Musculoskeletal System | Neuromuscular Junction | Sliding Filament Theory: Part 3
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- เผยแพร่เมื่อ 28 ก.ย. 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the neuromuscular junction and go into detail on the sliding filament theory. During part 3 of this series we talk about calcium's effect on the myofilaments, the cross bridge formation, and how that will affect the A bands, I bands, and Z discs. We also talk about the repolarization of the cell, and the movement of calcium back into the sarcoplasmic reticulum. We hope you enjoy this lecture and be sure to support us below!
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This is how all subjects should be taught. Most teachers teach in " pieces" that just leave the students confused .Thank you sir for making this concept very understandable may God bless you .
So true
The man carrying my medical degree👏i really appreciate you man!!!
You deserve a billion thumbs up for each video.
Your hardwork is really appreciated.
You’re the best. Always making hard subjects look easy. Thank you
Such a talented person he was born to be a teacher
this man is awesome....like literally awesome and his explanation makes the things crystal clear. If I still forgot than must be there is some problem with me. He makes the complex things understandable very easily. I want to meet this guy in real someday and want to thank him personally for saving me. I have no enough words to praise his way of teaching. thanku thanku thanku soooo much. Lots of love and keep going.
You've taught that lecture in a very unique way 💜 it's helping me alot.
I like your videos at the start of it
Because ik they are legit the best one
🤷🏻♀️♥️
Ninja nerd has certain red marks all over the body in his previous one i saw 2 in back of his neck and now one on the forearm in this video god bless him with long and healthy life
How can the titin stretch and the I band decrease at the same time? Aren't they linked?
Really excellent teaching I was literally stopped listening physiology classes in our after listening this classes 👏👏⚕
This course is legen..wait for it
DARY
Legendary bro keep it up !!
:D
Amazing Presentation
Underrated video. Thank you very much!
zach murphy sir....best explanation!!
really mindblowing explaination.
Thank you. Love your video!!!!!
Thank you so much😊
before i see the video , i am sure that it will be great , thank you
I really appreciate it
Thank you so much for the fantastic lecture! I have a few questions, if you don't mind. First, how many sarcomere units are present in a single myofibril? I'm wondering because each sarcomere contains a thick filament, and if I were to cut a myofibril, how many thick filaments would I find in the cross section? Additionally, each myofiber contains many myofibrils. How are these myofibrils connected to each other within the myofiber? Finally, is each myofibril connected to the sarcolemma through dystrophin? If so, can the myofibrils in the center of the myofiber also reach the sarcolemma?
doing nice work sir very very great channel for trainers
Loved the video ,great concept🤗🤗thank u very much sir
U r great ✨ , thanks
Respect it 💯💯💯
Super sir
the best
And can u please explain attachment of pattern of elastin and z disc 😢
Amazing
20:00 contractile mechanism
14:27
26:20
36:22
you are so awesome i appreciate :)
41:44
43:31
I am literally enjoying studying tho
0:40
Whats the role of troponin I?
Troponin I binds the troponin complex to the actin filament
I think I will release some Ach into the synaptic cleft to open my ligand gated ion channels to allow Na+ to enter my fiber cells and cause my Ryanodine receptor to open my sarcoplasmic reticulum allowing Ca+ to release and bind to my Troponin- C which changes the shape of Troponin- T causing my tropomyosin to move away from the active site of my actin allowing my myosin to bind to my actin which pulls my thin filaments using power stroke to finally get over one another
Which allows my palm and forearm muscles to contract in a way that moves my finger towards the like button and clicks it...
Hhahahha😃😃🤣🤣😂
👍👍🤣
Legend 😂🤙
O.m.g😂
This power comment
Underrated. Such a great teacher.
indeed
Not anymore
Q 🙏🙏q 🙏😂qq 🙏🙏🙏
No guys ...sir is here because of us ....And we love also very well....
Awesome
I've just contributed to your channel. Hats off for you guys. Amazing lectures. Please keep the excellent work. I hope you have plans for future videos, specially complex subjects like genetics and cancer.
mnhmmnmmnmnmnhmmmnnmnmmnmnmnmmmmnmnmnnmmnmwa.lp ip9h0le7plgmnNnm.nnmnnmmnn.c.
v..
This guy deserves a lot more appreciation. These videos helped me understand a lot more than I could from my teacher or any other TH-cam video.
Oh my God! Best teaching ever of the t and l sarcoplasmic tubules.May God bless this wonderful person for keeping it free
I've been struggling in physiology trying helplessly to understand the material by reading and reading over PowerPoint then I come across your youtube channels and holy crap.... It's the greatest thing since sliced bread. Seriously you are a life savor and I've never found such videos that are so in-depth yet so easy to understand by your illustrations and constant restating what you said. I can't say enough and I hope that thank you will suffice!
The best and most in depth lecture I know.
so sooo helpful! you have no idea how much your videos have helped me in Anatomy and Physiology. THANK YOU!!! your work is greatly appreciated :)
I am so grateful for this channel, my first time round at university TH-cam wasn't a thing, and learning this stuff hurt my brain and I could barely grasp it. Now, thanks to you guys, I can visualize a lot more so my foundations are improved, allowing me to understand concepts with better application. Thank you so, so much!
These myosin heads are like: Ooooh man!
:DDDDD Zach, you are the best !!!! Studying with you is BIG fun and I manage to concentrate the whole time. Wish you were my teacher :'( :(
I am still trying to understand how good this guy is.Indeed you an amazing illustrator,and teacher.Thank you so much for making complex stuff easy like Sunday morning.
Never stop doing what you do ❤
Hey dude, thanks once again. I want to add one thing, that I thought was a bit misleading:
The hydrolization of ATP moves Myosin to an "unconfortable position", since it's the position of high potential energy. Therefore you need energy to reach it.
The powerstroke occurs because this Myosin is moving from the "uncomfortable position" to it's "comfortable position". After the stroke it's NOT in an unconfortable position, it's simply bound to Actin. The position after the stroke is the preferred position of the Myosin head.
Then the detachment occurs just as you said and the cycle continues, as long as there is enough Calcium present to "unblock" the Actin-Binding-site
Must you be a Med student to find this EXTREMELY interesting? I build computers and find these videos overwhelmingly interesting. One thing I would greatly appreciate, though is someone giving me the link to the stuff that is being recapped in the beginning of this video. I feel left out in the cold and shivering (via muscular tissue) will not warm me up this way. :0
Not all heroes wear capes...❤️
next time please start a series on microbiology for medical students...:)...please ...so that we r gonna get benefitted ...:)...please my dear ninja nerd...thnx ..:)
THIS PLAYLIST IS A MOVIE, WHAT A WAY TO EXPLAIN TOPICS, PEAKK
Thanks for the video but Ihave got a question, hope you answer
Q:The z disk is common between two actin filaments I mean that the actins are bound to the z disc from both side , now at the moment of the contraction both actins are trying to slide one another in both sides of z disc, then z disk is going to which actin filaments side
Can anyone plz explain
Phenomenal lecture 👌 👏 🙌 Thank you so much ❤
Dude...your videos are amazing. The other day I was sitting around wondering how the food I eat is converted into kinetic energy, and now after about 18 hours of your channel, I see how it all works from the macro level all the way down to the base chemical reactions. You are doing great work.
Yo deserve more and more than thanks
Yo deserve more and more than thanks
how come you are so damn good at explaining! its so damn clear and its just prints in my brain!
If you were around when I was doing my pharmacology degree 20 years ago I would have gotten a 1st. You really have a gift. Thank you!
Why doesn't the length of I-band increases? I mean the thin filaments in all the adjacent sarcomere have moved forward (inward, towards the M-line) so the distance between them must have increased? Can anyone explain it plz really quick
That’s great video but you didn’t mention voltage gated sodium channel in the first lecture. You mentioned voltage gated calcium channel blast open when inside the cell becomes more positions due to influx of normal sodium channel
I have a doubt If I'm worng Correct me
ATP Binds to myosin so the myosin head get dettached from thin Filament (Actin).
ATP hydrolysised to ADP+ iP When ADP leave the myosin cross bridge gets Power Stroke.
When inorganic Phosphate leave the myosin the head attaches to another Myosin active Site on F-actin
Dude if only my professor explained it like this.... thank you
Greetings from Romania!! Thanks for suck an awesome explination series. I'm passing my finals thanks to this guy...
Im here because of Zagrean
The nicotinic acetylcholine receptor is structurally alpha2, beta, *epsilon*, delta. Gamma is only present in infantile membranes and in denervation states
Nothing to say about your capabilty to explain. Far better than any teacher I saw. Thank you from Bangladesh.
what is the final voltage of synaptic bulb when at the +30 Ca2+ also is rushing in? does it go beyond +30mV?
You're an amazing teacher and I can tell that you're passionate about what you teach. I hope your channel continues to grow and reach broader audiences
Doesn't the inorganic phosphate leave the myosin head as the myosin attaches to the actin and *then* the ADP leaves the myosin head as the myosin head goes through the power stroke? This is how it's presented in the other videos. In this video it says that the Pi leaving the myosin initializes the power stroke.
You are the best 👌 👍
Can u please explain it how can actin actually move ,,if either side of myosin forcing it to move in opposite direction to one another 😢😢😢😢😢😢 net force is zero in context at z disc
What drives the hydrolysis of the ATP in the first place?
I love u Zach ❤
I love you💗💗💗💗💗💗
15:00 sarcomere revision
You are the best person that happened to me❤️. Your lectures are bomb and very detailed and one process leads to another. Wish me luck, my test is coming up🙏🏽
Amazing depth and analysis... thanks. Your mighty clear tutoring has eased my copywriting for a course on fitness, so thanks again.
Amazing!
This is saving my grade in anatomy and physiology! thank you so much!
This man is singlehandedly carrying all our degrees on his back
You are the best
I'm gonna make all my juniors at college subscribe you like i have the authority to do that😆
Best
Very enough!
What's ur name...terrific !! Hats off for all ur vedios...I saw a few of them
❤❤❤❤
Your lectures are undoubtedly the most interesting one's on TH-cam.
I just became a member on your website! Can't wait to dig in !
Bruh.. I really love your explanations.. ❤Tysm
I rellay don't know how to thank you !!
Sir excuses me, i have question please.
.
If answer will be very thankful too you, because i am much more irritated by this.
.
Sir how many ATP will be utilized in the power and recovery stroke of just one cross Bridge or myosin head???????
19:30 - Muscle Contraction
34:57 - Sarcomere
The mature nicotinic acetylcholine receptor at the postsynaptic (muscular) membrane is composed of 5 subunits (two α, and one each of β, δ, and ε subunits).
You have got the best teaching skills .
I like your videos, keep up the great work 🩵
Let's say hypotheticaly, If you block acetylcholinesterase with an inhibitory drug.... Will the muscle fibre contract stronger (lift heavy weight) or it will contract to carry weight for longer period of time? Thanks
Is there a voltage gated channels in the knob ?