Yes these compounds change DNA by (intercalation, groove binding, etc.), enzymes (GPX4, topoisomerases, kinases, etc.), and proteins (tubulin, ABCG2/BRCP1, etc.) So they have great anti-cancer properties. Thanks for sharing. Alter more likely tumors etc due to rapid DNA replication I mean.
I also prepared this and got various yields but several were good.... I had to remove this from my MSc thesis due to failure in forming an ester of it (now I know several methods)
easiest way would be to start from 4-Hydroxytryptophan (there are some reaction of direct hydroxylation, but they require weird metal trifluoroacetates)
Yes these compounds change DNA by (intercalation, groove binding, etc.), enzymes (GPX4, topoisomerases, kinases, etc.), and proteins (tubulin, ABCG2/BRCP1, etc.) So they have great anti-cancer properties. Thanks for sharing. Alter more likely tumors etc due to rapid DNA replication I mean.
Thank you very much for adding some info! really appreciated
I also prepared this and got various yields but several were good.... I had to remove this from my MSc thesis due to failure in forming an ester of it (now I know several methods)
cool! would you mind sharing some esterification procedures?
I shouldn’t trust TH-cam subtitles
never do
Chimicazza
😂😂😂
How would you add a hydroxyl group at the 5 position?
easiest way would be to start from 4-Hydroxytryptophan (there are some reaction of direct hydroxylation, but they require weird metal trifluoroacetates)
@@ChemicalEuphoria I think you meant 5-HTP
no, in beta-carbolines you have 4 and 4a positions, so the 4 position on tryptophan becomes the 5 position on beta-carboline.
@@ChemicalEuphoria my bad, I did this too long ago
no worries mate, i too had to look up the numbering order of carbolines, it's so confusing...