great vidio sir, but i have a question. Does this apply to all types of oil and surfactants? Because the properties of oils are different, so are the surfactants. What parameters are used to select surfactants when mixing.
Sir, Nice presentation Please clarify two doubts 1. We have to take the mL of water at which turbidity is visualize or a point before the turbidity appears for the pseudoternary phase diagram. 2. While taking smix let say 1:1 they have to be prepared separately then added into the oil or we can add first surfactant and then co-s-surfactant
@@drswayamprakashpatel5436 Sir, Thanks for clearing the doubts, please also clarify if on adding the very first drop of water the system becomes turbid then in that case what should be taken as the volume of water. For eg. If my system becomes turbid at 1:2.3 and remains turbid throughout 1:0.11 then in that case what to do
Sir, In shaded region points should be selected as per your need. If you need higher amount of oil to load maximum drug than select point with maximum oil. If you need to focus globule size and stability then select point with higher amt of surfactants. You may also employ DoE for selected region.
Great video sir it helped me a lot to understand the formulation method development of microemulsion ❤️
Simply Superb ... Tq
Thanks a lot for this understanding!!!
You save me sir.. thank you very much.. love from sri lanka ❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤
thank you sir,, it was really helpfull
Very nice Sir.Thanks
Good sir...
great vidio sir, but i have a question. Does this apply to all types of oil and surfactants? Because the properties of oils are different, so are the surfactants. What parameters are used to select surfactants when mixing.
Thanks a lot sir
during preparation we use in % or in ml? if in ml, should we fixed the total surfactant concentration right?
sir what is end point of titration if we preforming graph for the Microemulsion
Thank you
In the case of Smedds when you select 4 points...as per its transparency...same this only points should be used in ternary phase diagram??
Sir, I have a doubt. How can we fix the amount of water for dilution in SMEDDS ternary phase diagram?
hello sir , please can you tell - how to compare microemulsion area of 2 different system or how to quantify the systems
How to identify nanoemulsion range?
Sir, Nice presentation
Please clarify two doubts
1. We have to take the mL of water at which turbidity is visualize or a point before the turbidity appears for the pseudoternary phase diagram.
2. While taking smix let say 1:1 they have to be prepared separately then added into the oil or we can add first surfactant and then co-s-surfactant
1) Theoretically, it should be just before turbidity appear.
2) First prepare Smix (so three phase: Oil, SMix and Water) for pseudo ternary graph
@@drswayamprakashpatel5436 Sir, Thanks for clearing the doubts, please also clarify if on adding the very first drop of water the system becomes turbid then in that case what should be taken as the volume of water.
For eg. If my system becomes turbid at 1:2.3 and remains turbid throughout 1:0.11 then in that case what to do
@@shashankchaturvedi1719 Count percent of water as zero.
How to dilute with fix amount of water and why sorry?
How to use tridraw for plotting of pseudoternary phase diagram
Sir , at 20:35 min ..that 4th,5th and 6th column in excel how u got that points 1.011 then 9.0901and 89.899?pls clarify it in detail
I have converted values of oil, surfactant and water into percentages. value multiplied by 100 divided by total volume (three column)
Sir, in case of pseudo ternary phase diagram for microemulsion, how to select the point in shaded region.
Sir, In shaded region points should be selected as per your need. If you need higher amount of oil to load maximum drug than select point with maximum oil. If you need to focus globule size and stability then select point with higher amt of surfactants. You may also employ DoE for selected region.
@@drswayamprakashpatel5436 thank you sir
Sir.....This information is suitable for self nano emulsifing drug delivery systems
Yes
How to dilute with fix amount of water and why sir ?
In SMEDDS It is expected to self emulsion formation when patients consume it with a glass of water. So in SMEDDS only diluting with water.
sir please tell me that of Smix is 2:1 best then which oil ratio must be used for preparation of nanoemulsion?
You need to find by preparing pseudo ternary phase diagram. That's what this video for.
Sir, Whats the difference between a TERNARY & Pseudo-TERNARY phase diagram??.....Why Pseudo word is used??
well explained in video. Three system - ternary, Four component in ternary diagram - Pseudo
Thank you sir