Remember the NMDA receptors are a type of glutamate receptor that play a crucial role in synaptic plasticity, learning, and memory. They are also involved in regulating neuronal excitability. The Magnesium ions (Mg2+) act as a natural blocker of NMDA receptors, preventing them from being activated by glutamate. Naturally When NMDA receptors are blocked by Mg2+, it can lead to a decrease in neuronal excitability. This is because NMDA receptors are important for generating action potentials. When NMDA receptors are blocked, neurons are less likely to fire action potentials, which can lead to a reduction in overall brain activity and this explains the use in management of seizures… However, in some cases, blocking the NMDA receptors can actually lead to increased neuronal excitability. This can happen when there is a sudden increase in the concentration of glutamate in the synapse. When this happens, the Mg2+ block is removed from the NMDA receptor, allowing it to be activated by glutamate. This can lead to a sudden and excessive influx of calcium ions into the neuron, which can trigger a cascade of events that ultimately lead to seizures.
with Phenobarbitone does not not only control seizures but also reduce the metabolism of the brain; so it also has synergistic neuroprotective effect when applied with therapeutic hypothermia, which is now considered as standard management for term newborns with moderate to severe encephalopathy for example
Thank you so much. You made my life easier a day to my final clinical assessment ❤
I’m glad the content is helping
all I can say is wooow! This is really life changing
may you please do a video on acute liver failure and maybe a series on blood and congenital heart diseases
I'm glad it is helping, will work on more content
Easy to understand content! Can't wait for more videos!!!
This was an amazing lecture, well explained and easy to understand. Thank you for the knowledge Dr. MK
you are welcome
absolutely, this was an amazing lecture, well explained and easy to understand. thanks Dr.
Glad it was helpful!
I needed this, thank you Doc
you’re welcome
hey, do have a video of celiac disease in pediatris please?
No not yet
Thank you 😊
Thanks doc, this is really informative
Glad it was helpful!
thanks for that amazing illustration
doctor could you drop the slides that had been used in the video please
arranging for that
@@DrMK7 Great, i wish the best for you.
Doctor it will be kind if you give us notification when you upload them.
والسلام عليكم ورحمة الله وبركاته
Awesome 👏🏻👏🏻
Thank you! Cheers!
❤❤❤
Bless you my friend
You are so kind
How does blockage of NMDA receptors by mg2+ cause epilepsy.i thought that would be rather a protective mechanism against epilepsy
Remember the NMDA receptors are a type of glutamate receptor that play a crucial role in synaptic plasticity, learning, and memory. They are also involved in regulating neuronal excitability.
The Magnesium ions (Mg2+) act as a natural blocker of NMDA receptors, preventing them from being activated by glutamate.
Naturally When NMDA receptors are blocked by Mg2+, it can lead to a decrease in neuronal excitability. This is because NMDA receptors are important for generating action potentials. When NMDA receptors are blocked, neurons are less likely to fire action potentials, which can lead to a reduction in overall brain activity and this explains the use in management of seizures…
However, in some cases, blocking the NMDA receptors can actually lead to increased neuronal excitability. This can happen when there is a sudden increase in the concentration of glutamate in the synapse. When this happens, the Mg2+ block is removed from the NMDA receptor, allowing it to be activated by glutamate. This can lead to a sudden and excessive influx of calcium ions into the neuron, which can trigger a cascade of events that ultimately lead to seizures.
I love this.
Can you do more on childhood seizure?
We will work on one
This was a great video.
Glad you enjoyed it
Great video🙌🙌
glad you liked the video
Your videos are the best
I am glad they are helping
Lovely lecture
Glad you liked it
please make a video on congenital heart disease
I did one on TOF
thank you so much dr
you’re most welcome 🙏
This video was very helpful thank you so much Dr Kazevu🙏
Thank you
Good content
thank you 🙏
Wow thank you for the good lecture,
I have a question why do we use phenobarbitone as a first dose in neonates, what's the physiology behind that??
with Phenobarbitone does not not only control seizures but also reduce the metabolism of the brain; so it also has synergistic neuroprotective effect when applied with therapeutic hypothermia, which is now considered as standard management for term newborns with moderate to severe encephalopathy for example
@@DrMK7 thank you so much Doc🙏
♥️
👍
Jaundice video please 🥺
Neonatal jaundice?
Yes neonatal jaundice
th-cam.com/video/WXwrYKYgRrM/w-d-xo.htmlsi=4yhCWobuEeNWzIoj
Exam tomorrow wish me luck
how did it go ?
We are waiting for more videos on seizures
Noted 💯