Not sure why this guest doe not give direct answers. OTC lithium goes up to 5mg/cap. The lowest Rx dose is 150mg. The does of Li is determined by a blood level. The window is about .6 mEq/l to 1.3 mEq/l I am a psych-pharmacologist trained at MGH. Li may extend life by inhibiting GSK3B. This helps activate Nrf2. This guest does not talk in a information dense way. I watch this type of video to get a information dense experience. Matt if you want a more direct answer about psychiatry practice give me a contact.
I bet this was a conscious dicision on his part, because he is not an influencer or a media personality. He wants to avoid even the chance of being accountable for saying something like "You must take 5 mg or 500 mg lithium for this and that effect." I don't mind this attitude, it's actually refreshing compared to all the longevity and anti-aging gurus' attitudes, who are directly advising people.
I had disregulated sleep rythm. Started taking very low dose lithium and suddenly I would sleep at night and wake up in the morning. This effect came as a total surprise, an intense experience. Life changing for sure.
@@courseinmircls started with 5mg elemental* lithium. That effected my sleep right away, but I tapered up to find a sweet spot and I like 15mg. *the dosing can be confusing since it's a salt. Docs prescribe doses in mg of the whole salt, but most over the counter product list the molecular weight of lithium present in a given dose of the salt. Thats the value I use, so my 15mg dose weighs more on the scale. The percentage varies according to which anion is present: lithium orotate, lithium carbonate, lithium chloride, etc.
That was an amazing and somewhat frustrating interview, that i wish had been 2x-3x as long. I think the greatest hurdle is finding an open-minded physician; you'll need to live in a metro area and have a lot of disposal income. Here in Europe, the medical establishment is even more conservative and "Do no harm" is frequently interpreted as, "Do nothing."
For what it’s worth, after a one and only bipolar episode at age 60 I switched from the prescription lithium to over the counter lithium aspartate, and then on the advice my psychiatrist to 5mg lithium orotate. It’s been over 20 years and so far no dementia or kidney problems, as well as no bipolar episodes. This isn’t a recommendation, just an anecdote.
You guys should've prefaced the Lithium discussion with a Lithium Orotate vs Lithium Carbonate talk. And the low doses of Orotate people general supplement with vs the high doses of Carbonate people are prescribed.
So strange that in this discussion nobody mentions how Lithium can increase the number of neutrophils, which Rapamycin unfortunately lowers. The two might be a great combination already for that reason alone.
So, 5 mg of Lithium, as available over the counter, or 500 mg as mild dementia patients are prescribed for? There are 2 orders of magnitude between them.
Too bad he wouldn't give actual doses. My doctor would never agree with me taking Lithium. I don't tell her what I take. I've lost several doctors in the past after they had a fit about me taking any supplements and how they aren't proven to be safe and effective. I don't want to argue with them. That won't be fruitful. I take 5mg x 2/day Lithium Orotate. Now I'm wondering if I should take a lot more. Its also cool that there's evidence of it being anti-viral.
I have been taking 5mg Lithium Orotate every other day for ten years. Ten years ago there was only one company that made Lithium Orotate, so it was pretty expensive, and dosage came down to what I could afford. There are a dozen companies that make it now, and it is more affordable. Not sure if I should be taking more now based upon his lack of guidance to the dosing question. I suspect he was engaging in gatekeeping.
I think he wasn't gatekeeping, just acting like a responsible MD or scientist, not a regular anti-aging or longevity "guru"/influencer, that we are used to. So he isn't advising people to take this or that dose of something through the internet. That's for the other types of guys.
I see that Labcorp has a whole suite of Alzheimer's tests, and I don't know which one Jon Berner was referring to as ATN. Was there one specifically or several?
Great talk BUT was very frustrated after listening the whole 52 minutes to get the "Sweet Spot" range of Lithium to take per day for longevity AND still not get it.
Why can’t this person just answer a question without telling a meandering story that has nothing to do with the question. So many great questions from Matt that feel completely unanswered.
Maybe because he is not a professional broadcaster Not sure what people expect for real knowledgeable individuals who are not influencers It is unfortunate that people have no patients and then insult him😊
“Hold my beer Peter”?! Attia clearly utilizes his brain..the difference is he also exercises his body and brain. This guy could do a little more of BOTH himself!
@@glennschromebookglenn511 he took an unprovoked swipe at Attia. I was simply laughing. Peter is academic researcher and physician. But he walks the walk when it comes to health and longevity. He also realizes the body/exercise is equally as important.
Not sure why this guest doe not give direct answers. OTC lithium goes up to 5mg/cap. The lowest Rx dose is 150mg. The does of Li is determined by a blood level. The window is about
.6 mEq/l to 1.3 mEq/l I am a psych-pharmacologist trained at MGH. Li may extend life by inhibiting GSK3B. This helps activate Nrf2. This guest does not talk in a information dense way.
I watch this type of video to get a information dense experience. Matt if you want a more direct answer about psychiatry practice give me a contact.
I bet this was a conscious dicision on his part, because he is not an influencer or a media personality. He wants to avoid even the chance of being accountable for saying something like "You must take 5 mg or 500 mg lithium for this and that effect."
I don't mind this attitude, it's actually refreshing compared to all the longevity and anti-aging gurus' attitudes, who are directly advising people.
I had disregulated sleep rythm. Started taking very low dose lithium and suddenly I would sleep at night and wake up in the morning. This effect came as a total surprise, an intense experience. Life changing for sure.
how many mg if you don't mind me asking?
@@courseinmircls started with 5mg elemental* lithium. That effected my sleep right away, but I tapered up to find a sweet spot and I like 15mg. *the dosing can be confusing since it's a salt. Docs prescribe doses in mg of the whole salt, but most over the counter product list the molecular weight of lithium present in a given dose of the salt. Thats the value I use, so my 15mg dose weighs more on the scale. The percentage varies according to which anion is present: lithium orotate, lithium carbonate, lithium chloride, etc.
@AndrewOudin i think it helps. my sleep and HRV improved dramatically taking low Li in Novos Core, melatonin, and Sirt6 activator.
That was an amazing and somewhat frustrating interview, that i wish had been 2x-3x as long. I think the greatest hurdle is finding an open-minded physician; you'll need to live in a metro area and have a lot of disposal income. Here in Europe, the medical establishment is even more conservative and "Do no harm" is frequently interpreted as, "Do nothing."
For what it’s worth, after a one and only bipolar episode at age 60 I switched from the prescription lithium to over the counter lithium aspartate, and then on the advice my psychiatrist to 5mg lithium orotate. It’s been over 20 years and so far no dementia or kidney problems, as well as no bipolar episodes. This isn’t a recommendation, just an anecdote.
You guys should've prefaced the Lithium discussion with a Lithium Orotate vs Lithium Carbonate talk. And the low doses of Orotate people general supplement with vs the high doses of Carbonate people are prescribed.
So strange that in this discussion nobody mentions how Lithium can increase the number of neutrophils, which Rapamycin unfortunately lowers. The two might be a great combination already for that reason alone.
I bit annoying that he turn every question into a "Can we even know". If there are uncertainties, just add them
So, 5 mg of Lithium, as available over the counter, or 500 mg as mild dementia patients are prescribed for? There are 2 orders of magnitude between them.
So is 5mg of lithium orotate the same or are they discussing script lithium?
That's what I'd like to know as well.
Well I still don’t know how much lithium to take now lol. I’ll stick to 5mg every morning
Too bad he wouldn't give actual doses. My doctor would never agree with me taking Lithium. I don't tell her what I take. I've lost several doctors in the past after they had a fit about me taking any supplements and how they aren't proven to be safe and effective. I don't want to argue with them. That won't be fruitful. I take 5mg x 2/day Lithium Orotate. Now I'm wondering if I should take a lot more. Its also cool that there's evidence of it being anti-viral.
It is kind of reprehensable that during this long talk there was not made a distinction between low dose lithium and psychiatric doses of lithium.
Hypothesis expressed: maintenance of microglia's stem cells
Anyone: You hungry?
This guy: "Again, it's a question of what is an adequate amount of data."
Thanks for this talk. I wonder if Lithium could benefit central sleep apnea that's very hard to treat with conventional methods.
i think it does.
I have been taking 5mg Lithium Orotate every other day for ten years. Ten years ago there was only one company that made Lithium Orotate, so it was pretty expensive, and dosage came down to what I could afford. There are a dozen companies that make it now, and it is more affordable. Not sure if I should be taking more now based upon his lack of guidance to the dosing question. I suspect he was engaging in gatekeeping.
I think he wasn't gatekeeping, just acting like a responsible MD or scientist, not a regular anti-aging or longevity "guru"/influencer, that we are used to. So he isn't advising people to take this or that dose of something through the internet. That's for the other types of guys.
great watch!
I see that Labcorp has a whole suite of Alzheimer's tests, and I don't know which one Jon Berner was referring to as ATN. Was there one specifically or several?
Here is the test: www.labcorp.com/providers/neurology/atn - Tara
Great talk BUT was very frustrated after listening the whole 52 minutes to get the "Sweet Spot" range of Lithium to take per day for longevity AND still not get it.
Lithium! I think taurine and lithium are a budget stack.
I'm curious, what happens to a mentally healthy person who just takes lithium? Are there mental health side effects?
Very curious about your opinion on Alpha GPC, me and your stack is almost identical I however have added Alpha GPC and have felt insane results
Can u discuss ginseng
Asian ginseng
Korean red ginseng etc
As disease prevention
Very good. What he said is true. Lithium is a super anti-age supplement, but not all will tolerate well. I can't. It gives me out of space feeling.
To penrose and hameroff who think consciousness comes from the micro tubular structures. Interestingly, lithium promotes structural integrity.
Yes Cholesterol and Lean mass hyper responders.....
Why can’t this person just answer a question without telling a meandering story that has nothing to do with the question. So many great questions from Matt that feel completely unanswered.
Might be a side effect of the lithium lol
@@Answeriz42 I suspect it is a side effect of sweaters. Too relaxed and cozy.
Unfortunately, I had to stop watching because it's almost an hour long. If you were talking about brain surgery I get it.
Maybe because he is not a professional broadcaster
Not sure what people expect for real knowledgeable individuals who are not influencers
It is unfortunate that people have no patients and then insult him😊
@@glennschromebookglenn511 perhaps
This guy was super annoying. Please be more direct.
“Hold my beer Peter”?! Attia clearly utilizes his brain..the difference is he also exercises his body and brain. This guy could do a little more of BOTH himself!
Why would you insult him
@@glennschromebookglenn511 he took an unprovoked swipe at Attia. I was simply laughing. Peter is academic researcher and physician. But he walks the walk when it comes to health and longevity. He also realizes the body/exercise is equally as important.