Cancer Immunotherapy - PD-1 and PD-L1
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- เผยแพร่เมื่อ 3 ส.ค. 2014
- Dan Chen MD, PhD from Stanford Medical Oncology and Genentech describes brilliantly how our immune system detects cancer cells and how tumors get past our immune system through PD-L1, PD-1, and B7.1 interactions. A must see!!! Brilliant way to understand the effects of checkpoint inhibitors and cancer immunotherapy.
If only we had videos like these throughout pharmacy school!! Thanks for the upload! :)
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RxPharmacist you’re right! Man, pharmacy school would’ve been entertaining!
Totally!!!
I started immunotherapy last week in part because the radiation and chemo, although effective against my mouth, neck and lymph tumors, were not effective against the cancer in my lungs. I am a reasonable candidate for this treatment, and I am cautiously optimistic. Attacking cancer on the cellular level seems like quite an advance, verse the poisoning through chemo, the burning by radiation, and the cutting by surgery. Medical science progress, an answer to the prayers of many people.
How are you now?
@@SA-ux7xbI STARTED KEYTRUDA. I’ve been very sleepy for four months, but now I’m starting to get stronger but I’m still sleepy but I think I’m going to live now.
Immunotherapy keytruda Sáved my dad from stage 4lung cancer to stage 0 but he did chemo with immutherapy after clean results they want to still do immunotherapy for as long as possible just in case .
Doctors are still saying that its a miracle what had happend they didnt expect this results not after 3 months treaťment
We prayed everyday we did even before that but believe in GOD pray be thankfull and trust me miracles happens
greatest, simplest and ...most of all, CUTEST explanation ever for PD-L1 !!! Thank you so much for the video.
Love the format and simplicity that this was developed! Many thanks
👏
Complex concept broken down to an easy, understandable demo. Thanks!
this was terrific. Thank you Dr. Chen.
Excellent explanation of this type of treatment. Helped me understand a lot better
Everything intuitive illustration. Thank you very much!
Thank you so much. Really amazing! I 'll pass this forward for sure!
immunotherapy is so interesting, hope might be near to those who need it!
Thank You for the info......thanks to TH-cam there is a lot of information available....!!!!!!
OMG !!! Amazing explanation....and the animation....too good !!!
Brilliantly explained!
This was amazing, thanks so much!
Awesome presentation !
Amazing video ,, very illustrative.
blocking the pd l1 and cd 47 can help more and more people.
SO helpful! thank you
شكرا لكم
Thank you
This is an awesome video.
Thank you for the great lecture :)
Love this!!
Thank you very much for these useful explanations, the lecture is easily understandable for everyone. It helped me a lot !
Wonderful !!!!!
OX40 stimulation may be able to prevent inactivation by PD-1/L1 interaction. Trials are underway to investigate that.
Thank youu so much!
Confused... I thought B71 (CD80) was only present on APCs for the purpose of costimulatory activity by interacting with T cell's CD28....?
So does pdl1 bind to pd1 and turn off the t-cell?
Thank u so much
Thanks
Very cool animation!
Is this mechanism workable with NHL
I'm really hopeful about this new branch of cancer research
Because of US estrangement from Cuba most cancer patients may be unaware that Cuban vaccines for stage IIIb-IV cancers are more efficient in terms of life expectancy and quality. Seen costs on www.doctorcuba.com affordable for self-pays and on-benefits.
Its not so simple because blocking the pathway also removes the self recognition of most other healthy cells in your body. They all can be attacked.
So what happens to the already deactivated T-cells. Does immunotherapy only prevents new T-cell to attach to tumor cells. If yes, then starting immunotherapy early can give better results (considering the patient has PDL-1 inhibitor )??
PD=programmed death receptor, T=thymus glands, As the Thymus glands ages , Thymus gland cells aka T-cells become less effective. In immunotherapy, PD-1 receptors on a tumor cell are blocked/molecularly locked so T-cells can recognize tumor cell that needs to be marked for destruction/autophagy. a very useful option in non-resectable cancer. It could be safer than surgery to remove tumors too.
Amazing
I am engaged in public scientific popularization , and I think the video is very vivid for people to understand immunotherapy, I want to ask for the permission of reprint it on our Wechat platform but reserve all marks of yours, may I?
How long will you all go down this alley?
3:00 T cells do not have B7.1 molecules. B7 costimulatory molecules express on APCs, the counter part CD28 express on T cells.
Mt didático!
In the next 2015-2025 there will be nothing to forecast, the spread of innovating technology will be unstoppable by big companies and governments, Wide access to the technical data and the resources will be beyond the borders and any control, and people will have access to the internet freely or very cheap. And i well be no exception. So the only way to work it is by working together.
Easily understandable Sir!
Nawww, this animation was so cute!
You barely scratched the surface my friends....it's here and somewhere along the lines of my Instagram
Nice animation
Is lenvatinib and Nivolumab injection...... Are immunotherapy drug ????
When did my childhood crush Lee Shang from Mulan get a PhD in immunology?
Nice
Great content and video but that marker hitting the board sound killed me inside a little.
just wondering if this discovery has been helping cancer patients to recover?
Yes it has. Pembrolizumab is a drug that was FDA approved in 2017
@@jamesjackson9374. AND NO ONE WROTE BACK. So we don’t know if they are alive or dead.
Hello Dr I'm Vivian from Nigeria, how can I access immunotherapy
Pls say bengali verson
Plz say which is the best for cancer treatment immunotherapy ya chemotherapy??
maybe chemotherapy should only be administered when nesecary.
2:40
whether this therapy can b apply at advanced stages
everybody's different, a patient has to try and find the right combination or right medicine for the body.
Proud to worked with Roche
heyhey people, sseth here
Why do only 20% have some response that’s good while 20% of people die from therapy and in 60% people it does nothing?
instructions unclear... removed all healthy cells wearing sunglasses.. oops
CovidImages need to be invested more than half19