@@jayg6138 thanks, I am a non student/layperson trying to self educate. This is what ChatGPT responded to my initial question with your information as well: SARS-CoV-2 also downregulates MHC class I expression, which can lead to impaired recognition by cytotoxic T cells. However, SARS-CoV-2 has mechanisms to avoid NK cell detection: Alteration of immune signaling: SARS-CoV-2 manipulates immune pathways, such as reducing interferon responses, which are critical for NK cell activation and function. Without proper signaling, NK cells may not become fully activated, even if MHC class I is downregulated. Suppressing NK cell activation: SARS-CoV-2 can induce the secretion of certain immunosuppressive cytokines (like IL-10 and TGF-β), which further impair NK cell function and reduce their ability to detect and kill infected cells.
SARS2 down regulates MHC1 do you think this could be driving some long covid possibly being chronic infection?
down regulation of MHC 1&2 is what triggers NK cells. Hopefully that answers your question. NK cells will be in a few lectures time.
@@jayg6138 thanks, I am a non student/layperson trying to self educate.
This is what ChatGPT responded to my initial question with your information as well:
SARS-CoV-2 also downregulates MHC class I expression, which can lead to impaired recognition by cytotoxic T cells. However, SARS-CoV-2 has mechanisms to avoid NK cell detection:
Alteration of immune signaling: SARS-CoV-2 manipulates immune pathways, such as reducing interferon responses, which are critical for NK cell activation and function. Without proper signaling, NK cells may not become fully activated, even if MHC class I is downregulated.
Suppressing NK cell activation: SARS-CoV-2 can induce the secretion of certain immunosuppressive cytokines (like IL-10 and TGF-β), which further impair NK cell function and reduce their ability to detect and kill infected cells.
I am trying to understand long Covid and the associated sequelae, namely lymphopenia and viral persistence.