Translation Initiation in Eukaryotes

Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recycling.
CAP-DEPENDENT AND CAP INDEPENDENT INITIATION PATHWAYS :
Initiation of translation usually involves the interaction of certain key proteins, the initiation factors, with a special tag bound to the 5'-end of an mRNA molecule, the 5' cap, as well as with the 5' UTR. These proteins bind the small (40S) ribosomal subunit and hold the mRNA in place. eIF3 is associated with the 40S ribosomal subunit and plays a role in keeping the large (60S) ribosomal subunit from prematurely binding. eIF3 also interacts with the eIF4F complex, which consists of three other initiation factors: eIF4A, eIF4E, and eIF4G. eIF4G is a scaffolding protein that directly associates with both eIF3 and the other two components.
The best-studied example of cap-independent translation initiation in eukaryotes uses the internal ribosome entry site (IRES). Unlike cap-dependent translation, cap-independent translation does not require a 5' cap to initiate scanning from the 5' end of the mRNA until the start codon.

[@AarushiK.P]

It's 3am right now, I am pulling an all-nighter and feel so relieved to have FINALLY understood all the eIAFs in this mechanism. Thank you so much.

[@izzanare2605]

i have my molecular biology exam in three days thanks for explaining this better than my professor

[@ridhimagaur1213]

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[@huzaifa2k1]

On 5th of January 2023 I'm having my final exam for molecular Biology (I'm doing Bsc in Biotechnology and Genetic Engineering currently 5th semester final exam gonna start).

[@achalrathore5564]

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[@izrai911]

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[@Scholarship_hunters]

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[@anxiousaquarius6926]

Thank you for explaining such a complicated process in detail!

[@HectixShorts]

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[@ankitayadav1123]

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[@thanglam7567]

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[@avinavsingh4463]

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[@fuzailahmad00786]

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[@ammarahchaudhary2820]

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[@surayajan190]

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[@getitdone0010]

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[@alirezahekmati7632]

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