💊 👨🏫 Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/ 💉 📜 My Notes, cases and courses www.medicosisperfectionalis.com/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis
your lecture's so impressive!! my med college professor almost got me crazy understanding this simple stuff and u really saved me from being so thxs a lot
Einstein says if you can’t explain it clearly then u don’t understand it clearly. That’s what happens with most of our professors. Thank god we have medicosis who understands medicine in a very logical and thorough way so he can explain it in an amazing way
You are easily one of my favorite lecturers on TH-cam. I hope your channel becomes increasingly popular in the future. I've been sending your videos to my peers in grad school. Thank you for taking the time to make these videos. Some of these topics are not easy to find information for. Especially, the specific cellular, protein, and biochemical interactions. Again, thanks so much!
sir ! its been few days that i found your videos. im just obssesed with them. thank you so much sir. just a struggling student from afganistan. you are life saver and im not afraid of my finals anymore ! live long sir ! god bless you.
Thanks for the excellent video. Would like to point out an error here - the HFE gene which binds to transferrin, as you rightly pointed out, is important to upregulate hepcidin production in the hepatocyte and it's sensing function is not on the 'enterocyte' as you mentioned. If the HFE gene is mutated, then hepcidin is not produced, which leads to a perpetually active ferroportin and consequently iron overload.
You know I was really only watching this video to prove a point that iron is pronunced i-ern to someone else. But I stayed for the lesson because I have strange iron levels (low ferritin and very very high blood iron) so I wasn't sure what it meant. It wasn't clear if I was anemic or experiencing acute iron toxicity. But as a chemist watching this very chemistry pov video, I understand what's happening. Thank you!
4:12 Absorption in enterocytes Through, i) *Heme carrier protein-1* ii) *DMT-1* (Divalent Metal Transporter-1) Out of the enterocyte through, *Ferroprotin-1* 9:17 Regulation of Iron absorption *Hepcidin*
Correct me if I am wrong. But according to my understanding Fe+2 iron is not called heme iron. Irons that you get from food can be available in 2 forms: Heme or Non heme. Heme = protoporphyrin IX + Fe. The iron here can be either Fe +2/ Fe+3. Fe+2 is more common because in this state when present in hemoglobin or myoglobin it can bind to O2. Heme in Fe+3 state is also present, which is a small percentage and if present in Hb is called methemoglobin with poor ability to bind to O2. Non heme iron that is consumed from other mostly vegetarian sources are present in both Fe+2 and Fe+3. Non heme iron is different from heme iron in just that it dont have a protoporphyrin IX ring.
3 YT COMMERCIALS DANG.. 5:35 minutes into this video, for real? Come on TH-cam. Hey friend thank you for this information, I’m having to donate plasma to survive during Covid because I’m high risk for catching the virus and I’ve been deferred three times. For blow blood iron /Hemoglobin. I’m very appreciated thank you.
I have zero interest in the medical field, but I'm believed to have an absorption problem so that's why I'm here! This video is easy to follow and I actually learned stuff. Bonus points for being entertaining (I laughed at hydroxyl Free radicals being "Freaking bad" lol). Now I wait for a random conversation at a party to be about iron so I can impress my friends.
In 10:15 you said the enterocytes have a sensor that senses transferrin carrying iron... However, earlier, you said only Fe2+ gets absorbed in the duodenum... and Fe3+ binds with transferrin AFTER it passes the duodenum i.e in the blood. Could you please clear that up? Am I misunderstanding something?
Hey doctor you said sth about when a cell stays a lot without regenerating, that’s when cancer happens. But I thought when cells regenerate a lot that’s when cancer is more likely to happen (gastric ulcer causes the side of the ulcer to regenerate a lot until the process gets by mistake mutated and then dysplasia starts and cancer happens. So now I feel like I’m not understanding it enough can you help me in this?
Thank you for this wonderful review! Would you happen to know the pharmacology of why orange juice increases iron absorption? Or an article that you could provide that describes the science behind that?
What about the Iron present in macrophages? Since the RBC undergoes destruction in spleen every 120 days? How is the iron in macrophages which are accumulated in a long time removed from the body?
So what's the conclusion how to improve absorption and make it to the correct pathway I didn't understand Do we need a better quality iron supplement or do we have to get it from whole food or do we have to get a better vitamin C To make it absorb better in the correct path
Doctor, I have anemia due to iron deficiency. Mycrocytic hypochromic rbc cell. If I don't take orofer xt, hb decreases. I don't get iron from foods but from tablet. Why it's so. Please help what to do.
Sir I have a doubt iron binds with transferrin when it goes into blood stream but in the last of video you tell with the help of HFE gene fe3+get absorbed but it absorbed here in the form of fe2+
Thank you for your video. I think I have discovered I have some inflammation as I have raised CRP, Raised Ferritin and negative numbers in Iron Serum and Transferrin......can you add anything to this?
what is the role of dietary copper in iron digestion and metabolism? are there adaptogen which will automatically chelate iron when it is present in excessive amount? i think so changes in cooking vessels have influenced our iron problems
Trying to figure out my Anemia.. Just had my blood work done on my own. Strange I have low and high #"s ?? Unsaturated IBC is 457 which is high... BUT Serum is only 17 and Calc % Iron Sat is 4 ??? and they are very low... What do these low and high numbers mean ??
You’re right. But the amount being shed it in stool relatively low, and healthy people cannot develop iron deficiency just by shedding enterocytes. Meanwhile, it can happen in menstruating females...Thanks for adding clarity.
So, I was studying about atrophic gastritis and in some notes it says that:> PLEASE does this means? I tried to find information about that but it doesn't make sense.How can they secrete it since we mammals we don't produce ascorbic acid.
@@MedicosisPerfectionalis Are your Fe2+ and Fe3+ representations referring to the ionic forms of iron? I'm from a physics background and very unfamiliar with biochemistry. I was wondering how a distinction could be made between the two given that I believe ions to be very short lived in tissue
Sweet ass video! I dont have the slightest degree of medical knowledge but I actually learned something in 11minutes Im sure takes professors many lectures.
Dr. I'm kinda confused. They say iron is bound to ferritin and ferritin is bound to transferin . Correct me please. When iron is out of enterocyte (duodenum) does it bound to ferittin or it is in ferric form before entering the blood vessel/before it bounds to transferin
Yup that is the point he missed and didn’t even mention. When iron is going out of enterocyte it converts back to ferric form by Hephaestin and then goes to blood as in ferric shape. Then bond with transferrin protein and circulate inside blood. But when it goes to organs for the storage then it store in shape of ferritin(means bond with ferritin and then store there)
Fe3+ is very poorly absorbed by human’s intestines. It requires the conversion into Fe2+ in the enterocytes. The main issue is the source and type of iron. Heme iron is better absorbed and the best source for humans is animal products (more easily absorbed) I wish you the best! Thanks for your question.
Medicosis Perfectionalis thank you for your reply. I would love to see a similar video about how the non heme iron is getting absorbed. The vegan topic is very pressing.
Jaxon Basra I would be happy to look at any piece of research that you recommend...I am open to change my mind...I am not giving any professional advice...I just tell you what I read in medical textbooks like Guyton’s and Harrison’s...Please let me know about research studies and I will take a look. Thanks 🙏
Your videos are very interesting and very informative to watch....I'm doing some research about thalassemia regardless of decreasing the conduction of motor units peripherally in MS.
But only if it doesn’t need to be used immediately. And we assume the ferroportin ‘gate’ also sends fe2 to bones for heme production (not just fe3 for storage)? So if I increase my macrophages I could potentially reduce iron toxicity and store more fe3?
💊 👨🏫 Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/
💉 📜 My Notes, cases and courses www.medicosisperfectionalis.com/
😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119
📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis
Medicosis Perfectionalis fantastic video .... your videos are really helping me a lot
Excellent!
I just love the way that you dissect the courses, even to the extent of breaking down the medical terms!
Wow 🤩
Thank you so much 😊
Resident doctor here. Excellent overview! You got yourself a new sub.
Welcome to the tribe 😊
your lecture's so impressive!! my med college professor almost got me crazy understanding this simple stuff and u really saved me from being so thxs a lot
My pleasure 😇
School professor don't know how to teach
Einstein says if you can’t explain it clearly then u don’t understand it clearly. That’s what happens with most of our professors. Thank god we have medicosis who understands medicine in a very logical and thorough way so he can explain it in an amazing way
You are easily one of my favorite lecturers on TH-cam. I hope your channel becomes increasingly popular in the future. I've been sending your videos to my peers in grad school. Thank you for taking the time to make these videos. Some of these topics are not easy to find information for. Especially, the specific cellular, protein, and biochemical interactions. Again, thanks so much!
Thank you so much! I am truly honored!
sir ! its been few days that i found your videos. im just obssesed with them. thank you so much sir. just a struggling student from afganistan. you are life saver and im not afraid of my finals anymore ! live long sir ! god bless you.
Thanks for the excellent video. Would like to point out an error here - the HFE gene which binds to transferrin, as you rightly pointed out, is important to upregulate hepcidin production in the hepatocyte and it's sensing function is not on the 'enterocyte' as you mentioned. If the HFE gene is mutated, then hepcidin is not produced, which leads to a perpetually active ferroportin and consequently iron overload.
I never see a good lecturer like you in every course you take
Thank you so much 😊
Going to be a MLT, you explain things better than my professor, only watched two videos so far but ima sub thx for great content!
Thank you so much 😊
Good luck to you!
Same
You know I was really only watching this video to prove a point that iron is pronunced i-ern to someone else. But I stayed for the lesson because I have strange iron levels (low ferritin and very very high blood iron) so I wasn't sure what it meant. It wasn't clear if I was anemic or experiencing acute iron toxicity. But as a chemist watching this very chemistry pov video, I understand what's happening. Thank you!
What does it mean ?
4:12 Absorption in enterocytes
Through, i) *Heme carrier protein-1*
ii) *DMT-1* (Divalent Metal Transporter-1)
Out of the enterocyte through, *Ferroprotin-1*
9:17 Regulation of Iron absorption
*Hepcidin*
Like your sassy manner of explaining really makes up my day 🙂🤣🤣🤣💖
Thank you 🙏
I'm lucky to see this video for my study, thanks alot
I appreciate you!
You guys make great easy to understand videos!!
Glad to hear that!
Correct me if I am wrong. But according to my understanding Fe+2 iron is not called heme iron. Irons that you get from food can be available in 2 forms: Heme or Non heme.
Heme = protoporphyrin IX + Fe. The iron here can be either Fe +2/ Fe+3. Fe+2 is more common because in this state when present in hemoglobin or myoglobin it can bind to O2. Heme in Fe+3 state is also present, which is a small percentage and if present in Hb is called methemoglobin with poor ability to bind to O2.
Non heme iron that is consumed from other mostly vegetarian sources are present in both Fe+2 and Fe+3. Non heme iron is different from heme iron in just that it dont have a protoporphyrin IX ring.
Nithin Kumar he explained all this ma’am
*sigh* I'm very disappointed in my medical education quality. You, sir, are amazing, though
Thank you so much for your kindness!
Had a buddy who asked me if I could send him my notes on iron...
I sent him this vid instead
Thank you so much 😊
You're the best!
Fenton reaction is ferrous iron with hydrogen peroxide. Your diagram and explanation made it sound like ferric was the cause.
3 YT COMMERCIALS DANG.. 5:35 minutes into this video, for real? Come on TH-cam. Hey friend thank you for this information, I’m having to donate plasma to survive during Covid because I’m high risk for catching the virus and I’ve been deferred three times. For blow blood iron /Hemoglobin. I’m very appreciated thank you.
Thankyou for making iron studies easier! 💯
My pleasure...I am happy to help!
Wow u made hematology so much more interesting..tysm
My pleasure 😇
I have zero interest in the medical field, but I'm believed to have an absorption problem so that's why I'm here! This video is easy to follow and I actually learned stuff. Bonus points for being entertaining (I laughed at hydroxyl Free radicals being "Freaking bad" lol). Now I wait for a random conversation at a party to be about iron so I can impress my friends.
Awesome 👏
Great video. My takeaway from this is - how did evolution manage all this ? Just amazing.
Subscribed.
In 10:15 you said the enterocytes have a sensor that senses transferrin carrying iron... However, earlier, you said only Fe2+ gets absorbed in the duodenum... and Fe3+ binds with transferrin AFTER it passes the duodenum i.e in the blood. Could you please clear that up? Am I misunderstanding something?
yourr voice is amazinggg ...😻
Thanks 😊
What an explanation Sir😘
Hey doctor you said sth about when a cell stays a lot without regenerating, that’s when cancer happens. But I thought when cells regenerate a lot that’s when cancer is more likely to happen (gastric ulcer causes the side of the ulcer to regenerate a lot until the process gets by mistake mutated and then dysplasia starts and cancer happens. So now I feel like I’m not understanding it enough can you help me in this?
Wow, you made everything comprehensible! Thank you!
+Lee Romeo Don’t mention it! So delighted I was able to help!
@@MedicosisPerfectionalis I have iron dificiency some that I feel when I am talking my tongue is heavy I can't talk what is that plz help
Amazing video...it's very clear and the first time understand iron study.....thanx doctor🌹🌸🌹
My pleasure 😇
wow, i needed this lecture for better understanding of iron studies .
I appreciate you!
3:50 sick mnemonic device bro!
Haha 🤣
you make every thing seem so easy thank you so much your channel is a life saver
Thank you for this wonderful review! Would you happen to know the pharmacology of why orange juice increases iron absorption? Or an article that you could provide that describes the science behind that?
Something I read: The Ferroxidase that oxidises iron molecules so that it can travel through the intestine is called Vitamin C Ferroxidase.
What about the Iron present in macrophages? Since the RBC undergoes destruction in spleen every 120 days? How is the iron in macrophages which are accumulated in a long time removed from the body?
i really appreciate your efforts, it was very helpful,,, but what about the (D cytochrom b), Is it has the same vit c function??? Why?
Thank you.❤️ Simple yet informative .
Glad it was helpful!
Thank You❤
Why is the Fe2 getting converted back to fe3 for usage in the blood stream? Why was it converted to f2 in the first place?
So what's the conclusion how to improve absorption and make it to the correct pathway I didn't understand Do we need a better quality iron supplement or do we have to get it from whole food or do we have to get a better vitamin C To make it absorb better in the correct path
Bro you are super good ❤😊
Thank you for simplifying the concept .
I don't know what to say to you bcz You always amaze me💓
Thank u so much and continue 🌹🌹
🩸 Hematology Playlist: th-cam.com/play/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU.html&si=tomFsUjAgOKhOJVq
Amazing !! Amazing !! Amazing!! All of your videos
Thank you 🙏
so, what happens when you supplement iron but have extremely low transferrin ? Do you poop it out?
Doctor, I have anemia due to iron deficiency. Mycrocytic hypochromic rbc cell. If I don't take orofer xt, hb decreases. I don't get iron from foods but from tablet. Why it's so. Please help what to do.
You are the best of the bests ❤️
Thank you very very very very much, i am from iraq ,i happy when i see your vedio
Thanks
Sir I have a doubt iron binds with transferrin when it goes into blood stream but in the last of video you tell with the help of HFE gene fe3+get absorbed but it absorbed here in the form of fe2+
Thank you for your video. I think I have discovered I have some inflammation as I have raised CRP, Raised Ferritin and negative numbers in Iron Serum and Transferrin......can you add anything to this?
what is the role of dietary copper in iron digestion and metabolism? are there adaptogen which will automatically chelate iron when it is present in excessive amount? i think so changes in cooking vessels have influenced our iron problems
what is Apoferritin and what is his work????
You’re AMAZING
Thank you 😊
How we get fe2+ in rbc . Absorbe fe2+ is converted to fe3+ and transferred as fe3+. Please clarify it medicosis
Thank u sir... Your teaching skill is amazing 💓❤
My pleasure 😇
Thanks for a great video. So, in other words; the F2+ (HEME-IRON) supplement would be better in terms of absorption and side-effects?
This was so amazing and informative.. thank you... Keep up the good work plz :)
I sure will...Thanks 😊
In the words of Karate Kid... You're the best... arooouund!
Thank you 😊
Trying to figure out my Anemia.. Just had my blood work done on my own. Strange I have low and high #"s ?? Unsaturated IBC is 457 which is high... BUT Serum is only 17 and Calc % Iron Sat is 4 ??? and they are very low... What do these low and high numbers mean ??
Which iron supplement should i take ferrous sulfate fe2 or fe3 ...?
Thank you very much for very useful info
My pleasure 😇
Can you please help me by sharing?
Thanks ❤
You're welcome 😊
Love u brother for such awesome videos jazakallah sir , thanks you tube.
Thank you so much!
Nice presentation
Thanks 🙏
Nice video
Thank you
this is amazing thank you! ferritin never made sense - this is very helpful!
You’re very welcome 😊
Your videos are really awesome ! I just love it ...u make topics quite easy to understand ...THANK YOU 😄😄
My pleasure...I am truly honored...Can you please help me by sharing my videos with others?
Why did you say in the beginning there is no way to get rid of iron except in mensuration, while it could shed with enterocytes in feces?
You’re right.
But the amount being shed it in stool relatively low, and healthy people cannot develop iron deficiency just by shedding enterocytes. Meanwhile, it can happen in menstruating females...Thanks for adding clarity.
So, I was studying about atrophic gastritis and in some notes it says that:> PLEASE does this means? I tried to find information about that but it doesn't make sense.How can they secrete it since we mammals we don't produce ascorbic acid.
I don't know what that means
thank you 💜
My pleasure 😇
Thankyou so much.. helpfulvideo 🌺
My pleasure 😇
I love your videos. Thank you!!
You’re very welcome 😊
Thank u so much, u make things so easy and enjoyable
My pleasure...Thanks for watching!
Thank you for the informative and useful video.
My pleasure 😇
very informative,,,appreciable...good work.:)
Thanks for your kind words! 😃
Are you referring to ions (Fe2+, Fe3+)? And if so don't they become neutral in compounds very quickly?
What do you mean?
@@MedicosisPerfectionalis Are your Fe2+ and Fe3+ representations referring to the ionic forms of iron? I'm from a physics background and very unfamiliar with biochemistry. I was wondering how a distinction could be made between the two given that I believe ions to be very short lived in tissue
Awesome video!! You are so funny and smart. Thank you
Thanks 🙏
Sweet ass video! I dont have the slightest degree of medical knowledge but I actually learned something in 11minutes Im sure takes professors many lectures.
Thank you so much ☺️
What makes the vit c compatible to iron??
Dr. I'm kinda confused.
They say iron is bound to ferritin and ferritin is bound to transferin . Correct me please. When iron is out of enterocyte (duodenum) does it bound to ferittin or it is in ferric form before entering the blood vessel/before it bounds to transferin
Yup that is the point he missed and didn’t even mention.
When iron is going out of enterocyte it converts back to ferric form by Hephaestin and then goes to blood as in ferric shape.
Then bond with transferrin protein and circulate inside blood.
But when it goes to organs for the storage then it store in shape of ferritin(means bond with ferritin and then store there)
Thank you so much.
Gracias
De nada!
Awesome 😎
Thank you 😊
A lot of thanks
Hi, I would like to know how is Fe3+ iron absorbed? I don't eat meat and I understand that Fe2+ comes from meat.
Fe3+ is very poorly absorbed by human’s intestines. It requires the conversion into Fe2+ in the enterocytes.
The main issue is the source and type of iron. Heme iron is better absorbed and the best source for humans is animal products (more easily absorbed)
I wish you the best!
Thanks for your question.
Nope!
Medicosis Perfectionalis thank you for your reply. I would love to see a similar video about how the non heme iron is getting absorbed. The vegan topic is very pressing.
Jaxon Basra I would be happy to look at any piece of research that you recommend...I am open to change my mind...I am not giving any professional advice...I just tell you what I read in medical textbooks like Guyton’s and Harrison’s...Please let me know about research studies and I will take a look.
Thanks 🙏
Iveta Grazule That’s a good topic for a video.
Thank youuu your videos are so well-constructed and helpful!!! ♡ keep up the great work!
Thanks for your kind words! You made my day!
Medicosis Perfectionalis you are making my exam period tolerable ;p
That’s the best thing to hear...I wish you best of luck from the bottom of my heart!
Incredible ♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️👏
Your videos are very interesting and very informative to watch....I'm doing some research about thalassemia regardless of decreasing the conduction of motor units peripherally in MS.
Great...But, I didn’t understand the last part.
Oh! Your are great.
Thanks
Thank you 🙏
You make medicine so lot easy! Thankyou
Could you make videos on other minerals as well (was particularly searching for Zinc and acrodermatitis)?
Sure!
Thank you so much 😊
Thank youuu💞
so no apoferritin, ceruloplasmin?
Well explained!!! Thank you 🙏🏻
You’re welcome 😇
Thanks
My pleasure 😇
So if I ingest fe2 it turns into fe3 and sent to the bone where it’s turned into heme fe2 again?
But only if it doesn’t need to be used immediately. And we assume the ferroportin ‘gate’ also sends fe2 to bones for heme production (not just fe3 for storage)? So if I increase my macrophages I could potentially reduce iron toxicity and store more fe3?
So iron deficiency is probably caused because my bones don’t make enough red blood not because iron intake deficiency
عاااااش
Thank you 🙏
Perfect
Thnxx❤🙌🏻
My pleasure 😇