Hello ma'am, I am a medical student from Bangladesh. Ma'am I watch your videos to clear my doubts. Your videos are simple and to the point. God bless you ma'am.
I have a quick question ma'am. So at 12:29 you mentioned that NH4 splits into H and NH3 and then then NH3 goes to the lumen to pick up H that was secreted and expels out. But what about the H that came from splitting NH4 itself? Wouldn't that create acidotic environment in the body?
Hello mam, I have a confusion how CO2 causing acidosis?? CO2 is producing both h+ ion and HCO3- ion at the same rate CO2 + H2O ➖H2CO3 ➖ H+ ➕HCO3- Won't HCO3 ions also affect ph along with h+ ion??
Ph depends on concentration of hydrogen ions...the reaction of bicarbonate ions combining with hydrogen ions can proceed backwards (thus mopping hydrogen ions) only when co2 concentration is less. If co2 increases...the reaction proceeds in this direction producing more h ions
Is my understanding right mam This topic is so confusing mam I have exam tmrw plzzz....say can i write this explanation in exam mam...plzzzzzzz reply as soon as possible mam🥺 what is happening in the acid-base balance of body means, normally due to metabolic processes, our body is constantly producing acids. So, the type of acids which we are producing are volatile and non-volatile acids. So, volatile acids are like h2co3 can be excreted out as carbon dioxide and non-volatile acids are which are metabolic acids, like lactic acid, So, normally the blood concentration of H+ is in the 50 nanograms so p the pH will be around 7.35 to 7.45 . this pH must be maintained, but the non-volatile acid which is produced will be equal to 50 milliequivalents by the body daily, so this will increase the pH drastically, so to avoid this what will happen is whatever the 50 milliequivalents of acid is produced that should be excreted out from the body. Now, this, these non-volatile acids which should be excreted out from the body by the kidneys, but before reaching the kidneys itself it will increase the pH drastically, so it will be initially buffered by bicarbonate ions in the blood , there are also other buffers like phosphate, ammonia, protein buffers, but the primary buffer is bicarbonate, this bicarbonate is utilised here now, the pH will not decrease, nonvolatile and bicarbonate (which are now together) can be taken very safely to the kidneys for excretion. Now, in the kidneys, what should happen in the sense, bicarbonate buffer which is utilized to buffer non volatile acid and got excreted along with nonvolatile acid should be regenerated and the bicarbonate which are reaching by filtration should also be reabsorbed...so for these two things to take place tubular cells secrete h+ ions...in pct,ascending limb,early distal tubules all the secreted h+ will be utilised for the reabsorption of bicarbonate (no excretion of h+)and and in late dct and collecting duct h+ secretion will be used for generating new hco3- (to compensate for hco3 that is lost with nonvolatile acid) but h+ cannot be secreted in in its free form because it will increase the tubular fluid ph more and van damage the tubular cells..so these are buffered by ammonia and phosphate and excreted
I think it’s a good understanding…very small mistakes but not important for exams…you can write this with elaboration of mechanisms in your exam Best wishes
This is sooo great mam the way u explain builds my concepts very much better thanks a lot for you help❤️❤️❤️❤️
Always glad when people find the video helpful. Thank you Vishal for liking
Hello ma'am, I am a medical student from Bangladesh. Ma'am I watch your videos to clear my doubts. Your videos are simple and to the point. God bless you ma'am.
Thanks. You made my day. Do like and share
You're the only tutor that makes physiology easy ma'am. You're much appreciated here at the University of Zambia.
Thank you so much…it’s an honour..makes my journey meaningful
I just love how you explain and clear the concepts. Keep making such videos.Much gratitude and respect ❤
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Very super fantastic great explanation 👍
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I have a quick question ma'am. So at 12:29 you mentioned that NH4 splits into H and NH3 and then then NH3 goes to the lumen to pick up H that was secreted and expels out. But what about the H that came from splitting NH4 itself? Wouldn't that create acidotic environment in the body?
Buffers need to be regenerated....so new ammonia which forms combines with h ions
Very good method for teaching
Thankyou 🙂
U r such a great teacher
Thank you 😊❤️
Really amazing video ma’am.
Glad you liked it
Soulful 😢❤
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Very goood explanation ma'am 😀
Thank you...wait for the one on buffers and clinical conditions
Thank you much, teacher!
My pleasure
Thank you mam😍😍 it's very usefull
Glad you liked it
Cristal clear explanation maa'm
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Very well explained mam
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Great simplified
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Wel explained ma'am
Thanks a lot
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Hello mam,
I have a confusion how CO2 causing acidosis?? CO2 is producing both h+ ion and HCO3- ion at the same rate
CO2 + H2O ➖H2CO3 ➖ H+ ➕HCO3-
Won't HCO3 ions also affect ph along with h+ ion??
Ph depends on concentration of hydrogen ions...the reaction of bicarbonate ions combining with hydrogen ions can proceed backwards (thus mopping hydrogen ions) only when co2 concentration is less. If co2 increases...the reaction proceeds in this direction producing more h ions
Thank you so much mam😍😍
My pleasure 😊
thank you mam
Always
Thank you mam 🙂
Welcome
GD explanation
Glad you liked it...thanks
Is my understanding right mam
This topic is so confusing mam
I have exam tmrw plzzz....say can i write this explanation in exam mam...plzzzzzzz reply as soon as possible mam🥺
what is happening in the acid-base balance of body means, normally due to metabolic processes, our body is constantly producing acids. So, the type of acids which we are producing are volatile and non-volatile acids. So, volatile acids are like h2co3 can be excreted out as carbon dioxide and non-volatile acids are which are metabolic acids, like lactic acid, So, normally the blood concentration of H+ is in the 50 nanograms so p the pH will be around 7.35 to 7.45 . this pH must be maintained, but the non-volatile acid which is produced will be equal to 50 milliequivalents by the body daily, so this will increase the pH drastically, so to avoid this what will happen is whatever the 50 milliequivalents of acid is produced that should be excreted out from the body. Now, this, these non-volatile acids which should be excreted out from the body by the kidneys, but before reaching the kidneys itself it will increase the pH drastically, so it will be initially buffered by bicarbonate ions in the blood , there are also other buffers like phosphate, ammonia, protein buffers, but the primary buffer is bicarbonate, this bicarbonate is utilised here now, the pH will not decrease, nonvolatile and bicarbonate (which are now together) can be taken very safely to the kidneys for excretion. Now, in the kidneys, what should happen in the sense, bicarbonate buffer which is utilized to buffer non volatile acid and got excreted along with nonvolatile acid should be regenerated and the bicarbonate which are reaching by filtration should also be reabsorbed...so for these two things to take place tubular cells secrete h+ ions...in pct,ascending limb,early distal tubules all the secreted h+ will be utilised for the reabsorption of bicarbonate (no excretion of h+)and and in late dct and collecting duct h+ secretion will be used for generating new hco3- (to compensate for hco3 that is lost with nonvolatile acid) but h+ cannot be secreted in in its free form because it will increase the tubular fluid ph more and van damage the tubular cells..so these are buffered by ammonia and phosphate and excreted
I think it’s a good understanding…very small mistakes but not important for exams…you can write this with elaboration of mechanisms in your exam
Best wishes
@@PhysiologyOpen thank you soo much mam🥰
May I know the mistakes mam
@user-hp2xu3if6e it’s very minor concept related…but not important for exams…for exams it’s more than good…do well in exams
@@PhysiologyOpen thank you mam🤗
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