Sepsis: Systemic inflammatory response syndrome (SIRS) to multiple organ dysfunction syndrome (MODS)
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- เผยแพร่เมื่อ 23 ก.ย. 2024
- Created by Ian Mannarino.
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Thanks for this information. I'm an RN and it's crazy how you can be taught this so many times and forget to apply it in a clinical setting. My pt was very lethargic and his HR was 140. Did an ECG and he was in sinus rhythm. I didn't know what was causing his change in condition but I spoke with an ICU nurse who looked at his bloodwork and realized his WBCs had been trending down. His last bloodwork was taken 3 days prior. She told me to call the doctor and order new bloodwork because he had chemo 1 week before and he bet that he was septic. Turns out his WBCs were 1,500 and neutrophils were 0.1. I should have known to look at his WBC count as it is part of SIRS! Great learning opportunity for me.
Whats the main way to identify sepsis bloodwork wbc being too high
Yeah did it cause stomach aches?
I had Sepsis 2 years ago, I was so close not going to ER since I thought it only was a cold or something similar. Turned out I had severe sepsis , if I had not had went I would be dead. When I came there my fever elevated to above 40 c, my oxygen was at 70% and I was puking. Scary stuff. Turned out that I had an abscess in my liver.
Scary scary stuff, my mother has Utis all the time and I'm worried she won't get sepsis, glad you are alive btw
I had severe Sepsis in 2019 & died at 119*F with Tachycardia. Sometimes Hospitals seem clueless. Thank you for telling me what my Dr’s in PA wouldn’t.
Great vid! I do think it is important to point out that in the sepsis stage, you could probably change it from “Confirmed” infection, to “suspected” infection, just due to the fact that a key in managing sepsis is how early on it is treated with broad spectrum antibiotics. I would say that starting broad spectrum antibiotics before you get any cultures back is probably the best way to go, and then narrowing ABX treatment based on culture results. The government actually has criterion of beginning to treat sepsis within 3 hours of the patient first having information put into the medical record. These reasons are why I would suggest changing it from confirmed to suspected. Nobody will fault you for giving a small amount of broad spectrum antibiotics if it turns out that that there was no infection associated with the SIRS criteria.
this was the BEST explain i've found! you put it in terms easy to understand AND remember!
Bacteremia
is the presence of bacteria in the bloodstream. This may be of primary origin (direct entry into the bloodstream via needles, contaminated infusions, catheters, etc.) or secondary (from a primary source of infection through hematogenous or lymphatic dissemination). Most of the time the body itself is able to eliminate them without the infection occurring. as for Septicemia it is more complicated to understand but you can read it more detaily here [mltexpo.blogspot.com/2018/04/bacteremia-and-septicemia-what-are.html
Wow, I was in the ICU with Covid19 viral sepsis. Everything in this video is how I progressed while I the hospital with the same 30ml per kl infusions and it didn't touch my HR, Idk if I got MODS but I sure had organ dysfunction of the heart, lungs, kidneys, gi tract and liver.
This is super helpful ! The way this is drawn and organized and displayed/explained is exactly how I learn best, this is a wonderful teacher! Thank you and please continue to post more of these educational videos for us nursing or healthcare/med students!
This was really well explained. I had sepsis but it was caught early, before organ dysfunction, septicaemia or shock. Some people and doctors don't understand because they don't know the difference between sepsis, septic shock, septicaemia and SIRS. 😕
what were your symptoms?
Yes it's true , my case doctor thought it was anaphylaxis shock but in fact it is sepsis which they failed to recognise then it progressed to sirs then septic shock with kidney dysfunction
I have always been confused about this spectrum. Thanks a lot for clarifying this
Thank you fro this video! It heps me a lot for my upcoming exam.
Im just trying to keep my mind off him, he was a firefighter, EMT, Truck Driver, Construction Worker and many, many other things. He grew up with adopted parents and his father died when he was 14.. and hes been a quadriplegic for almost my whole life... Since I was about 6 and hes always.. Always been positive.. Not one day have I heard him complain.. He was a big independent survivalist type guy, and he kept being that as much as he could.. He has always been sharp and smart.. Last night he called for me and was asking me the same thing over and over, eventually I did it, and just got him a comfortable as possible.. So I went back to bed.. When I woke up the Aid that comes into help was already here and waiting on another Nurse to look at him and decide weather we need to call 911.. Well as soon as I took a look at him 100% I knew we did, he had snot coming down his nose, and couldn't even notice I was there.. He was completely incoherent and calling for his long passed mother.. I immediately got him to the Hospital and here we are.. He was able to say "Love you" after I said it to him, and he responded to one of his oldest friends when he showed up, but since last night he hasn't said anything, and hes not lucid at all.. He apparently has "sepsis" which is a blood infection..I cant stand the thought of me not being there with him, Ive been there since last night.. I needed to leave to grab things and like I mentioned, I want more then anything to be there for him, but its grueling seeing him like this.. He hates it.. I know it. Hell Who wouldn't.
CJ Ware I'm in same position. Horrific
Prayers.
How did it go?
😢
Thank you so much love how clearly you have explain
Very informative and excellent presentation
I was so confused on sepsis vs septic shock thanks to this vid I understand now 🤗
Will u remake the video with the sepsis 3 guideline?
Thank you sir, learned so much from you so far, you are amazing! Keep the good work.
I had all this 2 yrs ago and many other things i was dieing my family was told i only had about many 2 hours left to live but theu saved me i still dont no how i got it i am very lucky to be alive my left arm side and leg doesnt work right anymore and i had to give up work because of it but thank god to my family who saved me...... if you think anyone has it call 911 or in the UK 999 it could save someone life
very simple to understand. Thank you
great presentation thanks for all you do
brilliant easy to digest information!
Great and succinct presentation. Highly appreciated. Do you have one on management of Sepsis?
The best explain I have found
Amazing video .. the best about sepsis .. thanks
Waow...What an explanation that was. Fabolous
Great job, very easy to understand.
A significant category patients also have recently had surgery
Can you please explain in brief
Thank you! So easy to understand!
No mention of the patient demographic either: the malady is most common among seasoned individuals, infants, and pregnant women. Also pretty sure there's a second scoring system not covered here.
I firstly thanks God for having you, secondly I'm really thankful for all your efforts. like What have we done without you khan!
Chemotherapy caused sepsis for me. I hope I never get that sick again! It damaged my leg muscles. But some people don’t survive so I guess I’m lucky
I got septic shock the end of this March, my second time getting septic shock in 2 years.
You lucky my wife just died of septic shock why do you keep getting it do you hsve a medical condition
@@bronxbully6261 holding my pee. Just a habit. I'm sorry to hear about your wife. 😔
Well explained !
thank alot ❤️
That was super helpful
LOL that second Pfizer vaccine gave me SIRS
You really didn't listen huh
great presentation!!
What about serum lactate levels and tests too? CBC, UA, etc.
Habib Olapade this is in the new definition of sepsis. This is an old video
thank you for your efforts
Please update the information!
Thank you 🙌
Great video
excellent video!
Question not covered here: How do anti inflammatory drugs mask sepsis? Asking after mother died and it was made clear on death finding.
thank you a lot doctor
Great vid!
Just had this 2 weeks ago with pneumonia. ICU for a few days. 9 days later I’ve now got cellulitis around my ankle! Think I’m almost due for a bullet!!
Can I share this on a powerpoint presentation?
TY , very informative
This video taught me more in 7 minutes than my entire medsurg lecture did hahahaha…
Metabolic Theory of Septic Shock
Please do a search for the above
Core tip: For decades septic shock has been attributed to an over-active immune response. However, immune modulation has failed to reduce mortality, casting doubt on a direct causal role for the immune response in the development of septic shock. A closer look suggests that septic shock is the result of a generalized build-up of hydrogen peroxide, a toxic cellular by-product generated as a consequence of the hypermetabolic state that accompanies a systemic immune response. This finding points to the systemic accumulation of hydrogen peroxide as a significant risk factor for the development of septic and non-septic shock syndromes.
Are you saying that immune system is not the cause to progress the infection or inflammation ?
www.ncbi.nlm.nih.gov/pmc/articles/PMC4038812/
Can MODS cause ascites with liver failure in sepsis, or is it something else that’s causing swelling, i.e. just the sepsis or other organ disfunction - I don’t really understand the pathophysiology and swelling with septic shock/sepsis? Also can someone please tell me how you can just be diagnosed with septic shock without going through the chronological steps of sepsis? As this happened to my Dear Grandmother last year. How can a doctor tell if it’s a new infection elsewhere, or just the same infection, also how do they know where it is coming from?
Band cells came out pretty cute LoL...
Greetings from Houston, Texas..
Normal RR 12-20 cpm
Is C-Reactive Protein (CRP) used as an indicator to support determining sepsis? When I was hospitalised from acute pancreatitis caused by gallstones, that was something my doctors kept checking twice a day. It was > 35 (maximum value they could measure) for over 6 days.
I think in this case it was probably used to measure ongoing tissue damage from the gallstone obstructive inflammation. CRP attaches to damaged cells to have them removed.
Yes CRP should be done primarily to understand if any inflammation is going on so that we can start antibiotics , but CBC alone won't help
I love you so much
Helpful
amazing!
Hello, I've been diagnosed with folliculitis since 2013 caused by staphylococcus infection. I also had furnacles & fear that I may have Sepsis. I heard that this is an uncurable deadly disease & I'm afraid to die from this. I don't know what to do.
Precise and useful👍
Thanks ♡
Zabardast 👍🏻
Had sepsis they told me I almost died
Now you are Live or dead 😅
Is Septic Shock reversible? or just MODS?
Thanks for this. Can you explain one thing for me. What is the difference between Primary and secondary MODS?
Primary mods is any insult in which organ dysfunction can be directly attributed to the insult itself eg, renal failure due to hemorrhagic shock
Secondary mods is any organ dysfunction that is not a direct response to the insult itself , but is a consequence of SIRS eg, acute respiratory distress syndrome in patients with acute pancreatitis
amina keita Much appreciated.
My sister got sepsis shock with organ dysfunction. Initially doctor said it was anaphylaxis shock from iron infusion but we got to know that it is sepsis shock from bacteria infection in the blood. So not sure how this iron infusion worsen the situation, if anybody aware please share the details.
No mention of the causes of infection? The majority (about 60%) are caused by gram negative bacilli. The next major group is gram positive bacilli.
You are right , this guy should have mentioned the gram negative bacteria names usually in my case it was Pseudomonas Aeruginosa and Stenotrophomonas Maltophilia
I was diagnosed with sepsis went to ICU
Miller Shirley Hernandez William Garcia John
Why am I watching this if i have anxiety
I have Health anxiety too
Because knowledge is power?
Im dying from this.
Great Video.... One thing I hate about SIRS criteria... is that some idiot decided to implement SIRS >2 assessment eval for Code Sepsis automatically in the hospitals! Its beyond annoying as you stated in the video going for a run would qualify you for Sepsis :D Imagine ICU patients.... (Afib, COPD, CHF, etc.) Ughhhhhhhh
You are right at the same time few idiots thought it was only anaphylaxis reaction but it is actually a sepsis which causes delay to treat actual cause and patients would die eventually with organ dysfunction
thanks for this information,
can you add indonesia subtitle please :)
Different voice, not Khan
Rodriguez Joseph Martin Ronald Davis Charles
CANNOT HEAR THE NARRATOR! MICROPHONE IS SET TOO LOW!
Beware of doxycycline
why this guy sound like Simba
or a hidden severe uti!
😢
Who's here for CORONA virus (Covid-19)? 🙂
My sister died from sepsis shock...i am sorry di
Sorry for the loss. If you don't mind can you brief on symptoms and consequences of sepsis your sister faced
maybe i had sepsis or septicemia weeks ago, my symptoms are chills, fever and vomit, and my leg was swollen twice as big and very red
2 minutes video on SIRS - th-cam.com/video/YgcPm4Ujk5Y/w-d-xo.html
I'm not the only one who misread the title right?
Why do our body have such flaws?
Nobody's perfect
Everyone has his/her own weaknesses
Immune systems for ya. They’re our worst enemy sometimes.
@@biasedjedi4353can you please elaborate why the immune system failed to fight off the bacteria infection
@@abhishek-bb6vg Sometimes the infection can be too severe for the immune system to fully fight off, and it can enter the bloodstream leading to sepsis. Bacterial infections are typically more severe than viral infections.
Come on with the cursor...informative though.
I know I will die soon and I am only 33
Arian Iranian you servive?
...are you there?
i hope you are ok
Hey, are you okay?
Why are all the Khan videos so quiet? The volume is always an issue that makes me want to avoid this channel- any other sound that comes through while watching these videos causes a blast of sound because the volume needs to be cranked so high.