When I was taking a genetics course in my undergrad I asked my professor about taking methylated B-vitamins to assist in methylation and she could not understand what I was asking. At the time I was working for a supplement company, so I was familiarizing myself with ingredients, so I just happened to make a connection when speaking about methylation and acetylation. It wasn't that I was asking the question incorrectly, but it was like she didn't even know what I was talking about.
Many doctors do not understand when I ask. All I know is I have MTHFR gene mutation (diagnosed by psychiatrist/testing) and I am prescribed “folic acid” every time. During pregnancy, primary doctor etc.
Fabulous interview! Thank you, I learned alot! I wouldn't worry about losing your viewers due to in depth and difficult scientific concepts. I can guarantee the people that are here (seeking these videos) watching you are fully capable and motivated to understand it. Thank you again! Very fascinating and helpful!
Very much agree! Having podcasts/conversations like this is very much needed, please don't underestimate that! I have been desperately searching for this particular topic and feel like it's assumed these things are either boring or too complicated for the average person to understand. Trust me, the ppl looking for these topics are intent on understanding and look at it more like you have the platform to provide truthful education for those people. I believe most ppl are sick of being sick and tired. Big pharma is not working and many ppl are waking up and desperately searching for ways to start back at the root cause and heal from there, not slap bandaids on symptoms. Thank you for this interview!!
Thank you Mike and thank you Doctor Walsh, my daughter needs to be tested for the MTHFR, no doctor has really helped her so far and as her Mom, this upsets me deeply! Why aren’t physicians trying to find the root of the problem anymore? All they do is 10 minutes in their office and they will prescribe you drugs to treat one symptom but not the root of the problem?!!… Pathetic…😔
what an absolute legend of a doctor... my sonn really sneaking into cancer conclaves, pretending to be a “cancer expert”. I wanna be like Dr. Bill Walsh when I grow up.
every self proclaimed 'expert' says that field has all the answers for cancer. It's a mix of ambition and delusion. The real answer is to be an expert in all fields.
@@user-nd1lx8co2g that won't happen though.... Typical doctors see too many patients, don't really learn new things. General under insurance model has become master of none.
We have a large problem with autism in the East African community in the West. It's not a condition that is common back home although there are cases. Guess what food that is rich in b12, cholesterol (you need it to make vitamin D from sunlight) and folate pregnant moms are told to avoid in the West? Liver. Guess what food is traditionally eaten back home and pregnant women are encouraged to eat a lot of? Yep, liver. Look at the Masai of Kenya and how well they are built. In North America, we have records of how the Inuit traditionally ate (mostly organ meats and animal fat). I wonder how much damage is done when people stop eating their traditional foods and follow the Standard American Diet. Great video. I always enjoy your interviews.
Clues of heart disease found in 16th-century mummies (from Greenland) news.harvard.edu/gazette/story/2019/01/evidence-of-atherosclerosis-found-in-16th-century-mummies-from-greenland/
In the final episode of Bob’s new show, he will wake up from another dream, this time it will be about how he was a comedian for decades when he was a doctor all along
Mike this was an awesome information that can possibly help my husband. The best part I live about 20 minutes away from Naperville, IL. Glad to know you came to Chicago. Really grateful for all the work you do. Thank you.
that was an AWESOME discussion... I was recently told I fall in the undermethylation category and wasn't quite sure what that meant or how to deal with it.
Just wow! This is just so jam packed with amazing, emerging information. I have to rewatch another 20 times for everything to sink in I think. Thank you so much for getting this interview! Just amazing!
This video has made me feel like there’s likely a connection with symptoms I’m experiencing and treatment. I’m a RN, not MD, but I’m easily teachable and found this so interesting. So much good info and great to see the passion he has in discovering the root cause of various illnesses instead of focusing on discovering a new drug. Thanks for sharing. Even though I’m just now seeing it 😂
I went to Dr. Abram Hoffer. Actually, three other family members also went to him. It was a wonderful visit and I learned a lot. He was a big believer in Niacin as he said schizophrenia was helped/cured with using it.
My reply is a bit late to reach you, but when I discovered Dr Abram Hoffer, I started giving 500 mg of niacin to my schizophrenic friend with every large meal, and the voices stopped completely. Now he has given up much of his sugar and white flour. He is completely off his 47 years of toxic drugs and getting his life back. NAC is also very important for him. Doctor Yourself . Com with Andrew Saul has most of his information. Namaste 🙏
🙈🙌❤️ what an incredible conversation Mike that you had with Dr Bill Walsh. I am blown away. I had to pause a couple times return back to the conversation to get through it once because this information was too incredible. Now I'm going to do it again. Somehow I've been taking a methylated B complex for a few months... I was simply looking for a product that had hydroxylcobalamine and adenosilcobalamine... Both forms of B12.... Certainly not cyanocobalami.... This brought methylated B complex vitamin to my forefront attention and finally after several months thought I need to find a good TH-cam video explains what the hell I'm taking.... Yours is the first and I'm not going to say will be the only but this will likely be the one that I share to everybody. Just start thinking about my zinc. Thinking zinc oxide and zinc gluconate... My vitamin D3 stack is growing I don't know if I can still call it a vitamin D3 stack or not. Okay here I go I'm starting my second round of listening 🙉
Profound Mike!!! Again, the one genius. I noticed a huge benefit once I stepped into ketosis. The most benefit I saw in clear vision - thinking, new perspective on life and BRAIN's health. When you step on the other side of yourself, I encourage everyone who is struggling to make a change in their life to try a low carb-keto even carnivore diet. The most benefit you can bear is your mental health and therefore everything else. You will see many perspectives on figuring out the life choices and challenges and bravely go forward with broad, abundant thinking, endurance and resilient. Mike, Thank You, as always, the best in this community!
So happy to hear of your positive results. I loved many things about being in ketosis but sadly for some reason it jacked my cortisol levels sky high and dangerously affected my heart rate and I almost ended up in hospital, even with all of the electrolytes and supplementation. I truly wish I could go back to it. Maybe I’m just the odd man out. Frustrating.
Hello I have followed Bill Walsh work for many years. He makes this information difficult to understand under and over methylation. You are very good at interpreting. Please add clarity and link any videos that you have done thanks.
Ok I’m not a complete idiot,and can grasp abstract thinking and he offers great insight to the medical field(of course clearly non of the hundreds of doctors work in any of my nearby facilities) and short of spending even more thousands of dollars on tests that most doctors cannot understand I need real world answers in real time
Mike look into PSSD, maybe you can find a doctor to have a discussion with about it. It is something that is affecting a lot of people and it is not being discussed enough, you can find countless people looking for answers online, there doesn't appear to be any sort of "Cure" at the moment and people have been trying all sorts of things to reverse it. Unfortunately it has been put on the back burner by the medical community, if you can shed light on it, it would probably be one of your most amazing videos ever. Thanks
Prashanth B Post-SSRI sexual dysfunction (PSSD) is a condition in which patients continue to have sexual side effects after discontinuation of SSRI use.
In my 30s and have had depression, among other health issues come up. Doctors can't make sense of it. I have my 23andme raw data, Prometheus, found my fitness report from Rhonda Patrick, Ben Lynch Dirty Genes book, and William Walsh's Nutrient Power and I still can't understand how to apply the knowledge to myself. If anyone is willing to help me understand a bit on how to apply the information I would be forever grateful. Also another great video Mike.
I have all of them also!! I sent some raw data to Chris MasterjohnPHD ( you Tube) he assessed the methylation SNIPs and said I needed 65% more folate/ biotin. I don't have mental health problems or any health problems really but just found all this info fascinating. Think Chris Masterjohn does have clients online. Also sent 23 and Me raw data to "GeneFood" ( years ago) and they sent me a food list and recipes - told me I was a "Hunter Gatherer" according to my genetics!! Lots of their information corresponded to "FoundMyFitness" health info but told me foods for my health. Hope this is helpful.
Try a carnivore diet. Walsh explains in this video that people with low serotonin or depression need SAM-E or Methionine. Methionine is high in red meat. You will also get other methyl donors like creatine, choline, carnatine, Carnosine, b12.
Though I appreciate this discussion, I found the information about SSRI/SNRI anti-depressants kind of frustrating. My opinion is that some depression is caused by many more factors than just a chemical imbalance in the brain. Personally in the last 12 months I have tried at least 6 different psychiatric drugs, the antidepressants came with a shit storm of side effects from gastrointestinal, panic attacks and debilitating depersonalisation/derealisation. I know they have helped many people, but if I could have had a blood test prior to being prescribed these medications that would have shown me they were incompatible with my genetics, I would have done it and saved myself a 10 month walk through mental health hell. The genetic compatibilty testing for medications need to be included in mainstream health care. Just my two cents worth on that issue. Love your work Mike 👍
Yes! When I FINALLY received the DNA test after decades of trying antidepressants, I found that I lack the ability to methylize folate and therefore no antidepressant affects would reach my brain.
Zero doubt in my mind that social isolation/rejection is always a factor in mental illness, either as a primary cause or as a serious consequence. Anyone who rules out or fails to address that issue has no concept of what mental health even is.
I work with adults with disabilities, primarily autistic! I fight every day at the wall between bio, chemistry and behavior! Mostly because of Self pose boxes by the doctors that serve them!
He started on it, but didn't specify. What testing should be done for a couple planning on having a child in the next year or two? At home testing available? I'm aware diet plays a huge role (we exercise and eat primal based), but asking what should be tested before a change is made. Thank you!
The blood work cost 900.00 and the Dr. fee for me in Illinois was 1500.00 in 2022. I am doing The Walsh protocol and feel almost nothing. I am exactly as Dr. Walsh describes , having Mal absorption. ,an inflammation level of 10,000 ( average being 2500) It has not been profound results so far. Still I persevere on.
@@The_New_Abnormal_World_Order yes , it does take a lot of time . Something I am used to . The first phase took over a year in which I gained 30 lbs and became 100% bed ridden and in a coma like state . After , finally meeting the Dr. in person fat e to face it was entirely different versus texting a nurse online . My supplements were adjusted and I the lithium oratate which had a horrible effect on me was taken out . I also refused to use the pharmacy they recommended for notes supplements . They were hundreds of dollars and the quality was deplorable to say the least . I was told buying my own supplements would be very hard to do . Regardless I did it and the results have been a vast positive difference . The pharmacy had been giving me oxidized supplements . I say all this to say , that I have yet to hear or read the underside m the truth m anyinbes real experiences in this . I only see glowing , glib seemingly fake glossed over unhelpful reviews . For myself I like the nitty gritty . I want to truth . I want to know what to expect . I am determined to see if this works . I have now adult children who need this help . But better to experiment on myself first to see of it actually works . Definitely is taking forever . On the upside , I am feeling better than in the beginning . I love your channel . Thank you for all that you do . I get very very depressed and hopeless sometimes . I have very late stage Lyme disease , many auto immune diseases . Through passionate , beautiful , genuine people like you I am able to piece together some path to having some quality of life . Thank you for your inspiration and dedication in helping others .
I am definitely MTHFR. I'll have to stop taking certain supplements because they have folic acid. I wish I wasn't MTHFR. It limits my diet. It has made me histamine intolerant and I ended up with IBS.
Is there anyone here with OCD who was treated by the Walsh Protocol? I am dealing with OCD and depression and wonder how much of a long-term difference this treatment would bring? Synthetic or some natural SSRI's have helped me but they couldn't by far give complete healing.
I thought it was widely agreed-upon that the importance of dietary antioxidants was overplayed. I listened to Dr. David Sinclair I’m pretty sure I heard him say that dietary or supplemental antioxidants don’t do much. Correct me if I’m wrong.
They are still important factors and contributors to living longer, healthier and assisting in preventing some damage leading to aging related illnesses. This is proven in many medical studies. For Dr. Walsh - he has studied so many past patients and their bloodwork. He mentions in his book something about how people dealing with a range of illnesses from autism to ocd to other similar or comorbid conditions - have problems with detoxing. So, antioxidants are very, very important for certain groups of people. My son has some health issues like this and to prevent his actual symptoms from becoming severe, antioxidants are vital and stop his syptoms for the most part, in addition to a healthy diet and avoiding triggers. I think not everything David Sinclair says needs to be taken as truth. :) I really like him by the way, but don't fully agree on this topic. Maybe he was talking about it in regards to anti-aging or longevity. Though, from medical studies I have read, antioxidants are still important and a key component of longevity. Younger people have higher levels of glutathione and older people have declining levels. NAC is a great supplement to help boost those levels of that powerhouse antioxidant, glutathione. This is studied a lot in the field of longevity. So, I know he downplayed their importance but I'm not quite sure why as the medial studies support how important it is in anti-aging (in conjunction with many other factors). Sorry for the long reply. :)
You know I love your content and respect that you're providing so much valuable and practical information but I believe if you would divide videos like these in smaller segments then you'll get atleast twice as views as now because you know all about will power and stuff and what I see is a very wide topic which should be sub categorised under playlist by the name of that respective topic. Anyways love your content and you're a great person (not that I need to address it) 👍♥️
Very true, I imagine there are many people who do not completely view this video because of the length. But it is equally important that all the viewers who value the lengthier vids let Mike know how well hes doing in regards to quality content
Kinda agree. An hour long video, tells me, don't have the time, so will skip to bits and pieces and leave. Needs to be broken down into smaller segments.
Akane Cortich Would you prefer smaller video chunking/separating subtopics, or keeping the video in its original long length but with some time stamps on screen
@@austinresch2362 I'd say if you choose to break things out then still making it discoverable is key! So maybe the time stamps? or as long as there is a playlist or something set up that's likely the most useful. I mention that because there are many podcasts now days that have the full length + shorter ones and well... it's easy to get lost and then you have to spend forever scrolling through and searching for the full length ones if you're like me and you just relisten to them a million times for the full length lol. xD. Either way just wanted to point that one out. an example of this chaos is actually peter attia's if you subscribe to his podcast (the paid version so all the qualys make it hard). Either way, love all you do mike!
Did buy a homocysteine lab from QD in 2021 and hope it was accurate (7) (have B12 defic symp. but high labs, but read most B12 analyzers us antibodies so a persons antibodies can cause inaacurate B12 lab results !!)
I did not understand, how you know if you are under, over or normal methylating from the SAM/SAH ratio... So (IF the SAH is over 40%), how much should the ratio be to be considered normal, and how much to be considered under or over methylating? As I understand, the lower the ratio (if again, SAH is over 40%), the lower the methylation status, is that correct? And that should give us an indication that MTHFR or some other enzyme, is not working properly, right? Great interview and great work! Thank you very much, extremely interesting!!
On this video he does not discuss how we now know that synthetic folic acid (form added to processes food in the USA) blocks the receptor an causes problems for those with mutation. Taking methyl folate form is more bio avail. Or atleast natl form.
So i have the mthfr gene defect. I'm trying to figure out the best care for me. Right now i avoid processed foods. I eat keto etc. But i can tell I'm missing something still. Do you have guidance for me?
I have heard that niacin helps with overmethylation. I wonder if you can be undermethylating while producing too much dopamine. That would mean that you need supplementation with niacin and on top of that extra methylators.
That is confusing. You could get testing done to know for sure. My son had neurotransmitter testing through ZRT and it was very accurate and interesting. You can test whole blood histamine to know your methylation status - whether normal, under or over.
Life & DIY yes, the histamine status does tell a lot but according to dr Ben Lynch (I think they don’t agree with each other on everything) there could be a problem with a certain gene that has to do with transformation of histamine and recycles back. It needs quite a lot of cofactors like vit C and quite a few others like Zink I believe. That would mean that it might not be a good measurement if this gene has a snip or is not being supported enough. I do know that vit C and quercetin help a lot to lower my hay fever symptoms to nearly non existent.
I think this is talked about in his book. I believe there is a supplement to take before supplementing with samE or methionine to be sure that homocysteine isn't elevated unnecessarily - sorry I can't recall what it is. I went through all this with my son and tested histamine and homocysteine after he was on SamE for a while and all was fine. But, testing is important. I know he does talk about this in the book though.
I'm confused about when best to take B vitamins. He says can't take before 3:30 else trouble sleeping, then says taking at 10p causes trouble sleeping. ??
Eric Shubert ...Walsh recommends taking B vitamins early in the day because they are energizing and stimulating. I try to take them at lunch...definitely before 3:00. Also if taking zinc he recommends taking later in the day with dinner because it can lower cortisol levels.
I have the mthfr c677tt mutation. Autism is in my family and I am prone to depression, t2d and heart disease. I'm an under methylator and I stick to a mainly carnivore diet with organ meat included for folate. As a health coach this information is very welcome. I also follow Dr Ben lynch (get him on your show Mike) and recommend his book dirty genes. The 85% solution by Dan Purser MD is also another very good read.
I think a very important nutrient is vitamin D. The healthiest cultures have the most sun and are the most resilient to illness. I was in kirkland, WA since this past Monday til Wednesday. Practically no sunlight at all..How do you love here Mike, its as gloomy as London over here lol
How is there still such green grass?? I'm from PA and its not as dark but the grass is dead but its like 20 degrees colder there so makes sense. Wish you the best Mike, thanks for the awesome content. I love learning from your channel. God bless you and your family. Happy holidays!
Under methelation is linked to autism...that's so interesting! I wonder in which sequence of genes that would be that leads to autism. Great interview!
SNP Heterozygous MTHFR C677T, if child has it, that means mother/father had it and was passed on. Methyl donors become more important to support lowered methylation ability: folate, b12, choline. Supporting inflammation is what methyl groups do, lower homocysteine etc.
@@LifeDIY sure, thank you,. you know i'm struggling with histamine intolerance (itchy skin and insomnia) that's why I'm wondering what to do; I received some benefit from methylfolate, that's for sure. but even a single coffee at midday trigger histamine response till midnight.
@@zambrocca have you tested your serum histamine levels? Sorry to hear about your symptoms. When I tested ages ago, I had low histamine but I had symptoms of itching a lot. At that time my thyroid was out of whack though and it might have been related.
@@LifeDIY no I didn't. maybe not so useful as It's like a pulsing histamine. I can be fine for some hours and all of a suddend feeling my skin like swelling, and not necessarily after a meal. but coffee mainly, but also chocolate and olive oil could be a trigger.
When I was taking a genetics course in my undergrad I asked my professor about taking methylated B-vitamins to assist in methylation and she could not understand what I was asking. At the time I was working for a supplement company, so I was familiarizing myself with ingredients, so I just happened to make a connection when speaking about methylation and acetylation. It wasn't that I was asking the question incorrectly, but it was like she didn't even know what I was talking about.
This is the state of education in the medical profession and it is only becoming worse.
Not surprised at all. It's sad
🇺🇸💪🏻👊🏻🤙🏼
Many doctors do not understand when I ask. All I know is I have MTHFR gene mutation (diagnosed by psychiatrist/testing) and I am prescribed “folic acid” every time. During pregnancy, primary doctor etc.
Because geneticist don’t bother with pseudoscience.
What kind of b complex are you taking now?
Fabulous interview! Thank you, I learned alot! I wouldn't worry about losing your viewers due to in depth and difficult scientific concepts. I can guarantee the people that are here (seeking these videos) watching you are fully capable and motivated to understand it. Thank you again! Very fascinating and helpful!
Can confirm!
Agreed 👍
Very much agree! Having podcasts/conversations like this is very much needed, please don't underestimate that! I have been desperately searching for this particular topic and feel like it's assumed these things are either boring or too complicated for the average person to understand. Trust me, the ppl looking for these topics are intent on understanding and look at it more like you have the platform to provide truthful education for those people. I believe most ppl are sick of being sick and tired. Big pharma is not working and many ppl are waking up and desperately searching for ways to start back at the root cause and heal from there, not slap bandaids on symptoms. Thank you for this interview!!
Thank you Mike and thank you Doctor Walsh, my daughter needs to be tested for the MTHFR, no doctor has really helped her so far and as her Mom, this upsets me deeply! Why aren’t physicians trying to find the root of the problem anymore? All they do is 10 minutes in their office and they will prescribe you drugs to treat one symptom but not the root of the problem?!!… Pathetic…😔
what an absolute legend of a doctor... my sonn really sneaking into cancer conclaves, pretending to be a “cancer expert”. I wanna be like Dr. Bill Walsh when I grow up.
every self proclaimed 'expert' says that field has all the answers for cancer. It's a mix of ambition and delusion. The real answer is to be an expert in all fields.
@@user-nd1lx8co2g that won't happen though.... Typical doctors see too many patients, don't really learn new things. General under insurance model has become master of none.
@@user-nd1lx8co2gMost scientific breakthroughs have come from outsiders. Insiders tend to incrementally expand knowledge.
We have a large problem with autism in the East African community in the West. It's not a condition that is common back home although there are cases. Guess what food that is rich in b12, cholesterol (you need it to make vitamin D from sunlight) and folate pregnant moms are told to avoid in the West? Liver. Guess what food is traditionally eaten back home and pregnant women are encouraged to eat a lot of? Yep, liver. Look at the Masai of Kenya and how well they are built. In North America, we have records of how the Inuit traditionally ate (mostly organ meats and animal fat).
I wonder how much damage is done when people stop eating their traditional foods and follow the Standard American Diet.
Great video. I always enjoy your interviews.
Clues of heart disease found in 16th-century mummies (from Greenland)
news.harvard.edu/gazette/story/2019/01/evidence-of-atherosclerosis-found-in-16th-century-mummies-from-greenland/
We are universally connected, Thank you for confirming my thoughts. I need to get back to my roots
We are universally connected, Thank you for confirming my thoughts. I need to get back to my roots
vaccines is the issue
You could say it literally is a KILLER DIET
Dr. Bill Walsh is a treasure! Great interview!!🙌
This interview is pure gold! Thank you both!
Wow, the great Dr. Walsh of the Walsh protocol. Amazing interview I learned a lot. Thank you.
The best host i have ever seen. All the questions are very necessary and right. Thank you so much.
One of the better interviews for being candid and respectful. I adored your mediation of this one. Cheers.
It’s so great that you got Bob Newhart to come on your show. For a comedian he was remarkably well versed in an obscure medical subject.
In the final episode of Bob’s new show, he will wake up from another dream, this time it will be about how he was a comedian for decades when he was a doctor all along
I thought it was him at first!! Too funny!
@@fiveandfour 🏆🏆🏆
🤣
Mike this was an awesome information that can possibly help my husband. The best part I live about 20 minutes away from Naperville, IL. Glad to know you came to Chicago. Really grateful for all the work you do. Thank you.
Its interesting that he said zinc and antioxidants because zinc is a mineral antioxidant. Its even used as an industrial antioxidant to prevent rust.
There’s multiple others besides zinc but zinc has a major function
@@SanctifiedLady Please share the multiple others besides Zinc.
@@lovingnature1151magnesium, selenium
Haven't really thought about it that way, great points.
Wow! I honestly can say your videos have been my favorite of 2019.
Thank you for sharing so much knowledge❤️
As always mike , thanks for the quality you putting out there .
Nice profile pic.
that was an AWESOME discussion... I was recently told I fall in the undermethylation category and wasn't quite sure what that meant or how to deal with it.
I'm watching this in Jan 2023 and I sure hope you found how to deal with it and fee better!
Just wow! This is just so jam packed with amazing, emerging information. I have to rewatch another 20 times for everything to sink in I think. Thank you so much for getting this interview! Just amazing!
This is one of the best interviews I have ever seen 🙏
This video has made me feel like there’s likely a connection with symptoms I’m experiencing and treatment. I’m a RN, not MD, but I’m easily teachable and found this so interesting. So much good info and great to see the passion he has in discovering the root cause of various illnesses instead of focusing on discovering a new drug. Thanks for sharing. Even though I’m just now seeing it 😂
I went to Dr. Abram Hoffer. Actually, three other family members also went to him. It was a wonderful visit and I learned a lot. He was a big believer in Niacin as he said schizophrenia was helped/cured with using it.
My reply is a bit late to reach you, but when I discovered Dr Abram Hoffer, I started giving 500 mg of niacin to my schizophrenic friend with every large meal, and the voices stopped completely. Now he has given up much of his sugar and white flour. He is completely off his 47 years of toxic drugs and getting his life back. NAC is also very important for him. Doctor Yourself . Com with Andrew Saul has most of his information. Namaste 🙏
🙈🙌❤️ what an incredible conversation Mike that you had with Dr Bill Walsh. I am blown away. I had to pause a couple times return back to the conversation to get through it once because this information was too incredible. Now I'm going to do it again. Somehow I've been taking a methylated B complex for a few months... I was simply looking for a product that had hydroxylcobalamine and adenosilcobalamine... Both forms of B12.... Certainly not cyanocobalami....
This brought methylated B complex vitamin to my forefront attention and finally after several months thought I need to find a good TH-cam video explains what the hell I'm taking.... Yours is the first and I'm not going to say will be the only but this will likely be the one that I share to everybody. Just start thinking about my zinc. Thinking zinc oxide and zinc gluconate... My vitamin D3 stack is growing I don't know if I can still call it a vitamin D3 stack or not.
Okay here I go I'm starting my second round of listening 🙉
what where your complication why do you use it
This guy is on to something
His book is awesome
And i pray and hope that he may have a successful breakthrough
it wont cure schizophrenia. always be one meds. But for anxiety, depression ADHD it works.
Incredible interesting knowledge of Bill Walsh! Every diagnosing Doctor should see (and understand) this...
Profound Mike!!! Again, the one genius. I noticed a huge benefit once I stepped into ketosis. The most benefit I saw in clear vision - thinking, new perspective on life and BRAIN's health. When you step on the other side of yourself, I encourage everyone who is struggling to make a change in their life to try a low carb-keto even carnivore diet. The most benefit you can bear is your mental health and therefore everything else. You will see many perspectives on figuring out the life choices and challenges and bravely go forward with broad, abundant thinking, endurance and resilient. Mike, Thank You, as always, the best in this community!
So happy to hear of your positive results. I loved many things about being in ketosis but sadly for some reason it jacked my cortisol levels sky high and dangerously affected my heart rate and I almost ended up in hospital, even with all of the electrolytes and supplementation. I truly wish I could go back to it. Maybe I’m just the odd man out. Frustrating.
Excellent amount of knowledge and well explain.
I understood more with this guy than at college.🎉
Great show! It touched on lots of things I've been researching.
Hello I have followed Bill Walsh work for many years. He makes this information difficult to understand under and over methylation. You are very good at interpreting. Please add clarity and link any videos that you have done thanks.
I started taking Dr. Best vitamin B-complex and started to get a deep sleep. After noticing what kind if B9 was in it, it started to make sense.
Ok I’m not a complete idiot,and can grasp abstract thinking and he offers great insight to the medical field(of course clearly non of the hundreds of doctors work in any of my nearby facilities) and short of spending even more thousands of dollars on tests that most doctors cannot understand I need real world answers in real time
Mike look into PSSD, maybe you can find a doctor to have a discussion with about it. It is something that is affecting a lot of people and it is not being discussed enough, you can find countless people looking for answers online, there doesn't appear to be any sort of "Cure" at the moment and people have been trying all sorts of things to reverse it. Unfortunately it has been put on the back burner by the medical community, if you can shed light on it, it would probably be one of your most amazing videos ever. Thanks
OK, thanks John!
What is PSSD ?
krix004 I said PSSD not PTSD
@@johnz8112 So I am asking again, What is PSSD ? If you care to answer.
Prashanth B Post-SSRI sexual dysfunction (PSSD) is a condition in which patients continue to have sexual side effects after discontinuation of SSRI use.
Great topic! So important to know all of this!
Fantastic information ! Bill Walsh is a treasure.
Your best video yet, so informative. You are realy starting to get me interested in epigenetics.
In my 30s and have had depression, among other health issues come up. Doctors can't make sense of it. I have my 23andme raw data, Prometheus, found my fitness report from Rhonda Patrick, Ben Lynch Dirty Genes book, and William Walsh's Nutrient Power and I still can't understand how to apply the knowledge to myself. If anyone is willing to help me understand a bit on how to apply the information I would be forever grateful. Also another great video Mike.
Please google "Personalized Prescribing Inc.", hope they can help to cure your depression.
I have all of them also!! I sent some raw data to Chris MasterjohnPHD ( you Tube) he assessed the methylation SNIPs and said I needed 65% more folate/ biotin. I don't have mental health problems or any health problems really but just found all this info fascinating. Think Chris Masterjohn does have clients online. Also sent 23 and Me raw data to "GeneFood" ( years ago) and they sent me a food list and recipes - told me I was a "Hunter Gatherer" according to my genetics!! Lots of their information corresponded to "FoundMyFitness" health info but told me foods for my health. Hope this is helpful.
Try a carnivore diet. Walsh explains in this video that people with low serotonin or depression need SAM-E or Methionine. Methionine is high in red meat. You will also get other methyl donors like creatine, choline, carnatine, Carnosine, b12.
Thanks for the summary notes
Though I appreciate this discussion, I found the information about SSRI/SNRI anti-depressants kind of frustrating. My opinion is that some depression is caused by many more factors than just a chemical imbalance in the brain. Personally in the last 12 months I have tried at least 6 different psychiatric drugs, the antidepressants came with a shit storm of side effects from gastrointestinal, panic attacks and debilitating depersonalisation/derealisation. I know they have helped many people, but if I could have had a blood test prior to being prescribed these medications that would have shown me they were incompatible with my genetics, I would have done it and saved myself a 10 month walk through mental health hell. The genetic compatibilty testing for medications need to be included in mainstream health care. Just my two cents worth on that issue. Love your work Mike 👍
Please google "Personalized Prescribing Inc.", hope they can help to cure your depression.
Yes! When I FINALLY received the DNA test after decades of trying antidepressants, I found that I lack the ability to methylize folate and therefore no antidepressant affects would reach my brain.
Zero doubt in my mind that social isolation/rejection is always a factor in mental illness, either as a primary cause or as a serious consequence. Anyone who rules out or fails to address that issue has no concept of what mental health even is.
@@dwanpetti9086 wow what did you do or take ? Still have depression ?
I would put a thousand likes, if I could. Great interview, smart doctor. It’s Helping in my house for sure.
Mike you were a superb athlete. Wonderful to be here listening to this interview.
Thank you so much for this wonderful interview 🔥👌🏻
2 confirmations for me thank you. Acetyl and zinc.
Mike, we need.updated information from this Doctor!! 😊
I work with adults with disabilities, primarily autistic! I fight every day at the wall between bio, chemistry and behavior! Mostly because of Self pose boxes by the doctors that serve them!
Everyone with a brain and DNA needs to watch this video. View count should be much higher.
Dr. please educate the public on gene therapies. Thank you 🙏
This guy knows his shit...the up side of of going deep and narrow
Brilliant interview, thank you, knowing this is paramount.
He started on it, but didn't specify. What testing should be done for a couple planning on having a child in the next year or two? At home testing available? I'm aware diet plays a huge role (we exercise and eat primal based), but asking what should be tested before a change is made. Thank you!
The blood work cost 900.00 and the Dr. fee for me in Illinois was 1500.00 in 2022. I am doing The Walsh protocol and feel almost nothing. I am exactly as Dr. Walsh describes , having Mal absorption. ,an inflammation level of 10,000 ( average being 2500) It has not been profound results so far. Still I persevere on.
I'm sorry to hear that!! Maybe it will take time.
@@The_New_Abnormal_World_Order yes , it does take a lot of time . Something I am used to . The first phase took over a year in which I gained 30 lbs and became 100% bed ridden and in a coma like state . After , finally meeting the Dr. in person fat e to face it was entirely different versus texting a nurse online . My supplements were adjusted and I the lithium oratate which had a horrible effect on me was taken out . I also refused to use the pharmacy they recommended for notes supplements . They were hundreds of dollars and the quality was deplorable to say the least . I was told buying my own supplements would be very hard to do . Regardless I did it and the results have been a vast positive difference . The pharmacy had been giving me oxidized supplements . I say all this to say , that I have yet to hear or read the underside m the truth m anyinbes real experiences in this . I only see glowing , glib seemingly fake glossed over unhelpful reviews . For myself I like the nitty gritty . I want to truth . I want to know what to expect . I am determined to see if this works . I have now adult children who need this help . But better to experiment on myself first to see of it actually works . Definitely is taking forever . On the upside , I am feeling better than in the beginning . I love your channel . Thank you for all that you do . I get very very depressed and hopeless sometimes . I have very late stage Lyme disease , many auto immune diseases . Through passionate , beautiful , genuine people like you I am able to piece together some path to having some quality of life . Thank you for your inspiration and dedication in helping others .
You can try eleiminaton diet and do only red meat and see how you will do, that helped for so much ppl.
Fascinating video!!!! Thank you so much for blowing up my brain!! Lol
I am definitely MTHFR. I'll have to stop taking certain supplements because they have folic acid. I wish I wasn't MTHFR. It limits my diet. It has made me histamine intolerant and I ended up with IBS.
Good interview / good question / good answer 👏👏👏
Is there anyone here with OCD who was treated by the Walsh Protocol? I am dealing with OCD and depression and wonder how much of a long-term difference this treatment would bring?
Synthetic or some natural SSRI's have helped me but they couldn't by far give complete healing.
I thought it was widely agreed-upon that the importance of dietary antioxidants was overplayed. I listened to Dr. David Sinclair I’m pretty sure I heard him say that dietary or supplemental antioxidants don’t do much. Correct me if I’m wrong.
They are still important factors and contributors to living longer, healthier and assisting in preventing some damage leading to aging related illnesses. This is proven in many medical studies. For Dr. Walsh - he has studied so many past patients and their bloodwork. He mentions in his book something about how people dealing with a range of illnesses from autism to ocd to other similar or comorbid conditions - have problems with detoxing. So, antioxidants are very, very important for certain groups of people. My son has some health issues like this and to prevent his actual symptoms from becoming severe, antioxidants are vital and stop his syptoms for the most part, in addition to a healthy diet and avoiding triggers. I think not everything David Sinclair says needs to be taken as truth. :) I really like him by the way, but don't fully agree on this topic. Maybe he was talking about it in regards to anti-aging or longevity. Though, from medical studies I have read, antioxidants are still important and a key component of longevity. Younger people have higher levels of glutathione and older people have declining levels. NAC is a great supplement to help boost those levels of that powerhouse antioxidant, glutathione. This is studied a lot in the field of longevity. So, I know he downplayed their importance but I'm not quite sure why as the medial studies support how important it is in anti-aging (in conjunction with many other factors). Sorry for the long reply. :)
So... arachnadonic acid is not just good for driving inflammation to the muscle cells to help stimulate growth.... awesome 🙂💪
6:00 which ones?
Answer: 42:24
You know I love your content and respect that you're providing so much valuable and practical information but I believe if you would divide videos like these in smaller segments then you'll get atleast twice as views as now because you know all about will power and stuff and what I see is a very wide topic which should be sub categorised under playlist by the name of that respective topic. Anyways love your content and you're a great person (not that I need to address it) 👍♥️
Very true, I imagine there are many people who do not completely view this video because of the length. But it is equally important that all the viewers who value the lengthier vids let Mike know how well hes doing in regards to quality content
Thanks for the great tip, plan to do something like that and appreciate the nudge to do so!!
Kinda agree. An hour long video, tells me, don't have the time, so will skip to bits and pieces and leave. Needs to be broken down into smaller segments.
Akane Cortich Would you prefer smaller video chunking/separating subtopics, or keeping the video in its original long length but with some time stamps on screen
@@austinresch2362 I'd say if you choose to break things out then still making it discoverable is key! So maybe the time stamps? or as long as there is a playlist or something set up that's likely the most useful. I mention that because there are many podcasts now days that have the full length + shorter ones and well... it's easy to get lost and then you have to spend forever scrolling through and searching for the full length ones if you're like me and you just relisten to them a million times for the full length lol. xD. Either way just wanted to point that one out. an example of this chaos is actually peter attia's if you subscribe to his podcast (the paid version so all the qualys make it hard). Either way, love all you do mike!
The music is too loud! Can you fix? I really wanna listen to this
would like to hear what he thinks the 20 theories behind undermethylation are?
Great podcast thanks - very interesting what he said about methylfolate...
How can we get in touch with Dr Walsh is he still seeing patients?
I have panic disorder so if that means that I'm over-methylated, what will help me?
Could under methylation include b12 deficiency even though you have the intrinsic factor?
I’d be very interested in what he thinks about the mRNA C19 shot???
It depends whether your are under-methylated or overmethylated...
Where can I get a DDI test?
Can u tell me more about the DDI PANEL u guys spoke of. How do we get it thank u
Did buy a homocysteine lab from QD in 2021 and hope it was accurate (7) (have B12 defic symp. but high labs, but read most B12 analyzers us antibodies so a persons antibodies can cause inaacurate B12 lab results !!)
I did not understand, how you know if you are under, over or normal methylating from the SAM/SAH ratio...
So (IF the SAH is over 40%), how much should the ratio be to be considered normal, and how much to be considered under or over methylating?
As I understand, the lower the ratio (if again, SAH is over 40%), the lower the methylation status, is that correct?
And that should give us an indication that MTHFR or some other enzyme, is not working properly, right?
Great interview and great work! Thank you very much, extremely interesting!!
This is truly interesting
What if you are under methylated but use SSRI for depression AND methylated vitamins make you more depressed. What do you do?
On this video he does not discuss how we now know that synthetic folic acid (form added to processes food in the USA) blocks the receptor an causes problems for those with mutation. Taking methyl folate form is more bio avail. Or atleast natl form.
Where can I find his BPD talk he mentioned? Thank you!
Brilliant, thank you
Learning about genetics is so interesting!! Thank you!
So i have the mthfr gene defect. I'm trying to figure out the best care for me. Right now i avoid processed foods. I eat keto etc. But i can tell I'm missing something still. Do you have guidance for me?
I'm sorry if it's answered here for me I'm a little confused though
Such a great episode, i feel this guy would be the guy to ask info on PSSD or at least have some idea where to look!
I have heard that niacin helps with overmethylation. I wonder if you can be undermethylating while producing too much dopamine. That would mean that you need supplementation with niacin and on top of that extra methylators.
That is confusing. You could get testing done to know for sure. My son had neurotransmitter testing through ZRT and it was very accurate and interesting. You can test whole blood histamine to know your methylation status - whether normal, under or over.
Life & DIY yes, the histamine status does tell a lot but according to dr Ben Lynch (I think they don’t agree with each other on everything) there could be a problem with a certain gene that has to do with transformation of histamine and recycles back. It needs quite a lot of cofactors like vit C and quite a few others like Zink I believe. That would mean that it might not be a good measurement if this gene has a snip or is not being supported enough. I do know that vit C and quercetin help a lot to lower my hay fever symptoms to nearly non existent.
@@ollymounara605 Olly should I take b-vit complex and methycobalamin? I dont know much about this stuff..
As the years have gone by, has a treatment to address this theory been found? Anyone know if his 2014 book has been updated? Thank you!
I love how he is baited into saying there's a single good food and he refuses to go for it like no it isn't one size fits all
Love this topic 👏
Big fan of Bill Walsh- why the sci-fi sound track?
Only if could have interviewed Dr Carl Pheiffer !!! Read a book of his and was funny and informative.
I hope I don't overmethylate myself by taking too much methylcobalamin b12
So interesting! Great interview! Amazing science!! Mike, just wondering why your palms are yellow....random, I know 🤪
Woow thank you!
Thanks for the interview.
Dr Rhonda Patrick, too, should interview this Dr William Walsh.
Excellent!
Is hemp oil good for insomnia?
80's Nostalgia Guy It helps me. 🙏🏽
Why would undermethylators need more methionine when that could potentially lead to elevated homocysteine levels in an undermethylator?
I think this is talked about in his book. I believe there is a supplement to take before supplementing with samE or methionine to be sure that homocysteine isn't elevated unnecessarily - sorry I can't recall what it is. I went through all this with my son and tested histamine and homocysteine after he was on SamE for a while and all was fine. But, testing is important. I know he does talk about this in the book though.
Thank u 😊
Csn you upload a version without music?
I'm confused about when best to take B vitamins. He says can't take before 3:30 else trouble sleeping, then says taking at 10p causes trouble sleeping. ??
Eric Shubert ...Walsh recommends taking B vitamins early in the day because they are energizing and stimulating. I try to take them at lunch...definitely before 3:00. Also if taking zinc he recommends taking later in the day with dinner because it can lower cortisol levels.
I have the mthfr c677tt mutation. Autism is in my family and I am prone to depression, t2d and heart disease. I'm an under methylator and I stick to a mainly carnivore diet with organ meat included for folate.
As a health coach this information is very welcome. I also follow Dr Ben lynch (get him on your show Mike) and recommend his book dirty genes. The 85% solution by Dan Purser MD is also another very good read.
dirty genes:)
@@przemeks577 well spotted! Cheers.
Mike has had Dr Lynch on a few times. It would be great to have him on again though!
Could a canivore diet help also fibromyalgia, anx/depression ? 🙏
Interesting! I thought with your mutation vegetable consumption would be really important?
Well the first twenty minutes so far is about over or under methylation but IDK even know what methylation is.
I think a very important nutrient is vitamin D. The healthiest cultures have the most sun and are the most resilient to illness.
I was in kirkland, WA since this past Monday til Wednesday. Practically no sunlight at all..How do you love here Mike, its as gloomy as London over here lol
It's hard, right? Dark as heck!
How is there still such green grass?? I'm from PA and its not as dark but the grass is dead but its like 20 degrees colder there so makes sense.
Wish you the best Mike, thanks for the awesome content. I love learning from your channel. God bless you and your family. Happy holidays!
If it weren't for endorphins from running and skiing I'd go nuts.
Under methelation is linked to autism...that's so interesting! I wonder in which sequence of genes that would be that leads to autism. Great interview!
SNP Heterozygous MTHFR C677T, if child has it, that means mother/father had it and was passed on. Methyl donors become more important to support lowered methylation ability: folate, b12, choline. Supporting inflammation is what methyl groups do, lower homocysteine etc.
@@brooksreed9609 does everybody who has it is autistic?
Será que tem tradução em português? Preciso muito...obrigada 💪
What happenes to his talk given on bipolar??
so what to do? in case of undermethylation taking sam-e and zinc, and in case of overmethylation taking folate?
Yes basically - but there is a lot more to it than that and a lot of other important supporting supplements he mentions in his book, Nutrient Power.
@@LifeDIY sure, thank you,. you know i'm struggling with histamine intolerance (itchy skin and insomnia) that's why I'm wondering what to do; I received some benefit from methylfolate, that's for sure. but even a single coffee at midday trigger histamine response till midnight.
@@zambrocca have you tested your serum histamine levels? Sorry to hear about your symptoms. When I tested ages ago, I had low histamine but I had symptoms of itching a lot. At that time my thyroid was out of whack though and it might have been related.
@@LifeDIY no I didn't. maybe not so useful as It's like a pulsing histamine. I can be fine for some hours and all of a suddend feeling my skin like swelling, and not necessarily after a meal. but coffee mainly, but also chocolate and olive oil could be a trigger.
Can you share Dr. Welsh’s contact ? Thank you