To conclude for T,2,3 rectal tumors short course radiation is appropriate as in RAPIDO trial, but for stage 3 or T4 tumors long course CRt is preferred. In either case surgery is performed 8-10 weeks after the last dose of radiation and chemo is given peri-operatively. TNT implies chemo radiation and 3months of chemo prior to TME. OPRA trial shows slight advantage of chemo ( consolidation) after radiation rather than before (induction chemo).
I'm starting immunotherapy with Keytruda beginning on March 4th. I have stage 4 rectal cancer, with a miss-matched mutant tumors. Eighteen patients were involved in a clinical trial at Memorial Sloan Kettering Cancer Center one year ago and they had a 100% success rate. All their tumors vanished. What better odds can I get.
To conclude for T,2,3 rectal tumors short course radiation is appropriate as in RAPIDO trial, but for stage 3 or T4 tumors long course CRt is preferred. In either case surgery is performed 8-10 weeks after the last dose of radiation and chemo is given peri-operatively. TNT implies chemo radiation and 3months of chemo prior to TME. OPRA trial shows slight advantage of chemo ( consolidation) after radiation rather than before (induction chemo).
I'm starting immunotherapy with Keytruda beginning on March 4th. I have stage 4 rectal cancer, with a miss-matched mutant tumors. Eighteen patients were involved in a clinical trial at Memorial Sloan Kettering Cancer Center one year ago and they had a 100% success rate. All their tumors vanished. What better odds can I get.
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