Part-2 Schizophrenia Pathophysiology - Dopamine hypothesis

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The video discusses the neurotransmitter hypothesis of schizophrenia.
Dopamine Hypothesis, Serotonin Hypothesis, and Glutamate Hypothesis.
The first part covers the pathophysiology of Schizophrenia, its subtypes, and symptoms and some anecdotes of the disease.
Link to the first part: • Part-1 Pathophysiology...
Subscribe to the channel and share the video.

[@gauravagarwal8743]

amazing 🥰🥰🥰🥰🥰......every second of this video is useful 🙏🙏

[@Iamolusegun]

This is my 6th time watching this video. Well-done 🤝

[@neelamsingh7614]

You explained the topic so well that even i could understand. I m not from this field

[@jelenajankovic1822]

This was great! Thank you very much !

[@cology9]

Glad it helped. Keep sharing.

[@dutchbag26]

Very understandable. Thank you so much. May god bless you.

[@udenilsonjunior]

Thank you! great explanation

[@mariyajacob4107]

Thank you sr it really have good explanation about schizophrenia. It clears all my doubts

[@shribalashukla9867]

Wonderful keep it up....thank you so much🥰

[@msa1518]

Your good. Keep up the good work.

[@michelangelocaravaggio5018]

But if DA increased in the last hypothesis (glutamate) the d2R will be decreased on the gabaergic neuron. So This will compensate the inhibitory signal. Also GlutR on the gabaergic neuron will be upregulated. So it would be solved with these upregulations and downregulations. So, I would think that there should be a gabaR dysfunction. At one time in a life, maybe neurons recieve too much signal. So this leads gabareceptors to dysfunction.

[@joshnayarramala8178]

Thank you so much sir. Very helpful video

[@Iamolusegun]

Thank you so much for the easy explanation

[@averagejonastoodles]

thank you so much sir

[@manpreetmaan3817]

Great❤

[@abdullahsiddiqui7600]

Excellent explanation sir..we need more topics keep going

[@cology9]

Sure 👍

[@mahtabkhan8256]

Thnkuh so much😍😍

[@sherrik.8333]

I thought serotonin inhibited dopamine production and antagonism of 5-HT2A-R can cause a slight increase in dopamine thus decreasing the adverse effects of dopinergic drugs

[@anfalziar507]

there r two pathways for serotonin just like with dopamine , in the mesolimbic area theres hyperactivation of serotonin and dopamin release resulting in post=itive symptoms, in the meso cortical hyperactivation of serotnin induces low levels of dopamine thus the negative symptoms

[@sanjaisrao484]

Thanks

[@nayanak.m3602]

Thnk u sir ....

[@bellyvelly]

thank u so much that was very helpful ❤

[@cology9]

Glad it helped!

[@TT-vd7sf]

Aside from studying Neuroscience, I have worked over a decade with clinical patients. SZ has a late onset. Brain changes can be observed in childhood but the illness will explode only After the age of 20. Many patients in fact are diagnosed in their early thirties. Secondly, bullying and abuse DO NOT cause psychosis per se. And certainly not SZ. They can worsen or anticipate the problem. BUT there's No proven causation. The mental issues related to abuse are instead anxiety and depression.

[@cology9]

Hello, thanks for adding value with the comment. Can we look at this like the children with onset of psychosis are undiagnosed and the condition is seen when they reach their thirties. If someone is bullied and abused there are possibilities of other parallel factors contributing in the development. I totally agree with your experience as I am not a practicing clinician and do not have any patient exposure.
But I am grateful for your comment. I am open for any further discussion on the topic.

[@TT-vd7sf]

@@cology9 Only marginally. Psychosis are a universe of their own. Bullying MAY worsen this as any other adverse experience, but relation and causation should never be confused.

[@mariyajacob4107]

Excellent

[@cology9]

Thanks

[@Randomnamepoop]

thank you. this is very helpful for my upcoming exam! now to hunt down references!!! xx

[@cology9]

Glad it was helpful!

[@joshna.p9724]

pls tell ur reference books

[@polydebnath3853]

Nice presentation. Pls inform me the reference book.

[@bchandu6811]

Your videos editing software

[@Padmashrinaren]

I was so engrossed in your lec. It was simply amazing 💯

[@cology9]

Wao.... This is probably the best compliment I have ever received. Thank you

[@ashikapaladi4143]

Tq sir

[@minhajakhtar8687]

Nice video

[@cology9]

Subscribe kia?

[@michelangelocaravaggio5018]

Lsd also creates auditary hallucinations

[@pharma-hub5204]

Sir please make more videos on antidepressants

[@cology9]

The video on anti depressants is already there in the channel

[@tekklover1489]

I get auditory hallucinations as well on LSD

[@khadarbasha7760]

Sir what about Genetic predisposition

[@markae0]

No genes have been found for a fake disease. No behaviour or misbehaviour is a disease. Jay Joseph has written at least four books. The Gene Illusion (Algora, 2004) The Missing Gene (Algora, 2006) The Trouble with Twin Studies (Routledge, 2015)Schizophrenia and Genetics (Routledge, 2023). BUT Billions of dollars are being made by selling drugs called medicines. "The global antipsychotic drugs market size was valued at USD 15.47 billion in 2022 " So it will continue.

[@ranpalsharma8048]

Sir, I am suffering from Schizophrenia and obsessive compulsive disorder since birth, attempted suicide 2 times no medicine relives the symptoms for long period of time. Would anyone recommend some kind of dietary or nutritional remedies for this.
Thank you

[@manmohansinghrao8200]

Let's count the positive things here:-
1. Even after getting schizophrenic symptoms the thing that is still in your favour is that you know how to use phone and how to comment on TH-cam video that means you can read, write, learn and express your feelings.
2. That brings to the second point that you are decently educated so you can learn new things.
3. Now why I am motivating you to learn new thing because the electrical activities in schizophrenic people are higher so it's the choice whether they choose to use that every in being depressed or learning new things.
4. People thing that schizophrenia is a curse but the thing if a person now how to channelise those energies then it can be a boon as Albert Einstein had also a same type of mind with high electrical activity and he used it to give theory of relativity.

[@ranpalsharma8048]

@@manmohansinghrao8200 Thank you so much for your reply... Manmohan Singh... I would do it what you said.. 🙏🙂

[@nintforce]

It's awesome your way to explain all these theories but I have a question, would you share with all of us your sources like scientific papers or at least the titles please?

[@cology9]

Sure, I will.

[@cology9]

www.sciencedirect.com/science/article/abs/pii/S030698771300131X#:~:text=In%20summary%2C%20the%20serotonin%20hypothesis,blockade%20in%20treating%20positive%20symptoms.

[@cology9]

www.sciencedirect.com/topics/medicine-and-dentistry/glutamate-hypothesis-of-schizophrenia#:~:text=The%20glutamate%20hypothesis%20of%20schizophrenia%20is%20centered%20on%20a%20deficiency,that%20dopamine%20inhibits%20%5B49%5D.

[@cology9]

There are several more but you can read them initially

[@pharmachem5121]

Need much more improvement sir in teaching 😀

[@cology9]

I am learning everyday..... Thank you

[@pharmachem5121]

@@cology9 happy pharmacist day sir😀