How to use Chai-1 for Biological Complex Modeling.

Link to the server: lab.chaidiscov...
Welcome to Bioinformatics Insights. This video demonstration will teach you the usage of Chai-1 developed by Chai Discovery Lab. You will also learn how to analyse model quality generated by Chai-1.
#chai #chai-1 #chai1 #chaidiscoverylab #chai_discovery_lab #google #deepmind #betalactamase #ndm1 #ndm-1 #autodockvina #alphafold3 #alphafoldserver #modeling #bioinformatics #bioinformaticsforbeginners #bioinformaticstools #biology #biologyinsights #neuralnetworks #deeplearning #ai #protein #ligands #ligand #ions #oligomerization #molecular_biology #molecularbiology #proteinresearch

[@Isaac_Wanas]

very informative content and competent speaker, waiting for new tutorials and thanks so much for your effort

[@Bioinformaticsinsights]

Thanks mate for your encouragement.

[@vishnudhakad4452]

I love your excellent efforts, 🎉🎉

[@Bioinformaticsinsights]

Thanks for good words

[@parachinar009]

Wonderful services, full of knowledge

[@Bioinformaticsinsights]

Thank you so much for the appreciation.

[@parachinar009]

@@Bioinformaticsinsights sir its very informative

[@abidaliyousafzai3123]

Thanks a lot Sir, for one of the special tutorials.

[@Bioinformaticsinsights]

Most welcome! Dear Abid.

[@AbdulMananMughal-n3e]

Dear Dr. Ashfaq, thank you for the this wonderful tutorial. I am waiting for the series "Protein design"

[@Bioinformaticsinsights]

Thanks for your appreciation. I have a plan to make series on protein design, hopefully soon. Waiting for some approvals, because I will use materials directly from the source peoples.

[@vishnudhakad4452]

@@AbdulMananMughal-n3e me too

[@parachinar009]

Waiting for series of protein design

[@Bioinformaticsinsights]

You will have to wait for sometime.

[@jijilpm1998]

Hi, Dr Ashfaq

[@Bioinformaticsinsights]

Hi, good to see you.

[@jaypalsingh6376]

Hi, Dear. Thanks for your efforts. Would you please suggest how we can use it without the server?

[@Bioinformaticsinsights]

You are welcome. Yes certainly, you can use Chai-1 in offline mode. Here are the source files, with proper installation details. github.com/chaidiscovery/chai-lab
Cheers

[@jaypalsingh6376]

@@Bioinformaticsinsights shall we use it as an open source? Thanks

[@Bioinformaticsinsights]

@@jaypalsingh6376 as far as usage is concerned, yes but if you are interested in modification, then i will suggest to go for Boltz-1 released by MIT.
th-cam.com/video/9ZV2rA5gy0Q/w-d-xo.html

[@abidaliyousafzai3123]

Dear Sir, I am having trouble predicting the IC50 values for new derivatives of a compound. While there is no available data for these compounds in PubChem, ChEMBL, or other databases. My question is: can I test similar compounds and use that data to predict the IC50 values for the 15 new derivatives, one by one?

[@Bioinformaticsinsights]

Abid you have asked your question under irrelevant video. Well, I am confused here. As you mentioned that you are not finding data. Please tell me, you are finding data to train the model, or your model is trained already?

[@abidaliyousafzai3123]

Yes Sir, I am finding data to train the model.

[@Bioinformaticsinsights]

@@abidaliyousafzai3123 then you can predict pIC50 either for 1 compound or thousands. I do not see any issue further, however if you interested to add similar compounds to the library of unknown compounds, sure you can.