Thank you for drawing the ascending loop on the LEFT side, the same side as the glomerulus! Almost no diagrams show it this way (presumably for simplicity's sake?) which makes the concept of a countercurrent exchange so much harder to understand.
this was such a fun journey, your passion for teaching and for science really comes through and inspires me to stay strong during school. Iv been not so lucky with my current professors but i guess you get some good and bad ones. Thanks it helped alot.
Excellent explanation. All the content i’ve seen before ignored the opposite direction of blood flow from the vasa recta and it just didn’t make sense to me. Kidney is indeed a pretty awesome organ. Thank you!
Thankyou so much for this video.... It really helped me understand this 100x better compared to the other 10 videos I watched.... Crystal clear explanation and the diagramatic representation
you're such a amazing 'teach'er really aprecciated for this. like you're not explain stuffs you are LIVING THAT FOR REAL!! so glad to discover your channel. thank u thank u so much
Thank you for all these videos. I'm a medical student currently studying for Step 1 boards and this is GOLD. Thank you for making these concepts easier to understand!
This is the absolute logical and memorable explanation ever. Wow. … The reasoning in this presentation, is the word of God the Almighty… The reason behind the design 👏🏽👏🏽👏🏽💯
I've been looking for videos on this topic to give myself relief understanding this and lastly u saved me ,,,,thank you so much ❤️ ,,,u r saving thousands like me
this is amaing, you explain in a really simple and joyfully way. and you love what you're doing to the extend that makes the listener loves it too! thank you for this amazing explanation :)
YOU ARE A LIFESAVER I AM COPYING YOUR SLIDE ONTO MY NOTES RIGHT NOW. lol Wonderful drawing and explanation!!! I have been looking for a drawing to explain this.Thank YOU THANK YOU!!!!
I watched a video for I guess 15 min and after it was finished I realized I didn't understand anything but after watching yours I finally understood the mechanism and your video was just 5 min ( quality not quantity) thaaanks
Thank you for the explanation and video representation, I have been watching for days other highly yield videos but I did not understand well enough the concept. The other videos did not explain at all the counter-exchange mechanism or did not include the vasa recta with the Loop of Henle and it was until you draw them together and explain the counter exchange that things began to click, this is by far a better representation of what other study programs provide. You blew my mind! Oh and thanks for the real direction that the DCT goes by in juxtaglomerular nephrons, because seeing the classical drawing and reading that DCT contains specialized macula dense cells that interact with the juxtaglomerular cells surrounding the afferent arteriole, the classical drawing made it impossible to imagine putting together the DCT surrounding the afferent cells.
How come the osmotic gradient/difference between the blood and the intersitial fluid isn‘t balanced out by water leaving the blood vessel but instead by the vessel picking up solutes?
is the counter current exchange refers to the opposite flow between (loop of henle and vasa recta) or (the descending and ascending loop of the vasa recta)? If the input and output of vasa recta are the same, what's the point of it?
Hey, this is a really helpful video. On other explanations I've come across, the point is made that actually solutes are left behind (dissolve out of vasa recta on it's way 'back up'), to maintain solute concentration in the medullary insterstitial fluid. You seem to be saying that actually solutes are carried away? Would you be able to clarify that inconsistency?
In the previous video, someone asked this in the comments: Won't the solute be picked up by the vasa recta??? If so, why won't the concentration in the interstitial fluid goes down ?? and the professor herself answered: "Every time a solute particle is picked up by the vasa recta (which it is!)-- the ALH pumps more solute into the interstitial space to replace it. Forever. (VERY GOOD QUESTION. A common source of misconception!)" I feel that this explains it, but in the same time, there is still a big question mark in my head.. it's like there still is something lacking there ..
Hi Wendy, I am a med student and I wanted to know more about the online tutoring programs that you have. I have listened to a few of your videos and have really enjoyed your explanations. What subjects do you teach and up to what level? Thanks
Is this an adequate summary, Professor? - Filtrate in Bowman’s = isotonic to blood. - In ALOH, solute sent out, increasing interstitum osm. - Therefore, H2O moves out of DLOH, decreasing interstitum osm, increasing filtrate osm - As a result, even more solute is sent out of ALOH = positive feedback loop - Vasa recta, w low osm, encounters ALOH, taking solute out of ALOH = increasing blood osm. - Then, vasa recta, now w high osm, encounters DLOH, taking water out = decreasing blood osm.
Yes! I think this is a confusing part. The concentration gradient in the INTERSTITIAL FLUID pulls the solutes/water out of the loop of henle...but then they are picked up by the blood (and this is facilitated by that counter-current flow).
So the blood is actually creating the gradient by picking up the water and dilutes, therefore the filtrate keeps feeding the interstitium. Is that correct?
Kinda. But two important points here are that a) the thin descending limb is permeable to water while the b)ascending limb is impermeable. So as filtrate travels down the limb it loses water due to the osmolarity of the blood in the vasa recta Interstitium by extension. As we head up the thin limb to the thick limb, there is no permeability to water so the filtrate in the tubule remains at a higher concentration than that of the interstitium. At the same time blood flowing in the opposite direction thru the vasa recta is of a lower osmolarity than that in the tubules. This helps to pull sodium ions from the tubule and further concentrate the interstitium and the blood flowing in the opposite direction. This is the basic principle it seems. But the collecting ducts can also affect the power of the counter current
I've watch at least 7 videos on this and after watching yours, I finally get it. THANK YOU, you are an insanely gifted professor.
Thank you for drawing the ascending loop on the LEFT side, the same side as the glomerulus! Almost no diagrams show it this way (presumably for simplicity's sake?) which makes the concept of a countercurrent exchange so much harder to understand.
Spencer Merrick
Yes. It was very helpful. That simple thing cleared many doubts .
Erghhh yeah, im so pissed off
@@nobrainer4771 me to it was confused
Exactly!!! I feel very stress free now, thanks to the diagram ^^
I'm confused because of this :l
this was such a fun journey, your passion for teaching and for science really comes through and inspires me to stay strong during school. Iv been not so lucky with my current professors but i guess you get some good and bad ones. Thanks it helped alot.
You have explained the countercurrent exchanger in an efficient manner...
Excellent explanation. All the content i’ve seen before ignored the opposite direction of blood flow from the vasa recta and it just didn’t make sense to me. Kidney is indeed a pretty awesome organ. Thank you!
SO. GREAT. After reading about kidneys for about 4 days straight this really helped solidify things for me. You are my favourite, Wendy Riggs!
Four years later and your explanation is still helping people! Thank you so much for this video.
7 years as of now
@@dr.dharaneeshpalanivel6469 and 9 years later! Way better than AI, and that's been most helpful this semester!
I've watched a few of these counter current multiplier videos and this is, by far, the most concise and easy to understand one.
You're a gem! I wish my med school professor explained it like this! Thank you!!
This explained a lot better than textbooks ever could thanks!
Wow.. what I struggled with for literally 2 years, a simple anatomical drawing made this very clear... thank you!
Honestly you are the best med lecturer I have ever seen! Thank you soooooooo much for this!!!!!!!!!!!!!!!!
Thank you
You made it sooooo much easier
I can’t thank you enough, this countercurrent was taken so much of my time , but you made it easy
You make it look so easy,.Thank you.everything is clear.
God knows how many hours I spent on my own trying to understand it.lol
Omg. I have tried watching many other youtube videos on this topic but yours is the best! I finally understand it now. Thank you
Thankyou so much for this video.... It really helped me understand this 100x better compared to the other 10 videos I watched.... Crystal clear explanation and the diagramatic representation
I finally passed physiology last semester and I just wanted to thank you because your videos helped me so much!
you're such a amazing 'teach'er really aprecciated for this. like you're not explain stuffs you are LIVING THAT FOR REAL!! so glad to discover your channel. thank u thank u so much
I have been looking for this explanation forever. Best video. Thanks!
THANK YOU THANK YOU THANK YOU! I watched so many other videos that didn't help nearly as much. I also like how excited you are in presenting the info!
I love your enthusiasm when teaching, it makes a video a lot more interesting to watch! Thank you! x
Wow. Amazing how you simplify such a complex mechanism
Thank you for this great explanation, had a hard time understanding all this until i saw this video.
Thank you professor, this is the first time I understand the counter current exchange.
Thank you for all these videos. I'm a medical student currently studying for Step 1 boards and this is GOLD. Thank you for making these concepts easier to understand!
This is the absolute logical and memorable explanation ever. Wow. … The reasoning in this presentation, is the word of God the Almighty… The reason behind the design 👏🏽👏🏽👏🏽💯
I've been looking for videos on this topic to give myself relief understanding this and lastly u saved me ,,,,thank you so much ❤️ ,,,u r saving thousands like me
I love your passion! It makes learning this so much easier and really drives me to understand more!!
usually never comment on videos but this was definitely the most useful video out there! thank you so so much!
Thanks for the diagram, it made 90% of the concept clear!!
That was an amazing diagram which cleared a lot of confusion of mine... Ur are just awsm ma'am ... 💯🔥🔥
this is amaing, you explain in a really simple and joyfully way. and you love what you're doing to the extend that makes the listener loves it too! thank you for this amazing explanation :)
Thank you so much!! Love your teaching style and how you’re smiling while teaching, really makes it more fun to understand:)
YOU ARE AN AMAZING TEACHER!!!!! You made me just as excited and in awe as you were in this video.
Hey Wendy, I love the way you explain! It makes me understand the concept so much better! Thank you
YOU ARE A LIFESAVER I AM COPYING YOUR SLIDE ONTO MY NOTES RIGHT NOW. lol Wonderful drawing and explanation!!! I have been looking for a drawing to explain this.Thank YOU THANK YOU!!!!
You are truly amazing... it's taken me so long to understand this concept and in 5mins you explained clearly.
wendy i love you so much, ur literally saving my grades from dying this semester
You are the best one to explain this difficult subject. Thank YOUU :)
Thank you! I can now move on from trying to understand the countecurrent exchange system after these 7 long years
777777?????
I watched a video for I guess 15 min and after it was finished I realized I didn't understand anything but after watching yours I finally understood the mechanism and your video was just 5 min ( quality not quantity) thaaanks
Ahhh! Sometime I'm not able to be brief-- so I'm glad it worked out this time!
Thank you, easier to grasp in your video then in a textbook illustration.
Excellent explanation on this topic. Really appreciate that you took your time to present this to us. Thank you!!!
Thank u so much for sharing,professor, understanding the mechanism making me cry,these r masterpiece
Ascending limb to the left and vasa recta explaination with the ascending limb has rapped all my previous concepts.
Infact made more complicated
God. You blow my mind, Ma. Thank you very much, Ma😭. I really appreciate this video
Thank you for your great video! I've understood countercurrent exchange perfectly.
Thank you for the explanation and video representation, I have been watching for days other highly yield videos but I did not understand well enough the concept. The other videos did not explain at all the counter-exchange mechanism or did not include the vasa recta with the Loop of Henle and it was until you draw them together and explain the counter exchange that things began to click, this is by far a better representation of what other study programs provide. You blew my mind! Oh and thanks for the real direction that the DCT goes by in juxtaglomerular nephrons, because seeing the classical drawing and reading that DCT contains specialized macula dense cells that interact with the juxtaglomerular cells surrounding the afferent arteriole, the classical drawing made it impossible to imagine putting together the DCT surrounding the afferent cells.
This chapter was one heck of a confusion and I just I understood this with ur videos just watching it once. Thank you so much ❤
you are making my studies so much easier. Thankyou so much
Just looove your passion. So beautifully explained.
Finally I got it!!!!! Thank you!!!!!!😭
May science bless this wonderful woman
How come the osmotic gradient/difference between the blood and the intersitial fluid isn‘t balanced out by water leaving the blood vessel but instead by the vessel picking up solutes?
GOD BLESS AND REWARDS YOU FOR what YOU HAVE done you made it makes sense
This is actually insane ! Not the peeing stuff but YOU who made me like and interested into something I hate at college ! Thanks !
OMG. I finally understand!!! THANK YOU SO MUCH! *-*
The BEST!! Should have more people view your video!!
Just stating the fact!!
finally a decent explanation and a decent visual representation to accompany it!
Finally understood.Thank you so much for such amazing explanation ❤️❤️
is the counter current exchange refers to the opposite flow between (loop of henle and vasa recta) or (the descending and ascending loop of the vasa recta)? If the input and output of vasa recta are the same, what's the point of it?
Thank you for helping me maintain my studying sanity equilibrium.
If the solutes from ascending limb are being picked up by blood, then how is the medullary interstitium gradient created?
Oh my!!! I can't thank you enough!!Thank you! Thank you!
Thank you so much. I apparently didn’t get it till your directional illustration❤
YESSS!!! Thank you SOOOOOO much!! Yeesh! It took me forever to understand! But this makes so much more sense with the way the drawing is set up.
Omg … I actually understand it now .. luv u Wendy ❤️
Hey, this is a really helpful video.
On other explanations I've come across, the point is made that actually solutes are left behind (dissolve out of vasa recta on it's way 'back up'), to maintain solute concentration in the medullary insterstitial fluid.
You seem to be saying that actually solutes are carried away?
Would you be able to clarify that inconsistency?
In the previous video, someone asked this in the comments: Won't the solute be picked up by the vasa recta??? If so, why won't the concentration in the interstitial fluid goes down ??
and the professor herself answered: "Every time a solute particle is picked up by the vasa recta (which it is!)-- the ALH pumps more solute into the interstitial space to replace it. Forever. (VERY GOOD QUESTION. A common source of misconception!)"
I feel that this explains it, but in the same time, there is still a big question mark in my head.. it's like there still is something lacking there ..
You are awesome and make it much easier to understand.
Great explanation! Thanks for taking the time our of your day to explain this tricky concept!
Hi Wendy, I am a med student and I wanted to know more about the online tutoring programs that you have. I have listened to a few of your videos and have really enjoyed your explanations. What subjects do you teach and up to what level? Thanks
Is this an adequate summary, Professor?
- Filtrate in Bowman’s = isotonic to blood.
- In ALOH, solute sent out, increasing interstitum osm.
- Therefore, H2O moves out of DLOH, decreasing interstitum osm, increasing filtrate osm
- As a result, even more solute is sent out of ALOH = positive feedback loop
- Vasa recta, w low osm, encounters ALOH, taking solute out of ALOH = increasing blood osm.
- Then, vasa recta, now w high osm, encounters DLOH, taking water out = decreasing blood osm.
But wouldn't the blood stream just wash away the solutes from the Medullary interstitium?
can you clarify on water leaving the vasa recta in relation to these concentrations?
thank you
I don't know if you look at these comments but I just wanted to say you are awesome.
This is incredible - saving me in my physiology course!!!! THANKS !!!
Wow!! My concept was all messed up but now things make sense... Thank you
you are SO GOOD it makes so much sense now thanks
WooooHOOOO! This stuff is hard!
This is such a good explanantion! Thank you so much!!
ur a QUEEN THANK YOU WENDY
does the blood take water and solutes from the interstitial fluid and not directly from the loop of henle?
Yes! I think this is a confusing part. The concentration gradient in the INTERSTITIAL FLUID pulls the solutes/water out of the loop of henle...but then they are picked up by the blood (and this is facilitated by that counter-current flow).
mam ur so good with ur lectures
This is amazing, the way you explain it!!! Seriously thank you so muchhh!!!
So the blood is actually creating the gradient by picking up the water and dilutes, therefore the filtrate keeps feeding the interstitium. Is that correct?
Solutes***, not dilutes
Kinda. But two important points here are that a) the thin descending limb is permeable to water while the b)ascending limb is impermeable. So as filtrate travels down the limb it loses water due to the osmolarity of the blood in the vasa recta Interstitium by extension. As we head up the thin limb to the thick limb, there is no permeability to water so the filtrate in the tubule remains at a higher concentration than that of the interstitium. At the same time blood flowing in the opposite direction thru the vasa recta is of a lower osmolarity than that in the tubules. This helps to pull sodium ions from the tubule and further concentrate the interstitium and the blood flowing in the opposite direction. This is the basic principle it seems. But the collecting ducts can also affect the power of the counter current
Best explanation on this topic .Thnak u mam.
Thank you so much!!!! Your video explained this concept so well, I now understand it.
Lots of respect and love to you..
love your lectures
Best lecture.THANKYOU SO MUCH
You just saved my damn Renal Unit Exam, Glod bless yaaa
but if we absorb the sels in the blood we won't have the cortico medullary gradient in the interstitium
Very true-- and we can maintain the gradient because we also reabsorb WATER into the blood. Whew!
Lol your so funny
You get so excited when you explain the material
Bless this woman
thanksss mam...I loved how u teach with beautiful smile on
Thanks for diagram.finally I understood counter current mechanism
Solutes like what NaCl?
I have an exam tomorrow on this stuff so THANK YOU SO MUCH!!!
Your are a BOSS! Thank you.
You are an angel - thank you!
you missed the part where vasa recta lets out the solutes into the interstitial fluid