Mitochondrial physiology in health and disease: Biogenesis, growth and function, Fleming Dela

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  • เผยแพร่เมื่อ 28 ก.ย. 2024

ความคิดเห็น • 10

  • @certifiedhoarder
    @certifiedhoarder ปีที่แล้ว

    The subtitle font not being transparent and placed right over the graphs certainly doesnt help one see them. I think his english is good enough to do without them.

  • @iblisthemage
    @iblisthemage 2 ปีที่แล้ว

    This is great!

  • @Rene-uz3eb
    @Rene-uz3eb ปีที่แล้ว

    12:47 I’m not sure why you assume more activity post exercise before returning to baseline is positive. It seems the high carbohydrate diet is done more quickly with what it needs to do. Clearly a low carb diet is not good for muscle mass so I doubt the argument is it’s building more muscles and mitochondria. Also, pgc1 is not only an indicator of mitochondrial biogenesis but simply fatty acid and glucose burning, ie, energy expenditure.
    12:53 P-p38 was another marker for mitochondrial biogenesis and that one was actually 40% higher in then high glycogen group.
    The paper was testing the same bicyclists with one exercise, with high vs low glycogen stores. This is silly, the low glyc group simply runs out of glucose first so you’ll see all the energy adaptations in that group.
    15:10 ok so nitrite from nitrate ingestion can be a substrate to produce NO when needed and the body is low on oxygen, increasing exercise performance, but paradoxically it can also react with blood and lead to methemoglobinemia, which reduces oxygen carrying capacity.
    They say only too high amounts lead to that, but it seems more likely to me that over time the nitrites will react with the red blood cells..also nitrite half life is like half an hour so you’d have to take it right before exercise.

  • @martinirving3824
    @martinirving3824 6 ปีที่แล้ว +1

    I'm going to comment the "all roads lead to Rome" section of the talk. My guard is up when we have such flippancy. "All diets work" is a mantra you hear from the established dogma (particularly those that have been advocating low fat diets). What this means is there will be some short-term weight loss no matter what diet you do, because of calorie restriction. (so might as well make it low fat, seems to be the implication) But the devil is in the details and certainly in the long term and the evidence clearly shows low fat diets don't work particularly .
    Similarly with this idea that it doesn't matter whether it is high-intensity or high volume exercise, it works to increase mitochondrial volume and function. How about some context on that? What age groups and athletic level are we talking about? What about general health vs athletic performance?
    AND: It is well known there are subjects who are considered "non-responders" or "low-responders" to endurance exercise. That is, there are people who can do 30 minutes of cardio per day for 6 weeks and see NO IMPROVEMENT in VO2 max. Surely this is something to take into consideration before we say "it doesn't matter" regarding volume vs intensity??
    I could go on and on.

    • @stefanweilhartner4415
      @stefanweilhartner4415 4 ปีที่แล้ว

      That "All diets work as long as you can stick to it" is of course stupid. Because it applies to weight loss in general. but i do not want to lose hair, teeth, brain, kidney, liver, toes, arms, eyes and muscle. i only want to lose body fat. a certifucked nutritionist who can not distinguish between body weight loss and body fat loss is the usual stupid nutritionist who tells everything as he/she learned without using any brain cell.

  • @akirafujiwara9390
    @akirafujiwara9390 4 ปีที่แล้ว +1

    Learned a lot,hope more people could see this.

  • @lauriemeerlarock5649
    @lauriemeerlarock5649 7 ปีที่แล้ว +1

    This is just wonderful, thank you!

  • @magicf7076
    @magicf7076 3 ปีที่แล้ว

    ZZZzzzzzz .....

    • @asswhole4195
      @asswhole4195 2 ปีที่แล้ว

      Go watch more PoodiePie or something then you fool