Yes, fluoride from drinking and bathing water can inhibit the synthesis and metabolism of proline, although this effect is indirect and related to its interference with certain enzymes. Fluoride has been shown to inhibit the activity of enzymes that are dependent on cofactors like magnesium or zinc, as well as those involved in the citric acid cycle (Krebs cycle), such as aconitase. Proline synthesis depends on intermediates from the citric acid cycle (e.g., glutamate), so disruption of this cycle can indirectly affect proline production. In particular: 1. Enzyme Inhibition: Fluoride inhibits enzymes like aldolase and enolase, which can disrupt glycolysis and energy metabolism, leading to downstream effects on amino acid biosynthesis. 2. Collagen Synthesis: Fluoride can reduce the availability of proline, which is essential for collagen synthesis, potentially affecting connective tissue health. This interaction is one of the reasons fluoride toxicity is associated with skeletal and connective tissue disorders when exposure is excessive.
I appreciate your insights. Is there are article you can reference to walk us through this process--it sounds complex. I'm also interested in whether this effect can be offset by increasing proline consumption. N.B.--I've stopped using fluoride toothpaste; hydroxyapatate is now available as a remineralizing ingredient.
wrong title: it is not about "proteins", it is about the tau-protein, which gets dubbed as a "cause". ...while it is just a stepping stone in a causal chain
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
NOT MUCH HERE ABOUT THE AMINO ACID HOMOCYSTEINE 🔹 Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Very interesting. Thank you. My first thought when I heard “seed” was that indeed the protein fibers seem prionic. My second thought was that inflammation plays a big role which means the immune system is very much involved in various dementia. It would not surprise me if later research was to reveal that individuals with early onstage dementia in addition to the substitution mutation of proline to lucine also have disrupted immunological response to infection/damage. If you recall in use of ChAdOx1 as an adjuvant, it elicited an immunological response, forming clumps in a small subset of individuals. Since your computer simulations showed that at higher temperatures more space was created for misfolded strains, please pursue the possibility that brain inflammation following repeated infections over a lifetime may lead to the fibril/misfolded plaques and disrupt the hairpin formation.
Seem "prionic"? The literature describes Alzheimers as a double prion disease. Substitution of one amino acid for another, hum, where have we heard that before?
The key is to eat plant-based protein. More and more research nowadays show that plant-based diet can be protective from Alzheimer's. Good gut microbiome promotes proline synthesis in our bodies. Studies found that vegans as a whole have the best gut bacteria. Legume, nuts, mushrooms and many other plants are good dietary sources of proline.
@@DinamoDeet101 i guess we need to wait for the studies oj carnivore diet, only problem is that carnivores might die of clogged arteries long before they get alzheimers.
Who told you that eating proline can cause any effect in the diseases? Its a mutation in the proteins, you can eat all the proline in the world and that will make no difference. The vegan myth is astrology, not science
@craigcrawford6749 the carnivore comment makes sense. In fact THE only reason to do carnivore is because it normalizes abnormal gut microbiomes. It is a medicinal diet with very limited applications but in gut imbalances it shines.
What if body starts making tau and abeta proteines to protect brain against inflamation caused by junkfoods, microbiome disbiose, glycation by refined sugars ...
It's like you found a burn down house, then found blackened wood frames, then runs billions of scenarios, to find out which scenarios would produce blackened wood!
Awesome lecture. Proline is protective agent; however, leucine take away this protection. Even if leucine is good for muscle synthesis, it is bad for overall health. Proteins are re-cycled if not much protein is eaten. Mutation or formation of Tau Proteins cannot occur in low protein diets and sufficiently intense exercise. High protein is bad according to Dr. Campbell, Dr. Dan Zatarski, Dr. Longo, Dr. Rosdale, Dr. Tim Spector and others)
@@felicisimomalinao1981 of course they can form in a low protein diet... Eat a diet comprised of 70 % carbs, flood the brain with uric acid from fructose and get insulin resistant and starve the neurons to death... Care about chronic under hydration to import inflammation to the brain... And there you get it
Interesting - she mentioned the football players head injuries but who typically supplement with lots of protein to build muscle mass. Could it be the increased protein rather than head injuries causing more brain disease?
I would only think that excessive consumption of non-essential amino acids along with a diet deficient in essential amino acids would lead to prolonged states where the body must convert and steal non-essential aminos to make essentials therefore robbing those necessary aminos from the process of making proline. Getting “enough” essential amino acids and proline in highly bioavailable forms would seem to be key. Perhaps not too much but enough for certain. Starving the body of dietary proline and the necessary building block amino acids for proline would likely become a worse issue than slight excess.
So intriguing. Apparently Proline is key. Although Proline is a non-essential amino acid, meaning the body can make it, perhaps that process is energetically expensive or perhaps becomes broken in people who starve themselves of dietary proline forcing the body to rob and convert other amino acids to make it. Therefore, wouldn’t consuming enough bioavailable proline be the most likely solution? A dietary chronology comes to mind here. We were diabolically told to stop eating red meat, cholesterol (eggs) and saturated animal fats which led to the influx of seed oils and animal replacement proteins. People started starving themselves of the best sources of proline, collagen and essential cholesterol like meat, chicken skin, eggs and bone broth which includes all of those proline rich, knuckles, joints, ligaments and tendons that humans once prized in their recipes. There is a small amount of proline in some vegetable matter but meat, dairy and eggs are truly rich in the amino acids that are also in the biologically similar ratios to humans and in an easily digestible and bioavailable forms. On the other hand, I would think that forcing the body to convert plant based amino acids that are in ratios not similar to human biology might create eventual proline conversion inefficiencies and deficiencies.
Actually eating plant-based protein is key. More and more research shows that a plant-based diet can be protective from Alzheimer's. Remember that Leucine is bad, which is found in abundance in animal products. Legumes, nuts and many other plants are good plant-based sources of proline. Moreover, good gut microbiome promotes proline synthesis in our bodies. Studies found that vegans as a whole have the best gut bacteria.
Some research reporting lower intake of protein in diet is better overall for longevity especially when limiting in under 50 to 60 yrs of age. But after 60 research indicating better to increase protein amount. Maybe limiting protein in younger years then have less materials for creating on tau tangles? Also any thoughts on the protein ingested and how the protein was created (cooked etc.) prior to ingesting? Please could comment?
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Most people don't ingest enough protein so it's no concern there's too much protein in the diet. Ingested protein that is not absorbed by the body is converted into carb but the conversion process is slow so there's no concern of too much glycemic load. Protein is a safer form of energy than straight carb because protein doesn't increase blood sugar level to dangerously high.
Hello - great work. Have read brain cells not really dividing much - so if cell gets tau tangles and not to divide then no new daughter cells created with this tangle issue. But many not fully true on brain cells not dividing and these cells do divide so new brain cells like have with many other cell types?
Metabolic proteins to empower the study of A.I. Parkinsons is where the neural systems become embedded in traits of neural resting disintegration. Too much of not enough mental activity and Parkinsons is yours to battle.
As a non-medically educated person, my takeaway is )1 not to let Taus fly out of its original positions; 2) limit leucine intakes and increase proline intakes. Am I missing a point?
Sensible, but my guess is that limiting your leucine intake with the hope of preventing aggregation of tau is unlikely to make a difference, because when you cells make tau they will use whatever leucine is available, not proline instead of leucine. Besides, your cells need leucine for innumerable other uses, so you probably don’t want your diet to be too leucine-deprived.
But that's only if you have the predisposition or genetic mutation that this can occur.. Unfortunately, these amino acids always come together.Especially in a protein powder.. So I guess avoid the processed protein powders and just eat the whole real food. So that it will be perfectly balanced by nature.
If your immune system in general, including your gut microbiome and mitochondria are all healthy, you’ll be able to neutralize misfolded and misassembled cells. Protein intake in general is a vital part of that.
Someone working on a method to change the genetics? To get less leucine and more proline in our brain? That the genetic start of plaque forming is taken away. This is not a cure for all dementia but it will help many. Looking forward to this genetic manipulation.
APOE4 carriers are prone to HSV-1 outbreaks cause their APOE contains more arginine which HSV-1 metabolize. Plant based proteins (usually contain more arginine than lysine) make them more prone to HSV-1 outbreaks, just saying.
Very interesting. Presented excellently for all to follow along. It was cool to see Newton’s F=ma in this cutting edge simulation. I thought after high school, everything is using that head spinning thing called quantum.
I just read that hydrogen bonds actually have a quantum aspect to them; Newton’s law may merely serve as an approximation. But I am by no means an expert on the subject.
Tau is a protective mechanism, it is not the root cause. They are in La La Land with supercomputers. Remove vegetable oils, eat fat C15 (pecorino cheese), keto, move, remove processed carbs and you will never get Alzheimer.
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Check Out: "Mind-Body Medicine to Build Stress Resilience" here: th-cam.com/video/OIRT2gFPHOE/w-d-xo.html
Not much about homocysteine hmmmmm
Yeah, be careful... they're is a lot of bullshit out there! Follow your common sense.
Yes, fluoride from drinking and bathing water can inhibit the synthesis and metabolism of proline, although this effect is indirect and related to its interference with certain enzymes. Fluoride has been shown to inhibit the activity of enzymes that are dependent on cofactors like magnesium or zinc, as well as those involved in the citric acid cycle (Krebs cycle), such as aconitase. Proline synthesis depends on intermediates from the citric acid cycle (e.g., glutamate), so disruption of this cycle can indirectly affect proline production.
In particular:
1. Enzyme Inhibition: Fluoride inhibits enzymes like aldolase and enolase, which can disrupt glycolysis and energy metabolism, leading to downstream effects on amino acid biosynthesis.
2. Collagen Synthesis: Fluoride can reduce the availability of proline, which is essential for collagen synthesis, potentially affecting connective tissue health.
This interaction is one of the reasons fluoride toxicity is associated with skeletal and connective tissue disorders when exposure is excessive.
As is often the case, I gleaned more useful insights from the comments than from the video. Thanks!❤
I appreciate your insights. Is there are article you can reference to walk us through this process--it sounds complex.
I'm also interested in whether this effect can be offset by increasing proline consumption. N.B.--I've stopped using fluoride toothpaste; hydroxyapatate is now available as a remineralizing ingredient.
These computer models are amazing. I always wonder what kids would say if they saw these interesting scientific images. Thanks so much.
wrong title: it is not about "proteins", it is about the tau-protein, which gets dubbed as a "cause". ...while it is just a stepping stone in a causal chain
Proteins other than tau can clump.
HOMOCYSTEINE CAUSES EVERYTHING FROM VASCULAR PLAQUES TO BONE ISSUES TO EPILEPSY STROKES HEART DISEASE DEMENTIAS GIVE HOMOCYSTEINE SOME ATTENTION
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Thank you. That’s annoying.
@@anyajohnson4471Read " chronic diseases associated with malassezia yeast "
Super interesting. I can’t wait to read more on the subject.
In the book The China Study. Higher protein diets were associated with cancer vs lower protien diets.
very informative subject. Thank you...please continue your great work
NOT MUCH HERE ABOUT THE AMINO ACID HOMOCYSTEINE 🔹 Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Very interesting. Thank you. My first thought when I heard “seed” was that indeed the protein fibers seem prionic. My second thought was that inflammation plays a big role which means the immune system is very much involved in various dementia. It would not surprise me if later research was to reveal that individuals with early onstage dementia in addition to the substitution mutation of proline to lucine also have disrupted immunological response to infection/damage. If you recall in use of ChAdOx1 as an adjuvant, it elicited an immunological response, forming clumps in a small subset of individuals. Since your computer simulations showed that at higher temperatures more space was created for misfolded strains, please pursue the possibility that brain inflammation following repeated infections over a lifetime may lead to the fibril/misfolded plaques and disrupt the hairpin formation.
Seem "prionic"? The literature describes Alzheimers as a double prion disease. Substitution of one amino acid for another, hum, where have we heard that before?
Great program ; So good to hear♒️📚⚕️
The key is to eat plant-based protein. More and more research nowadays show that plant-based diet can be protective from Alzheimer's. Good gut microbiome promotes proline synthesis in our bodies. Studies found that vegans as a whole have the best gut bacteria. Legume, nuts, mushrooms and many other plants are good dietary sources of proline.
Another people clame their Parkinson gone with Carnivor diet.
@@DinamoDeet101 i guess we need to wait for the studies oj carnivore diet, only problem is that carnivores might die of clogged arteries long before they get alzheimers.
Who told you that eating proline can cause any effect in the diseases? Its a mutation in the proteins, you can eat all the proline in the world and that will make no difference. The vegan myth is astrology, not science
hahahahahaha, ok.
@craigcrawford6749 the carnivore comment makes sense. In fact THE only reason to do carnivore is because it normalizes abnormal gut microbiomes. It is a medicinal diet with very limited applications but in gut imbalances it shines.
What if body starts making tau and abeta proteines to protect brain against inflamation caused by junkfoods, microbiome disbiose, glycation by refined sugars ...
That’s the most probable cause since majority of people are in these horrible diets
Metals like aluminum and mercury are more likely. Aluminum is highly associated with AD.
24:28 extra Prolines are added to the Spike mRNA encodings in the covid vaccine so it does not change shape, as well.
Excellent.
It's like you found a burn down house, then found blackened wood frames, then runs billions of scenarios, to find out which scenarios would produce blackened wood!
BREATHING IS RELATED TO ALZHEIMERS AND PARKINSON'S IN CERTAIN CASES..
100% of people with Alzheimer’s have water in their system.
Awesome lecture. Proline is protective agent; however, leucine take away this protection. Even if leucine is good for muscle synthesis, it is bad for overall health. Proteins are re-cycled if not much protein is eaten. Mutation or formation of Tau Proteins cannot occur in low protein diets and sufficiently intense exercise. High protein is bad according to Dr. Campbell, Dr. Dan Zatarski, Dr. Longo, Dr. Rosdale, Dr. Tim Spector and others)
@@felicisimomalinao1981 of course they can form in a low protein diet... Eat a diet comprised of 70 % carbs, flood the brain with uric acid from fructose and get insulin resistant and starve the neurons to death... Care about chronic under hydration to import inflammation to the brain... And there you get it
Interesting - she mentioned the football players head injuries but who typically supplement with lots of protein to build muscle mass. Could it be the increased protein rather than head injuries causing more brain disease?
Maybe it is not the intense exercise but the diversion of imbibed protein into the muscles following the intense exercise.
I would only think that excessive consumption of non-essential amino acids along with a diet deficient in essential amino acids would lead to prolonged states where the body must convert and steal non-essential aminos to make essentials therefore robbing those necessary aminos from the process of making proline.
Getting “enough” essential amino acids and proline in highly bioavailable forms would seem to be key. Perhaps not too much but enough for certain. Starving the body of dietary proline and the necessary building block amino acids for proline would likely become a worse issue than slight excess.
So intriguing.
Apparently Proline is key. Although Proline is a non-essential amino acid, meaning the body can make it, perhaps that process is energetically expensive or perhaps becomes broken in people who starve themselves of dietary proline forcing the body to rob and convert other amino acids to make it. Therefore, wouldn’t consuming enough bioavailable proline be the most likely solution?
A dietary chronology comes to mind here. We were diabolically told to stop eating red meat, cholesterol (eggs) and saturated animal fats which led to the influx of seed oils and animal replacement proteins. People started starving themselves of the best sources of proline, collagen and essential cholesterol like meat, chicken skin, eggs and bone broth which includes all of those proline rich, knuckles, joints, ligaments and tendons that humans once prized in their recipes.
There is a small amount of proline in some vegetable matter but meat, dairy and eggs are truly rich in the amino acids that are also in the biologically similar ratios to humans and in an easily digestible and bioavailable forms.
On the other hand, I would think that forcing the body to convert plant based amino acids that are in ratios not similar to human biology might create eventual proline conversion inefficiencies and deficiencies.
Actually eating plant-based protein is key. More and more research shows that a plant-based diet can be protective from Alzheimer's. Remember that Leucine is bad, which is found in abundance in animal products. Legumes, nuts and many other plants are good plant-based sources of proline. Moreover, good gut microbiome promotes proline synthesis in our bodies. Studies found that vegans as a whole have the best gut bacteria.
Some research reporting lower intake of protein in diet is better overall for longevity especially when limiting in under 50 to 60 yrs of age. But after 60 research indicating better to increase protein amount. Maybe limiting protein in younger years then have less materials for creating on tau tangles? Also any thoughts on the protein ingested and how the protein was created (cooked etc.) prior to ingesting? Please could comment?
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.
Most people don't ingest enough protein so it's no concern there's too much protein in the diet. Ingested protein that is not absorbed by the body is converted into carb but the conversion process is slow so there's no concern of too much glycemic load. Protein is a safer form of energy than straight carb because protein doesn't increase blood sugar level to dangerously high.
Hello - great work. Have read brain cells not really dividing much - so if cell gets tau tangles and not to divide then no new daughter cells created with this tangle issue. But many not fully true on brain cells not dividing and these cells do divide so new brain cells like have with many other cell types?
Metabolic proteins to empower the study of A.I.
Parkinsons is where the neural systems become embedded in traits of neural resting disintegration. Too much of not enough mental activity and Parkinsons is yours to battle.
Too bad that the negative effects of free radicals on proline protein as an anti-oxidant was not mentioned.
proline is an amino acid not a protein. Please let the people that make reasearch for years work
What about aluminum?
Bingo!
As a non-medically educated person, my takeaway is )1 not to let Taus fly out of its original positions; 2) limit leucine intakes and increase proline intakes. Am I missing a point?
How do you do that? What are you supposed to eat?
Sensible, but my guess is that limiting your leucine intake with the hope of preventing aggregation of tau is unlikely to make a difference, because when you cells make tau they will use whatever leucine is available, not proline instead of leucine. Besides, your cells need leucine for innumerable other uses, so you probably don’t want your diet to be too leucine-deprived.
But that's only if you have the predisposition or genetic mutation that this can occur..
Unfortunately, these amino acids always come together.Especially in a protein powder..
So I guess avoid the processed protein powders and just eat the whole real food. So that it will be perfectly balanced by nature.
If your immune system in general, including your gut microbiome and mitochondria are all healthy, you’ll be able to neutralize misfolded and misassembled cells. Protein intake in general is a vital part of that.
…bodybuilders are using a supplement called Branched Chain Amino Acids…which is high in Leucine…big muscles, small brain
Leucine is abundant in animal protein.
Animal protein, eggs and dairy are also the best, most bioavailable sources of Proline.🧐
Someone working on a method to change the genetics? To get less leucine and more proline in our brain? That the genetic start of plaque forming is taken away. This is not a cure for all dementia but it will help many. Looking forward to this genetic manipulation.
How about dairy product?
APOE4 carriers are prone to HSV-1 outbreaks cause their APOE contains more arginine which HSV-1 metabolize.
Plant based proteins (usually contain more arginine than lysine) make them more prone to HSV-1 outbreaks, just saying.
Thanks. 26:28
The persons i knew with neurodegeneration abused alcohol ,sugar , softdrunks, adiction
Sounds like type 3 diabetes.
I also avoid shellfish just in case.
Why avoid shellfish, "just in case?" 26:28 @@chamuuemura5314
Very interesting. Presented excellently for all to follow along. It was cool to see Newton’s F=ma in this cutting edge simulation. I thought after high school, everything is using that head spinning thing called quantum.
I just read that hydrogen bonds actually have a quantum aspect to them; Newton’s law may merely serve as an approximation. But I am by no means an expert on the subject.
Tau is not causal in regards to Alzheimer
Tau is a protective mechanism, it is not the root cause. They are in La La Land with supercomputers.
Remove vegetable oils, eat fat C15 (pecorino cheese), keto, move, remove processed carbs and you will never get Alzheimer.
Because you studied science for decades, or because you made some research on the internet ?
@@PierreDybman 1st option
Maybe because the woodpecker is eating a species appropriate diet?
What would be the cause , please? Thank you.
Seems a song to the joy of research. Cure? Theories?
22:40 - ???
See the 2024 study headed by Dr. Dean Ornish. Plant based eating is both preventative and healing.
Looks like anaesthetic poisoning to me.
So vegans and vegetarians don't get mad cow disease.
Cow got mad cow, because they were fed cow protein…it happens when mammals eat their own species’ proteins.
🤪
Not necessarily. Patients who took growth hormone when it was obtained from cadavers prion disease.
Most get enough exposure to micro plastics to have similar symptoms.
Seems a song to the joy of research. Cure? Theories?
Homocysteine not only raises the levels of the dangerous p-tau,5 but can also bind to tau,6 further generating the neurofibrillary tangles that then trigger brain-cell death.