Thank you so much for these videos! I passed my TEAs with an 87 today and I wanted to say thank you for what you do :) The more educators- the better the world !
Good video. One mistake is about parathyroid hormone. PTH actually doesn't affect osteoclasts at all as they have no PTH receptors. It affects the osteoblasts, which control the osteoclasts. At a low continuous dose of PTH in the body, the osteoblasts will secrete M-CSF and express RANK-L which stimulates the osteoclasts to break down bone. The RANK-L (ligand) on osteoblasts binds to RANK (receptor) on the osteoclasts to stimulate them. In addition, estrogen will affect the osteoblasts mainly. It downregulates RANK-L and decreases M-CSF expression. It also allows osteoblasts to create osteoprotegerin (OPG) which is a decoy receptor for RANK-L on osteoblasts, which decreases stimulation of RANK on osteoclasts. This all leads to increases bone formation from estrogen.
this is helping me a lot towards my level 2 gym instructor course, your voice is chill and the drawings with the labels really help. most science people on the youtube are nutjobs who i cant take serious.
god bless u susanheinze , ur an amazing talent ,please do keep on updating videos of anatomy of different systems also in the same way the way u did for this one .thk u very much u r a god send gift for lots of medics like us..
Thank you for this wonderfully detailed video. But I couldn't agree with you regarding the origin of the osteoclasts. As far as I know osteoclasts are derived from macrophages.
Thank you so much, you are very helpful and I like that you give details like hormones, and you explain the correlation between things, I was looking for a person like you, keep doing it! 🌸
I thank you very much God bless you. You make it easy for me I had hard time to understand bones well is only bones I watched most of your video it is awesome😍😍😍😍😍
theadrinka86 Not at all. I used this channel, decks, and a book called, "Dental Board Busters", that my classmate recommended. These resources were thorough, but not just the decks; they are good for general questions, but not for the small details within content.
amazing video.... but one correction is needed... PTH actually acts on osteoblast as it has receptor for the hormone.... and further this hormone stimulates osteoclast..... PTH does Not directly act on osteoclast...
Osteoblast and not osteoclasts have specific surface receptors for agent , such as 1,25-dihydroxy vitamin D3 and parathyroid hormone. So osteoclast in culture, which are therefore not in contact with osteoblast, do not respond to these agents.......please donot make mistakes.
Thank you so much for these videos!
I passed my TEAs with an 87 today and I wanted to say thank you for what you do :)
The more educators- the better the world !
you make anatomy and physiology so much easier to understand. Thank you!
Good video. One mistake is about parathyroid hormone. PTH actually doesn't affect osteoclasts at all as they have no PTH receptors. It affects the osteoblasts, which control the osteoclasts. At a low continuous dose of PTH in the body, the osteoblasts will secrete M-CSF and express RANK-L which stimulates the osteoclasts to break down bone. The RANK-L (ligand) on osteoblasts binds to RANK (receptor) on the osteoclasts to stimulate them.
In addition, estrogen will affect the osteoblasts mainly. It downregulates RANK-L and decreases M-CSF expression. It also allows osteoblasts to create osteoprotegerin (OPG) which is a decoy receptor for RANK-L on osteoblasts, which decreases stimulation of RANK on osteoclasts. This all leads to increases bone formation from estrogen.
It's amazing! It's so clear and easy to understand! Thank you so much for sharing your talent!
sangjeung kim Thank you for your encouraging comment! Please let me know of other topics you would like to see.
Very informative and you also have very nice hand writing.
Thanks a lot -- I have started my first semester in medicine and this was way better than the lecture I had .
this is helping me a lot towards my level 2 gym instructor course, your voice is chill and the drawings with the labels really help. most science people on the youtube are nutjobs who i cant take serious.
god bless u susanheinze , ur an amazing talent ,please do keep on updating videos of anatomy of different systems also in the same way the way u did for this one .thk u very much u r a god send gift for lots of medics like us..
Thank you so much for this very kind comment. I really appreciate it.
Excellent 👍
Thank you for this wonderfully detailed video. But I couldn't agree with you regarding the origin of the osteoclasts. As far as I know osteoclasts are derived from macrophages.
Yes, thanks for pointing that out. I need to redo this video because of that error.
thank u so much for sharing such amazing videos as they Help a lot in making our concepts really clear....... keep sharing your knowledge.... thank u
Vandana Pandey Thank you for taking the time to write this encouraging comment!
Thank you for posting this video very clear and easy information to understand
Helpful video hai
its very excellent and easy to understand
Wish my college professors were this thorough and clear. I would have been more interested.
Great examples this is going to help me a lot in my anatomy quiz today!!
Thank you so much, you are very helpful and I like that you give details like hormones, and you explain the correlation between things, I was looking for a person like you, keep doing it! 🌸
Great video BUT Quick note - osteoprogenitor cells do not turn into osteoclasts! Osteoclasts are derived from WBC's!!!!
Great video! Thank you for doing this!
Thank you so much! I'm going to play this for my kids for our homeschool anatomy and have them draw and label a bone with you as we go along.
I thank you very much God bless you. You make it easy for me I had hard time to understand bones well is only bones I watched most of your video it is awesome😍😍😍😍😍
Very helpful! Thanks for making this video!
Love it. Helpful. Thank you.
Osteoprogenitor cells do not give rise to osteoclasts. Osteoclasts come from macrophages.
+aznpercussionboy that's right, reading my textbook it states, "Osteoclasts originate within the red bone marrow monocyte/macrophage lineage."
hey could you please tell me which book you were reading?
Awesome video...I actually remember this info now!
Excellent clarification video! I'm using your series to study for my NBDE-I
nahoga same!! Good luck! 🍀
theadrinka86 Thank you! I passed, and this channel helped! ;)
nahoga great! I'm still studying, do you think studying only from the dental decks is enough?
theadrinka86 Not at all. I used this channel, decks, and a book called, "Dental Board Busters", that my classmate recommended. These resources were thorough, but not just the decks; they are good for general questions, but not for the small details within content.
nahoga I'll check it out, thank you for replying!!
amazing video.... but one correction is needed... PTH actually acts on osteoblast as it has receptor for the hormone.... and further this hormone stimulates osteoclast..... PTH does Not directly act on osteoclast...
Yes, thank you for the correction. Sometimes in my desire to make complex topics I over-simplify too much. Thank you for taking the time to comment.
what effect would an increase in parathyroid hormone secretion have on blood calcium levels
increase blood calcium levels
very systematic , nicely explained .
Thank you!
Thanks, very informative.
i love your videos!!! thank you so much!!
Good video, thanks.
thanks you are awesome, keep going!!!
bones you find in the woods? what lol
wonderful explaning. Could you please scan the papers which you have writed and upload them for us as PDF file ?!
These videos are great! Could you do something on osteogenesis?
Thank you for your comment! I will add osteogenesis imperfecta to my list of diseases to make a video on (at some point!)
Happy Studying!
Really good I enjoyed each minute of it
So helpful thank u so much
bundle of thanks for the video
great video thanks
Omg I love you
Osteoblast and not osteoclasts have specific surface receptors for agent , such as 1,25-dihydroxy vitamin D3 and parathyroid hormone. So osteoclast in culture, which are therefore not in contact with osteoblast, do not respond to these agents.......please donot make mistakes.
find bones in the woods??? lol
can i get copies of your notes?
Great
Lol! In the woods!
Thank you
perfect
bones in the wood. lol
Thanks
You are very welcome!
Sankesh Kumar am I still growing at 18
Bones
12:20
irritating