even then expect the worst case scenario)
I certainly did lol. To be fair the one saving grace is that the effective dose is large enough that you're pretty much safe so long as you don't intentionally ingest any.. mostly because it isn't a "drug" in the more traditional sense
Really enjoying your videos as i always leran new things everytime i come to ur channel. please keep it up and keep uploading new videos to help more students who are studying chemistry and look up for such a content 🎉🎉❤❤
I liked and subscribed for more dope chemistry dude! 10 minute's and you somehow managed to explain like everything and anything i couldve wanted to know
@Apoptosis: There are problems with the answers to the answers again - this time also via the PC browser. Regarding your question about textile dyeing with Para-Red: The concentration of the developer solutions influences the color depth of the dyed textile. Here is a recipe: Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B. The recipe is universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.
Nice presentation. After this I really want to ask if maybe* is it possible the synthesis of zipeprol or it's too difficult for a you tube video.i don't know. thank you.
I could check it out! It would definitely be much more complex, but my main concern would be with legality. I'll check first to make sure it wouldn't get me in trouble but if it clears I'd love to give it a try
Yeah my bad. Bromine is much more often used in this reaction and so the general mechanism I used shows bromine instead of chlorine. I made a note about it on screen but it's quite small
IME, smells like Pine-Sol. Also, it's hell on your liver, so maybe find a better sedative? But I never experienced a month of sedation...more like several hours. There are a few "trip reports" and none of them noted it being remarkably long-acting.
Yeah sodium hydroxide would work fine, I just used the KOH because it tends to dissolve easier in organic solvents. Carbonate aren't alkaline enough for effective deprotonation though
Nice video! Would be interesting to see if you could sublimate to purify it with a cold finger or something lol. I might go digging in literature or ask on sciencemadness if anyone can pull up a reaction scheme for the reaction tbh, curious that's not readily avialible if at all
the metabolism of the substance occurs in the liver and the 4 carbon chain might be more fat soluble leading to longer time for total bodily elimination. Just a thought
Ooh honestly this is one of the more feasible ideas I've heard. It is unfortunate that with chemicals like this that have clearly better alternatives, nobody is ever going to really bother with clinical trials at this point and so we can really only guess at the biochemical mechanisms for such things
@@integral_chemistry went to college for pharmacology and it reminded me of other halogenated hydrocarbons beyond the basic 2 carbon structure that would be more volatile and certainly not aromatic
Bro it has to be used by injection? Could you create or at least share some names that they show in movies. Chloroform obviously cant be used for smell. Thats just movie crap. Kindly do give this information.
Tymoleptic drug Not hypnotic. That would be a misnomer! It makes one care less about stuff. I don't know the word in English, but Norwegians calls it "likegladssprøyte" when administered to dogs before the final shot. Makes them a whole lot easier to kill!
@@chri-k Hypnotic drug(s) does not exist! OK I inferred from earlier readings. Still: The closest we have come to a "hypnotic" drug is to use tymoleptic before interrogation. I can't feel sorry for telling you this. I still don't have a source that tells me otherwise (I know this from 20+ years ago. Don't ask me how or why though)
@@jrnandreassen3338 Again, hypnotic drugs do exist, and have nothing to do with thymoleptic drugs, interrogation, or hypnosis. A hypnotic drug is one that induces sleep.
Sorry bro I came late to watch your video and I'm a new subscriber but I'm trying Comment here if not You read it up to you but if you read it I'm excited I have a question for you Apoptosis can you make Chloroacetone
Interesting and thanks. Don't think that I've heard of this one and I agree about the solubility, in fat most likely. Chloralhydrate used to be a very popular item, back in the 50s, I've heard. As it was cheap and easy to make, relatively, anyway. Medical doctors used to write a lot of prescriptions, back in the day. Never made it myself, read about it.
There's already like 20 uploads of this on TH-cam so I figured it was fine. I just thought it would be educational to go more in depth on the molecular mechanisms of this process than I've seen done before
@@integral_chemistry your intention may be good, but people will try this and abuse this and maybe even kill themselves or someone else with this info.
Narrator: all these hydrogens are replaced with chlorine.
Graphics: bromine, everywhere.
Audience: let’s make chloroform jokes.
Lol honestly that is my bad 😅 I should have made my own graphics with chlorine instead of bromine but the ones I found looks so clean I couldn't help it
That's shamefully inconsiderate,@@integral_chemistry
Feeling crossed for a month sounds like absolute hell on earth
Yeah sounds like the worst torture possible. Tbh this chemical got scarier and scarier the more I read about it
Some people looking to not be in this reality would find its extended action a positive, but the hat man will not have that 🎉
It doesn't work like that with super long acting benzos or phenobarbital. The high is still like 20 hours, and yes with phenobarbital it's half life is like 20 days, you are not feeling the phenobarbital for 20 days more like 10 to 12 hours yet you will test postive for weeks after it wears off.
Oh, yes, this is the longest acting substance, ever heard! 😮
Speak for yourself. My life be like ooooowah oowah
I've made this, definitely don't try taking it since a lot of the dosage information is incorrect and it's got a half life of something like 37 DAYS. I wasn't back to normal for nearly a month, my wife still brings it up occasionally...
Good job man! 😎👍 🛋️ 😴 💤
I'm gonna take it anyway. What dosage would you reccomend? I was thinking something like 200 mg would be active yet not too overwhelming.
@@lagrangiankid378 I'd keep it under 300mg which was the medical dose for sleep and I wouldn't take it more than once a month.
@lagrangiankid378 if you aren't going to listen to the SERIOUS AND EMPHATIC warnings to not do this, I would not recommend starting with something so large as 200mg. With a halflife of over a month, you would not process out all of the chlorobutanol for 5-8 months, with 6mg remaining at 5 months and finally reducing to >1mg at 8 months.
I will not provide a suggested dosing amount as I am not a pharmacist not do I want to encourage anyone to attempt this, but anyone stupid enough to do this needs to be aware that a half-life time is the time to half the original dosage and should plan accordingly. You will be in a highly suggestive state for at least a month, you will have a bad time and you will make regrettable actions.
@@jacobbrown7367 200 mg is not that large of a dose for something with this level of psychoactivity. For comparison chloral hydrate is dosed at 500 to 1000 mg. The OP of this thread ingested a gram or so if I remeber correctly and this lead to overdosing. And (unlike you) I know precisely what the elimination half-life is (which by the way usually refers to blood levels, not to the total amount in the body). And by the way 37 days is the half-life as measured in vitro at a pH of 7.4, terminal elimination half life in vivo in healthy human subjects is reported to be only 10.3 days (C Tung et al., Biopharm Drug Dispos 1982). I have quite some free time as I'm currently taking a vacation so there's plenty of time to recover and this self experimentation won't have any significant consequence. I know what I'm doing and I'm highly prepared, experienced and equipped. I just asked some anecdotal dosage information as there is little or no human data on this obscure and very old CNS depressant.
Whoah, loved to see a haloform reaction taken into practice!!! This is such a scary chemical... You have great video ideas!!
Thank you so much! The haloform reaction is super cool, been trying to think of ways to implement it lately.. maybe iodoform next?
You always take it a step further, I thought it would be just chloroform initially when I saw the title!👍
Btw, 1:52 the sep funnel is slowly dropping down, which is an alarming sign that accident could happen at some point.
I like to make every video a surprise that only rewards you if you actually take the time to watch to the end. I think its fun and a nice little way to foster continued interest (jury is still out on whether it'll work lol)
And yeah I actually noticed the same thing.. I think its a "settling" due to the weight of such a large sep funnel on such a tiny ring stand. I did leave it overnight once or twice and it never failed, but it is still not ideal by any means.
Think I'll probably bolt some bars to the inside of my fume hood for greater flexibility but also to support some of these heavier objects.
@@integral_chemistry I made a custom-made lattice inside my fume hood just to accommodate different clamps, I find setting up the clamp and stand every time quite annoying, stands are also prone to tip over which I am not a big fan of.
@DangerousLab thats exactly what I want to do, honestly I might have gotten the idea from one of your videos. Where did you source the metal bars you used for the scaffold?
@@integral_chemistry I didn't use metal bars, those are carbon fiber rods I got from Aliexpress, and the interconnection is made out of PP.
@@integral_chemistry Those are not metal bars, they are carbon fiber rods I got from Aliexpress, and the interconnections are made out of PP.
sounds like a drug given to hostages being interrogated
Tbh I doubt it would even work for that. The whole time you're drugged you're just kinda unable to speak properly or comprehend anything around you
@@integral_chemistry sweet jesus, "too toxic for Saddam." think about that.
you're thinking of sodium pentathol and it doesn't make you tell the truth you can even confess to things that never happened so it's worthless for interrogation,there was once a case where the police went looking for bodies a person claimed they buried in central park NY and there were never any bodies they just implanted the memory.
These types of hypnotic sedatives would likely render the person a deadhead and rather irritable as well similar to the first generation antihistamine like phenergan - horrible in large doses and even worse in even medium ones.
@@peter5.056 You know where the WMD's are? do tell 😂
Bro you're schizing out my NSA agent
Mines’ took three booths at the China Buffet.
I love this video. I enjoy how your videos go step by step and not too many technical terms. Would you consider doing a video on SLU PP 332 in a pill form instead of as an injection?
Considering how readily available the chemistry is id would not be surprised that this is actively used in bioweapon attacks, dirty little tricks indeed.
Thas chem. Bio would be flinging plague rats.
is someone gonna tell this guy about TATP?
@@PetkesPaintings that's not a bioweapon that's just homemade explosives
I wonder if ethanol could be used instead of acetone.
As a reagent one spatula tip of magneson I/azo violet in 100 ml of diluted sodium hydroxide solution is sufficient.
Hm so maybe I wasn't using too much.. this stuff is just STRONGLY pigmented.
As a side note I made para red as well and I want to try using it as a fabric dye, but I read that in order for the dye to be permanent it needs to be coupled with phenol or aniline. You know anything about this?
@@integral_chemistry
Yes, azo violet is a fairly rich dye.
The reference to phenols and amines refers to the coupling process itself and does not indicate an additional work step for fixation.
I have to admit that the last time I dealt with textile dyeing was in my senior year - that was over 30 years ago.
So here is a translated text from one of my school encyclopedias at the time:
Developmental coloration: In contrast to direct dyes, developing dyes are created on the fiber. They are often azo dyes. Two components are required for their production, namely an aromatic as a coupling component and an aromatic diazonium salt. The coupling component is dissolved in a basic, aqueous medium. The fibers, which are mostly cellulose fibers, are soaked with it and then dried. They are then treated with the diazonium salt solution. The coupling reaction that creates the dye therefore takes place on the fiber. Like the vat dyes, the developing dyes are not water-soluble and therefore very wash-fast. Naphtol AS (3-hydroxy-2-naphthoic acid anilide), a derivative of naphthalene, is often used as the coupling component, which is why it is also referred to as naphtol-AS dyes.
For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.
@@integral_chemistry
The mention of phenols and amines does not mean an additional work step, but rather the well-known coupling reaction itself, which must take place directly on the textile and thus leads to a wash-fast color.
For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.
@experimental_chemistry oh really? Huh so I'm guessing two different dilute baths? Does order matter?
@@integral_chemistry
The concentration of the developer solutions influences the color depth of the dyed textile.
Here are instructions for dyeing with Para-Red: Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B.
Following these instructions (I dug out my notes that are over 30 years old) we dyed T-shirts in our senior year of high school chemistry class (of course the amounts of the solutions were adjusted accordingly).
The instructions are probably universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.
Will it base-eliminate to the 1,1-dichloro, 2,2-dimethyl oxirane? Chlorines being about the same size as methyl groups...lipophilic!
Then...slowly...interesting.
Well done, but still looking forward to your azo violet video... 😉
Thanks! I did wrap up the azo violet a few weeks ago, but I've just been too busy to do the voice recording and editing. Likely have it out within the next week or so.
BTW I read that azo violet gives a color change with ammonium similar to the blue color change with magnesium. Would you happen to know anything about that?
@@integral_chemistry
No, but I will try it out and report about it.
Ammonium often is a disturbing ion in analytics, so it has to be driven out beforehand by boiling the test substance with sodium hydroxide solution.
@@integral_chemistry
Since this platform is ghosting my answering comments I have to answer via my German channel account:
So how did the date go?
With the chloroform, how could it go bad?
Nice synthesis! Is pursuing the fluorine analog even possible?
I doubt it would be using this route, and I can't find any literature about it. May indeed be possible by another route, but fluoroform is really hard to work with (boils at like -80 degrees) and deprotonation wouldn't work due to the extreme electronegativity of fluorine.
Also thank you very much! I was worried people wouldn't care much for this vid
Not by this route, also the end product would act like an acid more than an alcohol because fluorine is pretty greedy for electrons. 😂
For anybody that doesnt understand: never make and NEVER USE THIS STUFF.
THE "HIGH" WILL LAST FOR A MONTH MINIMUM.
An influencial German chemistry creator brought about my ban, because I dared to point out his mistakes publicly. 🙄
Feel free to ask the platform if they can reverse it. I am not overly optimistic about that.
Yeah youtube is not a particularly flexible platform.. and this guy doesn't sound very scientific. As scientists we are supposed to relish in and rely on other people out there with the knowledge to point out our mistakes. Can't imagine how boring science would be if I knew everything about everything and nobody out there knew enough to challenge me..
@@integral_chemistry
The creators on this platform are mostly not interested in scientific discourse, but rather in being soldiers of fortune and cultivating vanity. Accordingly, openness to criticism is weak. People like us, who see mistakes not as a personal flaw but as an opportunity to grow professionally, are the exception here.
@@experimental_chemistry I have noticed that to be the case unfortunately. It is to the point that I've had several commenters on here surprised by how open I've been to their critique because they've come to expect hostility and defensiveness. Its honestly quite sad considering how valuable an open discourse could be in the TH-cam chemistry community..
Okay but how much potassium hydroxide did you use to form the chloroform? How long was it reacted?
I didn't add any to make the chloroform, bleach already contains a good deal of hydroxide to keep it stable over long periods of storage
Is it possible that the dichlorocarbene reacts to form tetrachloroethylene? That might explain why there’s still so much chloride even after completion.
That is definitely possible, honestly probable. I'm convinced there are definitely multiple side reactions going on here, not least because after the formation of the deprotonated version of the chlorobutanol, there a big chance that free oxygen just displaces a chlorine and closes in a ring with the adjacent carbon
I volunteer as tribute Sir. We should link up! 😂
Chloral Hydrate smells similar to
Am I the only one that thinks the diagram at 4:00 describing the reaction looks like one guy puking and another guy with expolsive diarrhea followed by two crosses (presumably on the graves of the previous two guys)?
Just what the heck is going on in this reaction???
Cool. A one month high.
😊
wouldn't this half life lead to physical dependence after a single dose?
hmm thats a good question. Honestly I think this is one of those types of drugs that it isn't really possible to become physically addicted to, but if there was something that had the same effect as an amphetamine for an entire month yeah you'd probably be addicted after a single dose.
@integral_chemistry addiction=/= physical dependence. If you have sedatives constantly in your system for even a week or two (such as benzodiazepines, alcohol, sleeping pills, etc) you will have mild withdrawal after stopping. I bet if you dosed this compound you would sober up in a day or two, not because the drug cleared your system, but because your receptors downregulated to compensate for the drug. When you do actually clear the drug I bet you would feel WD after that single dose.
Guess a dialysis might help?
Only, how do u tell the people in the hospital what u did...
Good
Sounds like an all-round horrible sedation.
Yeah it honestly sounds hellish..
.
Excuse me, does this cloth smell like chlorobutanol?
very clever Jimmy Carr reference +1
😂🤣😂
Why yes! Yes it does in fact smell of chlorobutanol! Might I have another whiff?
They just haven't eaten before. It's loveliness smell is too nasty to consume, but to make that joke more fun, the question would have to be, "excuse me, does this cloth smell like chloroform?"
*thump*
The half-life is long because it's a tertiary alcohol, which cannot be readily oxidized like chloral, or trichloroethanol, or ethanol.
Yeah thats what I figured. I honestly am not sure if your body can even oxidize it at all, I think I read somewhere that it is metabolized by glucuronidation or sulphation, and then eliminated renally.
@@integral_chemistry I wonder if it could worsen liver or kidney function if there is already a reduced function of those organs. With its half life, I wonder if it could cause a stead and long term decrease in renal function for someone that has CKD and does not know it.
@@user-nu8in3ey8cif it’s that hydrophobic, probably not. Kidneys typically filter out H2O soluble compounds, that’s why the CYP enzymes and glucoronidation exists. I bet there is some reactive intermediate from depletion of glutathione from glucoronidation pathway saturation.
@@isaackimball6716 That sounds reasonable.
Some time ago i worked in a factory that (next to other stuff) made this bloody stuff in the tons range
Gave us all sorts of problems with the centrifuge and discoloration and quality control
Edit: The reason you can't find any literature about the reaction mecanism is, that the mecanism is not fully understood yet. I searched for it for the better part of a year and could only obtain some information on side products and reaction conditions
Never again but very nice video once again
Why would anyone make this stuff in the "tons range"?
@@Standing.W.Israel it is used as a preservative in cosmetics and pharmaceuticals
@@emmanueleferrarotto2986 imagine accidentally ingesting some lipstick and go to sleep for a month
This has given the confidence to go on dates again thank you !
We hibernating through winter with this one, boys!
Yeah good luck with that.
You are actually my favourite chemistry youtuber Apoptosis, you always cover reactions that I am interested in.
Thank you so much! I'm very glad to hear it. Feel free to shoot me an email if there's anything specific you'd like me to try
He is the GOAT 🐐
@@twirlyturd4364 :) I wish I was better at taking compliments lol. So happy you guys like my videos!
@@integral_chemistry pls adrenochrome synthesis lol
*In the Diagram you show Br. Where is that coming from????*
ODing on this seems like an alchemical trial a necromancer would do before getting to the next level
LMAO love it! I unironically want to work jokes like this into my videos someday I think all the old alchemy stuff is really funny
@@integral_chemistry like if the witcher was an INT only class
even taking it as a drug would NOT be fun you don't get "high"
@@Aaron-zu3xn it would put you in a state of feeling dead for a month and change which sounds like something a necromancer would do to get close enough to the other side to talk to it lol
There's a paper out there that even describes terminal self-harm from ingesting mouthwash that contained chlorobutanol. Whether or not the incident was concomitant with other ingested substances due to the past behavior of the poor soul could be debated but it isn't seen as an anti-fungal, antibacterial additive in personal care products anymore.
A 37 day half life sounds like severe and unending side effects.
I was hoping you would do a giveaway at the end of the video
Lmfao
This sounds like a terrifying chemical. Neat synthesis, mind you...and fantastic video.
Scary as shit substance though o__o.
Thank you so much! And yeah it got worse the more I read about it. Interestingly enough in my research I came across what is absolutely the most horrifying chemical I've ever heard of: EA-3167. It has the same effect as datura or extremely high dose Benadryl but with a psychoactive peak of 10 days instead of a few hours..
@@integral_chemistry Why do I get the feeling that EA-3167 got some research done on it by a certain 3 letter agency here in the states? They had a period where if it caused hallucinations or removed you from reality they figured they might be able to use it as a weapon of war. (Spoiler Alert: Not really, no.)
@@integral_chemistry on the scale of the things they were making and testing on people at Edgewood Arsenal, that stuff was relatively tame.
@@integral_chemistryI cannot begin to fathom how terrible this would be. I sitting here after the video thinking it would be like being on Ambien for a month...
I thought about how bad my ketamine treatment experiences lasting that long.
Not I'm sitting here trying to comprehend datura for a month.. absolutely wild stuff.
Thank you so much for the videos and comments.
this stuff smells like an artificial chemical trying to not smell like an artificial chemical
LMAO that is the best way I've heard it described
Hahahahaha
For anyone wondering, the effect is literally as having a flu without the pain and fever. You just get enormously letargic and dysphoric and fall asleep very easily. I imagine even hitting your head really hard is more recreational. The taste is like menthol flavoured sand.
Sounds wretched.. literally the more I hear about it, the worse it sounds
So I cant use it to hypnotize someone into robbing a bank for me? Damn XD
@@LeonardGreenpawno that’s scopolomine. Devils breath.
Which is now used as a motion sickness patch
@@SpecialistGuava interesting, do feel free to tell me more. For uh research purposes :D
Yes Ii was pouring ING swat and freezing at same time. I though I was dieing
Adding salt to your water/ice bath would help give better cooling.
Yeah.. that's something I need to do more often in general. I hate using chemicals unnecessarily, but salt is literally dirt cheap lol
@integral_chemistry I hope a 1/4 cup of salt won't break you.. lol. You can always recycl the salt.
This should be on the short list of true "zombie" drugs.
Literally. There's some scary ones out there, this one is in the same area as benadryl where it's such a miserable experience they don't bother regulating it
@@integral_chemistry ever done it?
@@integral_chemistrythey'd better
Can't imagine the damage of someone unleasheing this agent on a unknowing group of people
@@bromine_35 you can do worse than this,
Hey apoptosis wanna join a discord server I made for science youtubers only?❤
Idk how accurate this is but I´ve heard that Adolf Von Baeyer synthesized barbituric acid from human urine and apple juice, to make sodium thiopental? Maybe this is something you could try and make a video about. Definitely gives the opportunity for some good video titles; "Making anesthesia from apple juice and pee" 😂
Huh I've never heard of that before but definitely worth looking into. I know you can make barbituric acid from malonic acid (which does occur in apples) and urea (which is definitely in pee lol). I'll have to check it out and see if its feasible
Anyone heard of Telomir 1 ❤❤❤😮❤❤❤ live forever ❤
If you haven’t, you should check out the story about the Mad Gasser of Mattoon. This chemical sounds like what was used on the gasser’s victims.
sounds fun, let's watch this video before it gets shadow banned by youtube. Love your stuff bro keep up the good work, i know TH-cam can be a cruel mistress sometimes.
I dislike The whole substance
Same tbh^^
@Apoptosis: Since this platform is ghosting all answers to my answering comments (accept for the ones from the creator himself, but even my own), I have to answer your question as a new comment:
Never heard about the interfering properties of ammonium ions on detection of Mg with azo violet, so I tried it out immediately: no blue colorlack was formed nor did any other color change happen (except to yellow if the test solution is too acidic).
Did you use distilled water to dissolve the ammonium salt? Azo violet is so sensitive on magnesium that it will even detect the traces present in tap water.
Indeed ammonium often is an interfereing ion in analytics so it has to be boiled off as ammonia with sodium hydroxide beforehand then.
But in this case it doesn't cause any problems.
But there's one thing to take into account with this dye: the alkaline violet solution is sensitive to air. It becomes a brown liquid lost its indicator properties when standing open for a longer time. This can be prevented by adding a little ascorbic acid - and preparing the solution freshly everytime when needed.
Thank you very much for checking and letting me know! Also I don't have any idea why it keeps hiding your comments, I almost want to ask youtube support on Twitter why that might happen. In any case I hadn't tried the ammonium ion test yet (only read about it on Wikipedia). I also didn't realize until working with it just how EXTREMELY sensitive it is to magnesium ions. It's to the point that when diluted in a sufficient quantity of tap water it is certainly more blue than violet, and when I added 2M magnesium sulfate to a freshly-prepared alkaline sample of azo violet, I got a thick blue precipitate.. which I can't remember whether or not you mentioned in your video.
The intensity of the colors with this one are actually such that it's hard to get good footage, and in all honesty I might just be using to much of the azo dye. This stuff seems like a little goes quite a long way
You could easily further purify the chlorbutanol through sublimation. Mix it well with some calcium chloride in a beaker to further dehydrate, then heat from the bottom and crystallize on top on the exterior surface of a round bottom flask filled with ice water.
Is this a common method for recrystallizing compounds that sublimate? I’m not far along in my chem education but it seems like that would cause a bit of loss.
@michaelevans6216 as with any re-x there's always a loss.
Where do you guys learn this stuff? Genuinely curious
@@gyanjury6753 Sciencemadness forum, wikipedia and youtube obviously. Also, textbooks and college chemistry classes are also an option...
I’m sure acetone on its own could be a sedative just based on how nasty it smells. It might end up being a one time use kind of thing but I don’t know. I’m not a chemist.
I don't know how I got to this video, but now I bet I'm on a list.
Somebody liked my comment. I get a notification. Now I'm back again. I'm definitely on a list now.
So I tried this back in 2017. I ate some, and despite its flavor, didn't puke. It was like plastic cloves amd didn't knock me out at all. It was a waste of chloroform, albeit the science was cool. You did it way better than myself, and you were right to not eat it. Think headache ❤
This dude made his own tranquilizer at home way to freakin' go homie. Shit is getting deep here on TH-cam.
I've made chlorobutanol from chloroform and acetone. It smells really nice.
Right? Super unique and pleasant smell (at least at first)
The smell becoming overwhelming and gross is probably due to how our scent receptors oxidize aromatic compounds, something about them becoming overloaded or the accumulation of side-products of oxidation forming complex molecules with other organics (from your tissues - hence the cancer/degenerative disease risk from many volatiles) that also get processed but register as rancid or acrid due to similarity with rotting meat or spoiled fruit smells.
Huh.. to be completely honest I've never considered that explanation before but it does make perfect sense. Also would explain possibly why the more reactive molecules (like pyridine) just smell bad instantly from the get-go
I was expecting this to be a synthesis of chloral hydrate. I remember hearing about 20 years ago that it's a very easy synthesis. Requiring you to just bubble chlorine gas through I think ethanol. Which sounds suspect and comes from the same source that claimed you can separate ether from hexane by mixing it with water and draining off the bottom water layer. But it's got me wondering how easy/hard the actual synthesis of chloral hydrate is. It would be a real treat if you could cover this one. If legally possible.
Hmm ill definitely look into it. I'm pretty sure legally that would be fine, lately the big concern is not getting stuff removed by youtube's AI. Lots of things like that get auto-flagged
@@integral_chemistry Awesome. I appreciate it. Hopefully TH-cam's robot army leaves you alone.
Hope you’re not busy for about a month
Bravo!!! 👏🏽👌🏽🤙🏽
Now let's try to make something SPECIAL k... 😮😢😅
🤷🏽♂️ It's worth giving it a shot!!!
SFMF's 🦅🌎⚓
Could that be used on an unsuspecting date?
I'm just asking for my friend.
Not for me for my friend.
Would my date...uh I mean my friends date know what happened afterwards?
Just asking for my friend. Not for me. Hehehe .
Could I... uh I mean my friend get in serious trouble for that?
Just asking. Hehehe 😃👋
@Apoptosis:
By the way: if you have entered the same email address on your channel's AboutMe page as the one you used to set up your channel, I would strongly advise you to change your contact address as soon as possible. Otherwise, the risk of your channel being hijacked is high.
Oh yeah I had considered that possibility. I didn't use that email to set up the account, but for security reasons I'm considering setting up a third email just to be safe.. I always underestimate the willingness of bored idiots to hack into people's accounts just to make their lives miserable
Can you tell us the actual effect in plain English?
Some of us have no idea what crossed is.
Runaway haloforms are NO joke. I was doing one in an erlenmeyer flask and lost control of it. It sprayed hot bleach into my face and managed to get into my eyes, clouding my corneas for the rest of the evening. Instead of going to the ER, I went to sleep. Next morning I woke up fine. That was my last haloform
Glad to hear you were fine, that sounds terrifying.. You aren't kidding though, the sheer heat these type of reaction generate are honestly shocking and you really have to get it as cold as you possibly can (and even then expect the worst case scenario)
Exactly
37 DAYS? Even if the effects aren't lethal, that sounds like... carfentanil level dangerous. I uh, I hope you washed your hands when you were done.
I certainly did lol. To be fair the one saving grace is that the effective dose is large enough that you're pretty much safe so long as you don't intentionally ingest any.. mostly because it isn't a "drug" in the more traditional sense
Really enjoying your videos as i always leran new things everytime i come to ur channel. please keep it up and keep uploading new videos to help more students who are studying chemistry and look up for such a content 🎉🎉❤❤
I liked and subscribed for more dope chemistry dude! 10 minute's and you somehow managed to explain like everything and anything i couldve wanted to know
@Apoptosis:
There are problems with the answers to the answers again - this time also via the PC browser.
Regarding your question about textile dyeing with Para-Red:
The concentration of the developer solutions influences the color depth of the dyed textile.
Here is a recipe:
Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B.
The recipe is universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.
I will definitely be saving this! Thank you so much. Crazy how many azo dyes there are, might see how many I can make with what I have lying around
Ya better download it. The fascist Google censorship bots will eventually get around to taking all of this stuff down.
Chemistry. Addition and Subtraction at its finest.
Might be the lsd but I think your breaker is melting. 5:12
Ça va, ce shout est très Bon marché
All i know is i don't wanna go near the stuff...!
Nice presentation. After this I really want to ask if maybe* is it possible the synthesis of zipeprol or it's too difficult for a you tube video.i don't know.
thank you.
I could check it out! It would definitely be much more complex, but my main concern would be with legality. I'll check first to make sure it wouldn't get me in trouble but if it clears I'd love to give it a try
Sounds like scopolamine in steroids
This sounds like a really bad idea.
Yeah definitely would not ingest ever under any circumstances.. then again I wouldn't ingest any of the starting chemicals either lol
Some errors, but an entertaining video.
How long do effects last after boofing 😬
notice you said chloroform but the picture showed bromoform
@@GH-jl2tdOnce the graphic switches to bromine as the halogen it proceeds all the way to bromoform.
Yeah my bad. Bromine is much more often used in this reaction and so the general mechanism I used shows bromine instead of chlorine.
I made a note about it on screen but it's quite small
I though you was going to make 1,4 butandiol🎉 or ghb
Lol I've considered it but those are actually commonly abused so I think that might get the video taken down pretty fast
Ok but what did you do with the little vial ?
IME, smells like Pine-Sol.
Also, it's hell on your liver, so maybe find a better sedative? But I never experienced a month of sedation...more like several hours. There are a few "trip reports" and none of them noted it being remarkably long-acting.
As it is only slightly soluable in water, I take it that the historic use was mainly done as either a pill or dissolved in something like alcohol
I'm assuming a pill to be honest I'm not entirely sure. It still has limited uses these days but the concentration is so low they do just dissolve it
A month of hypnotic suggestability?
Sounds like the perfect compound for psychic driving.
If the potassium hydroxide is just a catalyst can you use something like sodium hydroxide instead, or even just sodium carbonate?
I’ve used sodium hydroxide and had no problem with it. I doubt sodium carbonate would work.
Yeah sodium hydroxide would work fine, I just used the KOH because it tends to dissolve easier in organic solvents. Carbonate aren't alkaline enough for effective deprotonation though
Did you figure out how to kill cancer cells using histotripsy yet, causing apoptosis in concentrated areas, using ultrasonic transducers?
Nice video! Would be interesting to see if you could sublimate to purify it with a cold finger or something lol. I might go digging in literature or ask on sciencemadness if anyone can pull up a reaction scheme for the reaction tbh, curious that's not readily avialible if at all
Chemistry freaks me out.
the metabolism of the substance occurs in the liver and the 4 carbon chain might be more fat soluble leading to longer time for total bodily elimination. Just a thought
Ooh honestly this is one of the more feasible ideas I've heard. It is unfortunate that with chemicals like this that have clearly better alternatives, nobody is ever going to really bother with clinical trials at this point and so we can really only guess at the biochemical mechanisms for such things
@@integral_chemistry went to college for pharmacology and it reminded me of other halogenated hydrocarbons beyond the basic 2 carbon structure that would be more volatile and certainly not aromatic
Bro it has to be used by injection? Could you create or at least share some names that they show in movies. Chloroform obviously cant be used for smell. Thats just movie crap. Kindly do give this information.
This is what Kanye West was talking about in that song “Stronger”
Tymoleptic drug
Not hypnotic. That would be a misnomer!
It makes one care less about stuff. I don't know the word in English, but Norwegians calls it "likegladssprøyte" when administered to dogs before the final shot. Makes them a whole lot easier to kill!
It is not a misnomer. Those are completely unrelated terms. Hypnotic means that it induces sleep.
@@chri-k Hypnotic drug(s) does not exist!
OK I inferred from earlier readings. Still: The closest we have come to a "hypnotic" drug is to use tymoleptic before interrogation. I can't feel sorry for telling you this. I still don't have a source that tells me otherwise (I know this from 20+ years ago. Don't ask me how or why though)
@@jrnandreassen3338 Again, hypnotic drugs do exist, and have nothing to do with thymoleptic drugs, interrogation, or hypnosis. A hypnotic drug is one that induces sleep.
Sorry bro I came late to watch your video and I'm a new subscriber but I'm trying Comment here if not You read it up to you but if you read it I'm excited I have a question for you Apoptosis can you make Chloroacetone
Interesting and thanks. Don't think that I've heard of this one and I agree about the solubility, in fat most likely. Chloralhydrate used to be a very popular item, back in the 50s, I've heard. As it was cheap and easy to make, relatively, anyway. Medical doctors used to write a lot of prescriptions, back in the day. Never made it myself, read about it.
Can I put this into geltabs to sell at the nearest gay bar?
Why?
Isn't there also a way to make chloral with ethanol as a starting point ?
Yes, you bubble Cl through it and then reflux to drive off HCl and hydrate if necessary to form chloral hydrate
Your first chemical synthesis breakdown showed bromine not chlorine. Just FYI.
Turksh translate plz
WHY? would you be showing people how to make this sort of substance?
There's already like 20 uploads of this on TH-cam so I figured it was fine. I just thought it would be educational to go more in depth on the molecular mechanisms of this process than I've seen done before
@@integral_chemistry your intention may be good, but people will try this and abuse this and maybe even kill themselves or someone else with this info.
@@davidolszowka3716 Not our problem.